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Acta Pharmaceutica Sinica B 2023年第1期13卷 1-28页

作者： Solène Marie kayla L.Frost Raymond k.Hau Lucy Martinez-Guerrero Jailyn M.Izu Cassandra M.myers Stephen H.Wright Nathan J.Cherrington College of Pharmacy Department of Pharmacology&ToxicologyUniversity of ArizonaTucsonAZ 85721USA College of Medicine Department of PhysiologyUniversity of ArizonaTucsonAZ 85724USA

The liver plays a central role in the pharmacokinetics of drugs through drug metabolizing enzymes and ***-alcoholic steatohepatitis(NASH)causes disease-specific alterations to the absorption,distribution,metabolism,and excretion(ADME)processes,including a decrease in protein expression of basolateral uptake transporters,an increase in efflux transporters,and modifications to enzyme *** can result in increased drug exposure and adverse drug reactions(ADRs).Our goal was to predict drugs that pose increased risks for ADRs in NASH *** research identified 71 drugs with reported ADRs in patients with liver disease,mainly non-alcoholic fatty liver disease(NAFLD),54 of which are known substrates of transporters and/or metabolizing *** NASH is the progressive form of NAFLD but is most frequently undiagnosed,we identified other drugs at risk based on NASH-specific alterations to ADME ***,we present another list of 71 drugs at risk of pharmacokinetic disruption in NASH,based on their transport and/or metabolism *** encompasses drugs from various pharmacological classes for which ADRs may occur when used in NASH patients,especially when eliminated through multiple pathways altered by the ***,these results may inform clinicians regarding the selection of drugs for use in NASH patients.

关键词： Non-alcoholic steatohepatitis Hepatic elimination Transporter Enzyme Pharmacokinetics Drug-drug interaction Liver Adverse drug reaction

Evaluation of the Validity of the Ratsnake Subspecies Elaphe carinata deqenensis(Serpent:Colubridae)

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Asian Herpetological Research 2012年第3期3卷 219-226页

作者： Peng GUO Qin LIU Edward A.myers Shaoying LIU Yan XU Yang LIU Yuezhao WANG College of Life Sciences and Food Engineering Yibin University Department of Biology Graduate School and University CenterCity University of New York Department of Biology College of Staten IslandCity University of New York Sichuan Academy of Forestry Chengdu University of Technology Chengdu Institute of Biology Chinese Academy of Sciences

Based on morphological character comparisons and molecular phylogenetic reconstruction, we assessed the validity of the ratsnake subspecies Elaphe carinata deqenensis. Phylogenetic relationships inferred from fragments of two mitochondrial genes(ND2 and ND4) and one nuclear gene(c-mos) revealed a well-supported and minimally divergent sister relationship between putative E. c. deqenensis and E. c. carinata. Morphological comparisons indicated that all diagnostic characters proposed in the original description of E. c. deqenensis are unable to separate this taxon from E. c. carinata. On the basis of these preliminary investigations, we provisionally suggest that E. c. deqenensis is not a valid subspecies, and should henceforth be treated as a synonym of E. c. carinata.

关键词： snake Colubrinae morphology hemipenis molecular phylogeny Hengduan Mountains

Does Resisted Sled Towing Improve the Physical Qualities of Elite Youth Soccer Players of Differing Maturity Status?

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Journal of Science in Sport and Exercise 2021年第1期3卷 75-87页

作者： Rhys Morris Tony myers Stacey Emmonds Dave Singleton kevin Till School of Life Sciences Coventry UniversityCoventryUK Sport Exercise and Health Research CenterNewman University BirminghamBirminghamUK Carnegie School of Sport Leeds Beckett UniversityLeedsUK Birmingham City Football Club BirminghamUK Leeds Rhinos RLFC LeedsUK

Purpose Sled towing has been shown to be an effective method to enhance the physical qualities in youth *** aim of this study was to evaluate the impact of a 6-week sled towing intervention on muscular strength,speed and power in elite youth soccer players of differing maturity *** Seventy-three male elite youth soccer players aged 12-18 years(Pre-Peak Height Velocity[PHV]n = 25;Circa-PHV n = 24;Post-PHV n = 24)from one professional soccer academy participated in this *** assessments(10 m and 30 m),countermovement jump and isometric mid-thigh pull were undertaken before(T1)and after(T2)a 6-week *** training intervention consisted of 6 weeks(2xper week,10 sprints over 20 m distance)of resisted sled towing(linear progression 10%-30%of body mass)during the competitive *** regression models analysed differences between T1 and T2 within each maturity *** There were minimal changes in strength,speed and power(P=0.35-0.80)for each maturity group across the 6-week *** there were changes with greater certainty,they are unlikely to represent real effect due to higher regres-sion to the mean(RTM).Conclusion It appears that a 6-week sled towing training programme with loadings of 10%-30%body mass only maintains physical qualities in elite youth soccer players pre-,circa-,and *** research is required to determine the effectiveness of this training method in long-term athletic development programmes.

关键词： Youth development Long-term athletic development Maturation Strength Speed IMTP

PERIOPERATIVE STROkE AFTER CAROTID ENDARTERECTOMY ETIOLOGICAL RISk FACTORS AND MANAGEMENT

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Chinese Medical Journal 1994年第6期 62-65页

作者：叶建荣 k.A.myers D.F.Scott T.J.Devine C.Flanc

291 patients were subjected to carotid endarterectomy from January 1985 to June 1992 in two Australian medical institutions. Of the 291 patients, perioperative stroke occurred in 22 (6.3%) after 347 operations (moderate 17 and severe 5). The 22 patients were studied with Doppler scan, angiography, reexploration and CT. Reexploration showed that 12 of 14 patients had thrombosis in the internal carotid artery at operation. The etiological factors for perioperative strokes included thrombosis at the operative sites in 14 patients (64%), cerebral embolism after operation in 4, clamping ischemia in 2, intracerebral hemorrhage in 1 and unknown cause in 1. Six patients (27%) recovered completely in 4 weeks, 10 (45%) had mild residual neurological deficits, 5 (23%) had moderate neurological deficits and 1 died 3 days after operation. Only 6 patients had permanent neurological deficits (6 / 347, 17%).

关键词： In PERIOPERATIVE STROkE AFTER CAROTID ENDARTERECTOMY ETIOLOGICAL RISk FACTORS AND MANAGEMENT

The Relationship Equation & Relationship Circle. The Importance of Reciprocal Interaction in Functional Relationships, Role of Context & the “Happinewness” key.

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Sociology Study 2021年第4期11卷 154-164页

作者： Yaacov myers Independent scholar MelbourneAustralia.

Truly opposite is defined by identity of units with complementary anatomy or structure to form a pair,*** and *** or corresponding structure or form permits reciprocal function of these units or“opposites”.Focus on“Identity”or“function”determines one’s view as to whether these units are“opposites”or“complementary”.“Identity”is unique&exclusive,whereas,function requires inclusivity,specificity&reciprocal interaction,contributed to by both units to form a dynamic partnership or *** interaction matters as it permits an inclusive ***&awareness of surroundings that impact on relationships and/or personal interaction is represented here by a surrounding circle or sense of purpose and represents the extension of immediate context involving both units in a paired relationship of structural complementary units within their encompassing surroundings or contextual *** reference is the ethical key to understanding situations&circumstance so serves as the key to ethics,morality&*** Relationship Equation,E=1=m.c-1,provides a simple model of understanding usually viewed as complex *** offers an approach to solving identity issues by viewing these as complementary and functional rather than as *** place of identity as the focus it introduces context and reciprocal interaction of complementary units of a *** as part of a whole transfers the focus from self to other or both and to an awareness of higher purpose in the Oneness of function of Creation as(m.c-1)=E=*** influence is taken into account by viewing the Eco-social environment or Eco-society as *** of environment on one or other unit in a pair or on both&vice versa affects ***&adaptation to environmental change leads to evolution when the pair thrives better in this new Eco-social *** part of a functional whole,as a functional unit or as a functioning pair,adds purp

关键词： relationships the Relationship Equation&Relationship Circle health&wellbeing parenting higher purpose G-dliness is connection&awareness reciprocal interaction function conflict resolution context opportunity&time the“Happinewness”key

Medical Ethics: Context Is the key Word

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International Journal of Clinical Medicine 2014年第16期5卷 1030-1045页

作者： John myers Wellspring’s Universal Environment P/L Melbourne Australia

Medical Ethics is no different to Ethics, but relates specifically to the doctor-patient relationship. This relationship is based on mutual trust—trust in the doctor’s expertise and knowledge and trust that the patient is consulting the doctor, for his/her/their own health, wellbeing and welfare, without agenda or bias. In other words, the basis of the doctor-patient relationship is one of mutual trust and confidence. Thus, what is imparted between them is held in the strictest confidence. The doctor must act within the law. No third party influence can be brought to bear on this relationship without the patient’s consent. In the case of minors the relationship is between the child’s guardians as well as the doctor who must act within the law. In the category of “elderly” or adult guardianship or advocacy, those appointed and in positions of trust must take the person’s wishes into account if the patient has capacity to make decisions or has indicated their wish prior to any such appointment. Capacity is defined as consistent belief or wish, awareness of what one does not wish for, satisfaction when wishes are respected and fulfilled and the opposite when they are not. Ethical practice is determined by taking context into account in decision-making and ensuring the sanctity of the patient’s rights and wishes. Abuse is just the opposite, where actions taken or not taken are against a person’s wishes. Personal wish determines best interest. Best interest may also be defined in terms of social functioning and psychological wellbeing. Discussion of ethics in terms of General Systems Theory is also addressed, and affects an action on the environment or others, i.e. ethics in the wider medical context may pertain if the person has a contagious disease and a period of quarantine or “isolation” or barrier” nursing is required, and where precedent is given to society’s best interest over the person’s wishes, as part of an educational process and as required for strategic dis

关键词： Medical Ethics and Context Rights Behaviour and Abuse

Computed X-ray Tomography Investigation of Porosity and Permeability of the Liujiagou Formation Sandstone Exposed to CO_(2)-Saturated Brine

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Acta Geologica Sinica(English Edition) 2023年第3期97卷 946-955页

作者： XUE Quan ZHANG Liwei XU Liang Matthew myers Cameron WHITE MEI kaiyuan WANG Hanwen LI Qi LI Xiaochun State key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhan 430071China University of Chinese Academy of Sciences Beijing 100049China CSIRO Energy Australian Resources Research CentreKensingtonWestern Australia 6151Australia School of New Energy and Materials Southwest Petroleum UniversityChengdu 610500China

In order to improve CO_(2) capture,utilization and storage(CCUS) to solve carbon emission,sandstone from the Triassic Liujiagou Formation(LF) from the Ordos Basin in China was investigated using permeability tests and computed X-ray tomography(CT) *** presence of reactive minerals within the geological CO_(2) sequestration target storage formation can allow reaction with injected CO_(2),which changes the porosity and permeability of the LF beds,affecting storage *** investigate the effect of chemical reactions on the pore structure and permeability of sandstone cores representing the LF CO_(2) storage,tests were conducted to analyze the changes in porosity and permeability of sandstone cores induced by CO_(2)-saturated brine at different reaction times(28-day maximum reaction period).Porosity and permeability of the sandstone increased after reaction with CO_(2)-saturated brine due to mineral *** sandstone exhibited an increase in porosity and permeability after 15 days of reaction with CO_(2)-saturated ***,there was an increase in the volume of large pores in the sandstone after the 28-day *** pore network of the sandstone was established through CT results,and the porosity calculated based on the obtained pore network was close to that measured in the test,demonstrating the feasibility to use CT to study the evolution of the microstructure of sandstone after long-time exposure to CO_(2)-saturated brine.

关键词： CO_(2)capture-utilization-storage Triassic sandstone permeability porosity Ordos Basin

Molecular Phylogeny of the Genus Gloydius(Serpentes: Crotalinae)

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Asian Herpetological Research 2012年第2期3卷 127-132页

作者： Yan XU Qin LIU Edward A myers Lian WANG Song HUANG Yun HE Peihao PENG Peng GUO College of Tourism and Urban-Rural Planning Chengdu University of Technology College of Life Sciences and Food Engineering Yibin University College of Staten Island Department of Biology 6S-143 2800 Victory Blvd.Staten IslandNY 10314 United States City University of New York Graduate Center 365 Fifth AvenueNew YorkNY 10016-4309 United States College of Life and Environment Sciences Huangshan University

Based on two mitochondrial genes (cyt b, ND4) and one nuclear gene (c-mos), we explored the relationships within the Asian pit viper genus Gloydius. In total, 23 samples representing 10 species were analyzed. All phylogenetic analyses support a monophyletic Gloydius with two major clades, one comprising G. brevicaudus, G. blomhoffii, and G. ussuriensis with the sister clade consisting of G. intermedius, G. saxatilis, G. halys and G. shedaoensis. The relationships among the three montane species G. strauchi, G. qinlingensis and G. liupanensis, as well as the two monophyletic groups, are unstable, and discussed. Divergence date estimation indicates that Gloydius lineage formed 15 Ma and diversification of the genus occurred at 9.89 Ma. Issues regarding the taxonomy of this genus are discussed where necessary.

关键词： molecular phylogenetics venomous snake pit viper mtDNA nDNA

Using Films as a Learning Tool

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语数外学习(高中版高三年级) 2007年第10期 44-46页

作者： Travis myers

Most people would agree that watching movies is one of their favorite free-time activities. We often think of movies as fun entertainment, but

关键词： Using Films as a Learning Tool

Design and analysis of a novel dual source vapor injection heat pump using exhaust and ambient air

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能源与人工环境(英文) 2022年第1期3卷 95-104页

作者： Jing Li Yi Fan Xudong Zhao Xiaoman Bai Jinzhi Zhou Ali Badiei Steve myers Xiaoli Ma Research Centre for Sustainable Energy Technologies University of HullHull HU67RXUK Environment Design Centre School of Art and MediumHefei Normal UniversityHefei 230601China School of Mechanical Engineering Southwest Jiaotong UniversityChengduSichuanPR China

A novel dual source vapor injection heat pump(DSVIHP)using exhaust and ambient air is *** air exhausted from the building first releases energy to the medium-pressure evaporator and is then mixed with the ambient air to heat the low-pressure evaporator.A vapor injection(VI)compressor of two inlets is connected with the low and medium pressure ***’s first time that a VI compressor is employed to recover the ventilation *** system can minimize the ventilation heat loss and provide a unique defrosting approach by using the exhaust waste *** of the proposed DSVIHP are *** models are *** energetic and exergetic analyses are carried out under variable *** results indicate that the DSVIHP has superior thermodynamic *** superiority is more appreciable at a lower ambient *** has a higher COP than the conventional vapor injection heat pump and air source heat pump by 11.3%and 23.2%respectively at an ambient temperature of-10°C and condensation temperature of 45°*** waste heat recovery ratio from the exhaust air is more than 100%.The novel DSVIHP has great potential in the cold climate area application.

关键词： Dual source vapor injection heat pump Exhaust air Waste heat recovery COP Defrosting