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Effect of molybdenum on interfacial properties of titanium carbide reinforced Fe composite

Journal of Materials Science & Technology 2022年第12期107卷 252-258页

作者： Seungchan cho Junghwan Kim Ilguk Jo Jae Hyun Park Jaekwang Lee Hyun-Uk Hong Bong Ho Lee wook Ryol Hwang Dong-woo Suh Sang-Kwan Lee Sang-Bok Lee Composites Research Division Korea Institute of Materials Science(KIMS)Changwon 51508South Korea Advanced Materials Engineering Dong-Eui UniversityBusan 47340South Korea Department of Aerospace and Software Engineering Gyeongsang National UniversityJinju 52828South Korea Department of Physics Pusan National UniversityBusan 46241South Korea Department of Materials Convergence and System Engineering Changwon National UniversityChangwon 51140South Korea Center for Core Research Facilities Daegu Gyeongbuk Institute of Science and TechnologyDaegu 42988South Korea School of Mechanical Engineering Gyeongsang National UniversityJinju 52828South Korea Graduate Institute of Ferrous Technology Pohang University of Science and TechnologyGyeongbuk 37673South Korea

This study shows that the mechanical strength of the composite of Fe matrix and titanium carbide(Ti C)ceramic particles is significantly enhanced with addition of molybdenum(Mo) atoms. Ti C reinforced Fe(Fe-0.2C-7Mn) composites with and without Mo were fabricated by a liquid pressing infiltration(LPI)process and the effect of Mo on interfacial properties of TiC–Fe composite was investigated using atomic probe tomography(APT) analysis, molecular dynamics(MD) simulations, first-principle density functional theory(DFT), and thermodynamic calculations. First, DFT calculations showed that total energies of the Mo-doped Ti C–Fe superlattices strongly depend on the position of Mo defects, and are minimized when the Mo atom is located at the TiC/Fe interface, supporting the probable formation of MoC-like interphase at the TiC/Fe interface region. Then, APT analysis confirmed the DFT predictions by finding that about6.5 wt.% Mo is incorporated in the Ti C–Fe(Mo) composite and that sub-micrometer thick(Ti,Mo)C interphase is indeed formed near the interface. The MD simulations show that Mo atoms migrate to the Mo-free TiC–Fe interface at elevated temperatures and the mechanical strength of the interface is considerably enhanced, which is in good agreement with experimental observations.

关键词： Metal matrix composites(MMCs) Titanium carbide Fe matrix composite Infiltration Molybdenum Interfacial property

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Effects of pulsed radiofrequency on spasticity in patients with spinal cord injury:a report of two cases

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Neural Regeneration Research 2017年第6期12卷 977-980页

作者： Min Cheol Chang Yun woo cho Department of Physical Medicine and Rehabilitation College of Medicine Yeungnam University

Spasticity following spinal cord injury（SCI） results in functional deterioration and reduced quality of life. Herein, we report two SCI patients who presented with good response to pulsed radiofrequency（PRF） for the management of spasticity in the lower extremities. Patient 1（a 47-year-old man） had complete thoracic cord injury and showed a phasic spasticity on the extensor of both knees（3–4 beats clonus per every 30 seconds） and tonic spasticity（Modified Ashworth Scale： 3） on both hip adductors. Patient 2（a 64-yearold man） had incomplete cervical cord injury and showed a right ankle clonus（approximately 20 beats） when he walked. After the application of PRF to both L2 and L3 dorsal root ganglion（DRG）（patient 1） and right S1 DRG（patient 2） with 5 Hz and 5 ms pulsed width for 360 seconds at 45 V under the C-arm guide, all spasticity disappeared or was reduced. Moreover, the effects of PRF were sustained for approximately 6 months with no side effects. We believe that PRF treatment can be useful for patients with spasticity after SCI.

关键词： radiofrequency thoracic tonic pulsed sustained seconds incomplete deterioration dorsal stimulation

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Phytogenic feed additives alleviate pathogenic Escherichia coli-induced intestinal damage through improving barrier integrity and inhibiting inflammation in weaned pigs

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Journal of Animal Science and Biotechnology 2023年第1期14卷 295-306页

作者： Se Yeon Chang Min Ho Song Ji Hwan Lee Han Jin Oh Yong Ju Kim Jae woo An Young Bin Go Dong Cheol Song Hyun Ahcho Seung Yeol cho Dong Jun Kim Mi Suk Kim Hyeun Bum Kim Jin Ho cho Department of Animal Science Chungbuk National UniversityCheongju 28644South Korea. Division of Animal and Dairy Science Chungnam National UniversityDaejeon 34134South Korea. Eugene-Bio Suwon 16675South Korea. Department of Animal Resources Science Dankook UniversityCheonan 31116South Korea.

Background:This study was conducted to investigate the effects of each phytogenic feed additive(PFA;PFA1,bitter citrus extract;PFA2,a microencapsulated blend of thymol and carvacrol;PFA3,a mixture of bitter citrus extract,thymol,and carvacrol;PFA4,a premixture of grape seed,grape marc extract,green tea,and hops;PFA5,fenugreek seed powder)on the growth performance,nutrient digestibility,intestinal morphology,and immune response in weaned pigs infected with Escherichia coli(***).Results:A total of 634-week-old weaned pigs were placed in individual metabolic cages and assigned to seven treatment *** seven treatments were as follows:1)NC;basal diet without *** challenge,2)PC;basal diet with *** challenge,3)T1;PC+0.04%PFA1,4)T2;PC+0.01%PFA2,5)T3;PC+0.10%PFA3,6)T4;PC+0.04%PFA4,7)T5;PC+0.10%*** experiments lasted in 21 d,including 7 d before and 14 d after the first *** *** the *** challenge treatments,all pigs were orally inoculated by dividing a total of 10 mL of *** F18 for 3 consecutive *** PFA-added groups significantly increased(P<0.05)average daily gain and feed efficiency and decreased(P<0.05)the fecal score at d 0 to 14 post-inoculation(PI).Tumor necrosis factorαwas significantly lower(P<0.05)in the PFA-added groups except for T1 in d 14 PI compared to the PC *** T3 had a higher(P<0.05)immunoglobulin G and immunoglobulin A concentration compared to the PC treatment at d 7 ***,T3 showed significantly higher(P<0.05)villus height:crypt depth and claudin 1 expression in ileal mucosa,and significantly downregulated(P<0.05)the expression of calprotectin compared to the PC ***:Supplementation of PFA in weaned pigs challenged with *** alleviated the negative effects of *** and improved growth *** them,the mixed additive of bitter citrus extract,thymol,and carvacrol showed the most effective results,improving immune response,intestinal morphology,and expression of tight junction

关键词： Barrier integrity Escherichia coli Immunity Phytogenic feed additive Post-weaning diarrhea Weaned pigs

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A novel IRAK4/PIM1 inhibitor ameliorates rheumatoid arthritis and lymphoid malignancy by blocking the TLR/MYD88-mediated NF-κB pathway

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Acta Pharmaceutica Sinica B 2023年第3期13卷 1093-1109页

作者： Sae-Bom Yoon Hyowon Hong Hee-Jong Lim Ji Hye choi Yoon Pyo choi Seong wook Seo Hyuk woo Lee chong Hak Chae woo-Kyu Park Hyun Young Kim Daeyoung Jeong Tran Quang De Chang-Seon Myung Heeyeong cho Therapeutics&Biotechnology Division Korea Research Institute of Chemical TechnologyYuseong-guDaejeon 34114Republic of Korea Department of Pharmacology Chungnam National University College of PharmacyYuseong-guDaejeon 34134Republic of Korea Future Medicine Co. Ltd.Rm616 LH-Business Growth CenterSeongnamGyeonggido 13449Republic of Korea Department of Chemistry College of Natural SciencesCan Tho UniversityCan Tho city 9000Viet Nam

Interleukin-1 receptor-associated kinase 4(IRAK4)is a pivotal enzyme in the Toll-like receptor(TLR)/MYD88 dependent signaling pathway,which is highly activated in rheumatoid arthritis tissues and activated B cell-like diffuse large B-cell lymphoma(ABC-DLBCL).Inflammatory responses followed by IRAK4 activation promote B-cell proliferation and aggressiveness of ***,proviral integration site for Moloney murine leukemia virus 1(PIM1)functions as an anti-apoptotic kinase in propagation of ABC-DLBCL with ibrutinib *** developed a dual IRAK4/PIM1 inhibitor KIC-0101 that potently suppresses the NF-κB pathway and proinflammatory cytokine induction in vitro and in *** rheumatoid arthritis mouse models,treatment with KIC-0101 significantly ameliorated cartilage damage and ***-0101 inhibited the nuclear translocation of NF-κB and activation of JAK/STAT pathway in *** addition,KIC-0101 exhibited an anti-tumor effect on ibrutinib-resistant cells by synergistic dual suppression of TLR/MYD88-mediated NF-κB pathway and PIM1 *** results suggest that KIC-0101 is a promising drug candidate for autoimmune diseases and ibrutinib-resistant B-cell lymphomas.

关键词： Drug discovery IRAK4 PIM1 NF-κB pathway Rheumatoid arthritis ABC-DLBCL Ibrutinib resistance Dual inhibitor

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Gamichunggan汤对高血脂的作用

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Acta Pharmacologica Sinica 2003年第2期24卷 133-139页

作者： SON Chang-Gue choI woo-Jin SHIN Jang-woo HAN Seung-Hyun cho Jung-Hyo SONG Kee-Cheol cho chong-Kwan Department of Internal Medicine College of Oriental Medicine Daejeon University Daejeon 301-724 Korea Department of Internal Medicine College of Oriental Medicine Daejeon University Daejeon 301-724 Korea nstitute of Traditional Medicine and Bioscience Daejeon University Daejeon 301-724 Korea International Vaccin Institute Seoul University Seoul Korea Department of Internal Medicine College of Oriental Medicine Daejeon University Daejeon 301-724 Korea Department of Internal Medicine College of Oriental Medicine Daejeon University Daejeon 301-724 Korea

AIM: To evaluate the therapeutic effects of Gamichunggantang (GCT) on hyperlipidemia through high cholesterol diet model. GCT is an Oriental herbal medication, which has been used for-the treatment of fatty liver, hyperlipidemia or alcoholic liver disease in Daejeon University Oriental Hospital, Korea since 1999. METHODS: Rats were fed with high cholesterol diet for 4 weeks and GCT was administrated for 2 weeks from 2 weeks later in expermental days. The levels of serum total cholesterol, HDL-cholesterol, and triglyceride were analyzed every week. Absolute and relative liver weight to body, and histophathological changes were determined at last day. And, lipid metabolism-related gene expressions (ACAT and DGAT) in liver tissue were analyzed by using RT-PCR. RESULTS:In GCT group, TG levels were reduced at 3 and 4 weeks after GCT administration (39.4%, Pcholesterol levels also were reduced at 3 weeks (20.5%, Pcholesterol levels were increased significantly (Pcholesterol.

关键词：高脂血症甘油三酯胆甾醇 O-酰基转移酶甾醇

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A conformal titanyl phosphate amorphous overlayer for enhancing photoelectrochemical hydrogen peroxide production

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Journal of Energy Chemistry 2023年第11期86卷 399-408,I0009页

作者： Jaekyum Kim Young Eun Kim Minyeong Je Won Tae Hong Chang-Lyoul Lee Tae-Hoon Kim Sung Min cho Chang Hyuck choi Heechae choi woo-Seok choe Jung Kyu Kim School of Chemical Engineering Sungkyunkwan University(SKKU)Suwon 16419Republic of Korea SKKU Advanced Institute of Nano Technology(SAINT) Sungkyunkwan University(SKKU)Suwon 16419Republic of Korea Theoretical Materials&Chemistry Group Institute of Inorganic ChemistryUniversity of CologneGreinstr.650939CologneGermany Advanced Photonics Research Institute(APRI) Gwangju Institute of Science and Technology(GIST)Gwangju 61005Republic of Korea Department of Materials Science and Engineering Chonnam National UniversityGwangju 61186Republic of Korea Department of Chemistry Pohang University of Science and Technology(POSTECH)Pohang 37673Republic of Korea Institute for Convergence Research and Education in Advanced Technology(I-CREATE) Yonsei UniversitySeoul 03722Republic of Korea Department of Chemistry Xi’an Jiaotong-Liverpool UniversitySuzhou 215123JiangsuChina

Photoelectrochemical(PEC)H_(2)O_(2)production through water oxidation reaction(WOR)is a promising strategy,however,designing highly efficient and selective photoanode materials remains challenging due to competitive reaction ***,for highly enhanced PEC H_(2)O_(2)production,we present a conformal amorphous titanyl phosphate(a-TP)overlayer on nanoparticulate TiO_(2)surfaces,achieved via lysozyme-molded in-situ surface *** a-TP overlayer modulates surface adsorption energies for reaction intermediates,favoring WOR for H_(2)O_(2)production over the competing O_(2)evolution *** density functional theory calculations reveal that a-TP/TiO_(2)exhibits a substantial energy uphill for the O·*formation pathway,which disfavors O_(2)evolution but promotes H_(2)O_(2)***,the a-TP overlayer strengthens the built-in electric field,resulting in favorable ***,a-TP/TiO_(2)exhibits 3.7-fold higher Faraday efficiency(FE)of 63%at 1.76 V *** hydrogen electrode(RHE)under 1 sun illumination,compared to bare TiO_(2)(17%),representing the highest FE among TiO_(2)-based WOR H_(2)O_(2)production *** the a-TP overlayer constitutes a promising strategy for controlling reaction pathways and achieving efficient solar-to-chemical energy conversion.

关键词： Solar H_(2)O_(2) production In-situ surface reforming Titanyl phosphate Amorphous overlayer Reaction pathway control

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Stress-induced cardiomyopathy with electrocardiographic ST-segment elevation in a patient with pneumothorax

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World Journal of Emergency Medicine 2020年第4期11卷 260-262页

作者： Jun woo cho Chi Hoon Bae Department of Thoracic and Cardiovascular Surgery School of MedicineCatholic University of DaeguDaeguRepublic of Korea

Dear editor,In many cases,S T-segment changes on electrocardiogram(ECG)are suggestive of acute coronary syndrome,but there may be other causes,[12]such as stress induced ***,reports of such changes in patients with pneumothorax are very rare.[3-1]Here,we report a case of ST-segment elevation due to stress-induced cardiomyopathy in a patient with pneumothorax.

关键词： cardiomyopathy acute patient

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Effects of Ag Seed on Synthesis of FeCo Nano-Particles Prepared via the Polyol Method

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Journal of Materials Science & Technology 2010年第7期26卷 660-664页

作者： Uk-Rae cho Geun-woo Kim Bon-Heun Koo School of Nano and Advanced Materials Engineering Changwon National UniversityChangwonGyeongnam641-773Korea

Nano-particles have several interesting properties which are not shown in bulk materials because of their high ratio of surface area to volume. FeCo alloy nano-particles with soft magnetic properties are demanded for various applications such as optics, eletronics and magnetics. Through the polyol method, highly purified particles with mono-dispersibility in various sizes can be produced and used as high-tech functional materials. In this study, the magnetic characteristics of FeCo alloy with Ag seed added in the production process of mono-dispersed nano-particles through the polyol method were investigated.

关键词： Polyol method FeCo Ag Seed

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Beach stabilization by the laying of a drainage layer

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Science China(Technological Sciences) 2012年第9期55卷 2625-2639页

作者： HUR Dong-Soo LEE woo-Dong cho Won-Chul Department of Ocean Civil Engineering(Institute of Marine Industry) Gyeongsang National University445 Inpyeong-dongTongyeong 650-160Korea Department of Ocean Civil Engineering Gyeongsang National University445 Inpyeong-dongTongyeong 650-160Korea Department of Civil and Environmental Engineering Chung-Ang University221 Heuksuk-dong Dongjak-guSeoul 156-756Korea

In the present study,the stabilization effects of the laying of a drainage layer in a sandy beach were *** numerical model developed by Hur et al.(2011) was used to examine the characteristics of wave-sandy beach interaction with/without a drainage *** numerical model directly simulates Wave-Structure-Seabed/Sandy(WASS) beach interaction by considering flow through a porous medium with inertia,laminar and turbulent resistances,and determines the eddy viscosity with the Large Eddy Simulation(LES) turbulent model in a 3-D wave field(LES-WASS-3D).Based on the numerical results,it appears that the installation of a drainage layer in the beach results in a decrease in both the mean groundwater level around the foreshore and the flow moving offshore on the beach *** distributions of the mean groundwater level and wave setup around the foreshore with various arrangements of the drainage layer and conditions of the incident wave are also discussed in this paper.

关键词：排水层海滩铺设稳定数值模型湍流模型地下水位多孔介质

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An Evaluation of the Machinability of Nitinol SMA Using Combined Process of EP and MR Polishing

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Journal of Iron and Steel Research(International) 2012年第S2期19卷 629-632页

作者： HA Seok-Jae SHIN Bong-Cheol cho myeong-woo LEE Eun-Sang choI Seung-Bok Department of Mechanical Engineering Inha University Samsung Electro-Mechanics

Nitinol,a shape memory alloy(SMA),is manufactured from titanium and *** is employed in various fields for use in devices such as micro sensors,ultra-precision devices and satellite *** is highly recommended as a material in medical stents for insertion into the body because it has excellent organic ***,because they are intended to be inserted into the human body,products such as medical stents require a high-quality *** nitinol has more of the characteristics of titanium than of nickel,one of its drawbacks is that heat generated in nitinol during machining is not discharged smoothly,leading to areas of inner stress which occur when traditional machining methods are *** overcome this difficulty,various non-traditional machining methods,including non-contact machining,have been investigated for use with *** study is focused on the application of an effective fabrication method that combines electrolytic polishing(EP)and MR polishing to improve the surface integrity of nitinol through a series of *** roughness variations of the polished nitinol were investigated by changing the imposed polishing conditions of EP and MR polishing,***,the variations in the surface roughness were observed with polished previously performed via the EP process.

关键词： electrolytic polishing(EP) magnetorheological(MR)fluids Ni-Ti alloy shape memory alloy(SMA) surface roughness

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