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Sarcopenia is associated with Framingham risk score in the Korean population： Korean National Health and Nutrition Examination Survey （KNHANES） 2010-2011

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Journal of Geriatric Cardiology 2015年第4期12卷 366-372页

作者： Chae-Hwa byeon Kee-Young Kang Se-Hun Kang Eun-Jin Bae Department of Family Medicine DaeDong Hospital Myeongnyun-dong Dongnae-gu Busan South Korea

Background Sarcopenia is a risk factor for metabolic disorders and cardiovascular disease, but the association between sarcopenia and cardiovascular risk factors according to age and obesity status in the general population remains unknown. We thus investigated these associations in the Korean population. Methods We included 8,958 and 8,518 subjects from the fifth Korean National Health and Nutrition Examination Survey （KNHANES）（from 2010 and 2011, respectively）. The study was restricted to participants 〉 20 years old who had completed the health examination survey, including whole body dual-energy X-ray absorptiometry scans. After exclusion, 7,366 subjects （3,188 men, 4,178 women） were included in our final analysis. Age was categorized according to three age groups （20-39, 40-59, mad 〉 60 years）, and subjects were catego- rized according to their sarcopenic and obesity status. Cardiovascular risk was assessed with Framingham risk score （FRS）. Results The sarco- penic obese group had a higher FRS than the non-sarcopenic obese group, which had a higher FRS than the non-sarcopenic non-obese group. Age-wise, the 20-39 year-old group showed a non-significant association between sarcopenia and FRS. In the 40-59 year-old group, regardless of obesity status, sarcopenic subjects had a higher FRS than non-sarcopenic subjects. In the 〉 60 year-old group, sarcopenic subjects had a higher FRS than non-sarcopenic subjects for the non-obese group. Conclusions Sarcopenia was associated with cardiovascular disease and may be an early predictor of its susceptibility in both elderly and middle-aged subjects. Thus, management of sarcopenia is necessary to prevent cardiovascu- lar disease.

关键词： Age Cardiovascular disease Cardiovascular risk factor Framingham risk score Sarcopenia

Effect of post heat-treatment on the microstructure and high-temperature oxidation behavior of precipitation hardened IN738LC superalloy fabricated by selective laser melting

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Journal of Materials Science & Technology 2021年第17期76卷 95-103页

作者： Kyu-Sik Kim Sangsun Yang myeong-Se Kim Kee-Ahn Lee Department of Materials Science and Engineering Inha UniversityIncheon 22212Republic of Korea Korea Institute of Materials Science Changwon51508Republic of Korea Auratech Co. Ltd.Seongnam13449Republic of Korea

The present study investigated the effect of as-built and post heat-treated microstructures of IN738LC alloy fabricated via selective laser melting process on high temperature oxidation *** as-built microstructure showed fine cell and columnar structure due to high cooling *** element segregation was observed in inter-cell/inter-columnar *** post heat-treatment,the initially-observed cell structure disappeared,instead bimodal Ni_3(Al,Ti)particles *** temperature(1273 K and 1373 K)oxidation test results showed parabolic oxidation curves regardless of temperature and initial *** as-built IN738LC fabricated via the selective laser melting process displayed oxidation resistance similar to or slightly better than that of IN738LC fabricated via wrought or cast ***-treated SLM IN738LC,although had similar oxidation weight-gain values to those of the SLM asbuilt material at 1273K,showed relatively better oxidation resistance at 1373 *** Ni_3(Al,Ti)precipitate formed in the post heat treatment changed the local chemical composition,thereby led to changes in alumina former/chromia former location and fraction on the alloy *** was concluded that in heat-treated IN738LC increased alumina former fraction was found,and this resulted in excellent oxidation resistance and relatively low weight-gain.

关键词： IN738LC Selective laser melting High temperature oxidation Post heat-treatment Oxidation mechanism

Microstructural evolution of pre-twinned Mg alloy with annealing temperature and underlying boundary migration mechanism

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Journal of Magnesium and Alloys 2023年第8期11卷 2953-2966页

作者： Ye Jin Kim Jong Un Lee Gyo myeong Lee Sung Hyuk Park School of Materials Science and Engineering Kyungpook National UniversityDaegu 41566Republic of Korea

This study investigates the variations in the microstructural characteristics of a pre-twinned Mg alloy with the temperature of the subsequent annealing *** this end,a rolled AZ31 alloy is compressed to 3%plastic strain along the rolling direction(RD)to activate{10-12}twinning and is subsequently annealed at 200,250,300,350,and 400℃.Numerous{10-12}twins are formed throughout the compressed material,leading to the formation of a RD-oriented *** an annealing temperature of 200℃,no microstructural variations occur during *** the annealing temperature increases from 250 to 400℃,the residual strain energy and remaining twin boundaries of the annealed material decrease owing to the promoted static recovery and the increased area fraction of twin-free grown ***,an increase in the annealing temperature results in a gradual microstructural transition from a fully twinned grain structure to a completely twin-free grain *** microstructural evolution during annealing is predominantly governed by the movement of high-angle grain boundaries via a strain-induced boundary migration mechanism,and a few twin boundaries migrate above 350℃because of their lower boundary *** boundary migration behavior and resultant microstructural evolution are discussed in detail based on the variations in boundary mobility and driving force for boundary migration with annealing temperature.

关键词： Rolled Mg alloy {10-12}twin Grain growth Boundary migration Annealing

Probiotic modulation of dendritic cells co-cultured with intestinal epithelial cells

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World Journal of Gastroenterology 2012年第12期18卷 1308-1318页

作者： Ji Yeun Kim myeong Soo Park Geun Eog Ji Department of Food and Nutrition Research Institute of Human EcologyCollege of Human EcologySeoul National University Research Institute Bifido Inc.HongcheonGangwondo 250-804South Korea

AIM： To investigate cytokine production and cell surface phenotypes of dendritic cells （DC） in the presence of epithelial cells stimulated by probiotics.METHODS： Mouse DC were cultured alone or together with mouse epithelial cell monolayers in normal or in- verted systems and were stimulated with heat-killed probiotic bacteria, Bifidobacterium lactis ADO 11 （BL）, Bifidobacterium bilfidum BGN4 （BB）, Lactobacillus casei IBS041 （LC）, and Lactobacillus acidophilus AD031 （LA）, for 12 h. Cytokine levels in the culture supernatants were determined by enzyme-linked immunosorbent as say and phenotypic analysis of DC was investigated by flow cytometry.RESULTS： BB and LC in singlecultured DC increased the expression of I-Ad, CD86 and CD40 （I-Ad, 18.51 vs 30.88, 46.11, CD86, 62.74 vs 92.7, 104.12; CD40, 0.67 vs 6.39, 3.37, P 〈 0.05）. All of the experimental probiot-ics increased the production of inflammatory cytokines, interleukin （IL）-6 and tumor necrosis factor （TNF）-α. However, in the normal coculture systems, LC and LA decreased the expression of I-A^α （39.46 vs 30.32, 33.26, P 〈 0.05）, and none of the experimental probiotics increased the levels of IL-6 or TNF-α. In the inverted coculture systems, LC decreased the expression of CD40 （1.36 vs -2.27, P 〈 0.05）, and all of the experimental probiotics decreased the levels of IL-6. In addition, BL increased the production of IL-10 （103.8 vs 166.0, P 〈 0.05） and LC and LA increased transforming growth factor-13 secretion （235.9 vs 618.9, 607.6, P 〈 0.05）.CONCLUSION： These results suggest that specific pro- biotic strains exert differential immune modulation mediated by the interaction of dendritic cells and epithelial cells in the homeostasis of gastrointestinal tract.

关键词： Dendritic cells Intestinal epithelial cells Pro-biotics Co-culture Immune modulation

Recurrent intramuscular lipoma at extensor pollicis brevis:A case report

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World Journal of Clinical Cases 2023年第3期11卷 684-691页

作者： Je Yeon byeon Yong Seon Hwang Ji Hye Lee Hwan Jun Choi Plastic and Reconstructive Surgery Soonchunhyang University HospitalCheonan-si 31151South Korea Department of Pathology Soonchunhyang University HospitalCheonan-si 31151South Korea

BACKGROUND This report describes and discusses recurrent intramuscular lipoma(IML)of the extensor pollicis brevis(EPB).An IML usually occurs in a large muscle of the limb or *** of IML is *** IMLs,especially those with unclear boundaries,necessitate complete *** cases of IML in the hand have been ***,recurrent IML appearing along the muscle and tendon of EPB on wrist and forearm has not been reported *** SUMMARY In this report,the authors describe clinical and histopathological features of recurrent IML at EPB.A 42-year-old Asian woman presented with a slowgrowing lump in her right forearm and wrist area six months *** patient had a history of surgery for a lipoma of the right forearm one year ago with a scar of 6cm on the right *** resonance imaging confirmed that the lipomatous mass,which had attenuation similar to subcutaneous fat,had invaded the muscle layer of *** and biopsy were performed under general *** histological examination,it was identified as an IML showing mature adipocytes and skeletal muscle ***,surgery was terminated without further *** recurrence occurred during a follow-up of five years after *** Recurrent IML in the wrist must be examined to differentiate it from *** to surrounding tissues should be minimized during excision.

关键词： Intramuscular Lipoma Recurrence Wrist Case report

High scored thyroid storm after stomach cancer perforation: A case report

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World Journal of Clinical Cases 2022年第24期10卷 8768-8774页

作者： Seung Min Baik Yejune Pae Jae-myeong Lee Department of Surgery Ewha Womans University Mokdong HospitalEwha Womans University College of MedicineSeoul 07985South Korea Department of Surgery College of MedicineGraduate School of Korea UniversitySeoul 02841South Korea Department of Acute Care Surgery Korea University Anam HospitalSeoul 02841South Korea

BACKGROUND Thyroid storm is a life-threatening ***,the prevalence of thyroid storm is 1%-2%among patients admitted to the hospital for *** and Wartofsky(1993)introduced a scoring system using precise clinical criteria to identify thyroid *** 17 cases of thyroid storm with a score>70 points have been *** thyroid storms are uncommon,their clinical findings resemble those of *** SUMMARY A 48-year-old man was referred to the emergency room from a local clinic owing to suspicion of gastric ulcer perforation;medications for hypertension,diabetes mellitus,and hyperthyroidism had been suspended 1 year prior to this *** performed an emergency distal gastrectomy with Billroth II anastomosis for gastric cardia cancer perforation,and the patient was referred to the surgical intensive care unit(ICU).On the 2nd d in the ICU,his body temperature(BT)increased to 41.3℃ at 19:00,with the thyroid storm score(90 points)peaking at 18:00(BT;41.2℃,pulse rate;138/min,irritable status).The patient was administered propylthiouracil,intravenous glucocorticoids,acetaminophen,and Lugol’s solution ***,we performed bladder irrigation with cold saline using a Foley catheter and applied a hypothermic blanket to decrease the patient's *** vital signs were stable on the 8th day in the *** Thyroid storms are uncommon,with few reports in the literature;however,their clinical findings resemble those of sepsis and require further *** an untreated thyroid storm results in a high mortality rate,it should be investigated when managing sepsis.

关键词： Thyroid storm Stomach cancer Severity score Sepsis Case report

Transarterial chemoembolization with drug-eluting beads in hepatocellular carcinoma

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World Journal of Gastroenterology 2016年第40期22卷 8853-8861页

作者： Hee Chul Nam Bohyun Jang myeong Jun Song Department of Internal Medicine College of Medicine the Catholic University of Korea Division of Hepatology Department of Internal Medicine Daejeon St. Mary’s Hospital College of Medicine The Catholic University of Korea

Transarterial chemoembolization(TACE) is a widely used standard treatment for patients with hepatocellular carcinoma(HCC) who are not suitable candidates for curative treatments. The rationale for TACE is that intra-arterial chemotherapy using lipiodol and chemotherapeutic agents, followed by selective vascular embolization, results in a strong cytotoxic effect as well as ischemia(conventional TACE). Recently, drugeluting beads(DC Beads?) have been developed for transcatheter treatment of HCC to deliver higher doses of the chemotherapeutic agent and to prolong contact time with the tumor. DC Beads? can actively sequester doxorubicin hydrochloride from solution and release it in a controlled sustained fashion. Treatment with DC Beads? substantially reduced the amount of chemotherapeutic agent that reached the systemic circulation compared with conventional, lipiodol-based regimens, significantly reducing drug-related adverse events. In this article, we describe the treatment response, survival, and safety of TACE used with drugeluting beads for the treatment of HCC and discuss future therapeutic possibilities.

关键词： Hepatocellular carcinoma Transarterial chemoembolization Conventional TACE Drug-eluting beads Treatment response

Cardiac diagnostics before oral propranolol therapy in infantile hemangioma: retrospective evaluation of 234 infants

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World Journal of Pediatrics 2018年第3期14卷 254-258页

作者： Giovanni Frongia Ji-Oun byeon Raoul Arnold Arianeb Mehrabi Patrick Günther Division of Pediatric Surgery Department of GeneralVisceral and Transplantation SurgeryUniversity Hospital of HeidelbergIm Neuenheimer Feld 11069120 HeidelbergGermany Department of Pediatric Cardiology Center for Pediatrics and Adolescent MedicineUniversity Hospital of HeidelbergHeidelbergGermany Department of General Visceral and Transplantation SurgeryUniversity Hospital of HeidelbergHeidelbergGermany

Background The indication and extent of cardiac screening before oral propranolol therapy (OPT) in patients with infantile hemangioma (IH) has been challenged. In this study, we evaluated pre-OPT cardiac diagnostics in a pediatric IH cohort in our department. Methods Retrospective chart review of infants ≤ 12 months old with IH undergoing OPT. The diagnostics prior to OPT, occurrence of complications, and outcome were recorded. Results A total of 234 patients were evaluated. The mean age at the onset of OPT was 4.2 ± 0.3 months, the average dura-tion of OPT was 6.1 ± 0.1 months, and the average follow-up was 12.3 ± 0.7 months. Echocardiograms and electrocardio-grams were performed prior to OPT in all patients. One hundred and three (44.0%) echocardiograms revealed pathological findings, 19 (8.1%) of which were minor (including atrial septal defects, pulmonary stenosis, and patent ductus arteriosus). Pathological findings were observed in 17 (7.3%) of electrocardiograms, only one (0.4%) of which was minor (suspected cardiac arrhythmia, subsequently excluded by long-term electrocardiogram analysis). These findings did not contraindicate OPT and no severe adverse events associated with OPT occurred during the follow-up period. Conclusions Routine cardiac screening by electrocardiogram and echocardiogram before OPT is debatable and not routinely indicated in children with IH. Further studies are necessary to draw definite conclusions on the reasonable indication and extent of this diagnostic approach.

关键词： Cardiac diagnostics Echocardiogram Electrocardiogram Hemangioma Propranolol

On-the-fly dopant redistribution in a silicon nanowire p-n junction

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Nano Research 2017年第8期10卷 2845-2855页

作者： Dong-II Moon myeong-Lok Seol Jin-Woo Han M. Meyyappan Center for Nanotechnology NASA Ames Research Center Moffett Field CA 94035 USA

Dopant redistribution in a silicon nanowire （SiNW） p-n junction is found to occur owing to self-heating effects. A SiNW is doped to form back-to-back diodes and is thermally isolated by an oxide layer on its bottom side and by air on the other sides. When a high level of current flows, the inner body temperature is found to increase enough to cause dopant diffusion and even to reach the silicon melting point due to Joule heating. This experimentally observed electrothermal behavior is also validated through numerical simulation. The conductivity change is dependent on the total power density and the change becomes permanent once the device suffers self-heating beyond a threshold point. Finally, the dopant redistribution is directly visualized using scanning capacitance microscopy for the first time.

关键词： nanowire degradation Joule heating dopant redistribution scanning capacitance microscopy