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Loss of microRNAs in thymus perturbs invariant NKT cell development and function

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Cellular & Molecular Immunology 2010年第6期7卷 447-453页

作者： kook-Heon Seo Li Zhou Dongmei Meng Jianrui Xu Zhong Dong Qing-Sheng Mi Henry Ford Immunology Program Henry Ford Health SystemDetroitMIUSA Department of Dermatology Henry Ford Health SystemDetroitMIUSA Department of Internal Medicine Henry FordHealth SystemDetroitMIUSA Center for Biotechnology and Genomic Medicine Medical College of GeorgiaAugustaGAUSA Department of Internal Medicine the Affiliated Hospital of Qingdao University Medical CollegeQingdaoChina Department of Cellular Biology and Anatomy Medical College of GeorgiaAugustaGAUSA

microRNAs(miRNAs)are small noncoding RNAs that mediate RNA interference to suppress protein expression at the translational *** evidence indicates that miRNAs play critical roles in various biological processes and disease development,including autoimmune *** natural killer T(iNKT)cells are an unusual CD1d-restricted subset of thymus-derived T cells that are potent regulators of diverse immune *** previous studies with the mouse model of bone marrow-specific Dicer deletion suggest the involvement of Dicer-dependent miRNAs in the development and function of iNKT *** the present study,to further dissect the functional levels of Dicer-dependent miRNAs in regulating iNKT cell development,we generated a mouse model with the Dicer deletion in the *** data indicate that lack of miRNAs following the deletion of Dicer in the thymus severely interrupted the development and maturation of iNKT cells in the thymus and significantly decreased the number of iNKT cells in the peripheral immune ***-deficient peripheral iNKT cells display profound defects in activation and cytokine production upon a-galactosylceramide(a-GalCer)*** results demonstrate a critical role of the miRNA-dependent pathway in the thymus in the regulation of iNKT cell development and function.

关键词： autoimmunity development iNKT cells microRNAs

Plant lncRNAs are enriched in and move systemically through the phloem in response to phosphate deficiency

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Journal of Integrative Plant Biology 2019年第4期61卷 492-508页

作者： Zhaoliang Zhang Yi Zheng Byung-kook Ham Shupei Zhang Zhangjun Fei William J.Lucas State Key Laboratory of Tea Biology and Utilization Anhui Agricultural University Boyce Thompson Institute for Plant Research Cornell University Global Institute for Food Security Department of Biology University of Saskatchewan Department of Plant Biology College of Biological Sciences University of California

In response to phosphate(Pi) deficiency, it has been shown that micro-RNAs(miRNAs) and mRNAs are transported through the phloem for delivery to sink tissues. Growing evidence also indicates that long noncoding RNAs(lncRNAs) are critical regulators of Pi homeostasis in plants. However, whether lncRNAs are present in and move through the phloem, in response to Pi deficiency, remains to be established. Here, using cucumber as a model plant, we show that lncRNAs are enriched in the phloem translocation stream and respond,systemically, to an imposed Pi-stress. A well-known lncRNA, IPS1, the target mimic(TM) of miRNA399,accumulates to a high level in the phloem, but is not responsive to early Pi deficiency. An additional 24 miRNA TMs were also detected in the phloem translocation stream; among them miRNA171 TMs and miR166 TMs were induced in response to an imposed Pi *** studies identified 22 lncRNAs which move systemically into developing leaves and root tips. A CU-rich PTB motif was further identified in these mobile lncRNAs. Our findings revealed that lncRNAs respond to Pi deficiency, non-cell-autonomously, and may act as systemic signaling agents to coordinate early Pi deficiency signaling, at the whole-plant level.

关键词： Plant lncRNAs enriched phloem phosphate deficiency

Identification of differentially expressed miRNAs associated with chronic kidney disease-mineral bone disorder

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Frontiers of Medicine 2017年第3期11卷 378-385页

作者： Kyung Im Kim Sohyun Jeong Nayoung Han Jung Mi Oh kook-Hwan Oh In-Wha Kim College of Pharmacy Korea University Sejong 30019 Republic of Korea College of Pharmacy and Research Institute of Pharmaceutical Sciences -Seoul National University Seoui 08826 Republic of Korea Divisionof-Nephrology Department of Internai Medicine Seoul National University Hospital Seoul 03080 Republic of Korea

The purpose of this study is to characterize a meta-signature of differentially expressed mRNA in chronic kidney disease （CKD） to predict putative microRNA （miRNA） in CKD-mineral bone disorder （CKD- MBD） and confirm the changes in these genes and miRNA expression under uremic conditions by using a cell culture system. PubMed searches using MeSH terms and keywords related to CKD, uremia, and mRNA arrays were conducted. Through a computational analysis, a meta-signature that characterizes the significant intersection of differentially expressed mRNA and expected miRNAs associated with CKD-MBD was determined. Additionally, changes in gene and miRNA expressions under uremic conditions were confirmed with human Saos-2 osteoblast-like cells. A statistically significant mRNA meta-signature of upregulated and downregulated mRNA levels was identified. Furthermore, miRNA expression profiles were inferred, and computational anaIyses were performed with the imputed mieroRNA regulation based on weighted ranked expression and putative microRNA targets （IMRE） method to identify miRNAs associated with CKD occurrence. TLR4 and miR-146b levels were significantly associated with CKD-MBD. TLR4 levels were significantly downregulated, whereas pri- miR-146b and miR-146b were upregulated in the presence of uremic toxins in human Saos-2 osteoblast-like cells. Differentially expressed miRNAs associated with CKD-MBD were identified through a computational analysis, and changes in gene and miRNA expressions were confirmed with an in vitro cell culture system.

关键词： chronic kidney disease microRNA mineral bone disorder uremia

Multi-Wavelength Conversion Using FP-LD with Linear Optical Amplifier

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光学学报 2003年第S1期23卷 623-624页

作者： Jeung-Mo Kang Yong-Ook Kim Sang-kook Han Department of Electrical & Electronic Engineering Yonsei University Shinchon-dong Seodaemoon-gu Seoul KoreaDepartment of Electrical & Electronic Engineering Yonsei University Shinchon-dong Seodaemoon-gu Seoul KoreaDepartment of Electrical & Electronic Engineering Yonsei University Shinchon-dong Seodaemoon-gu Seoul Korea

We propose and demonstrate a multi-wavelength converter using FP-LD with linear optical amplifier (LOA) which based on cross-gain modulation can convert an input signal to many wavelengths simultaneously for reconfigu... 详细信息

关键词： FP LD Multi-Wavelength Conversion Using FP-LD with Linear Optical Amplifier mode LOA with SOA of

Long-lasting,reinforced electrical networking in a high-loading Li_(2)S cathode for high-performance lithium–sulfur batteries

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Carbon Energy 2023年第8期5卷 1-14页

作者： Hun Kim Kyeong-Jun Min Sangin Bang Jang-Yeon Hwang Jung Ho Kim Chong SYoon Yang-kook Sun Department of Energy Engineering Hanyang UniversitySeoulRepublic of Korea Department of Materials Science and Engineering Chonnam National UniversityGwangjuRepublic of Korea Institute for Superconducting&Electronic Materials(ISEM) Australian Institute of Innovative Materials(AIIM)University of WollongongNew South WalesNorth WollongongAustralia Department of Materials Science and Engineering Hanyang UniversitySeoulRepublic of Korea

Realizing a lithium sulfide(Li_(2)S)cathode with both high energy density and a long lifespan requires an innovative cathode design that maximizes electrochemical performance and resists electrode ***,a high-loading Li_(2)S-based cathode with micrometric Li_(2)S particles composed of two-dimensional graphene(Gr)and one-dimensional carbon nanotubes(CNTs)in a compact geometry is developed,and the role of CNTs in stable cycling of high-capacity Li–S batteries is *** a dimensionally combined carbon matrix,CNTs embedded within the Gr sheets create robust and sustainable electron diffusion pathways while suppressing the passivation of the active carbon *** a unique point,during the first charging process,the proposed cathode is fully activated through the direct conversion of Li_(2)S into S_(8) without inducing lithium polysulfide *** direct conversion of Li_(2)S into S_(8) in the composite cathode is ubiquitously investigated using the combined study of in situ Raman spectroscopy,in situ optical microscopy,and cryogenic transmission electron *** composite cathode demonstrates unprecedented electrochemical properties even with a high Li_(2)S loading of 10 mg cm^(–2);in particular,the practical and safe Li–S full cell coupled with a graphite anode shows ultra-long-term cycling stability over 800 cycles.

关键词： carbon nanotubes electrical network high energy high loading Li_(2)S cathode lithium-sulfur batteries

Effects of Applied Stresses on Martensite Transformation in AISI4340 Steel

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Journal of Iron and Steel Research International 2007年第6期14卷 63-67页

作者： ZHAO Hong zhuang Seok-jae LEE Young-kook LEE LIU Xiang-hua WANG Guo-dong State Key Laboratory of Rolling and Automation Northeastern University Shenyang 110004 Liaoning China Department of Metallurgical Engineering Yonsei University Seoul 120-749 South Korea

This study aims at the experimental analysis of the transformation induced plasticity （TRIP） phenomenon. Experiments are conducted in which martensite is allowed to grow under the influence of a series of externally applied stresses. The magnitude of the applied stresses is less than 67% of the yield strength of austenite σγ （Ts）. Since there is no obvious difference between the transformation plasticity under tension and the compression for the lower applied stresses, only compressive stresses are applied. The results confirm that the transformation plasticity is proportional to the applied stress if the latter does not exceed 67 % of σγ （Ts）. The TRiP-strain, the kinetics, and their dependence on the applied stresses are studied. The comparison between calculated results and experimental results shows that the model accurately describes the phenomenon.

关键词： applied stress TRIP martensite transformation low-alloy steel

HoLEP does not affect the overall sexual function of BPH patients： a prospective study

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Asian Journal of Andrology 2014年第6期16卷 873-877页

作者： Sung Hart Kim Hyung-kook Yang Hahn-Ey Lee Jae-Seung Paick Seung-June Oh Department of Urology Prostate Cancer Center National Cancer Center Goyang Korea Department of Epidemiology and Statistics and Cancer Policy Branch of National Cancer Control Research Institute National Cancer Center Goyang Korea Department of Urology Seoul National University Hospital Seoul Korea.

We aimed to prospectively evaluate the influence of holmium laser enucleation of the prostate （HoLEP） on the overall postoperative sexual function of benign prostatic hyperplasia （BPH） patients with lower urinary tract symptoms （LUTS） and to explore the relationship between sexual function and LUTS. From January 2010 to December 2011, sixty sexually active consecutive patients with BPH who underwent HoLEP were prospectively enrolled in the study. All patients filled out the Male Sexual Health Questionnaire （MSHQ） for evaluation of their overall sexual function and the International Prostatic Symptom Score （IPSS） for pre- and post-operative 6 months evaluation of their voiding symptoms. The LUTS and sexual function changes were statistically analyzed. The preoperative and 6 months postoperative status of the patients was compared using uroflowmetry and IPSS questionnaires. The analysis revealed significant improvements following HoLEP. Among the sub-domains of the MSHQ, postoperative sexual function, including erection, ejaculation, sexual satisfaction, anxiety or sexual desire, did not significantly change after HoLEP （P 〉 0.05）, whereas satisfaction scores decreased slightly due to retrograde ejaculation in 38 patients （63.3%）. Sexual satisfaction improved significantly and was correlated with the improvements of all LUTS and the quality-of-life （QoL） domains in IPSS after surgery （QoL; relative risk [RR]： -0.293; total symptoms, RR： -0.411; P 〈 0.05）. The nocturia score was associated with the erectile function score （odds ratio 0.318, P = 0.029）. The change in ejaculatory scores did not show significant association with IPSS scores. HoLEP did not influence overall sexual function, including erectile function. In addition, sexual satisfaction improved in proportion with the improvement of LUTS.

关键词： benign prostatic hyperplasia ejaculation erectile dysfunction lasers prostatectomy sex disorders

Utilization of biomarkers for the prognostic prediction of cardiac arrest survivors using a multi-modal approach

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World Journal of Emergency Medicine 2024年第2期15卷 131-134页

作者： Changshin Kang Yeonho You Jung Soo Park Byeong Kwon Park Jae Kwang Lee Byung kook Lee Department of Emergency Medicine College of MedicineChungnam National UniversityDaejeon 35015Republic of Korea Department of Emergency Medicine Chungnam National University HospitalDaejoen 35015Republic of Korea Department of Emergency Medicine Konyang University HospitalCollege of MedicineDaejeon 35015Republic of Korea Department of Emergency Medicine Chonnam National University Medical SchoolChonnam National University HospitalGwangju 61469Republic of Korea

International guidelines for post-cardiac arrest care recommend using multi-modal strategies to avoid the withdrawal of life-sustaining therapy(WLST)in patients with the potential for neurological recovery.[1]However,a clear methodology for multi-modal approaches has yet to be ***-specific enolase(NSE)is currently the only recommended biomarker,and the European Resuscitation Council(ERC)and the European SocietyofIntensiveCareMedicine(ESICM)have proposed a cutoff value of 60μg/L at 48 and/or 72 h after the return of spontaneous circulation(ROSC)as a multimodal prognostic tool for predicting poor neurological outcomes.

关键词： cardiac modal return

An effective method to reduce residual lithium compounds on Ni-rich Li[Ni0.6Co0.2Mn0.2]O2 active material using a phosphoric acid derived Li3PO4 nanolayer

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Nano Research 2015年第5期8卷 1464-1479页

作者： Chang-Heum Jo Dae-Hyun Cho Hyung-Joo Noh Hithshi Yashiro Yang-kook Sun Seung Taek Myung Department of Nano Engineering Sejong University 98 Gunja-dong Gwangjin-gu Seou1143-747 Republic of Korea Department of Chemical Engineering Iwate University Morioka Iwate 020-8551 Japan Department of Energy Engineering Hanyang University Seongdong-gu Seou1133-791 Republic of Korea

The Ni-rich Li[Ni0.6Co0.2Mn0.2]O2 surface has been modified with H3PO4. After coating at 80 ℃, the products were heated further at a moderate temperature of 500 ℃ in air, when the added H3PO4 transformed to Li3PO4 after reacting with residual LiOH and Li2CO3 on the surface. A thin and uniform smooth nanolayer （〈 10 nm） was observed on the surface of Li[Ni0.6Co0.2Mn0.2]O2 as confirmed by transmission electron microscopy （TEM）. Time-of-flight secondary ion mass spectroscopic （ToF-SIMS） data exhibit the presence of LIP＋, LiPO-, and Li2PO2＋ fragments, indicating the formation of the Li3PO4 coating layer on the surface of the Li[Ni0.6Co0.2Mn0.2]O2. As a result, the amounts of residual lithium compounds, such as LiOH and Li2CO3, are significantly reduced. As a consequence, the LigPO4-coated Li[Ni0.6Co0.2Mn0.2]O2 exhibits noticeable improvement in capacity retention and rate capability due to the reduction of residual LiOH and Li2CO3. Further investigation of the extensively cycled electrodes by X-ray diffraction （XRD）, TEM, and ToF-SIMS demonstrated that the LiBPO4 coating layers have multi-functions： Absorption of water in the electrolyte that lowers the HF level, HF scavenging, and protection of the active materials from deleterious side reactions with the electrolyte during extensive cycling, enabling high capacity retention over 1,000 cycles.

关键词： Li3PO4 coating positive electrode lithium batteries