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Acupuncture for Pain:An Overview of Cochrane Reviews

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Chinese Journal of Integrative Medicine 2011年第2期17卷 187-189页

作者： myeong soo lee Edzard Ernst Brain Disease Research Center Korea Institute of Oriental MedicineDaejeonSouth Korea Complementary Medicine Peninsula Medical SchoolUniversity of ExeterExeterUK

Objective： Cochrane reviews have the reputation for being more transparent and rigorous than other reviews. The aim of this overview was to evaluate and summarize Cochrane reviews of acupuncture for the treatment of any type of pain. Methods： We searched the Cochrane Database and evaluated the Cochrane reviews that were concerned specifically with the effectiveness of acupuncture for pain. Data were extracted according to pre-defined inclusion criteria by two independent reviewers. Results： Eight Cochrane reviews were included. They were all of high methodological quality. They related to a wide range of pain syndromes. Four reviews concluded that acupuncture is effective for migraines, neck disorders, tensiontype headaches, and peripheral joint osteoarthritis; one review failed to demonstrate the effectiveness of acupuncture for rheumatoid arthritis; and three reviews were inconclusive for shoulder pain, lateral elbow pain, and low back pain. Conclusion： Several Cochrane reviews of acupuncture for a wide range of pain conditions have recently been published. All of these reviews were of high quality. Their results suggest that acupuncture is effective for some but not all types of pain.

关键词： acupuncture pain Cochrane review evidence

Recognition of Association Between Blood Stasis Syndrome and Traumatic Injury among Doctors of Korean Medicine:A Cross-Sectional Observation Study

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Chinese Journal of Integrative Medicine 2018年第4期24卷 254-259页

作者： Jeeyoun Jung Mi Mi Ko Ju Ah lee myeong soo lee Korean Medicine Fundamental Research Division Korea Institute of Oriental Medicine Clinical Research Division Korea Institute of Oriental Medicine

Objective： To investigate the diagnostic indicators and herbal treatments for blood stasis syndrome（BSS） patients with traumatic injuries and to identify the association between BSS and traumatic injury in Korea. Methods： Two-hundred and four patients with traumatic injury were recruited from the Gangnam and Daejeon branches of Jaseng Hospital of Oriental Medicine between June 2014 and December 2014. Two independent doctors of Korean medicine（DKMs） determined the diagnosis of BSS or non-BSS based on the subjects＇ signs and symptoms. The scores assigned to BSS symptoms and DKMs＇ reasons for diagnosing BSS in patients with traumatic injury were investigated. Both medication and herbal prescription records from a 3-month period were collected for all patients diagnosed with BSS by both DKMs. Results： A total of 169 of 204（82.8%） patients received consistent diagnosis related to BSS by two DKMs. Among them, 54.4%（92 cases） were diagnosed with BSS, and 45.6%（77 cases） were not diagnosed with BSS. DKMs most frequently cited symptoms of recent traumatic injury as justifications for BSS diagnoses, and also selected pain-related indicators such as abdominal pain, sharp pain and nocturnal pain as important reasons in diagnosing BSS. In addition, an inconsistency in the pattern identification theory with respect to traumatic injury was observed. Although only 92 cases（54.4%） of patients were diagnosed with BSS, 77.6% of them were prescribed decoctions for BSS. Conclusions： DKMs considered traumatic injury could cause BSS, and utilized decoction for BSS in patients with traumatic injury without confirming a diagnosis of BSS because they assumed the main symptoms or pathologies of traumatic injury to be closely related to BSS.

关键词： blood stasis syndrome Korean medicine traumatic injury herbal medicine diagnosis pattern identification

Inter-observer Reliability of Indicators and Decision of Pattern Identification Using Diagnostic Flowchart with Traditional Korean Medicine

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Chinese Journal of Integrative Medicine 2017年第5期23卷 338-344页

作者： Ju Ah lee Jeeyoun Jung Mi Mi Ko myeong soo lee Korean Medicine Fundamental Research Division Korea Institute of Oriental Medicine Daejeon 305-811 Republic of Korea Clinical Research Division Korea Institute of Oriental Medicine Daejeon 305-811 Republic of Korea

Objective： To evaluate the consistency of patterns and pattern identification（PI）, and the improvement in the diagnosis of blood stasis after the standard operating procedures（SOPs） were enhanced by using a diagnostic flowchart. Methods： A total of 358 subjects who were admitted by the Jaseng Hospital of Korean Medicine between June 2013 and December 2014 were included in the study. Each patient was independently diagnosed by two experts from the same department. In 2014, the SOPs included the use of a diagnostic flowchart for each indicator. Inter-observer consistency was assessed by simple percent agreement and by the kappa and AC1 statistics. Results： The improvements in inter-observer agreement for the indicators（for al patients） and PI were greater in 2014 than in 2013. In 2013, the j-value measure of agreement between the two experts ranged from ＂poor＂（κ=–0.051） to ＂good＂（κ=0.968）. The AC1 measure of agreement between the experts was generally high for the indicators and ranged from –0.010 to 0.978. In most cases, agreement was considerably lower when it was assessed by the j-values compared with the AC1 values. In 2014, the j-value measure of agreement on the indicators（for the subjects） general y ranged from poor to good, with the values ranging from –0.007 to 0.994. Moreover, the AC1 measure of agreement between the experts was general y high for al of the indicators and ranged from ＂moderate＂（AC1=0.408） to ＂excel ent＂（AC1=0.996）. Conclusions： In four examinations, there was moderate agreement between the clinicians on the PI indicators of blood stasis. To improve clinician consistency（e.g., in the diagnostic criteria used）, it is necessary to analyse the reasons for inconsistency and to improve clinician training.（Trial registration No. KCT0000916）

关键词： blood stasis inter-observer reliability pattern identification traditional Chinese medicine traditional Korean medicine

Effects of betaine on etnanol-stimulated secretion of IGF-I and IGFBP-1 in rat primary hepatocytes: involvement of p42/44 MAPK activation

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World Journal of Gastroenterology 2006年第11期12卷 1718-1722页

作者： myeong soo lee Myung-Sunny Kim soo Young Park Chang-Won Kang Complementary Medicine Peninsula Medical School Universities of Exeter and PlymouthExeterEX2 4NTUnited Kingdom Korea Food Research Institute Kyongki-do 463-746Republic of Korea Department of Animal Resources and Biotechnology Chonbuk National University Jeonju 561-756Republic of Korea Department of Physiology College of Veterinary Medicine Chonbuk National UniversityJeonju 561-756Republic of Korea

瞄准: 用放射性免疫测定并且西方的弄污在 IGF-I 和 IGFBP-1 的导致乙醇的分泌物上评估甜菜硷的效果，分别地在主要有教养的老鼠 hepatocytes。方法：从男 Sprague-Dawley 老鼠孤立的 Hepatocytes 与乙醇和 PD98059 过程的各种各样的集... 详细信息

瞄准: 用放射性免疫测定并且西方的弄污在 IGF-I 和 IGFBP-1 的导致乙醇的分泌物上评估甜菜硷的效果，分别地在主要有教养的老鼠 hepatocytes。方法：从男 Sprague-Dawley 老鼠孤立的 Hepatocytes 与乙醇和 PD98059 过程的各种各样的集中被孵化。hepatocytes 也与甜菜硷的不同剂量被对待(10 (-5), 10 (-4), 并且 10 (-3) mol/L ) 。我们用放射性免疫测定并且分别地的西方的弄污测量了 IGF-I 和 IGFBP-1。结果: IGF-I 分泌物的导致乙醇的抑制被甜菜硷在主要有教养的老鼠 hepatocytes 以一种集中依赖者方式稀释。在 10 点(-3) mol/L，甜菜硷显著地增加了 IGF-I 分泌物，但是减少 IGFBP-1 分泌物。另外， p42/44 激活 mitogen 的蛋白质激酶(MAPK ) 活动与 10 从 10 min 显著地被加速到 5 h 术后疗法(-3) mol/L 甜菜硷。而且，在 IGF-1 和 IGFBP-1 分泌物从增加的导致 betaine 的 p42/44 MAPK 活动导致主要有教养的老鼠 hepatocytes 的变化被处理与 MAPK 禁止者 PD98059 堵住。甜菜硷处理堵住了 IGF-I 的导致乙醇的抑制分泌物和 p42/44 MAPK 活动，和 IGFBP-1 的导致乙醇的增加分泌物。结论：甜菜硷在主要有教养的老鼠 hepatocytes 经由 p42/44 MAPK 的激活调制 IGF-I 和 IGFBP-1 的分泌物。甜菜硷也改变乙醇导致的 MAPK 激活。

关键词：甜菜碱三甲铵乙内酯乙醇肝细胞 p42 p44

Diagnostic Indicators for Blood Stasis Syndrome Patients with Gynaecological Diseases

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Chinese Journal of Integrative Medicine 2018年第10期24卷 752-757页

作者： Jeeyoun Jung Mi Mi Ko myeong soo lee So Min lee Ju Ah lee Korea Medicine Fundamental Research Division Korea Institute of Oriental Medicine Clinical Research Division Korea Institute of Oriental Medicine

Objective： To investigate the important diagnostic indicators for blood stasis syndrome （BSS） in patients of childbearing age with gynaecological diseases. Methods： A partial least squared-discriminant analysis （PLS-DA） were applied to BSS symptoms data of patients with gynaecological diseases, and the diagnostic indicators used by doctors of Korean medicine （DKMs） among BSS patients with gynaecological diseases were also investigated. Results： A total of 103 patients of childbearing age with gynaecological diseases and 40 healthy controls were enrolled. Among the 103 patients, 63 （61.7%） and 40 （38.8%） were diagnosed with BSS and non-BSS, respectively, and BSS patients exhibited a more severe extent of disease. A score plot of PLS-DA showed clearly different patterns among the 3 groups. Based on the variable importance on projection of PLS-DA model, menstrual pains, dark lumps in the menstrual blood, ileocoecal tenderness and resistance, sharp pains, and sublingual varicosities were selected as the top five most important indicators. Moreover, more than 75% of DKMs chose dark lumps in menstrual blood, menstrual pain, and dark menstrual blood as the diagnostic indicators of BSS in patients with gynaecological diseases, and more than 49% of them also considered sharp pains, dark red tongue, sublingual varicosities, and tendency to bruise easily as diagnostic indicators of BSS. Conclusion： DKMs focused on menstrual symptoms and certain gynaecological symptoms to diagnose BSS patients of childbearing age with female diseases.

关键词： blood stasis syndrome diagnosis gynaecological disease pattern identification

Electroacupuncture on PC6 Prevents Opioid-Induced Nausea and Vomiting after Laparoscopic Surgery

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Chinese Journal of Integrative Medicine 2013年第4期19卷 277-281页

作者： Siwoo lee myeong soo lee Deok Hwa Choi Su Kyung lee Korea Institute of Oriental Medicine University of Science and Technology DaejeonSouth Korea Department of Anesthesiology Wonkwang University School of MedicineIksanSouth Korea Department of Oriental Rehabilitation Medicine Wonkwang University School of Oriental MedicineIksanSouth Korea

Objective： To investigate the treatment time dependence of electroacupuncture （EA） on Neiguan （PC6） for preventing postoperative nausea and vomiting （PONV）. Methods： One hundred and seventy-eight patients, who had received intravenous patient-controlled analgesia （PCA） with Fentanyl, were assigned randomly to three groups using random numbers： a pre-operative EA group （PrEA）, a post-operative EA group （PoEA）, and a non-acupuncture control group （NC）. An anesthetist evaluated the incidence and severity of nausea and vomiting for 48 h after surgery blindly. The main outcomes were severity and freguency of PONV, which were measured with a self-reported questionnaire and a confirmation from the anesthetist. The data were analyzed with ANOVA and Z-test. Results： The incidence of nausea and vomiting was significantly lower in the PrEA group than the NC group during 48 h after surgery （P〈0.01, P〈0.05）. The incidence of vomiting was also significantly lower in the PrEA group than the PoEA group （P〈0.05）. The PoEA subjects evidenced no significant differences compared with the NC subjects in terms of the incidence of nausea and vomiting （P〈0.05）. The severity of nausea was significantly lower in the PrEA group than in the NC and PoEA groups （P〈0.05）. Conclusions： EA on PC6 is effective in the prevention of PONV, and pre-operative acupuncture is more effective than post-operative acupuncture.

关键词： electroacupuncture Neiguan （PC6） postoperative nausea and vomiting

Insights of Chinese Medicine Syndrome Study:From Current Status to Future Prospects

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Chinese Journal of Integrative Medicine 2014年第5期20卷 326-331页

作者：卞兆祥徐浩吕爱平 myeong soo lee Hollie Cheung School of chinese Medicine Hong Kong Baptist University HKSAR China Xiyuan Hospital China Academy of Chinese Medical Sciences Korea Institute of Oriental Medicine Daejeon Republic of Korea

Syndrome differentiation is a key feature of Chinese medicine （CM） system. With CM receiving more and more attention from the mainstream medical systems, researchers from both traditional medical systems and the Western medical system are putting more effort into studying why and how the CM system works, particularly about CM syndromes. This paper reviews the current status of syndrome study and its future development. The major aspects include：（1） Usage of syndrome differentiation in clinical practice; （2） Formalization of syndrome diagnostic criteria; （3） Evidence-based determination of the common syndrome（s） of a disease; （4） Systems biology study of syndromes; and （5） Usage of syndrome in randomized controlled trials. It is expected to integrate the syndrome concept into the main stream medical system, in terms of diagnosis, treatment and prevention.

关键词： syndrome diagnosis criteria practice research

Red Ginseng for Type 2 Diabetes Mellitus:A Systematic Review of Randomized Controlled Trials

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Chinese Journal of Integrative Medicine 2011年第12期17卷 937-944页

作者： Sina Kim Byung-Cheul Shin myeong soo lee Hyangsook lee Edzard Ernst School of Korean Medicine Pusan National UniversityYangsan(626-870)South Korea Brain Disease Research Centre Korea Institute of Oriental MedicineDaejeon(305-811)South Korea Complementary Medicine Peninsula Medical SchoolUniversity of Exeter(EX2-4NT)ExeterUK Acupuncture and Meridian Science Research centre College of Korean MedicineKyung Hee UniversitySeoul(130-701)South Korea

Objective： Red ginseng （RG, Panax ginseng C.A. Meyer） is one of the widely used herbs for treating type 2 diabetes mellitus （DM）. However, no systematic review of the effectiveness of RG for type 2 DM is available. This systematic review aimed to evaluate the current evidence for the effectiveness of RG in patients with type 2 DM. Methods＂ Electronic searches of 14 electronic databases were conducted without language restrictions. All randomized clinical trials （RCTs） with RG as a treatment for type 2 DM were considered for inclusion. Their methodological quality was assessed using the Cochrane criteria. Results： Four RCTs met our inclusion criteria. Their methodological quality was variable. Three of the RCTs compared the effectiveness of RG with placebo. The meta-analysis of these data failed to favor RG over placebo for fasting plasma glucose （FPG） [n=76, weighted mean difference （WMD）： -0.43 mmol/L; 95% confidence interval （CI）： -1.16 to 0.30, P=0.25] and fasting plasma insulin （FPI）（n=76, WMD： -8.43 pmol/L; 95% Ch -19.54 to 2.68, P=0.14） for 12 weeks of treatment. One RCT compared the effects of RG with no treatment. The results did not suggest favorable effects of RG on FPG, hemoglobin Alo （HbAlc） or 2-h blood glucose after a meal （PP2h）. Conclusions： The evidence for the effectiveness of RG in controlling glucose in type 2 DM is not convincing. Few included studies with various treatment regimens prohibit definitive conclusions. More rigorous studies are needed to clarify the effects of RG on this condition.

关键词： red ginseng Panax ginseng type 2 diabetes mellitus systematic review meta-analysis

Scalp Acupuncture for Parkinson's Disease:A Systematic Review of Randomized Controlled Trials

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Chinese Journal of Integrative Medicine 2013年第4期19卷 297-306页

作者： Hun-soo lee Hye-Lim Park Seung-Jin lee Byung-Cheul Shin Jun-Yong Choi myeong soo lee School of Korean Medicine Pusan National UniversityYangsanSouth Korea School of Korean Medical Science Pusan National University YangsanSouth Korea Hospital of Korean Medicine Pusan National UniversityYangsanSouth Korea School of Korean Medical Science Pusan National UniversityYangsanSouth Korea Medical Research Division Korea Institute of Oriental MedicineDaejeonSouth Korea

Objective： To evaluate the effectiveness of scalp acupuncture （SA）, a modern acupuncture technique specialized to neurological disorders, in managing motor function and symptoms for Parkinson＇s disease （PD） patients. Methods： Two independent reviewers extracted data from all of the randomized clinical trials （RCTs） that assessed the efficacy of SA for PD compared with conventional therapies （CTs）. Sixteen electronic databases were searched. The risk of bias was appraised with the Cochrane Collaboration tool, and the reporting of the included studies was evaluated by the Consolidated Standards of Reporting Trials （CONSORT） 2010 checklist and the revised Standards for Reporting Interventions in Clinical Trials of Acupuncture （STRICTA） guidelines. Results： In total, 4 RCTs met the inclusion criteria. As assessed by the Unified PD Rating Scale （UPDRS）, 2 RCTs showed that SA combined with CTs proved superior to CTs alone [60 cases; weighted mean difference, -3.94; 95% confidence interval （CI）, -6.05 to -1.64, P=0.01; 12=0%]. Based on the Webster scale, however, 3 RCTs showed no superior effect of SA when combined with CTs with high heterogeneity （154 cases; risk ratio, 1.29; 95% CI, 0.79 to 2.12, P=0.30; 12=84%）. The Cochrane risk of bias, adherence to the CONSORT and the STRICTA checklist showed that the quality of all the included RCTs was generally low. Conclusions： The result of our systematic review and meta-analysis suggested that the effectiveness of SA for PD is promising, however, the evidence is not convincing. A sham-controlled RCT design that adheres to the CONSORT and STRICTA guidelines to overcome methodological weakness and that includes a large sample size is strongly recommended to confirm the precise effect of SA on PD.

关键词： scalp acupuncture Parkinson＇s disease randomized controlled trials systematic review metaanalysis