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Dieckol isolated from Eisenia bicyclis extract suppresses RANKL-induced osteoclastogenesis in murine RAW 264.7 cells

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Asian Pacific Journal of Tropical Biomedicine 2022年第6期12卷 262-269页

作者： Su-Hyeon Cho Tae-Hyung Kwon Hoibin jeong Jin Sook Kim Song-Rae Kim myeong seon jeong seonJu Park Miri Choi Jung-Hee Woo Juhee Ahn Kil-Nam Kim Chuncheon Center Korea Basic Science InstituteChuncheon 24341Republic of Korea Department of Medical Biomaterials Engineering College of Biomedical SciencesKangwon National UniversityChuncheon 24341Republic of Korea Department of Research and Development Chuncheon Bio-industry FoundationChuncheonRepublic of Korea Marine Industry Research Institute for East se rim Uljin-gunGyeongsangbuk-doRepublic of Korea Department of Bio-analysis Science University of Science&TechnologyDaejeon34113Republic of Korea

Objective:To demonstrate the effect of dieckol from Eisenia bicyclis on osteoclastogenesis using RAW 264.7 ***:Murine macrophage RAW 264.7 cells were subjected to dieckol treatment,followed by treatment with receptor activator of nuclear factor kappa-B ligand(RANKL)to induce ***-resistant acid phosphatase(TRAP)activity was examined using a TRAP activity *** blotting analysis was conducted to examine the level of osteoclast-related factors,including TRAP and calcitonin receptor(CTR),transcriptional factors,including c-Fos,c-Jun,and nuclear factor of activated T cells cytoplasmic 1(NFATc1),nuclear factor kappa-B(NF-κB),extracellular signal-regulated kinase(ERK),and c-Jun N-terminal kinase(JNK).Immunofluorescence staining was conducted to examine the expression of c-Fos,c-Jun,and ***:Among the four phlorotannin compounds present in Eisenia bicyclis,dieckol significantly hindered osteoclast differentiation and expression of RANKL-induced TRAP and *** addition,dieckol downregulated the expression levels of c-Fos,c-Jun,NFATc1,ERK,and JNK,and suppressed NF-κB ***:Dieckol can suppress RANKL-induced ***,it has therapeutic potential in treating osteoclastogenesis-associated diseases.

关键词： Eisenia bicyclis Dieckol Osteoclasts ERK JNK NF-κB RANKL TRAP Calcitonin receptor NFATc1 RAW 264.7 cell

RUFY4 deletion prevents pathological bone loss by blocking endo-lysosomal trafficking of osteoclasts

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Bone Research 2024年第2期12卷 407-420页

作者： Minhee Kim Jin Hee Park Miyeon Go Nawon Lee jeongin Seo Hana Lee Doyong Kim Hyunil Ha Taesoo Kim myeong seon jeong Suree Kim Taesoo Kim Han Sung Kim Dongmin Kang Hyunbo Shim Soo Young Lee Department of Life Science Ewha Womans UniversitySeoul 03760South Korea The Research Center for Cellular Homeostasis Ewha Womans UniversitySeoul 03760South Korea Department of Biomedical Engineering Yonsei UniversityWonju 26493South Korea KM Convergence Research Division Korea Institute of Oriental MedicineDaejeon 34054South Korea Chuncheon Center Korea Basic Science InstituteChuncheon 24341South Korea Fluorescence Core Imaging Center and Bioimaging Data Curation Center Ewha Womans UniversitySeoul 03760South Korea Multitasking Macrophage Research Center Ewha Womans UniversitySeoul 03760South Korea

Mature osteoclasts degrade bone matrix by exocytosis of active proteases from secretory lysosomes through a ruffled ***,the molecular mechanisms underlying lysosomal trafficking and secretion in osteoclasts remain largely ***,we show with GeneChip analysis that RUN and FYVE domain-containing protein 4(RUFY4)is strongly upregulated during *** lacking Rufy4 exhibited a high trabecular bone mass phenotype with abnormalities in osteoclast function in ***,deleting Rufy4 did not affect osteoclast differentiation,but inhibited bone-resorbing activity due to disruption in the acidic maturation of secondary lysosomes,their trafficking to the membrane,and their secretion of cathepsin K into the extracellular ***,RUFY4 promotes late endosome-lysosome fusion by acting as an adaptor protein between Rab7 on late endosomes and LAMP2 on primary ***,Rufy4-deficient mice were highly protected from lipopolysaccharide-and ovariectomy-induced bone ***,RUFY4 plays as a new regulator in osteoclast activity by mediating endo-lysosomal trafficking and have a potential to be specific target for therapies against bone-loss diseases such as osteoporosis.

关键词： osteoclast inhibited traffic

Attractor landscape analysis of the cardiac signaling network reveals mechanism-based therapeutic strategies for heart failure

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Journal of Molecular Cell Biology 2018年第3期10卷 180-194页

作者： Daebeom Park Ho-Sung Lee Jun Hyuk Kang seon-myeong Kim jeong-Ryeol Gong Kwang-Hyun Cho Laboratory for Systems Biology and Bio-inspired Engineering Department of Bio and Brain Engineering Korea Advanced Institute of Science and Technology (KAIST) Daejeon 34141 Republic of Korea Graduate School of Medical Science and Engineering KAIST Daejeon 34141 Republic of Korea

Apoptosis and hypertrophy of cardiomyocytes are the primary causes of heart failure （HF）, a global leading cause of death, and are regulated through the complicated intracellular signaling network, limiting the development of effective treatments due to its complexity. To identify effective therapeutic strategies for HF at a system level, we develop a large-scale comprehensive mathematical model of the cardiac signaling network by integrating all available experimental evidence. Attractor landscape analysis of the network model identifies distinct sets of control nodes that effectively suppress apoptosis and hypertrophy of cardiomyocytes under ischemic or pressure overload-induced HF, the two major types of HF. Intriguingly, our system-level analysis suggests that intervention of these control nodes may increase the efficacy of clinical drugs for HF and, of most importance, different combinations of control nodes are suggested as potentially effective candidate drug targets depending on the types of HF. Our study provides a systematic way of developing mechanism-based therapeutic strategies for HF.

关键词： heart failure mathematical modeling cardiac signaling network systems analysis disease mechanism mechanism-based therapeutic strategy systems biology

Oxidative coupling of methane over LaAlO3 perovskite catalysts prepared by a co-precipitation method: Effect of co-precipitation pH value

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Journal of Energy Chemistry 2019年第8期28卷 1-8,I0001页

作者： Yujin Sim Jihoon Yoo jeong-myeong Ha Ji Chul Jung Department of Chemical Engineering Myongji UniversityYongin 17058 Republic of Korea Clean Energy Research Center Korea Institute of Science and TechnologySeoul 02792 Republic of Korea

Oxidative coupling of methane(OCM) was conducted over LaAlO3X catalysts that were prepared by a coprecipitation method using different co-precipitation pH values(X = 6–10). The aim is to investigate the effect of p H values on the catalytic activity of La AlO3 catalysts in this reaction. The results showed that the co-precipitation pH value affected greatly on the formation of chemical species of precipitate precursors in the co-precipitation step, leading to different phases of the finally obtained LaAlO3 *** the co-precipitation pH value increased up to 8, the lanthanum-related phases such as La2 O3 and La(OH)3 were gradually formed as by-products, preventing the formation of LaAlO3 perovskite crystalline structure and facilitating the formation of oxygen vacancies on catalyst surface. However, at pH value of9 or higher, the lanthanum content in the precipitate precursor was increased greatly. Not LaAlO3 perovskite but lanthanum-related phases were developed as main phases, reducing their catalytic activities in this reaction. Among LaAlO3 catalysts, the one prepared at pH = 8 showed the highest C2 yield due to its well-developed oxygen vacancies and electrophilic lattice oxygen. Therefore, the co-precipitation pH value strongly affected the LaAlO3 catalyst activity in OCM reaction. A precious pH control should be required to prepare various perovskite catalysts for the OCM.

关键词： LaAlO3 Perovskite Oxidative coupling of methane Co-precipitation pH value

Endoscopic band ligation: Beyond prevention and management of gastroesophageal varices

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World Journal of Gastroenterology 2013年第27期19卷 4271-4276页

作者： jeong-seon Ji Young-Seok Cho Division of Gastroenterology Department of Internal MedicineIncheon St. Mary's HospitalThe Catholic University of Korea College of Medicine Division of Gastroenterology Department of Internal MedicineUijeongbu St. HospitalThe Catholic University of Korea College of Medicine

Endoscopic band ligation (EBL) is the preferred endoscopic technique for the endoscopic treatment of acute esophageal variceal bleeding. EBL has also been used to treat nonvariceal bleeding. Recently, Han et al demonstrated that EBL can be a feasible and safe alternate technique for the management of iatrogenic gastric perforation especially in cases in which closure with endoclips is difficult. EBL is technically simpler to perform than other methods and provides a good view of the lesions under direct pressure and suction from the transparent ligation cap. EBL can be used even if the diameter of the perforation is greater than 10 mm or if there is a severe tangential angle. In this commentary, we discuss the efficacy and safety of EBL for the closure of iatrogenic gastrointestinal perforation. We also discuss the advantages and disadvantages of EBL for the treatment of nonvariceal bleeding.

关键词： Band ligation Endoscopy Intestinal perforation Gastrointestinal hemorrhage

Flexible thermocouple using a thermoelectric graphene fiber with a seamless junction

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Journal of Materials Science & Technology 2024年第5期172卷 15-22页

作者： Seungwon Kim Soomook Lim myeong Hee jeong Wonjoon Kim Seunghyun Baik Ji Won Suk School of Mechanical Engineering Sungkyunkwan UniversitySuwonGyeonggi-do 16419Republic of Korea Department of Smart Fab.Technology Sungkyunkwan UniversitySuwonGyeonggi-do 16419Republic of Korea SKKU Advanced Institute of Nanotechnology(SAINT) Sungkyunkwan UniversitySuwonGyeonggi-do 16419Republic of Korea

Temperature is an important physical variable that indicates the condition of the human body and artificial *** wearable applications require the development of temperature sensors with different form *** this study,a fiber-shaped thermoelectric temperature sensor is fabricated using a continuous graphene fiber whose two halves possess different reduction states.A seamless junction is formed by partially reducing a wet-spun graphene oxide fiber with hydroiodic acid(HI)solutions of different ***-half of the fiber is mildly reduced with 0.97 wt%HI,while the other half is highly reduced with 30.6 wt%*** different reduction states of the graphene composite fiber result in different Seebeck coefficients,allowing for the fabrication of a fiber-shaped graphene thermocou-ple without any laborious *** flexible graphene thermocouple exhibits high sensitivity with a thermopower of 12.5μV K^(-1)in the temperature range of room temperature to∼70℃.Furthermore,it exhibits high linearity with a correlation coefficient exceeding 0.995 and fast response with a time constant of 0.24 *** to its mechanical robustness and flexibility,the stand-alone graphene ther-mocouple can be knitted into a cotton fabric glove,which presents a fast response to environmental changes without any external power *** work offers a unique fabrication method for producing a high-performance,flexible thermocouple that features a seamless and clear junction without the use of additional *** alternative method eliminates the complicated assembly processes typically required for conventional thermocouples.

关键词： Graphene fiber Thermocouple Reduced graphene oxide Flexible temperature sensor Seebeck coefficient

Impact of adolescent complex regional pain syndrome on the psychopathology of young men ahead of military service: A retrospective cohort analysis of Korean conscription data

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Military Medical Research 2021年第3期8卷 363-372页

作者： Shin-Heon Lee myeong-Jin Ko Taek-Kyun Nam jeong-Taik Kwon Yong-Sook Park Department of Neurosurgery College of MedicineChung-Ang UniversitySeoul 06973South Korea

Background: The relationship between physical and psychopathological features in complex regional pain syndrome(CRPS) has been a subject of constant interest, but no data are available in adolescents. Therefore, we aimed to identify the factors associated with psychopathology in adolescents with CRPS ahead of military ***: We retrospectively reviewed all conscription examinees who had completed a Military Personality Inventory(MPI) during a period between February 2013 and December 2016. A total of 63 persons with a history of CRPS(19-years of age for all) were enrolled. Basic demographic and pain-related data were analyzed to examine their association with MPI results. The mean FGR score as well as the 8 subdomain scores were compared between those with pain duration at <15 months(n=30) vs. ≥15 months(n=33). Binary MPI results(normal-abnormal) were also compared between the two ***: In multivariate analysis, abnormal MPI was associated with pain duration, with an odds ratio(OR) at 1.05 for every 1-month increase [95% confidence interval(CI) 1.02–1.08;P=0.002]. Subjects with pain duration at ≥15 months have lower faking good response score(P<0.001 vs. those with pain duration at <15 months), and higher abnormal MPI result rate, faking bad response, inconsistency, anxiety, depression, somatization, paranoid, personality disorder cluster A, and personality disorder cluster B scores(P<0.05). Pain duration was significantly associated with the MPI ***: Pain duration is associated with psychopathology in adolescents with CRPS. Psychopathologic features increased as the disease duration increased. A comprehensive understanding of time-dependent psychopathological factors could support the planning of multimodal approaches for managing adolescent CRPS.

关键词： Chronic pain Complex regional pain syndromes Psychopathology Personality inventory Adolescent Military personnel

Ternary layered double hydroxide oxygen evolution reaction electrocatalyst for anion exchange membrane alkaline seawater electrolysis

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Journal of Energy Chemistry 2022年第12期75卷 127-134,I0004页

作者： Yoo Sei Park Jae-Yeop jeong myeong Je Jang Chae-Yeon Kwon Geul Han Kim Jaehoon jeong Ji-hoon Lee Jooyoung Lee Sung Mook Choi Department of Hydrogen Energy Materials Surface&Nano Materials DivisionKorea Institute of Materials Science(KIMS)Changwon 51508Republic of Korea Department of Advanced Material Engineering Chungbuk National University1 Chungdae-roSeowon-guCheongjuChungbuk 28644Republic of Korea Department of Chemical Engineering University of WaterlooWaterlooOntario N2L 3G1 Canada School of Materials Science and Engineering Gyeongsang National UniversityJinju 52828Republic of Korea Department of Materials Science and Engineering Pusan National UniversityBusan 46241Republic of Korea Energy Industry Support Center Daegu Mechatronics&Materials InstituteDaegu 42704Republic of Korea Advanced Materials Engineering University of Science and Technology(UST)Yuseong-guDaejeon 34113Republic of Korea

Anion exchange membrane(AEM)water electrolyzers are promising energy devices for the production of clean hydrogen from ***,the lack of active and robust electrocatalysts for the oxygen evolution reaction(OER)severely impedes the development of this *** this study,a ternary layered double hydroxide(LDH)OER electrocatalyst(NiFeCo-LDH)is developed for high-performance AEM alkaline seawater *** AEM alkaline seawater electrolyzer catalyzed by the NiFeCo LDH shows high seawater electrolysis performance(0.84 A/cm^(2)at 1.7 Vcell)and high hydrogen production efficiency(77.6%at 0.5 A/cm^(2)),thus outperforming an electrolyzer catalyzed by a benchmark IrO_(2)*** NiFeCo-LDH electrocatalyst greatly improves the kinetics of the AEM alkaline seawater electrolyzer,consequently reducing its activation loss and leading to high *** on the results,this NiFeCo-LDH-catalyzed AEM alkaline seawater electrolyzer can likely surpass the energy conversion targets of the US Department of Energy.

关键词： Anion exchange membranes water electrolysis Oxygen evolution reactions Alkaline seawater electrolysis Hydrogen production

Enhancement parameters of contrast-enhanced computed tomography for pancreatic ductal adenocarcinoma: Correlation with pathologic grading

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World Journal of Gastroenterology 2020年第28期26卷 4151-4158页

作者： Woorim Seo Young Chul Kim seon jeong Min Sang Min Lee Department of Radiology Hallym University Dongtan Sacred Heart HospitalGyeonggi-do 18450South Korea Department of Radiology Hallym University Sacred Heart HospitalGyeonggido 14068South Korea

BACKGROUND Pancreatic ductal adenocarcinoma(PDA)is a malignancy with a high mortality rate and short survival *** conventional computed tomography(CT)has been worldwide used as a modality for diagnosis of PDA,as CT enhancement pattern has been thought to be related to tumor angiogenesis and pathologic grade of *** To evaluate the relationship between the pathologic grade of pancreatic ductal adenocarcinoma and the enhancement parameters of contrast-enhanced *** In this retrospective study,42 patients(Age,mean±SD:62.43±11.42 years)with PDA who underwent surgery after preoperative CT were *** radiologists evaluated the CT images and calculated the value of attenuation at the aorta in the arterial phase and the pancreatic phase(VAarterial and VApancreatic)and of the tumor(VTarterial and VTpancreatic)by finding out four regions of *** between the tumor and the aorta enhancement on the arterial phase and the pancreatic phase(TARarterial and TARpancreatic)was figured out through dividing VT arterial by VAarterial and VTpancreatic by ***-to-aortic enhancement fraction(TAF)was expressed as the ratio of the difference between attenuation of the tumor on arterial and parenchymal images to that between attenuation of the aorta on arterial and pancreatic *** Kruskal-Wallis analysis of variance and Mann-Whitney U test for statistical analysis were *** Forty-two PDAs(23 men and 19 women)were divided into three groups:Welldifferentiated(n=13),moderately differentiated(n=21),and poorly differentiated(n=8).TAF differed significantly between the three groups(P=0.034)but TARarterial(P=0.164)and TARpancreatic(P=0.339)did *** median value of TAF for poorly differentiated PDAs(0.1011;95%CI:0.01100-0.1796)was significantly higher than that for well-differentiated PDAs(0.1941;95%CI:0.1463-0.3194).CONCLUSION Calculation of TAF might be useful in predicting the pathologic grade of PDA.

关键词： Computed tomography Pancreatic ductal carcinoma Diagnostic imaging Clinical pathology Neoplasm grading Prognosis