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碰撞激活诱导的双势阱势能面可以实现9-甲基-8-氧鸟嘌呤-9-甲基腺嘌呤碱基对阳离子自由基的质子转移

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Chinese Journal of Chemical Physics 2024年第2期37卷 330-340,I0022-I0039,I0104页

作者： May myat Moe 刘剑波美国纽约城市大学皇后学院化学与生物化学系纽约11367 美国纽约城市大学研究生院纽约10016

8-氧鸟嘌呤(OG)是最常见的核碱基氧化损伤,它在复制过程中可以用Hoogsteen的模式与腺嘌呤(A)错误配对.0G.A碱基对不仅可以诱发G·C→T·A的颠换突变,而且由于OG的电离势和氧化电位低于天然DNA碱基更容易受到电离辐射和单电子氧化的影响... 详细信息

8-氧鸟嘌呤(OG)是最常见的核碱基氧化损伤,它在复制过程中可以用Hoogsteen的模式与腺嘌呤(A)错误配对.0G.A碱基对不仅可以诱发G·C→T·A的颠换突变,而且由于OG的电离势和氧化电位低于天然DNA碱基更容易受到电离辐射和单电子氧化的影响,本文报道了[9MOG9MA]^(+)碱華对阳离子自由基的形成.和碰撞诱导解离,该碱基对利用9-甲基8-氧鸟嘌呤(9MOG)和9-甲基腺嘌呤(9MA)模拟相对应的核苷酸.实验通过电喷雾产生Cu(Ⅱ)碱基复合物继之以氧化分离产生[9MOG·9MA]^(+),并使用导向离子束串级质谱仪检测[9MOG·9MA]^(+)的碰撞诱导解离、通过测量在不同碰撞能量下的解离产物和反应截面,可以得出[9MOG-H]+[9MA+H]^(+)(主要解离通道)和9MOG·++9MA(次要通道)的0 K解离阈能分别为1.8和1.65 eV.使用密度泛函理论对[9MOG·9MA]+的结构计算发现其所有重要构象都发生了质子转移生成[9MOG-H]·[9MA+H]+.另一方面,9MOG++9MA的解离通道却需要9MOG+9MA作为中间体.看似矛盾的结果可以用碰撞活化后反应势能面上出现的双重势阱和由此触发的激发态质子转移平衡([9MOG-H]·[9MA+H]+)→←(9MOG+.9MA)*来解释.本文实验和理论研究揭示了这种生物学上重要的非规范碱基对如何在氧化和电离损伤时发生解离.

关键词：碱基对阳离子自由基碰撞诱导解离碱基对内质子转移反应势能面电喷雾电离质谱导向离子束散射

Multi-environment BSA-seq using large F3 populations is able to achieve reliable QTL mapping with high power and resolution: An experimental demonstration in rice

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The Crop Journal 2024年第2期12卷 549-557页

作者： Yan Zheng Ei Ei Khine Khin Mar Thi Ei Ei Nyein Likun Huang Lihui Lin Xiaofang Xie Min Htay Wai Lin Khin Than Oo myat myat Moe San San Aye Weiren Wu College of Life Sciences Fujian Agriculture and Forestry UniversityFuzhou 350002FujianChina Fujian Provincial Key Laboratory of Crop Breeding by Design Fujian Agriculture and Forestry UniversityFuzhou 350002FujianChina Key Laboratory of Genetics Breeding and Multiple Utilization of CropsMinistry of EducationFujian Agriculture and Forestry UniversityFuzhou 350002FujianChina Department of Botany Mawlamyine UniversityMon StateMawlamyineMyanmar Department of Botany Dagon UniversityNorth DagonYangonMyanmar

Bulked-segregant analysis by deep sequencing(BSA-seq) is a widely used method for mapping QTL(quantitative trait loci) due to its simplicity, speed, cost-effectiveness, and efficiency. However, the ability of BSA-seq to detect QTL is often limited by inappropriate experimental designs, as evidenced by numerous practical studies. Most BSA-seq studies have utilized small to medium-sized populations, with F2populations being the most common choice. Nevertheless, theoretical studies have shown that using a large population with an appropriate pool size can significantly enhance the power and resolution of QTL detection in BSA-seq, with F_(3)populations offering notable advantages over F2populations. To provide an experimental demonstration, we tested the power of BSA-seq to identify QTL controlling days from sowing to heading(DTH) in a 7200-plant rice F_(3)population in two environments, with a pool size of approximately 500. Each experiment identified 34 QTL, an order of magnitude greater than reported in most BSA-seq experiments, of which 23 were detected in both experiments, with 17 of these located near41 previously reported QTL and eight cloned genes known to control DTH in rice. These results indicate that QTL mapping by BSA-seq in large F_(3)populations and multi-environment experiments can achieve high power, resolution, and reliability.

关键词： BSA-seq QTL mapping Large F3 population Multi-environment experiment Cross-validation

AcWRKY28 mediated activation of AcCPK genes confers salt tolerance in pineapple(Ananas comosus)

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Horticultural Plant Journal 2024年第2期10卷 398-412页

作者： Qiao Zhou Samaranayaka Vidana Gamage Nirosha Priyadarshani Rongjuan Qin Han Cheng Tiantian Luo myat Hnin Wai Mohammad Aqa Mohammadi Yanhui Liu Chang Liu Hanyang Cai Xiaomei Wang Yeqiang Liu Yuan Qin Lulu Wang Guangxi Key Lab of Sugarcane Biology State Key Laboratory for Conservation and Utilization of Subtropical Agro-BioresourcesCollege of AgricultureGuangxi UniversityNanningGuangxi 530004China State Key Laboratory of Ecological Pest Control for Fujian and Taiwan Crops College of Life ScienceCollege of Plant ProtectionCollege of AgricultureCollege of HorticultureFujian Provincial Key Laboratory of Haixia Applied Plant Systems BiologyCenter for Genomics and BiotechnologyFujian Agriculture and Forestry UniversityFuzhouFujian 350002China Pingtan Science and Technology Research Institute of Fujian Agriculture and Forestry University PingtanFujian 350400China National Education Commission BMICHColombo00700Sri Lanka Fishery Multiplication Management Station of Lijiang River Water Supply Hub Project GuilinGuangxi 541001China Horticulture Research Institute Guangxi Academy of Agricultural SciencesNanning Investigation Station of South Subtropical Fruit TreesMinistry of AgricultureNanningGuangxi 530007China

Unfavorable environmental cues severely affect crop productivity resulting in significant economic losses to farmers. In plants, multiple regulatory genes, such as the WRKY transcription factor (TF) family, modulate the expression of defense genes. However, the role of the pineapple WRKY genes is poorly understood. Here, we studied the pineapple WRKY gene, AcWRKY28, by generating AcWRKY28 over-expressing transgenic pineapple plants. Overexpression of AcWRKY28 enhanced the salt stress resistance in transgenic pineapple lines. Comparative transcriptome analysis of transgenic and wild-type pineapple plants showed that “plant-pathogen interaction” pathway genes, including 9calcium-dependent protein kinases (CPKs), were up-regulated in AcWRKY28 over-expressing plants. Furthermore, chromatin immunoprecipitation and yeast one-hybrid assays revealed AcCPK12, AcCPK3, AcCPK8, AcCPK1, and AcCPK15 as direct targets of AcWRKY28. Consistently, the study of AcCPK12 over-expressing Arabidopsis lines showed that AcCPK12 enhances salt, drought, and disease resistance. This study shows that AcWRKY28 plays a crucial role in promoting salt stress resistance by activating the expression of AcCPK genes.

关键词： Pineapple AcWRKY AcCPK Transcription factor Salt stress ChIP

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镜像

中学生英语 2024年第3期 18-20页

作者： myat Yati Hmu 任新超(译) 不详湖北省襄阳市东津新区金源中学

在我班上,没有人喜欢罗茜。她是一个非常自负的女孩。由于她出身富裕家庭,所以她总是看不起别人。她住在我家附近,所以我对她很了解。她的父母总是任由她为所欲为。无论她是对是错,他们都站在女儿一边。还有一个女孩叫梅。和罗茜不同,... 详细信息

在我班上,没有人喜欢罗茜。她是一个非常自负的女孩。由于她出身富裕家庭,所以她总是看不起别人。她住在我家附近,所以我对她很了解。她的父母总是任由她为所欲为。无论她是对是错,他们都站在女儿一边。还有一个女孩叫梅。和罗茜不同,梅是个性格很好的女孩。她总是很开朗并乐于助人。对罗茜来说,她从不懂得分享。由于梅的友善,比起罗茜,我们所有人似乎都更亲近梅。罗茜嫉妒梅,嫉妒夺走了她内心的平静。她看起来总是闷闷不乐。

关键词：嫉妒镜像乐于助人

Review on Possible Factors for Outbreak of Wood Boring Isopod, Sphaeroma spp. Which Causes Destructive Impact on Mangrove Forest in China

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Open Journal of Ecology 2022年第3期12卷 211-235页

作者： myat Thiri Yunan Yang School of Space and Environment Beihang University Beijing China Biotechnology Research Department Ministry of Education Naypyidaw Myanmar

The tropical and subtropical mangrove biomes form the foundation of a highly productive and biologically rich ecosystem providing essential goods and services to human beings. Despite its values, the stability and survival of mangroves are consistently threatened by anthropogenic activities and their associated degradation, resulting in their disappearance. After realizing their ecological importance, in recent years, rehabilitation and restoration programs for mangrove forests have been launched globally. Unfortunately, most mangrove restoration efforts yielded negative results and failed to re-establish mangrove forests because of technical and social failures. Besides, the continued outbreak of wood borer, Sphaeroma spp., in mangrove forests has become one of the destructive causes of natural and restored mangrove forests in some nations including China. However, few studies on the biology of Sphaeroma spp. found in Chinese mangrove ecosystem have been done, and little is known concerning the factors affecting their outbreak in China. In this review, we discussed the possible factors that affect the rapid growth and recruitment of Sphaeroma spp. in the mangrove ecosystem by examining the information of the wood borer Sphaeroma spp. from the scattered pieces of literature with great regard. We discussed the relationship between the recruitment of Sphaeroma spp. and the tide and flow of water, food availability from the surrounding water and water quality including salinity, temperature, and the pollution of water. In addition to these factors, the reduced biodiversity of restored mangrove forest could be one of the main reasons for the outbreak of isopod. We also discussed the destructive impact of the isopod’s outbreak and the possible ways to control their outbreak in mangrove forest.

关键词： Isopod’s Outbreak Sphaeroma Species Destructive Impact Mangrove Forest Restoration

Can adequate hemodynamic management of brain-dead donors improve donor organ procurement?

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World Journal of Transplantation 2022年第4期12卷 79-82页

作者： myat Soe Thet Alessandra Verzelloni Sef Davorin Sef Department of Cardiac Surgery St Bartholomew’s HospitalLondon EC1A 7BEUnited Kingdom Department of Surgery and Cancer Faculty of MedicineImperial College London&Imperial College Healthcare NHS TrustLondon W21NYUnited Kingdom Department of Anaesthesia and Critical Care Harefield HospitalRoyal Brompton and Harefield HospitalsPart of Guy’s and St Thomas’NHS Foundation TrustLondon UB96JHUnited Kingdom Department of Cardiothoracic Surgery and Transplant Unit Harefield HospitalRoyal Brompton and Harefield HospitalsPart of Guy’s and St Thomas’NHS Foundation TrustLondon UB96JHUnited Kingdom

There is increasing evidence that adequate donor management with a goal of optimization of organ function is essential to maximize the number of organs that can be procured.Therefore,identification of the cause of hemodynamic instability is crucial in order to direct the right therapy.Several donor management goals for better hemodynamic management including serial echocardiography can guide hemodynamic management in potential donors to increase both number and quality of donor hearts.

关键词： Brain-dead donors Hemodynamic Management Organ procurement

Development of Epstein-Barr virus-associated gastric cancer:Infection,inflammation,and oncogenesis

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World Journal of Gastroenterology 2022年第44期28卷 6249-6257页

作者： Hisashi Iizasa Andy Visi Kartika Sintayehu Fekadu Shunpei Okada Daichi Onomura Afifah Fatimah Azzahra Ahmad Wadi Mosammat Mahmuda Khatun Thin myat Moe Jun Nishikawa Hironori Yoshiyama Department of Microbiology Shimane University Faculty of MedicineIzumo 693-8501ShimaneJapan Faculty of Medicine Muslim University of IndonesiaMakassar 90231Indonesia Department of Medical Microbiology and Parasitology Hawassa UniversityCollege of Medicine and Health ScienceHawassa 1560Ethiopia Faculty of Laboratory Science Yamaguchi University Graduate School of MedicineUbe 755-8505Japan

Epstein-Barr virus(EBV)-associated gastric cancer(EBVaGC)cells originate from a single-cell clone infected with EBV.However,more than 95%of patients with gastric cancer have a history of Helicobacter pylori(H.pylori)infection,and H.pylori is a major causative agent of gastric cancer.Therefore,it has long been argued that H.pylori infection may affect the development of EBVaGC,a subtype of gastric cancer.Atrophic gastrointestinal inflammation,a symptom of H.pylori infection,is observed in the gastric mucosa of EBVaGC.Therefore,it remains unclear whether H.pylori infection is a cofactor for gastric carcinogenesis caused by EBV infection or whether H.pylori and EBV infections act independently on gastric cancer formation.It has been reported that EBV infection assists in the oncogenesis of gastric cancer caused by H.pylori infection.In contrast,several studies have reported that H.pylori infection accelerates tumorigenesis initiated by EBV infection.By reviewing both clinical epidemiological and experimental data,we reorganized the role of H.pylori and EBV infections in gastric cancer formation.

关键词： Helicobacter pylori Epstein-Barr virus Epstein-Barr virus-associated gastric cancer Coreceptor Inflammation Oncogenesis

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缅甸对华外交政策研究

缅甸对华外交政策研究

作者： The myat Mon Shein 吉林大学

学位级别：硕士

外交政策是与国家和组织管理国家事务的综合系统,通常是公开的。外交政策是多变的,但随着国际和地区形势的变化而变化。它的制定和应用取决于一套宪法和法律规则。外交政策在危机时期和与国际伙伴的接触中很活跃,而且在许多情况下,外交... 详细信息

外交政策是与国家和组织管理国家事务的综合系统,通常是公开的。外交政策是多变的,但随着国际和地区形势的变化而变化。它的制定和应用取决于一套宪法和法律规则。外交政策在危机时期和与国际伙伴的接触中很活跃,而且在许多情况下,外交政策是在预期可能出现的问题时制定的。外交政策是实现国家安全、经济进步和建立外交关系的工具。它还旨在显示一个国家在国际社会中的崇高地位,并可能有助于政治思想的传播。国际关系和外交政策是一个国家对外关系的基本原则。一国的外交政策以国家利益和战略目标为目标。外交政策加强了其他国家的积极回应,因为它与其他国家打交道。此外,自1948年独立以来,缅甸的国家利益始终如一:改善国家安全、促进国家发展、增强地区社会和国际地位,此后其外交政策始终保持独立、积极和不结盟。另一方面,缅甸的对外行为根据其对军事统治前后等特定事件的反应而发生了变化。本研究探讨了2016-2020年缅甸对华外交政策的变化”。缅甸实际上是在寻求外援和经济援助。中缅两国自独立以来一直保持友好合作关系。缅甸于2011年开始进行民主转型,并在缅甸实行新的文职政府制度。国际社会开始与文职政府合作,使缅甸的民主更加有效,并帮助该国翻开了新的篇章。2016-2020年的外交政策是外交关系的改善。在此期间,国家外交有了很大改善。外交政策比以前更加发达。中国帮助缅甸改善国家经济,一直是友好伙伴。在面对缅甸的内政时,中国也提供了帮助。因此,本文研究了2016-2020年缅甸对华外交政策的执行情况,并维护了两国之间的友好关系和经济合作。本论文由五章组成。第一章为绪论部分,介绍了研究的背景。中缅历史上,缅甸向西摇摆,却被西方阻挠,而中国却帮助了缅甸。两国遵循和平共处五项原则,中国??是缅甸的好邻居。它包括解释研究问题和研究假设的理论方法。并且,本章还阐明了研究的意义、文献综述和论文结构。第二章介绍了SLORC的外交政策。在其中,东盟批评缅甸违反了人文法。缅甸试图退出东盟成员国,但中国在解决缅甸内部冲突方面发挥了积极作用。此外,一个国家的军事力量也是影响其外交政策的主要因素。并且,SLORC政府表示,缅甸将继续奉行“独立和积极的外交政策”。中国在缅甸具有重要的政治作用。缅甸拥有丰富的自然资源和投资的战略地理位置。缅甸人民使用双边兄弟情谊一词。中国是缅甸的忠实朋友,在经济危机和国际压力下始终站在缅甸一边。第三章考察了USDP和NLD政府内部的对外关系。缅甸在USDP的政府中实行民主。缅甸新的USDP政府正在寻求克服该国与世界其他地区长期孤立的问题。缅甸对华政策是关于合作的。自2011年3月上台以来,吴登盛政府制定了新的外交政策目标,即让缅甸重新融入国际社会。在2015年11月选举开始之前,中国与全国民主联盟合作。中国实施扩大人文交流,提供发展援助。缅甸与中国建立了经济联系。在民盟政府内部,缅甸和中国比以往任何时候都更加重视对外关系。中国在缅甸的投资更加发达。第四章讨论了缅甸与中国在外交政策上的相互关系。缅中关系建立在积极参与中国“一带一路”倡议的基础上,可以使缅中两国的合作更好。国际法院,21世纪的彬龙会议和中国在COVID-19危机期间对缅甸的援助,是在民盟政府时代引起的,与中国相关。最后一章为研究简报。按照新古典现实主义的观点,缅中外交政策是由内外因素共同决定的。缅中两国在困难时期相互帮助、相互依靠。中缅经济关系良好,政治互信,中国将在缅甸未来转型中发挥关键和重要作用。研究者逐章描述了新古典现实主义理论的标杆。它使用不同的外交政策分析方法,根据权力分配和外交政策决策者的行动自由来评估国家活动。

关键词：外交政策政府缅甸中国

吴登盛政府时期的中缅关系研究（2011-2016）

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吴登盛政府时期的中缅关系研究（2011-2016）

作者： Hsu myat Thazin 北京外国语大学

学位级别：硕士

在吴登盛总统的领导下,缅甸进入了民主过渡的新时代。在总统吴登盛领导的政府上台后,缅甸进行了政治、经济和行政改革。缅甸还重新审视了其外交政策并改善了与国际社会的关系。其与包括中国在内的大国的双边关系也似乎发生了一些变化。... 详细信息

在吴登盛总统的领导下,缅甸进入了民主过渡的新时代。在总统吴登盛领导的政府上台后,缅甸进行了政治、经济和行政改革。缅甸还重新审视了其外交政策并改善了与国际社会的关系。其与包括中国在内的大国的双边关系也似乎发生了一些变化。缅中关系可以追溯到几个世纪前。几十年来,中国一直是缅甸最亲密的邻国和主要经济伙伴,两国在双边和区域组织中的各个领域开展合作。基于这种情况,本文旨在考察吴登盛总统领导下的缅中关系的性质并找出缅甸推动双边关系发展的因素。纵观历史,中缅关系的发展并非一帆风顺,但吴登盛政府在中缅关系发展中实施的政策总体看仍然有利于两国利益。研究发现,政治、社会经济关系是缅中关系发展的两个关键方面。缅甸在双边关系中的行为存在三个国内动机,即中国在缅甸和平进程中的作用、缅甸的经济改革和发展,以及吴登盛总统寻求合法性和形象的行为。总的来说,这些因素使得中缅合作能够在缅甸国内政治发生变化的情况下持续下去。中国和缅甸在贸易和投资、互联互通、包括港口和经济特区在内的基础设施建设方面建立牢固的双边关系,中缅双边都从中受益匪浅。

关键词：缅中关系改革合作外交