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基于平行共聚焦激光技术并考虑操作者经验和种植角度及深度的种植数字化印模系统的精度分析

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中国口腔医学继续教育杂志 2016年第2期19卷 77-84页

作者： Beatriz Gimenez mutlu ozcan Francisco Martinez-Rus Guillermo Pradies 周文娟柳忠豪不详滨州医学院附属烟台市口腔医院山东省烟台市芝罘区北大街142号264008

目的：对一种基于平行共聚焦激光技术的种植数字化印模系统的精度进行评价，将诸如操作者经验和种植体角度及长度等方面的临床参数考虑在内。材料和方法：在含6颗种植体（位置为双侧第二磨牙，第二前磨牙及侧切牙）的上颔主模型上安装6... 详细信息

目的：对一种基于平行共聚焦激光技术的种植数字化印模系统的精度进行评价，将诸如操作者经验和种植体角度及长度等方面的临床参数考虑在内。材料和方法：在含6颗种植体（位置为双侧第二磨牙，第二前磨牙及侧切牙）的上颔主模型上安装6个聚醚醚酮扫描体。其中一个第二前磨牙植体近中倾斜30°;对侧种植体远中倾斜30°；侧切牙植入龈下2mm或4mm。由两名有经验的医师和两名没有经验的操作者进行口内扫描．测量5个不同的种植体间距,扫描所得到的数据输入逆向工程软件。使用一个坐标测量机进行测量，从主模型上得到的数据作为参考值，计算实际值的误差。统计分析有经验的医师与没有经验的医师以及不同的种植体角度和深度之间的差异。结果：总体上,操作者3得到了明显低精度的结果。与平行植入的植体相比，倾斜植入的植体对于精度没有显著影响。不同象限的误差量存在差异，第二扫描象限的结果比第一象限结果差。种植体植入水平位于软组织的．其精度低于植入龈下2mm及4mm的种植体。结论：操作者影响测量的精度，但是并不一定依赖经验。倾斜种植体不会降低数字化印模系统的精度。扫描距离影响扫描仪精度的可预测性，扫描区长度的增加会导致误差增加。

关键词：精度牙种植数字印模种植体角度种植体深度口内扫描

种植体钛基台和氧化锆基台粘结冠修复体的抗折强度：无饰瓷全瓷冠和饰面瓷全瓷冠系统的比较研究

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中国口腔医学继续教育杂志 2015年第3期18卷 151-157页

作者： Francisco Martinez-Rus Alberto Ferreiroa mutlu ozcan Dr Med Dent Jose F. Bartolome Guillermo Pradies 华泽乾汤春波不详北京瑞尔齿科北京市朝阳区酒仙桥路18号颐堤港LG100 100621 南京医科大学附属口腔医院种植修复科南京市汉中路136号 210005

目的：研究种植体钛基台和氧化锆基台上全瓷冠修复体的抗折强度。材料与方法：内连接式种植体修复右上中切牙，分别制作个性化钛基台30个和氧化锆基台30个。两组基台分别以以下全瓷系统进行修复。每组10个：①计算机辅助设计／计算机辅... 详细信息

目的：研究种植体钛基台和氧化锆基台上全瓷冠修复体的抗折强度。材料与方法：内连接式种植体修复右上中切牙，分别制作个性化钛基台30个和氧化锆基台30个。两组基台分别以以下全瓷系统进行修复。每组10个：①计算机辅助设计／计算机辅助制作硅酸锂（MLD）；②热压铸造硅酸锂（PLD）；③二氧化锆（YTZP）。其中PLD和YTZP底冠表面经氟磷灰石饰瓷完成修复体。各组修复体分别粘固于两组种植体基台，在万能测试机上以0．5mm／min的速度加载至断裂。数据采用双因素方差分析（ANOVA）和Tukey’stest检验（CX=O05）。结果：基台材料（P=0．0001）和全瓷冠系统（P=O．028）均对实验结果有显著影响．组间交互作用不显著（P=O，598）；Ti—MLD组平均抗折强度{558．54-35N）相比其他各组（340．3±62～495．9±53N）为最高（P〈O．05L钛基台各组的抗折强度（558．54-35～495．9±53N）远高于氧化锆基台各组（392．94-55～340．34-62N）（P〈O05）：无论是钛基台还是氧化锆基台的MLD组其抗折强度均高于饰面瓷全瓷冠组（P〈0．05）。在Ti—MLD组和Ti-PLD组断裂模式仅为冠破裂，无基台断裂；在Zr-YTZP组则发生基台断裂，无冠破裂；在zr—MLD组和Zr-PLD组既有基台断裂也有冠破裂：Ti—YTZP组仅表现为种植体颈部的形变结论：钛基台结合无饰瓷冠修复抗折强度最高．而钛基台结合氧化锆全瓷冠修复整体断裂模式最理想。

关键词：计算机辅助设计/计算机辅助制作硅酸锂陶瓷无饰瓷冠铸造陶瓷钛氧化锆

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磨耗前牙的薄型瓷贴面美学修复

中国口腔医学继续教育杂志 2012年第4期15卷 225-234页

作者： Marco Gresnigt mutlu ozcan Warner Kalk 陈铭晟(译) 孟玉坤(审) 四川大学华西口腔医学院修复学系四川省成都市人民南路三段14号 610041

粘接性瓷修复是一种结果可预期且效果持久的治疗方式．它能同时恢复患牙美观的外形、强度和生理功能。现代牙科治疗中最重要的问题之一是要尽量保存健康的牙釉质。根据仿生学的原则．采用侵入性最小的治疗手段和粘接技术。对修复治疗的... 详细信息

粘接性瓷修复是一种结果可预期且效果持久的治疗方式．它能同时恢复患牙美观的外形、强度和生理功能。现代牙科治疗中最重要的问题之一是要尽量保存健康的牙釉质。根据仿生学的原则．采用侵入性最小的治疗手段和粘接技术。对修复治疗的成功极为重要。在精确预备薄型瓷贴面所需的最小空间时，推荐使用实体模拟（模拟修复）技术。在最小侵入性牙体预备的同时，治疗的远期成功还取决于贴面的粘接效果。本文展示了一例由于前牙区切缘磨耗影响笑容的修复病例。在瓷贴面粘接之前．用复合树脂采用口内直接法恢复切缘长度，并对牙龈缘形态进行修整。采用实体模拟技术．牙体预备量达到最小化，并使预备轮廓线控制在牙釉质层范围之内。同时．也详细介绍了薄型瓷贴面树脂粘接的临床步骤。

关键词：美学修复瓷贴面前牙区薄型磨耗最小侵入性治疗方式模拟技术

Scour and liquefaction issues for anchors and other subsea structures in floating offshore wind farms: A review

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Water Science and Engineering 2022年第1期15卷 3-14页

作者： B.mutlu Sumer Veysel Sadan Ozgur Kirca BM SUMER Consultancy&Research ITU ARI Teknokent 1Nol5Istanbul 34467Turkey Department of Civil Engineering Istanbul Technical UniversityMaslak 34467Turkey

This article reviews scouring and liquefaction issues for anchor foundations of floating offshore wind farms.The review is organized in two sections:(1)the scouring issues for drag-embedment anchors(DEAs)and other subsea structures associated with DEAs such as tensioners,clump weights,and chains in floating offshore wind farms;and(2)the liquefaction issues for the same types of structures,particularly for DEAs.The scouring processes are described in detail,and the formulae and design guidelines for engineering predictions are included for quantities like scour depth,time scale,and sinking due to general shear failure of the bed soil caused by scoui\The latter is furnished with numerical examples.Likewise,in the second section,the liquefaction processes are described with special reference to residual liquefaction where pore-water pressure builds up in undrained soils(such as fine sand and silt)under waves,leading to liquefaction of the bed soil and precipitating failure of DEAs and their associated subsea structures.An integrated mathematical model to deal with liquefaction around and the resulted sinking failure of DEAs,introduced in a recent study,has been revisited.Implementation of the model is illustrated with a numerical example.It is believed that the present review and the existing literatures from the"neighboring"fields form a complementary source of information on scour and liquefaction around foundations of floating offshore wind farms.

关键词： Floating structures Liquefaction Offshore structures Offshore wind energy Renewable energy Scouring

Improving Brain Tumor Classification with Deep Learning Using Synthetic Data

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Computers, Materials & Continua 2023年第3期74卷 5049-5067页

作者： Muhammed mutlu Yapici Rukiye Karakis Kali Gurkahraman Elmadag Vocational School Department of Computer TechnologiesAnkara UniversityAnkaraTurkey Faculty of Technology Department of Software EngineeringSivas Cumhuriyet UniversitySivas58140Turkey Faculty of Engineering Department of Computer EngineeringSivas Cumhuriyet UniversitySivas58140Turkey

Deep learning(DL)techniques,which do not need complex preprocessing and feature analysis,are used in many areas of medicine and achieve promising results.On the other hand,in medical studies,a limited dataset decreases the abstraction ability of the DL model.In this context,we aimed to produce synthetic brain images including three tumor types(glioma,meningioma,and pituitary),unlike traditional data augmentation methods,and classify them with DL.This study proposes a tumor classification model consisting of a Dense Convolutional Network(DenseNet121)-based DL model to prevent forgetting problems in deep networks and delay information flow between layers.By comparing models trained on two different datasets,we demonstrated the effect of synthetic images generated by Cycle Generative Adversarial Network(CycleGAN)on the generalization of DL.One model is trained only on the original dataset,while the other is trained on the combined dataset of synthetic and original images.Synthetic data generated by CycleGAN improved the best accuracy values for glioma,meningioma,and pituitary tumor classes from 0.9633,0.9569,and 0.9904 to 0.9968,0.9920,and 0.9952,respectively.The developed model using synthetic data obtained a higher accuracy value than the related studies in the literature.Additionally,except for pixel-level and affine transform data augmentation,synthetic data has been generated in the figshare brain dataset for the first time.

关键词： Brain tumor classification deep learning cycle generative adversarial network data augmentation

Gallium containing bioactive materials: A review of anticancer, antibacterial, and osteogenic properties

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Bioactive Materials 2022年第11期7卷 125-146页

作者： Fatih Kurtuldu Nurshen mutlu Aldo R.Boccaccini Dusan Galusek FunGlass Alexander Dubcek University of TrencínStudentska 291150TrencínSlovakia Institute of Biomaterials Department of Material Science and EngineeringUniversity of Erlangen-Nuremberg91058ErlangenGermany Joint Glass Centre of the IIC SAS TnUAD and FChFT STUStudentska 291150TrencínSlovakia

The incorporation of gallium into bioactive materials has been reported to enhance osteogenesis,to influence blood clotting,and to induce anti-cancer and anti-bacterial activity.Gallium-doped biomaterials prepared by various techniques include melt-derived and sol-gel-derived bioactive glasses,calcium phosphate bioceramics,metals and coatings.In this review,we summarize the recently reported developments in antibacterial,anti-cancer,osteogenesis,and hemostasis properties of Ga-doped biomaterials and briefly outline the mechanisms leading to Ga biological effects.The key finding is that gallium addition to biomaterials has great potential for treating bone-related diseases since it can be efficiently transferred to the desired region at a controllable rate.Besides,it can be used as a potential substitute for antibiotics for the inhibition of infections during the initial and advanced phases of the wound healing process.Ga is also used as an anticancer agent due to the increased concentration of gallium around excessive cell proliferation(tumor)sites.Moreover,we highlight the possibility to design different therapeutic approaches aimed at increasing the efficiency of the use of gallium containing bioactive materials for multifunctional applications.

关键词： Antibacterial Bioactive materials Cancer treatment Hemostasis Osteogenesis

Experimental investigation on combustion and emission characteristics of reactivity controlled compression ignition engine powered with iso-propanol/biodiesel blends

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Propulsion and Power Research 2022年第2期11卷 224-239页

作者： Müjdat Fırat S¸ehmus Altun mutlu Okcu Yasin Varola Department of Automotive Engineering Fırat UniversityElazıg23119Turkey Department of Mechanical Engineering Batman UniversityBatman72100Turkey Department of Electrical-Electronic Engineering Ardahan UniversityArdahan75002Turkey

Recently, reactivity controlled compression ignition (RCCI) has been proposed inorder to achieve a higher thermal efficiency with lower emissions than conventional combustion. In RCCI mode, as the fuel types and their combinations affects the reactivity stratificationinside cylinder, thus combustion control, in present study, iso-propanol was evaluated as lowreactivity fuel (LRF) when petroleum diesel, commercial biodiesel and their blends were highreactivity fuels. It is of great importance that iso-propanol and biodiesel be used together inRCCI mode, as they significantly affect the in-cylinder stratification due to their high octane/cetane number. Therefore, the reactivity controlled compression ignition (RCCI) combustioncharacteristics was investigated in a diesel research engine using iso-propanol, petroleumdiesel, biodiesel and their blends as fuels. Tests were conducted on varying loadings (from20% to 60% of max torque) and premixed ratios of LRF (Rp Z 0, 0.15, 0.30, 0.45, and0.60) at a constant engine speed of 2400 rpm. Results, which were compared with conventionaldiesel combustion (CDC), showed that, as the premixed ratio (Rp) of low-reactivity fuel (isopropanol) increased, ignition delay (ID) period prolonged while combustion duration (CD) and rate of pressure rise (RoPR) reduced assisted to reduce NO emissions and smoke opacity in theexhaust. NO and smoke opacity reduced simultaneously for biodiesel-propanol combinationsup to 40% under 20% load and 0.60 premixed ratio of LRF compared to CDC. Propanol premixed ratio of 0.30 at 60% load was found to be optimum concerning lowest emissions. In conventional mode, HC emissions reduced by up to 52% when biodiesel and its blends with dieselfuel are used, whereas they increased significantly in RCCI mode. According to overall results,it is concluded that RCCI performed better than CDC at entire load.

关键词： Reactivity controlled compression ignition(RCCI) Propanol Biodiesel Combustion Emissions

Modulating of food glycemic response by lactic acid bacteria

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Food Bioscience 2022年第3期47卷 1090-1097页

作者： Ceren mutlu Cihadiye Candal-Uslu Hazal Özhanlı Sultan Arslan-Tontul Mustafa Erbas Department of Food Engineering Engineering FacultyAkdeniz University07058AntalyaTurkey Department of Food Engineering Engineering FacultyBalikesir University10145BalikesirTurkey Faculty of Health Science Nutrition and DieteticsArtvin Coruh University08100ArtvinTurkey Department of Food Engineering Agricultural FacultySelcuk University42130KonyaTurkey

There are some strategies for modulating the glycemic response of food through synthesized metabolites such as organic acids,fatty acids,sugar alcohols,bioactive peptides,and exopolysaccharides by bacteria,yeast,and/or fungi during fermentation.The different species of lactic acid bacteria (LAB) are the most important option in fermented food production because they are considered food-grade,their products can be directly used in food,their usability of a cheap and wide range of substrate,and suitable for genetic modification.They can contribute to lowering the glycemic load of nutrition through their organic acid,alcohol,polysaccharides,and vitamin production.This study aimed to review the effects of lowering the glycemic responses of foods by LAB via metabolites produced and their contribution to human well-being in this way.

关键词： Lactic acid bacteria Starch digestibility Exopolysaccharides Sugar alcohol Glycemic index Diabetes

Influence of Fluoride Content of Artificial Saliva on Metal Release from 17-4 PH Stainless Steel Foam for Dental Implant Applications

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Journal of Materials Science & Technology 2013年第6期29卷 582-588页

作者： Ilven mutlu Enver Oktay Department of Metallurgical and Materials Engineering Istanbul UniversityIstanbulTurkey

Highly porous 17-4 PH stainless steel foam for implant applications was produced by space holder technique. Metal release and weight loss from 17-4 PH stainless steel foams were investigated in fluoride added artificial saliva environment by static immersion test. An inductively coupled plasma-mass spectrometer was employed to measure the concentrations of various metal ions. Effects of fluoride content of artificial saliva on metal release and weight loss from the steel foams were investigated. Effects of immersion time, pH value and process parameters on the weight loss and metal release were determined. Pore morphology, pore size and mechanical properties of the 17-4 PH stainless steel foams were also characterized.

关键词： Metal release Dental implant Metal foam Fluoride Artificial saliva