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Ethanolic extracts of babandotan leaves(Ageratum conyzoides L.)prevents inflammation and proteoglycan degradation by inhibiting TNF-αand MMP-9 on osteoarthritis rats induced by monosodium iodoacetate

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Asian Pacific Journal of Tropical Medicine 2017年第3期10卷 256-262页

作者： Anton Bahtiar mutiara nurazizah Tirza Roselina Anita Paulina Tambunan Ade Arsianti Faculty of Pharmacy Universitas IndonesiaKampus UIDepok 16424Indonesia Faculty of Medicine Universitas IndonesiaKampus UI Salemba Raya no 6Indonesia

Objective:To analyze the effects of Ageratum conyzoides *** the monosodium iodoacetate induced osteoarthritis ***:Thin layer chromatography was performed to analyze the constituents of the babandotan extract *** male Sprague-Dawley rats used in this study were divided into 6 groups:normal control and negative control groups,both given0.5%carboxymethyl cellulose;the positive control group that was given glucosamine and chondroitin suspension(486 mg/200 g B.W.);the 3 dose variation extract groups including dose 1,2,and 3 that were given 40,80,and 160 mg/200 g *** on day 29 *** the groups were induced with 0.05 mL monosodium iodoacetate(20 mg/mL)on day1,except normal control induced by *** of edema volume of rat knees was performed on day 0,8,15,22,29,43,and *** data was measured at day 1,29and *** was collected at day 50 to evaluate TNF-α and MMP-9 by *** histopathology was evaluated by staining with H&E and Safranin-o-fast green staining on day ***:The babandotan leaves extract dose 2(80 mg/200 g B.W.)and dose 3(160mg/200 g B.W.)could decrease the edema volume,increase the area and thickness of articular cartilage,and increase proteoglycan ***,dose 3(160 mg/200 g B.W.)of extract babandotan leaves were able to significantly decrease the number of leukocytes,lymphocytes and udem volume,and decrease TNF alpha and MMP-9 ***:Babandotan leaves extract can recover inflammation and cartilages degradation by inhibiting TNF-αin inflammation processes and MMP-9 in the collagenase reaction in the cartilages.

关键词： Inflammation Osteo arthritis Ageratum conyzoides Hematology parameters TNF-α MMP-9

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