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Studies of the Relationship between Structure and Antioxidant Activity in Interesting Systems, Including Tyrosol, Hydroxytyrosol Derivatives Indicated by Quantum Chemical Calculations

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Soft 2013年第3期2卷 13-18页

作者： Rogaie rezaei-Sadabady Nosratollah Zarghami Abolfazl Barzegar Akram Eidi Abolfazl Akbarzadeh mustafa rezaei-tavirani Department of Biology Science and Research Branch Islamic Azad University Tehran Iran Department of Clinical Faculty of Sciences Shahid Beheshti University Tehran Iran Department of Medical Nanotechnology Faculty of Advanced Medical Science Tabriz University of Medical Science Tabriz Iran Research Institute for Fundamental Sciences (RIFS) University of Tabriz Tabriz Iran

In nature, tyrosol (TY) and hydroxytyrosol (HT) are found in olive leaves which are for medical aims, with immune stimulant and antibiotic properties as well as the ability to be used for the treatment of neurodegenerative diseases such as Alzheimer. This ability of phytochemical TY and HT compounds are mainly believed to be of higher radical scavenging potential with effective antioxidant properties. In order to establish the possible structure-antioxidant activity relationship of tyrosol, hydroxytyrosol, hydroxytyrosol acetate and two designed hydroxytyrosol derivatives were studied by the help of quantum chemical calculations. The molecular electronic properties such as heat formation of the neutral, radical and orbitals energies were calculated as descriptors to predict the H atom donating abilities of compounds. Considering the results from the calculated descriptors, the derivatives having OH group substitutions in position number four of the aromatic ring can be classified highly active and better antioxidant compound. Therefore, the designed hydroxytyrosol derivatives showed most active feasible H atom donation. This work can be useful to design novel antioxidants.

关键词： Antioxidant Free Radical Hydroxytyrosol

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Platform Evolution in an Oligo-Miocene Back-arc Basin:An Example from the Central Iran Basin

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Acta Geologica Sinica(English Edition) 2024年第1期98卷 185-206页

作者： Masoud SHARIFI-YAZDI Amirhossein ENAYATI Jamal SALEHI AGHDAM Mohammad BAHREHVAR Seyed mustafa rezaei Department of Geology Faculty of Earth SciencesGeography and AstronomyUniversity of Vienna1090 Vienna.Austria Geology and Geophysics Department Tehran Energy Consultants(TEC Co.)TehranIran School of Geology College of ScienceUniversity of TehranTehranIran Department of Geology Tarbiat Modares UniversityTehranIran

The Qom Formation is the most important hydrocarbon reservoir target in Central *** Qom platform developed in a back-arc basin during the Oligo-Miocene due to the closing of the Tethyan *** formation consists of a variety of carbonate and non-carbonate facies deposited on a platform ranging from supratidal to basin.A combination of tectonic and eustatic events led to some lateral and vertical facies variations in the study *** third-order depositional sequences and related surfaces were identified regarding vertical facies changes in the studied sections of this Oligo-Miocene *** to all results and data,this succession was initially deposited during the Chattian upon a distally steepened ramp of siliciclastic-carbonate composition,including the Bouma ***,from the late Chattian to the Aquitanian,the platform changed into a homoclinal carbonate ramp with a gentle *** respect to tectonic activity,this phase was a calm period during the deposition of the Qom ***,a drowned carbonate platform and a rimmed shelf emerged during the Burdigalian,terminated by the continental deposits of the Upper Red *** all geological characteristics,three main tectono-eustatic evolutionary phases have been recognized in the Qom back-arcbasin.

关键词： carbonate ramp depositional facies submarine fan eustasy basement faults back-arc basin

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Aqueous extract of lavender(Lavandula angustifolia) improves the spatial performance of a rat model of Alzheimer's disease

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Neuroscience Bulletin 2011年第2期27卷 99-106页

作者： Masoud Soheili Kashani Mostafa rezaei tavirani Sayyed Alireza Talaei Mahmoud Salami Shaheed Beheshti医科大学蛋白质组研究中心卡珊医科大学生理学研究中心

Objective Alzheimer＇s disease（AD） is one of the most important neurodegenerative *** is characterized by dementia including def icits in learning and *** present study aimed to evaluate the effects of aqueous extract of lavender（Lavandula angustifolia） on spatial performance of AD *** Male Wistar rats were f irst divided into control and AD *** model of AD was established by intracerebroventricular injection of 10 ？g A？1-42 20 d prior to administration of the lavender *** in both groups were then introduced to 2 stages of task learning（with an interval of 20 d） in Morris water maze,each followed by one probe *** the f irst stage of spatial learning,control and AD animals received different doses（50,100 and 200 mg/kg） of the lavender *** In the first stage of experiment,the latency to locate the hidden platform in AD group was significantly higher than that in control ***,in the second stage of experiment,control and AD rats that received distilled water（vehicle） showed similar performance,indicating that the maze navigation itself could improve the spatial learning of AD ***,in the second stage of experiment,control and AD rats that received lavender extract administration at different doses（50,100,and 200 mg/kg） spent less time locating the platform（except for the AD rats with 50 mg/kg extract treatment）,as compared with their counterparts with vehicle treatment,*** addition,lavender extract significantly improved the performance of control and AD rats in the probe test,only at the dose of 200 mg/kg,as compared with their counterparts with vehicle *** The lavender extract can effectively reverse spatial learning def icits in AD rats.

关键词： Alzheimer's disease Lavandula angustifolia spatial learning rat water maze

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Clearance of Amyloid Beta Plaques from Brain of Alzheimeric Rats by Lavandula angustifolia

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Neuroscience & Medicine 2012年第4期3卷 362-367页

作者： Masoud Soheili Mostafa rezaei tavirani Mahmoud Salami Physiology Research Center Kashan University of Medical Sciences Kashan Iran. Proteomics Research Center Faculty of Paramedical Sciences Shaheed Beheshti University of Medical Sciences Tehran Iran Student Research Committee Faculty of Paramedical Sciences Shaheed Beheshti University of Medical Sciences Tehran Iran

An important marker in neurodegenerative Alzheimer’s disease (AD) is abnormal production of amyloid beta (Aβ) peptide leading to formation of plaques in the brain. Through decreasing Aβ aggregates, anti-inflammatory agents, phagocytosis, and proteolytic enzymes are known to decline risk of Aβ plaque formation. In the previous study we showed that aqueous extract of Lavandula angustifolia (lavender), with known anti-inflammatory effects, improves memory deficits in animal model of Alzheimer. Here, we assess if lavender play a role in clearance of Aβ plaques in the hippocampus. The Alzheimeric animals were created with intracerebroventricular injection of Aβ 1-42. To confirm formation of Aβ plaques, brain sections were stained by Congo red method. Twenty days post-injection they were administered with different doses (50, 100 and 200 mg/kg) of the aqueous extract of lavender for duration of 20 days. Our results demonstrated that 50 mg/kg of lavender not effectively influenced the Aβ plaques. On the other hand, the herbal medicine at the doses of 100 and 200 mg/kg markedly decreased the extent of Aβ aggregates. We concluded that the lavender extract dose dependently underlies elimination of Aβ plaques. The exact mechanism by which the herbal medicine removes the Aβ aggregates needs to be elucidated.

关键词： Alzheimer Amyloid Beta Lavandula angustifolia

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Study of Contributing Factors for Cure Response in Patients with Acute Myeloblastic Leukemia （AML）

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Journal of Life Sciences 2012年第5期6卷 570-576页

作者： Sahamaz Ahmadit Mostafa rezaei-tavirani Adeleh Divsalar Soheila Khodakarim and Leila Tahmasebi Department of Biology Science and Research Branch Islamic Azad University Tehran *** lran Clinical Proteomics Research Center Faculty of Paramedical Sciences Shahid Beheshti University (M. C.) Tehran ***Iran Department of Biological Sciences Tarbiat Moallem niversity Tehran *** Iran Department of Biostatistics Faculty of Paramedical Sciences Shahid Beheshti University of Medical Sciences Tehran*** Iran Department of Hematology Faculty of Paramedical Sciences Shahid Beheshti University of Medical Sciences Tehran***. lran

Leukemia comprises a diverse group of malignancies which is accompanied with genetic disorderliness in hematopoietic cells. We evaluated effective risk factors in recovery process of under treatment patients suffering from acute myeloblastic leukemia （AML）. This study conducted a cross-sectional descriptive-analytical study on a population of 76 samples obtained non-randomly from patients in Taleghani Hospital （Tehran, Iran）. 30.3% patients resulted in death. According to logistic regression results, sexes [OR = 6.40, 95% CI = （0.27, 3.45）], ALT [OR = 1.03, 95% CI = （0.01, 0.05）] and HCT [OR = 0.55, 95% CI = （-1.12, -0.06）] were recognized as significant in prognoses. We predicted the probability of death with an error of 20.03% based on a prognoses system using support vector machine （SVM） classifier. Using this theory, we experienced an error of 20.03%. 46.6% patients with a positive and 20.8% patients without positive drug history resulted in death, which shows a significant correlation between patients＇ drug history and their death.

关键词： Acute myeloblastic leukemia risk factors support vector machine.

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