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Incorporating the Istanbul-Ankara high-speed railway into the Belt and Road Initiative:Negotiation,institutional alignment and regional development

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Journal of Geographical Sciences 2021年第5期31卷 747-762页

作者： Seth SCHINDLER mustafa kemal BAYIRBAG GAO Boyang Global Development Institute University of ManchesterM139PL ManchesterUnited Kingdom Department of Political Science and Public Administration Middle East Technical UniversityAnkara 06800Turkey School of Management Science and Engineering Central University of Finance and EconomicsBeijing 100081China

This article contributes to a small but growing body of multi-sited and multi-scalar research on the Belt and Road *** focus on relations at the national,regional and international scales,and present original research from China and Turkey,to show how the Istanbul-Ankara high-speed railway has served as a testing ground for China's Belt and Road Initiative(BRI).Its construction was initially funded by the European Investment Bank,but it is now part of the backbone of the Turkish Government's Middle Corridor plan which enhances west-east connectivity and integration with the Caucasus and Central *** show that in contrast to multinational corporations from the OECD that seek to remain footloose,Chinese state-owned enterprises(SOEs)seek to adapt to,apprehend and ultimately shape local *** the case of Turkey this proved difficult given its institutional alignment with the European ***,while the railway project was completed successfully by a consortium led by a Chinese SOE,Turkey's dynamic and complex regulatory environment discourages Chinese SOEs in the infrastructure *** conclude that the Turkish and Chinese governments are currently pursuing complementary territorial visions yet their cooperation is project-based and pragmatic.

关键词： Belt and Road Initiative infrastructure high speed rail regional development Turkey China

Development of therapeutic options on type 2 diabetes in years:Glucagon-like peptide-1 receptor agonist’s role intreatment; from the past to future

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World Journal of Diabetes 2019年第8期10卷 446-453页

作者： Hakan Dogruel mustafa kemal Balci Department of Internal Medicine Antalya Ataturk State HospitalAntalya 07040Turkey Akdeniz University Faculty of Medicine Department of Internal MedicineDivision of Endocrinology and MetabolismAntalya 07070Turkey

Diabetes mellitus (DM) is a chronic metabolic disease characterized by *** 2 diabetes (T2DM) accounting for 90% of cases *** worldwide prevalence of DM is rising dramatically over the last decades,from 30 million cases in 1985 to 382 million cases in ***’s estimated that 451 million people had diabetes in *** the pathophysiology was understood over the years,treatment options for diabetes ***-based therapy is one of ***-like peptide-1 receptor agonist (GLP-1 RA) not only significantly lower glucose level with minimal risk of hypoglycemia but also,they have an important advantage in themanagement of cardiovascular risk and ***,we will review here GLP-1 RAsrole in the treatment of diabetes.

关键词： Incretin-basedtherapy Incretin mimetics Glucagon-like peptide-1 receptor agonist Dipeptidyl peptidase-4 inhibitor

Management of diabetic foot ulcers and the challenging points:An endocrine view

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World Journal of Diabetes 2022年第1期13卷 27-36页

作者： Hakan Doğruel mustafa Aydemir mustafa kemal Balci Division of Endocrinology and Metabolism Department of Internal MedicineAkdeniz University HospitalKonyaaltı07059AntalyaTurkey Division of Endocrinology and Metabolism Department of Internal MedicineAkdeniz University Faculty of MedicineKonyaaltı07059AntalyaTurkey

Diabetic foot ulcers(DFU)are one of the most challenging complications of *** to one-third of patients with diabetes mellitus(DM)may suffer from DFUs during their *** is one of the leading causes of morbidity in patients with *** treatment period is challenging,and the recurrence rate of DFUs is ***,establishing prevention strategies is the most important point to be emphasized.A multidisciplinary approach is necessary in the prevention and treatment of *** at risk should be identified,and prevention measures should be taken based on the risk *** a DFU is formed,the appropriate classification and evidence-based treatment interventions should be *** control,diagnosis and treatment of vascular disease,local wound care,diagnosis,and treatment of infection should be addressed along with the proper evaluation and management of general health status.

关键词： Diabetic foot Diabetic foot ulcer Amputation Diabetic foot infection

Efficacy and safety of pegylated-interferon α-2a in hemodialysis patients with chronic hepatitis C

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World Journal of Gastroenterology 2008年第2期14卷 255-259页

作者： Celal Ayaz mustafa kemal Celen Ugur Nedim Yuce Mehmet Faruk Geyik Department of Clinical Microbiology and Infectious Diseases Dicle University Hospital Diyarbakir Turkey Private Diyarbakir Hemodialysis Center Diyarbakir Turkey

AIM： To evaluate the efficacy and safety of pegylated- interferon alpha-2a in hemodialysis patients with chronic hepatitis C. METHODS： Thirty-six hemodialysis patients with chronic hepatitis C were enrolled in a controlled and prospective study. All patients were treatment naive, positive tested for anti-HCV antibodies, and positive tested for serum HCV-RNA. Twenty-two patients received 135 μg peglyated-interferon α-2a weekly for 48 wk （group A）. The remaining patients were left untreated, eleven refused therapy, and three were not candidates for kidney transplantation and were allocated to the control group （group B）. At the end of the treatment biochemical and virological response was evaluated, and 24 wk after completetion of therapy sustained virological response （SVR） was assessed. Side effects were monitored. RESULTS： Of 22 hemodialysis patients, 12 were male and 10 female, with a mean age of 35.2 ± 12.1 years. Virological end-of-treatment response was observed in 14 patients （82.4%） in group A and in one patient （7.1%） in group B （P = 0.001）. Sustained virological response was observed in 11 patients （64.7%） in group A and in one patient in group B （7.1%）. Biochemical response parameters normalized in 10/14 patients （71.4%） at the end of the treatment. ALT levels in group B were initially high in six patients and normalized in one of them （25%） at the end of the 48 wk. In five patients （22.7%） therapy had to be stopped at mo 4 due to complications of weakness, anemia, and bleeding. CONCLUSION： SVR could be achieved in 64.7% of patients on hemodialysis with chronic hepatitis C by a treatment with peglyated-interferon α-2a. Group A had a significantly better efficacy compared to the control group B, but the side effects need to be concerned.

关键词： Peglyated-interferon Hemodialysis Chronichepatitis C Treatment Efficacy Safety

Wolbachia pipientis:A potential candidate for combating and eradicating dengue epidemics in Pakistan

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Asian Pacific Journal of Tropical Medicine 2015年第12期8卷 963-973页

作者： Uruj Tahir Umair Hassan Khan Muhammad Saad Zubair bahar-e-mustafa Department of Environmental Sciences Fatima Jinnah Women University Department of Microbiology.University of Agriculture Faisalabad Department of Microbiology.Government College University Faisalabad

Dengue virus syndrome is an emerging global health challenge which is endemic in tropical countries like *** recent years dengue incidences have increased considerably in different areas of Pakistan with more sever impacts on urban and peri-urban *** review is an effort to highlight the changing epidemiology of dengue fever,role of Government of Pakistan in disease management and control using preventive and community based approaches in the ***,there is an emphasis on application of Wolbachia as novel,inexpeasive and environmentally benign candidate for control and eradication of dengue transmitting vectors.

关键词： Dengue Pakistan Antiviral agents Chemical methods

Effect of latanoprost/timolol and dorzolamide/tiomolol on intraocular pressure after phacoemulsification surgery

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International Journal of Ophthalmology(English edition) 2011年第2期4卷 190-194页

作者： Haydar Erdogan Ayse Vural Ozec Cengiz Caner mustafa Ilker Toker mustafa kemal Arici Aysen Topalkara Departments of Ophthalmology School of MedicineUniversity of Cumhuriyet

·AIM:To evalaute the effect of fixed-combination latanoprost 0.005%/timolol maleate 0.5% and dorzolamide hydrochloride 2%/timolol maleate 0.5% on postoperative intraocular pressure after phacoemulsification cataract surgery.·METHODS:This study is a prospective,randomized,double-masked and *** study included 90 eyes of 90 patients which were scheduled to have phacoemulsification *** were randomly assigned preoperatively to 1 of 3 groups (30 eyes of 30 patients).Two hour before surgery,the patients received one drop latanoprost/timolol (group 1),dorzolamide/timolol (group 2) and placebo (group 3,control group).The IOPs were measured at preoperative and postoperative 4,8,and 24 hours.·RESULTS:The preoperative mean intraocular pressure was not statistically significant between both drug groups and control *** group 1 and 2,the postoperative mean IOP [group1:(14.03?à3.15)mmHg and group 2:(14.16?à4.43)mmHg] at 24 hours were significantly lower than the control group [(16.93?à3.70)mmHg,(P 0.05).·CONCLUSION:When compared with placebo,the use of preoperative fixed combination of latanoprost/timolol and dorzolamide/timolol is an effective method for preventing intraocular pressure elevation in 24 hours after phacoemulsification surgery,but did not completely prevent IOP spikes.·

关键词： dorzolamide/timolol latanoprost/timolol intraocular pressure phacoemulsification cataract surgery

Comparison of the effects of bevacizumab and ranibizumab injection on corneal angiogenesis in an alkali burn induced model

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International Journal of Ophthalmology(English edition) 2012年第4期5卷 448-451页

作者： Ayhan Dursun mustafa kemal Arici Feyza Dursun Ayse Vural Ozec mustafa Ilker Toker Haydar Erdogan Aysen Topalkara Department of Ophthalmology School of MedicineCumhuriyet UniversitySivasTurkey

·AIM:To investigate the effects of bevacizumab and ranibizumab on corneal neovascularization in an alkali burn-induced model of corneal angiogenesis. ·METHODS:Fifteen Wistar-Albino rats were divided randomly into 3 groups after chemical cauterization of the cornea. The first group received a single dose of 0.1mL saline solution as a control group whereas second and third groups received a single dose of 2.5mg bevacizumab or 1mg ranibizumab by subconjunctival injection, respectively. After three weeks, the rat corneas were evaluated by biomicroscopy and corneal photographs were taken. The percentage of neovascularization area, length of the longest new vessel, corneal oedema and corneal opacity scores were assessed. ·RESULTS:The analysis of digital photographs showed that the percentage of neovascularization area to the total corneal area, the length of the longest new vessel, corneal oedema and opacity scores were significantly lower in both study groups compared to the control group (P <0.05). Additionally, the percentage of corneal neovascularization area, the length of the longest new vessel and corneal opacity score were less with bevacizumab than ranibizumab. ·CONCLUSION:Subconjunctival bevacizumab and ranibizumab treatments may be effective methods in reducing corneal neovascularization. Furthermore, bevacizumab is more effective than ranibizumab in the inhibition of corneal neovascularization.

关键词： corneal neovascularisation bevacizumab ranibizumab

Total oxidative stress, paraoxonase and arylesterase levels at patients with pseudoexfoliation syndrome and pseudoexfoliative glaucoma

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International Journal of Ophthalmology(English edition) 2015年第5期8卷 985-990页

作者： Feyza Dursun Ayse Vural Ozec Huseyin Aydin Aysen Topalkara Ayhan Dursun mustafa Ilker Toker Haydar Erdogan mustafa kemal Arici Department of Ophthalmology Cumhuriyet University School of Medicine Department of Biochemistry Cumhuriyet University School of Medicine

AIMTo investigate the oxidative stress status of the aqueous humor and serum of patients with pseudoexfoliation (PEX) syndrome and pseudoexfoliative glaucoma (PEG) and to measure paraoxonase (PON) and arylesterase (ARE) *** total of 78 patients were enrolled in the study, with 26 patients in each separate group. The patients were divided into three groups: the first group entailed PEX syndrome patients, while the second group consisted of patients with PEG and the third group involved patients with no additional systemic diseases, other than the diagnosis of cataract as control. Total oxidative stress (TOS), total antioxidant capacity (TAC), PON, and ARE levels in aqueous humor and serum were ***, PON and arylesterase levels in aqueous humor and serum of the PEX syndrome and PEG patients were significantly decreased compared with control group (P<0.05). TOS values were higher in patients with PEX syndrome and PEG than controls (P<0.05). TAC, PON and ARE levels of aqueous humor did not differ significantly between the PEX syndrome and PEG groupsCONCLUSIONThese findings are potentially of significance and add to the growing body of evidence for oxidative stress in PEX syndrome and PEG. Decreased antioxidant defense and increased oxidative stress system may play an important role in the pathogenesis of PEX syndrome and PEG.

关键词： pseudoexfoliation syndrome oxidative stress paraoxonase arylesterase

Endoscopic and histopathological evaluation of acute gastric injury in high-dose acetaminophen and nonsteroidal anti-inflammatory drug ingestion with suicidal intent

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World Journal of Gastroenterology 2008年第43期14卷 6704-6710页

作者： Aliye Soylu Can Dolapcioglu kemal Dolay Aydin Ciltas Nurgul Yasar mustafa kalayci Halil Alis Nurten Sever Gastroenterology Bakirkoy Dr Sadi Konuk Research and Training HospitalIstanbul 34147Turkey Gastroenterology Dr.Lutfi Kirdar Kartal Research and Training HospitalIstanbul 34865Turkey General Surgery Bakirkoy Dr Sadi Konuk Research and Training HospitalIstanbul 34147Turkey Internal Medicine Bakirkoy Dr Sadi Konuk Research and Training HospitalIstanbul 34147Turkey Pathology Bakirkoy Dr Sadi Konuk Research and Training HospitalIstanbul 34147Turkey

AIM： To evaluate endoscopic and histopathologic aspects of acute gastric injury due to ingestion of high-dose acetaminophen and nonsteroidal antiinflammatory drugs （NSAIDs） with respect to some risk factors and patient characteristics. METHODS： The study group consists of 50 patients admitted to emergency department with high dose analgesic ingestion （group Ⅰ ） with suicidal intent. Thirty patients with or without mild complaints of dyspepsia （group Ⅱ） were selected as the control group. The study group was stratified according to the use of type and number of analgesics. Endoscopic findings were evaluated according to the Lanza score （LS）, expressing the severity of the gastroduodenal damage and biopsies according to a scoring system based on histopathologic findings of acute erosive gastritis. RESULTS： Gastroduodenal damage was significantly more severe in group Ⅰ compared to group Ⅱ （P 〈 0.01）. The LS was similar in both groups Ⅰ a and Ⅰb. However LS was significantly higher in patients who had ingested multiple NSAIDs （group Ⅰ c） compared to other patients （P 〈 0.01）. The LS was correlated to age （P 〈 0.01） and total amount of drug ingested （P 〈 0.05） in group Ⅰ ; but it was not correlated with Helicobacter pylori （H pylori） infection or duration of exposure （P 〉 0.05）. The biopsy score （BS） was higher in group Ⅰ than group Ⅱ （P 〈 0.01）, and higher in group Ⅰb than group Ⅰa （P 〈 0.05）. CONCLUSION： The histopathologic damage was more severe among NSAID ingesting patients compared to those ingesting only acetaminophen and there is no significant difference in the endoscopic findings between the groups. There is no significant difference in the LS between the groups. This lack of significance is remarkable in terms of the gastric effects of highdose acetaminophen.

关键词： Acute gastric injury Nonsteroidal anti-inflammatory drug Acetaminophen Endoscopic lesion Gastroscopy