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Management of diabetic foot ulcers and the challenging points:An endocrine view

World Journal of Diabetes 2022年第1期13卷 27-36页

作者： Hakan Doğruel mustafa aydemir mustafa Kemal Balci Division of Endocrinology and Metabolism Department of Internal MedicineAkdeniz University HospitalKonyaaltı07059AntalyaTurkey Division of Endocrinology and Metabolism Department of Internal MedicineAkdeniz University Faculty of MedicineKonyaaltı07059AntalyaTurkey

Diabetic foot ulcers(DFU)are one of the most challenging complications of *** to one-third of patients with diabetes mellitus(DM)may suffer from DFUs during their *** is one of the leading causes of morbidity in patients with *** treatment period is challenging,and the recurrence rate of DFUs is ***,establishing prevention strategies is the most important point to be emphasized.A multidisciplinary approach is necessary in the prevention and treatment of *** at risk should be identified,and prevention measures should be taken based on the risk *** a DFU is formed,the appropriate classification and evidence-based treatment interventions should be *** control,diagnosis and treatment of vascular disease,local wound care,diagnosis,and treatment of infection should be addressed along with the proper evaluation and management of general health status.

关键词： Diabetic foot Diabetic foot ulcer Amputation Diabetic foot infection

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Oxidative stress in portal hypertension-induced rats with particular emphasis on nitric oxide and trace metals

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World Journal of Gastroenterology 2005年第23期11卷 3570-3573页

作者： Titiz Izzet Krand Osman Unal Ethem Yavuz Nihat Kusaslan Ramazan Dogan mustafa Uzun Hafize Kiziler Ali Riza aydemir Birsen Genc Habibe Aydin Seval Simsek Gonul Department of Surgery Department of Biochemistry Department of Biophysics Department of Physiology

AIM: To investigate the oxidative-stress-related changes in rats with portal hypertension with particular emphasis on nitric oxide (NO) and trace metals. METHODS: Cirrhosis was induced by partial portal vein ligation (PVL) in Wistar rats. The lipid peroxidation marker (malondialdehyde, MDA), antioxidant defense enzymes including superoxide dismutase (SOD), catalase (CAT), glutathione (GSH), and agents known to have antioxidant features including nitric oxide (NO), zinc (Zn), copper (Cu) were determined both in serum and in liver tissue at 4 wk after surgery in PVL and sham-operated rats. Portal pressure of all experimental animals was measured. MDA was detected by thiobarbituric acid reactivity *** activity was determined by inhibition of nitroblue tetrazolium reduction with xanthine/xanthine oxidase used asa superoxide generator. CAT activity was determined by the breakdown of hydrogen peroxide. GSH concentrations were measured by using metaphosphoric acid for protein precipitation and 5'-5'-dithio-bis-2-nitrobenzoic acid for color development. NO was detected by the Griess method after reduction of nitrate to nitrite with nitrate reductase, and the concentrations of Zn and Cu were measured by a Shimadzu 680 AA atomic absorption spectrometer. Histopathological confirmation was done under light microscope. Statistical analyses were done by Student's t-test, and significance of the difference was tested by the unpaired Mann-Whitney test. P＜0.05 was considered statistically ***: Histopathological studies confirmed PVL induced cirrhotic changes. There was a statistically significant difference in portal pressure between PVL and control groups (P＜0.001). The results showed significant increases in the levels of MDA and NO in both tissue and serum (P＜0.05 and P＜0.001, respectively in tissue; P＜0.001 for each in serum), and Zn only in tissue (P＜0.001)in rats with PVL compared with sham-operated rats. Besides, PVL rats exhibited reduced plasma and tis

关键词：肝门静脉高压氧化损伤小鼠动物实验一氧化氮

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Clinical evaluation of submucosal colonic lipomas: Decision making

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World Journal of Gastroenterology 2006年第31期12卷 5075-5077页

作者： Oge Tascilar Güldeniz Karadeniz Cakmak Banu Dogan Gün Bülent Hamdi U(?)an Hakan Balbaloglu Ali Cesur Ali Ugur Emre mustafa Comert Lütfü Oktay Erdem Selim aydemir Department of SurgeryZonguldak Karaelmas University School of MedicineKozlu-ZonguldakTurkey Department of pathologyZonguldak Karaelmas University School of MedicineKozlu-ZonguldakTurkey Department of RadiologyZonguldak Karaelmas University School of MedicineKozlu-ZonguldakTurkey Department of GastroenterologyZonguldak Karaelmas University School of MedicineKozlu-ZonguldakTurkey

甚至脂肪瘤是胃肠道的最普通的间充质的良性瘤，征兆的结肠的表示是稀罕的。此处，我们评估了受不了结肠的脂肪瘤的各种各样的尺寸的四个病人并且由不同治疗学的形式来临了。

关键词：黏膜下结肠疾病结肠癌并发症病理机制

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