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重组脊髓灰质炎病毒用于治疗复发胶质母细胞瘤（英文）

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中华神经外科疾病研究杂志 2018年第4期17卷 375-375页

作者： Desjardins A Gromeier M Herndon JE 2nd Beaubier N Bolognesi DP Friedman AH Friedman HS McSherry F muscat am Nair S Peters KB Randazzo D Sampson JH Vlahovic G Harrison WT McLendon RE Ashley D Bigner DD

Background The prognosis of patients with recurrent World Health Organization(WHO)grade IV malignant glioma is dismal,and there is currently no effective *** conducted a dose-finding and toxicity study in this population of patients,evaluating convection-enhanced,intratumoral delivery of the recombinant nonpathogenic polio-rhinovirus chimera(PVSRIPO).PVSRIPO recognizes the poliovirus receptor CD155,which is widely expressed in neoplastic cells of solid tumors and in major components of the tumor *** We enrolled consecutive adult patients who had recurrent supratentorial WHO grade IV malignant glioma,confirmed on histopathological testing,with measurable disease(contrast-enhancing tumor of≥1 cm and≤5.5 cm in the greatest dimension).The study evaluated seven doses,ranging between 107 and 1010 50%tissue-culture infectious doses(TCID50),first in a dose-escalation phase and then in a dose-expansion *** From May 2012 through May 2017,a total of 61 patients were enrolled and received a dose of *** level-1(5.0×107TCID50)was identified as the phase 2 *** dose-limiting toxic effect was observed;a patient in whom dose level 5(1010TCID50)was administered had a grade 4 intracranial hemorrhage immediately after the catheter was *** mitigate locoregional inflammation of the infused tumor with prolonged glucocorticoid use,dose level 5 was deescalated to reach the phase 2 *** the dose-expansion phase,19%of the patients had a PVSRIPO-related adverse event of grade 3 or *** survival among the patients who received PVSRIPO reached a plateau of 21%(95%confidence interval,11 to 33)at 24 months that was sustained at 36 *** Intratumoral infusion of PVSRIPO in patients with recurrent WHO grade IV malignant glioma confirmed the absence of neurovirulent *** survival rate among patients who receivedPVSRIPO immunotherapy was higher at 24 and 36 months than the rate among historical controls.

关键词： WHO

Convergent Agency:Encouraging Transdisciplinary Approaches for Effective Climate Change Adaptation and Disaster Risk Reduction

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International Journal of Disaster Risk Science 2016年第4期7卷 430-435页

作者： américa Bendito Edmundo Barrios Department of Civil Engineering Universidad de Los Andes World Agroforestry Centre(ICRAF)

Three recent global agreements have been established to facilitate the implementation of global-level responsibilities to deal with disaster risk reduction(DRR),human development,and climate change adaptation(CCA)*** these agreements have a common goal of reducing social,economic,and environmental vulnerability,they have been developed by largely independent communities of *** has limited cross-fertilization despite the inherent multidimensional nature of global challenges and the considerable thematic *** argue that developing a transdisciplinary strategy that effectively integrates disciplines,approaches,and knowledge systems will lead to greater and more sustainable impacts,together with a more efficient use of financial *** approaches should be encouraged during planning of future development efforts so that risk reduction is conducted simultaneously with *** processes are central to generating contextsensitive knowledge to support decisions on CCA and DRR options that minimize trade-offs and maximize synergies and complementarities required to guide sustainable development ***,building codes together with climate and risk-smart research,education,and awareness raising,are identified as priority entry points to materialize the blending of DRR and CCA approaches and effectively reduce risk while mitigating and adapting to climate change.

关键词： Building codes Climate change adaptation Disaster risk reduction Sustainable development goals Transdisciplinary knowledge

Elevated levels of the pollutant PM2.5 in crowded subways of cities with high COVID-19 related mortality-when COVID-19 went underground

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Infectious Diseases Research 2021年第3期2卷 35-41页

作者： Yves muscat Baron Liberato Camilleri Mater Dei Hospital University of Malta Medical SchoolMsidaMalta

Background:Recent literature indicates that the pollutant,particulate matter PM2.5,may have an impact on COVID-19 related infection and *** coding for SARS-CoV-2 has been found adherent to PM2.5 and possibly the COVID-19/PM2.5 complex may be involved in the transmission and the exacerbation of COVID-19 ***2.5 levels in deep underground subways have been found up to 90 times higher than roads closer to the ***:The levels of PM2.5 were retrieved from literature assessing particulate matter PM2.5 measured on subway platforms in two groups of *** cities were differentiated by the COVID-19 population percentage mortality rate(0.007%vs 0.19%)(P<0.0004).Data regarding the number of stations,length of the networks(km)and the annual ridership were also obtained from literature related to underground ***:The population percentage mortality related to SARS-CoV-2 infection correlated significantly for both minimum(P<0.01)and maximum(P<0.00001)levels of *** cities’subways with low COVID-19 mortality had minimum platform PM2.5 levels of 27.4(SD+/-17.2μg/m3)compared to 63.4μg/m3(SD+/-10.8μg/m3)in cities with high SARS-CoV-2 associated mortality(P<0.01).Subway maximum levels of PM2.5 in cities with low COVID-19 mortality was 53.4μg/m3(SD+/-21.8μg/m3)while that of underground networks with high COVID-19 mortality had maximum platform PM2.5 levels of 172.1μg/m3(SD+/-98μg/m3)(P<0.001).Conclusion:Underground networks may have inherent characteristics accelerating spread of SARSCoV-2 infection and consequent *** highly elevated levels of PM2.5 in overcrowded subways with extensive reach,may have acted as a co-factor to disseminate the pandemic in a number of metropolises.

关键词： COVID-19/SARS-CoV-2 Mortality PM2.5 Subway/underground

THE STOCHASTIC BOUNDARY ELEMENT METHOD IN STATISTICAL ANALYSIS OF MODERATELY THICK PLATES

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Acta Mechanica Solida Sinica 1995年第2期8卷 163-170页

作者： JINAG, am DING, HJ ZHEJIANG UNIV HANGZHOU 310027PEOPLES R CHINA

In this paper a stochastic boundary element method (SEEM) is developed to analyze moderately thick plates with random material parameters and random thickness. Based on the Taylor series expansion, the boundary integration equations concerning the mean and deviation of the generalized displacements are derived, respectively. It is found that the randomness of material parameters is equivalent to a random load, so the mean and covariance matrices of unknown generalized boundary displacements and tractions can be obtained. Furthermore, the mean and covariance of generalized displacements and forces at internal points can also be obtained. A numerical example has been worked out with the method proposed and necessary analysis is made for the results.

关键词： ISOTROPIC MODERATELY THICK PLATES STOCHASTIC BOUNDARY ELEMENT METHOD STATISTICAL ANALYSIS COVARIANCE

Interactive Effect of Potassium and Phosphorus on Grain Quality and Profitability of Sunflower in Northwest Pakistan

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Pedosphere 2011年第4期21卷 532-538页

作者： am ANULLAH M.W.KHAN Department of Agronomy Khyber Pakhtunkhwa Agricultural University

A field experiment was conducted using a split plot randomized complete block design with three replications to study the effects of potassium (K) and phosphorus (P) application on sunflower (Helianthus annuus L.) growth at the New Developmental Research Farm of Khyber Pakhtunkhwa Agricultural University in Peshawar,*** levels of K (0,25,50,75,100 and 125 kg K ha-1) were main plots while four levels of P (0,45,90 and 135 kg P ha-1) were *** in both K and P levels enhanced grain oil concentration of *** in P level increased grain protein concentration,while increase in K level decreased grain protein *** oil and protein yields increased significantly with increase in K and P *** increase in oil and protein yields of sunflower was mainly attributed to the improvement in yield components (grains per head,grain weight and head size) and the significant increase in grain *** highest net returns of 297 and 368 US$ ha-1 based on grain and oil yields,respectively,were obtained from a combination of 100 kg K ha-1 + 45 kg P ha-1.

关键词： economic analysis grain yield oil content protein content

A procedure of determining potential energy surfaces of triatomic molecules from inversion of spectroscopic data

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Chinese Journal of Chemistry 1995年第6期13卷 510-514页

作者： Xie, DQ Yan, GS Tian, am SICHUAN UNIV DEPT CHEMCHENGDU 610064SICHUANPEOPLES R CHINA

In this paper, we have suggested an iterative procedure of optimization of the linear parameters in an analytic potential energy function for a triatomic molecule, by combining both variational and second order perturbation methods. The most important feature of this procedure is that the objective function is an analytical expression which can be optimized easily. The application to the water molecule is presented.

关键词： potential energy surface triatomic molecule molecular vibrations variational method

Structure Based Library Approach to Photosynthesis Inhibitors:The Solid Phase Synthesis of Hydro-Uracils and Thiouracils

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Chinese Chemical Letters 1998年第2期9卷 139-142页

作者： Yu, am Yang, HZ Zhang, ZP Nankai Univ State Key Lab Elementoorgan Chem Tianjin 300071 Peoples R China Nankai Univ State Key Lab Funct Polymer Mat Adsorpt & Separat Tianjin 300071 Peoples R China

A general method for the solid phase synthesis of hydro-uracils and thiouracils is described. Resino ester 2 reacts with various primary amines to give secondary amines 3, which are converted to the resino ureas (thioureas) 4 by treatment with isocyanates (isothiocyanates). Preparation of the hydro-uracils and thiouracils 5 is achieved by acidic cyclization-cleavage from the resin. The synthesis is designed to be amenable for structure based library approach to photosystem II D1 protein inhibitors.

关键词： solid phase synthesis hydro-uracils and thiouracils photosynthesis inhibitors

Assessing Potential Earthquake Loss in Me′rida State, Venezuela Using Hazus

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International Journal of Disaster Risk Science 2014年第3期5卷 176-191页

作者： américa Bendito Jesse Rozelle Douglas Bausch Civil Engineering Department Universidad de Los AndesMe´rida 5101Venezuela Mitigation Division Federal Emergency Management Agency(FEMA)Region VIIIDenverCO 80225USA

The focus of the Hazus earthquake model has been largely U.S. centric due to a lack of standardized building-infrastructure data formats applicable *** a combined effort between FEMA Region VIII and the Universidad de Los Andes, Venezuela, the present study uses the Hazus 2.1 software to simulate earthquake loss estimations for Venezuela. Population totals and demographic distributions were developed using Oak Ridge National Labs Landscan 2008 population data and the census 2011 for Venezuela. The accuracy of the model was further enhanced for Me′rida State, located in western Venezuela, by collecting, incorporating, and developing region and specific inventories including soil maps, liquefaction and landslide susceptibility studies, demographic data, and building inventory information. We used USGS Shake Maps scenarios for two potential earthquake events with peak ground accelerations proposed within Performance Based Seismic Engineering of Buildings, VISION 2000 recommendations. The region has not witnessed an earthquake with a magnitude greater than M 7 in the last120 years. Given the historical record of seismicity and the seismotectonics in the region, it becomes increasingly important to understand the potential implications from moderate to large earthquakes in Me′rida State, Venezuela.

关键词： Disaster loss estimation Earthquake damage Hazus Seismic risk Venezuela

Method for the determination of polonium-210 in tea samples using response surface methodology(RSM)

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Nuclear Science and Techniques 2019年第3期30卷 75-81页

作者： Sermin ?am Kaynar ümit H.Kaynar Physics Department Faculty of Science and Letters Manisa Celal Bayar University Science Education Faculty of Education Manisa Celal Bayar University

The method based on solvent parameters(mass,cycle of acidification, and autodeposition time), combined with response surface methodology(RSM) modeling and optimization, has been developed for maximizing ^(210)Po activity in tea samples, as observed by an alpha spectrometer. RSM based on 3-factor and 5-level composite center design was used to obtain the optimal combination of solvent conditions. As solvent parameters for ^(210)Po activity, different masses(0.5, 0.75, 1, 1.5, and 2 g), different cycles of acidification(2, 3, 4, 5, and 6 times), and different autodeposition times(2, 3, 4, 5, and 6 h) were studied. The 3D response surface plot and the contour plot derived from the mathematical models were used to determine the optimal conditions. According to the obtained results, the experimental value of ^(210)Po activity was in good agreement(R^2=0.96) with the value predicted by the model. We found a favorable effect of mass on the ^(210)Po activity(p\0.05).

关键词： ^210Po activity Tea Response surface methodology