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Prenatal bisphenol A exposure impairs the aversive and spatial memory reduces the level of NMDA receptor subunits in the hippocampus of male Sprague Dawley rats

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Brain Science Advances 2022年第1期8卷 57-69页

作者： Norazirah Mat Nayan Andrean Husin Siti Hamimah Sheikh Abd Kadir Che Badariah Abd Aziz musalmah mazlan Rosfaiizah Siran Centre for Neuroscience Research(NeuRon) Faculty of MedicineUniversiti Teknologi MARASungai Buloh 47000SelangorMalaysia Institute of Molecular Medicine Biotechnology(IMMB) Faculty of MedicineUniversiti Teknologi MARASungai Buloh 47000SelangorMalaysia Faculty of Dentistry Universiti Teknologi MARASungai Buloh 47000SelangorMalaysia Neuroscience Research Group(NRG) Faculty of MedicineUniversiti Teknologi MARASungai Buloh 47000SelangorMalaysia Faculty of Medicine Universiti Sains MalaysiaKubang Kerian 15200Kota Bharu KelantanMalaysia

Memory impairment in children is an ongoing issue worldwide related to a learning disability. This neurobiological condition has been suggested to associate with bisphenol A (BPA) exposure during pregnancy. BPA is an inorganic compound used to produce polycarbonate plastics and epoxy resins. We conduct this study to investigate the effects of prenatal BPA exposure on the level of the N-methyl-D-aspartate (NMDA) receptor subunits, synaptic markers of the hippocampus and neurobehavioral outcomes in rats. The pregnant rats were given a daily dose of 5 mg/kg and 50 mg/kg of BPA with 0.5% Tween 80 orally from gestation day 2 until 21 (GD21). The level of GluN2A, GluN2B, PSD-95 and synapsin I in the hippocampus and its neurobehaviour outcomes were quantified and evaluated in the male foetus and adolescent rat. Prenatal BPA exposure reduced GluN2A, GluN2B, synapsin I and PSD-95 (Postsynaptic Density-95) in the male foetus and adolescent rat hippocampus compared to the control group. The prenatal BPA exposed rats demonstrated anxiety-related behaviour and impairment in aversive and spatial memory. The findings suggested that the impairment in neurobehavioral performance may inhibit the signalling pathway in the NMDA receptor subunits in the male foetus rat hippocampus leading to learning and memory deficits when reaching adolescence.

关键词： bisphenol A memory NMDA receptor subunits neurobehavioral

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Bimetallic reduced graphene oxide/zeolitic imidazolate framework hybrid aerogels for efficient heavy metals removal

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Frontiers of Chemical Science and Engineering 2024年第8期18卷 49-66页

作者： Nurul A.mazlan Allana Lewis Fraz Saeed Butt Rajakumari Krishnamoorthi Siyu Chen Yi Huang School of Engineering Institute for Materials&ProcessesThe University of EdinburghEdinburgh EH93FBUK

Graphene oxide is a promising adsorption ***,it has been difficult to recycle and separate graphene oxide in the *** alleviate this problem,graphene oxide was thermally reduced to produce porous hydrogel which was then functionalized with *** functional groups act as not only adsorption sites but also nucleation sites for in situ crystallization of cobalt-doped zeolitic-imidazolate-framework-8 *** effects of cobalt-doping contents on the physicochemical and adsorption properties of the resulting aerogel were also evaluated by varying the cobalt *** instance,the reduced graphene oxide-polydopamine/50cobalt-zeolitic-imidazolate-framework-8 aerogel exhibited a high surface area of 900 m^(2)·g^(-1)and maintained the structure in water after ten *** as-synthesized aerogels showed an ultrahigh adsorption capacity of 1217±24.35 mg·g^(-1)with a removal efficiency of>99%of lead,as well as excellent adsorption performance toward other heavy metals,such as copper and cadmium with adsorption capacity of 1163±34.91 and 1059±31.77 mg·g^(-1),*** importantly,the lead adsorption stabilized at 1023±20.5 mg·g^(-1)with a removal efficiency of>80%after seven cycles,indicating their potential in heavy metal removal from industrial wastewater.

关键词： rGO Co-doped ZIF-8 heavy metals adsorption aerogel

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Improving the hydrostability of zeolitic imidazolate framework coatings using a facile silk fibroin protein modification method

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Nano Research 2024年第7期17卷 6247-6257页

作者： Xiuming Wei Ting Chen Siyu Chen Qian Jia Nurul Ain mazlan Allana Lewis Norbert Radacsi Yi Huang School of Engineering Institute for Materials&ProcessesThe University of EdinburghRobert Stevenson RoadEdinburghEH93FBUK EASTCHEM School of Chemistry The University of St AndrewsPurdie BuildingNorth HaughSt AndrewsKY169STUK

Zeolitic imidazolate frameworks(ZIFs)are an important subclass of metal-organic frameworks(MOFs)with zeolite-type topology,which can be fabricated under ambient synthesis ***,the applications of ZIFs are commonly limited due to the weak hydrostability of their metal–ligand coordination bonds,particularly under humid and aqueous *** this work,as an example,the hydrolysis behaviours of ZIF-L with a special focus on ZIF-L coatings were tested at aqueous conditions with a wide range of pHs to systematically study and fundamentally understand their structural stability and degradation *** ZIF-L powder and ZIF-L coatings were severely damaged after only 24 h in aqueous ***,the ZIF-L coatings showed two distinct hydrolyzation pathways regardless of pH conditions,exhibiting either a ring-shaped etching or unfolding *** the ZIF-L powders were hydrolyzed almost identically across all pH *** this new understanding,a facile silk fibroin(SF)protein modification method was developed to enhance the hydrostability of ZIF-L coatings in aqueous *** effect of protein concentration on surface coating was systemically ***-L coating retained its surface morphology after soaking in water and demonstrated switchable super wetting properties and superior separation performance for oil/water *** a result,the quick SF protein modification significantly enhanced the stability of ZIF-L coatings under various pHs,while retaining their switchable wetting property and excellent separation performance.

关键词： zeolitic imidazole framework-L(ZIF-L) ZIF-L coatings silk fibroin protein hydrostability enhancement oil/water separation

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Erratum to:Improving the hydrostability of zeolitic imidazolate framework coatings using a facile silk fibroin protein modification method

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Nano Research 2024年第7期17卷 6776-6776页

The name of the seventh author,Norbert Radacsi in the first pages of the maintext and the ESM of the original article was unfortunately *** corrections have been made to the online version of the original article.

关键词： stability correction method

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Modeling sprawl of unauthorized development using geospatial technology: case study in Kuantan district, Malaysia

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International Journal of Digital Earth 2011年第3期4卷 223-238页

作者： mazlan Hashim Norzailawati Mohd Noor Maged Marghany Institute of Geospatial Science&Technology(INSTEG) Faculty of Geoinformation Sciences and EngineeringUniversiti Teknologi Malaysia81300 UTM SkudaiJohor BahruMalaysia

The paper explores a framework combining remote sensing and GIS-cellular automata(CA)concepts aimed at improving the modeling of unauthorized land use *** sensing data have been used in urban modeling and analysis,the use of high-resolution remote sensing data in assessing unauthorized development is quite *** work has demonstrated systematic combination utilization of geospatial analyses tools to acquire a new level of information to enable urban modeling and sprawl analysis in assisting urban sustainable *** this study,Kuantan city,Malaysia was selected in simulation of the unauthorized land use with CA concept for a period of 15 years(20002015),with main input time-series land use observation from 1995 to *** 2000 and 2005 land use input was also used as calibrated and test assessment of the *** results show excellent agreement between in-situ changes of the unauthorized land use classes and the corresponding simulated classes within the same *** conclusion,CA model can lead to new levels of understanding of how urban areas grow and change as in view of digital earth aspiration.

关键词： cellular automata sprawl remote sensing GIS urban simulation

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3-D visualizations of coastal bathymetry by utilization of airborne TOPSAR polarized data

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International Journal of Digital Earth 2010年第2期3卷 187-206页

作者： Maged Marghany Arthur P.Cracknell mazlan Hashim Institute for Science and Technology Geospatial(INSTEG) Faculty of Geoinformation Science and EngineeringUniversiti Teknologi Malaysia81310 UTMSkudaiJohore BahruMalaysia

Multi-frequency C and L bands in the TOPSAR data have been utilized to reconstruct three-dimensional(3-D)bathymetry *** main objective of this study is to utilize fuzzy arithmetic to reduce the errors arising from speckle in synthetic aperture radar(SAR)data when constructing ocean bathymetry from polarized SAR *** doing so,two 3-D surface models,the Volterra algorithm and a fuzzy B-spline(FBS)algorithm,which construct a global topological structure between the data points,were used to support an approximation to the real *** algorithm was used to express the non-linearity of TOPSAR data intensity gradient based on the action balance equation(ABC).In this context,a first-order kernel of Volterra algorithm was used to express ABC *** inverse of Volterra algorithm then performed to simulate 2-D current velocities from CVV and LHH ***,the 2-D continuity equation then used to estimate the water *** order to reconstruct 3-D bathymetry pattern,the FBS has been performed to water depth information which was estimated from 2-D continuity *** best reconstruction of coastal bathymetry of the test site in Kuala Terengganu,Malaysia,was obtained with polarized L and C bands SAR acquired with HH and VV polarizations,*** 10 m spatial resolution of TOPSAR data,bias of0.004 m,the standard error mean of 0.023 m,r2 value of 0.95,and 90%confidence intervals in depth determination was obtained with LHH band.

关键词： TOPSAR polarized data Volterra algorithm fuzzy B-spline algorithm bathymetry

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3-D reconstruction of coastal bathymetry from AIRSAR/POLSAR data

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Chinese Journal of Oceanology and Limnology 2009年第1期27卷 117-123页

作者： Maged MARGHANY mazlan HASHIM Arthur P. CRACKNELL Department of Remote Sensing Faculty of Geoinformation Science and Engineering Universiti Teknologi Malaysia 81310UTM Skudai Johore Bahru Malaysia

This paper introduces a new method for reconstructing three-dimensional （3D） coastal bathymetry changes from Airborne AIRSAR/POLSAR synthetic aperture data. The new method is based on integration between fuzzy B-spline and Volterra algorithm. Volterra algorithm is used to simulate the ocean surface current from AIRSAR/POLSAR data. Then, the ocean surface current information used as input for continuity equation to estimate the water depths from AIRSAR/POLSAR data. This study shows that 3D ocean bathymetry can be reconstructed from AIRSAR/POLSAR data with root mean square error of ±0.03 m.

关键词： AIRSAR/POLSAR data Volterra algorithm Fuzzy B-spline 3D bathymetry

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Ontogenetic changes in feeding and food preferences of the dog conch Laevistrombus canarium Linnaeus 1758 (Mollusca： Gastropoda) from Merambong shoal, Malaysia

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Chinese Journal of Oceanology and Limnology 2017年第5期35卷 1230-1238页

作者： HUSNA Wan Nurul Wan Hassan mazlan Abd Ghaffar COB Zaidi Che School of Environmental and Natural Resource Science Faculty of Science and Technology Universiti Kebangsaan Malaysia 43600 Bangi Selangor Malaysia Marine Ecosystem Research Centre (EKOMAR) Faculty of Science and Technology Universiti Kebangsaan Malaysia 43600 Bangi Selangor Malaysia School of Fisheries andAquaculture Sciences Universiti Malaysia Terengganu 21030 Kuala Terengganu Terengganu Malaysia

Laevistrombus canarium is one of the marine gastropod mollusks that have high commercial value, particularly in the aquaculture sector in Malaysia. This study was conducted to determine the feeding and food items of L. canarium at different ontogenetic stages （juveniles, sub-adults and adults） from Merambong shoals, Malaysia. Field observations on feeding activity were conducted, followed by detailed laboratory analysis on the stomach content. Five-minutes observations on randomly selected individuals were conducted at the field sampling site and their feeding activities were recorded with reference to age stage. Various shell sizes from each ontogenetic stage were randomly collected and quickly anaesthetized with ice and preserved in 10% formalin before being transported to the laboratory for stomach content analyses. Field observations showed that L. canarium mainly grazed on epiphytes occurring on seagrass （46.67%）, followed by sediment surface （40%） and epiphytes occurring on macroalgae （13.33%）. Stomach content analyses showed a significant difference （P〈0.05） in gastro-somatic index （Gasi） between the juveniles （0.39±0.05）, sub-adults （0.68±0.09） and adults （0.70±0.05）（P〈0.05）. Food items found in the conch stomach include diatoms, detritus, foraminifera, seagrass and macroalgae fragments, sand particles and shell fragments. The Index of Relative Importance （%IRI） indicates three main types of food dominated the three ontogenetic stages namely diatoms, sand particles and detritus. However, no significant difference （P〉0.05） was detected between the three main food items （diatoms, sand particles and detritus） among the ontogenetic stages. Therefore, feeding activity revealed the role of the dog conch in the marine food network. While, classification of the types of food consumed by L. canarium through stomach content analysis determines the particular position of the gastropod in the food chain. Further studies are needed to provide a better insight between tr

关键词： Laevistrombus canarium feeding activity gut contents Merambong shoal

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Mesoscale surface circulation and variability of Southern Indian Ocean derived by combining satellite altimetry and drifter observations

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Acta Oceanologica Sinica 2015年第9期34卷 12-22页

作者： BENNY N.Peter SHENBAKAVALLI Ranjan mazlan Hashim MOHD Nadzri Reba MOHD Razali Mahmud Department of Coastal and Offshore Engineering School of Ocean Engineering and Underwater TechnologyKerala University of Fisheries and Ocean Studies Department of Geomatic Engineering Faculty of Geoinformation and Real EstateUniversity of Technology Malaysia Institute of Geospatial Science & Technology Faculty of Geoinformation and Real EstateUniversity of Technology Malaysia

High resoultion Eulerian mean velocity field has been derived by combining the satellite tracked surface drifter data with satellite altimetry and ocean surface winds. The drifter data used in this study includes Argos and surface drifter data from Global Drifter Program. Maps of Sea Level Anomaly （MSLA） weekly files with a resolution of （1/3）° in both Latitude and Longitude for the period 1993-2012 have been used. The Ekman current is computed using ocean surface mean wind fields from scatterometers onboard ERS 1/2, Quikscat and ASCAT. The derived mean velocity field exhibits the broad flow of Antarctic Circumpolar Current with speeds up to 0.6 m/s. Anomalous field is quite significant in the western part between 20~ and 40~E and in the eastern part between 80~E and 100~E with velocity anomaly up to 0.3 m/s. The estimated mean flow pattern well agrees with the dynamic topography derived from in-situ observations. Also, the derived velocity field is consistent with the in-situ ADCP current measurements. Eddy kinetic energy illustrates an increasing trend during 1993-2008 and is in phase coherence with the Southern Annular Mode by three month lag. Periodic modulations are found in the eddy kinetic energy due the low frequency Antarctic Circumpolar Wave propagation.

关键词： Antarctic Ocean circulation satellite altimetry eddy kinetic energy Southern Indian Ocean antarctic circumpolar wave

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Morphometric and meristic variation in two congeneric archer fishes Toxotes chatareus (Hamilton 1822) and Toxotes jaculatrix (Pallas 1767) inhabiting Malaysian coastal waters

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2010年第11期11卷 871-879页

作者： K.D.SIMON Y.BAKAR S.E.TEMPLE A.G.mazlan Marine Science Programme School of Environmental and Natural Resource SciencesFaculty of Science and TechnologyUniversiti Kebangsaan Malaysia Biology Programme School of Biological SciencesUniversiti Kebangsaan Malaysia School of Biomedical Sciences University of Queensland Marine Ecosystem Research Centre Faculty of Science and TechnologyUniversiti Kebangsaan Malaysia

A simple yet useful criterion based on external markings and/or number of dorsal spines is currently used to differentiate two congeneric archer fish species Toxotes chatareus and Toxotes *** we investigate other morphometric and meristic characters that can also be used to differentiate these two *** component and/or discriminant functions revealed that meristic characters were highly correlated with pectoral fin ray count,number of lateral line scales,as well as number of anal fin *** results indicate that *** can be distinguished from *** by having a greater number of lateral line scales,a lower number of pectoral fin rays,and a higher number of anal fin *** contrast,morphometric discriminant analyses gave relatively low distinction:76.1% of fish were ascribed to the correct species *** observed morphometric differences came from the dorsal and anal spines lengths,with *** having shorter dorsal and longer anal spines than ***,meristic traits were more useful than morphometrics in differentiating the two species;nevertheless,meristics and morphometrics together provide information about the morphological differentiation between these two closely related archer fishes.

关键词： Archer fish Toxotes chatareus Toxotes jaculatrix Species identification Multivariate analysis

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