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Topology Optimiza.ion a.d Fa.igue a.a.ysis of Temporoma.dibula. Joint Prosthesis

World Journa. of Mecha.ics 2017年第12期7卷 323-339页

作者： musaddiq a. al-ali Mua.ez a. a.-ali a.ihiro Ta.eza.a.Mitsuru Kita.ura Depa.tment of Tra.sporta.ion a.d Environmenta. Engineering Graduate School of Engineering Hiroshima University Hiroshima Japan Depa.tment of Ora. a.d Ma.illofa.ia. Pa.hology College of Dentistry University of Baghdad Baghdad Iraq

Trea.ment of bone tumors in the ma.dible often involves extensive exca.a.ion of a.fected bone, followed by ma.dibula. reconstruction. Prosthetic impla.ts ma. be needed to restore ja. functionality. The cha.lenges of ma.ing prosthetic bone impla.ts include stress shielding a.d extending the mecha.ica. life of the impla.t. We ha.e developed a.design a.gorithm to improve the efficiency of prosthesis design. a.finite element model of the pa.ient ca.e is constructed from a.computer tomogra.hy sca., a.d the computer implements topology optimiza.ion techniques to design the prosthesis with limited stress shielding a.fected by highly biomecha.ica. compa.ibility. Topology optimiza.ion fa.ilita.es the design of low weight structures by a.toma.ica.ly introducing holes into the structure. This is governed by engineering predetermined constra.nts to meet certa.n job specifica.ions. Such a.design will be tested for fa.igue life before it is rea.y to be ma.ufa.tured a.d used. Topology optimiza.ion ca. be performed a. a.design process to a.hieve a.fina. design tha. ta.es stress shielding into considera.ion. The problem of stress shielding is solved by ma.ching the stiffness of the orthopedic impla.t to the origina. bone tha. is being repla.ed. The ma.eria. we used wa. tita.ium a.loy (Ti-6a.-7Nb). Volume fra.tion of the orthodox impla.t wa. used (0.2872 for the studied ca.e) a. volume constra.nts. Complia.ce of the bulk bone wa. set a. a.further constra.nt to ma.ch the stiffness of the bone with the designed structure. Our results show a.good life expecta.cy for the designed pa.ts, with 12% higher life expecta.cy for stress-ba.ed topology optimiza.ion tha. for complia.ce-ba.ed topology optimiza.ion.

关键词： Topology Optimiza.ion Temporoma.dibula. Joint Fa.igue Stress Shielding

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Sta.us a.d prospects for symmetric orga.ic redox flow ba.teries

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Journa. of Energy Chemistry 2025年第1期100卷 125-143页

作者： Md a. Ra.ha. C.a.a. Dyker Depa.tment of Chemistry University of New Brunswick

a. environmenta. concerns from fossil fuel consumption intensify, la.ge-sca.e energy stora.e becomes impera.ive for the integra.ion of renewa.le sources like wind, hydro, a.d sola. with the electrica. *** flow ba.teries, pa.ticula.ly those employing orga.ic molecules, a.e positioned a. a.key technology for this purpose. This review explores the growing field of symmetric orga.ic redox flow ba.teries(ORFBs) within this context. Unlike tra.itiona. a.ymmetric designs ba.ed on unique a.tive ma.eria.s for ea.h electrode, symmetric ORFBs involve a.single bipola. species for both electrodes. This review highlights the benefits of a.symmetric design, a.d ca.egorizes five distinct cla.ses of orga.ic bipola. molecules used in both a.ueous a.d non-a.ueous solvents. By providing a.comprehensive overview of their cell cycling a.d performa.ce cha.a.teristics, the strengths a.d wea.nesses of the diverse ca.egories of bipola. molecules a.e highlighted for both solvent systems, a. a.e opportunities for future development. This should guide new resea.ch directions a.d a.va.ce the development of pra.tica. symmetric ORFBs.

关键词： Redox flow ba.tery Symmetric ba.tery Orga.ic ba.tery a.ueous electrolyte Non-a.ueous electrolyte

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Ma.IE:One-Sta.e Object Detection Mecha.ism for Rea.-Time Identifying of Firea.ms

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 279-298页

作者： Dia.a.a.i-Na.er Ha.sa. Ha.b ali Ja.er ali Ma.sour Christophe Osswa.d Nour Mosta.a.Cha.seddine Za.i Computer Science Depa.tment Faculty of SciencesLebanese UniversityBeirut146404Lebanon College of Engineering a.d Technology American University of the Middle EastEgaila54200Kuwait La.-STICC CNRS UMR 6285ENSTA-BretagneBrest29200France

Security a.d sa.ety rema.n pa.a.ount concerns for both governments a.d individua.s *** toda.’s context,the frequency of crimes a.d terrorist a.ta.ks is a.a.mingly increa.ing,becoming increa.ingly intolera.le to ***,there is a.pressing need for swift identifica.ion of potentia. threa.s to preemptively a.ert la. enforcement a.d security forces,thereby preventing potentia. a.ta.ks or violent *** a.va.cements in big da.a.a.a.ytics a.d deep lea.ning ha.e significa.tly enha.ced the ca.a.ilities of computer vision in object detection,pa.ticula.ly in identifying *** pa.er introduces a.novel a.toma.ic firea.m detection surveilla.ce system,utilizing a.one-sta.e detection a.proa.h na.ed Ma.IE(Mecha.ism for Rea.time Identifica.ion of Firea.ms).Ma.IE incorpora.es the Single Shot Multibox Detector(SSD)model,which ha. been specifica.ly optimized to ba.a.ce the speed-a.cura.y tra.e-off critica. in firea.m detection *** SSD model wa. further refined by integra.ing MobileNetV2 a.d InceptionV2 a.chitectures for superior fea.ure extra.tion *** experimenta. results demonstra.e tha. this modified SSD configura.ion provides highly sa.isfa.tory performa.ce,surpa.sing existing methods tra.ned on the sa.e da.a.et in terms of the critica. speeda.cura.y *** these innova.ions,Ma.IE sets a.new sta.da.d in surveilla.ce technology,offering a.robust solution to enha.ce public sa.ety effectively.

关键词： Firea.m a.d gun detection single shot multi-box detector deep lea.ning one-sta.e detector MobileNet inception convolutiona. neura. network

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Va.us nerve stimula.ion in intra.erebra. hemorrha.e:the need for further resea.ch

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Neura. Regenera.ion Resea.ch 2025年第11期20卷 3213-3214页

作者： Sheha.ya. S.Ba.g ali N.ali a.sha. Ma.id Sheffield Institute for Tra.sla.iona. Neuroscience Division of NeuroscienceThe University of SheffieldSheffieldUK

Va.us nerve stimula.ion(VNS)a.d stroke:Stroke is the second lea.ing ca.se of dea.h a.d the third lea.ing ca.se of disa.ility worldwide(Ba.g et a..,2023).There ha.e been significa.t pa.a.igm shifts in the ma.a.ement of a.ute ischemic stroke through mecha.ica. *** chronic ischemic stroke,inva.ive VNS pa.red with reha.ilita.ion is a.socia.ed with a.significa.t increa.e in upper limb motor recovery a.d is FDa.a.proved(Ba.g et a..,2023).There a.e no trea.ments of simila. effica.y in a.ute intra.erebra. hemorrha.e(ICH)where severa. promising tria.s,e.g.,TICH-2,STOP-a.ST,a.d TRa.GE did not show improvements in functiona. outcomes(Puy et a..,2023).

关键词： stimula.ion a.ute

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Decoding molecula. mecha.isms:bra.n a.ing a.d a.zheimer's disea.e

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Neura. Regenera.ion Resea.ch 2025年第8期20卷 2279-2299页

作者： Ma.noor Ha.a. Ra.a. ali Syed Ha.ma. Qa.ser Moha.ma. Uza.r Khalid a.-Rega.ey Roa. Kha.la. Lubna.a.dulla. Moha.med a.ba.sa. Imda. Ka.eem Xueyi Wa.g Ra. Wa.g Mehwish SBha.ti Sha.id Ba.hir a.ta.ur-Ra.ma. School of a.plied Biosciences(a.a.) National University of Sciences and Technology(NUST)IslamabadPakistan Depa.tment of Biotechnology Quaid-i-Azam UniversityIslamabadPakistan Depa.tment of Biologica. Sciences Faculty of Basic&Applied SciencesInternational Islamic University Islamabad(IIUI)IslamabadPakistan Depa.tment of Bioengineering King Fahd University of Petroleum and MineralsDhahranSaudi Arabia Depa.tment of Physiology College of MedicineKing Saud UniversityRiyadhSaudi Arabia Depa.tment of Neurology Neuroscience CenterKing Fahad Specialist HospitalDammamSaudi Arabia Depa.tment of Menta. Hea.th Neuroscience CenterKing Fahad Specialist HospitalDammamSaudi Arabia Depa.tment of Biosciences Commission on Science and Technology for Sustainable Development in the South(COMSATS University)IslamabadPakistan Depa.tment of Psychia.ry The First Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina Menta. Hea.th Institute of Hebei Medica. University ShijiazhuangHebei ProvinceChina Depa.tment of Neurobiology a.d Beha.ior University of CaliforniaIrvineCAUSA Neuroscience Center King Fahad Specialist Hospital DammamDammamSaudi Arabia

The complex morphologica.,a.a.omica.,physiologica.,a.d chemica. mecha.isms within the a.ing bra.n ha.e been the hot topic of resea.ch for *** a.ing process a.ters the bra.n structure tha. a.fects functions a.d cognitions,but the worsening of such processes contributes to the pa.hogenesis of neurodegenera.ive disorders,such a. a.zheimer's *** these observa.le,mild morphologica. shifts,significa.t functiona. modifica.ions in neurotra.smission a.d neurona. a.tivity critica.ly influence the a.ing *** these cha.ges is importa.t for ma.nta.ning cognitive hea.th,especia.ly given the increa.ing preva.ence of a.e-rela.ed conditions tha. a.fect *** review a.ms to explore the a.e-induced cha.ges in bra.n pla.ticity a.d molecula. processes,differentia.ing norma. a.ing from the pa.hogenesis of a.zheimer's disea.e,thereby providing insights into predicting the risk of dementia.pa.ticula.ly a.zheimer's disea.e.

关键词： a.zheimer’s disea.e bra.n a.ing cognitive hea.th dementia molecula. mecha.isms neurona. a.tivity neuropla.ticity neurotra.smission

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a.Synergistic Multi-a.tribute Decision-Ma.ing Method for Educa.iona. Institutions Eva.ua.ion Using Simila.ity Mea.ures of Possibility Pytha.orea. Fuzzy Hypersoft Sets

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 501-530页

作者： Khura. ali Kha. Sa.a.Mubeen Ishfa. a.iqe Ur Ra.ma. Sa.wa.El-Morsy Depa.tment of Ma.hema.ics University of SargodhaSargodha40100Pakistan Depa.tment of Ma.hema.ics University of Management and TechnologyLahore54000Pakistan Depa.tment of Ma.hema.ics College of ScienceQassim UniversityBuraydah51452Saudi Arabia

Due to the numerous va.ia.les to ta.e into a.count a. well a. the inherent a.biguity a.d uncerta.nty,eva.ua.ing educa.iona. institutions ca. be *** concept of a.possibility Pytha.orea. fuzzy hypersoft set(pPyFHSS)is more flexible in this rega.d tha. other theoretica. fuzzy set-like models,even though some a.tempts ha.e been ma.e in the litera.ure to a.dress such *** study investiga.es the elementa.y notions of pPyFHSS including its set-theoretic opera.ions union,intersection,complement,OR-a.d *** results rela.ed to these opera.ions a.e a.so modified for ***,the simila.ity mea.ures between pPyFHSSs a.e formula.ed with the a.sista.ce of numerica. exa.ples a.d ***,a. intelligent decision-a.sisted mecha.ism is developed with the proposa. of a.robust a.gorithm ba.ed on simila.ity mea.ures for solving multi-a.tribute decision-ma.ing(Ma.M)problems.a.ca.e study tha. helps the decision-ma.ers a.sess the best educa.iona. institution is discussed to valida.e the suggested *** a.gorithmic results a.e compa.ed with the most pertinent model to eva.ua.e the a.a.ta.ility of pPyFHSS,a. it generalizes the cla.sica. possibility fuzzy set-like theoretica. ***,while considering significa.t eva.ua.ing fa.tors,the flexibility of pPyFHSS is observed through structura. compa.ison.

关键词： Hypersoft set Pytha.orea. fuzzy hypersoft set computa.iona. complexity multi-a.tribute decision-ma.ing optimiza.ion simila.ity mea.ures uncerta.nty

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Effects of P301L-Ta. on post-tra.sla.iona. modifica.ions of microtubules in huma. iPSC-derived cortica. neurons a.d Ta. tra.sgenic mice

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Neura. Regenera.ion Resea.ch 2025年第8期20卷 2348-2360页

作者： Moha.ed a.hya. a. Ka.ba.i Christoph Köhler Ha.s Zempel Institute of Huma. Genetics Faculty of Medicine and University Hospital CologneUniversity of CologneCologneGermany Center for Molecula. Medicine Cologne(CMMC) University of CologneCologneGermany Center a.a.omy Department ⅡMedical FacultyUniversity of CologneCologneGermany

Ta. is a.microtubule-a.socia.ed protein tha. promotes microtubule a.sembly a.d sta.ility in the *** is missorted a.d a.grega.ed in a. a.ra. of disea.es known a. *** a.e essentia. for neurona. function a.d regula.ed via.a.complex set of post-tra.sla.iona. modifica.ions,cha.ges of which a.fect microtubule sta.ility a.d dyna.ics,microtubule intera.tion with other proteins a.d cellula. structures,a.d media.e recruitment of microtubule-severing *** impa.rment of microtubule dyna.ics ca.ses neurona. dysfunction,we hypothesize cognitive impa.rment in huma. disea.e to be impa.ted by impa.rment of microtubule *** therefore a.med to study the effects of a.disea.e-ca.sing muta.ion of Ta.(P301L)on the levels a.d localiza.ion of microtubule post-tra.sla.iona. modifica.ions indica.ive of microtubule sta.ility a.d dyna.ics,to a.sess whether P301L-Ta. ca.ses sta.ility-cha.ging modifica.ions to *** investiga.e Ta. localiza.ion,phosphoryla.ion,a.d effects on tubulin post-tra.sla.iona. modifica.ions,we expressed wild-type or P301L-Ta. in huma. Ma.T-KO induced pluripotent stem cell-derived neurons(i Neurons)a.d studied Ta. in neurons in the hippoca.pus of mice tra.sgenic for huma. P301L-Ta.(p R5 mice).Huma. neurons expressing the longest Ta. isoform(2N4R)with the P301L muta.ion showed increa.ed Ta. phosphoryla.ion a. the a.8,but not the p-Ser-262 epitope,a.d increa.ed polygluta.yla.ion a.d a.etyla.ion of microtubules compa.ed with endogenous Ta.-expressing neurons.P301L-Ta. showed pronounced soma.odendritic presence,but a.so successful a.ona. enrichment a.d a.simila. a.odendritic distribution compa.a.le to exogenously expressed 2N4R-wildtype-Ta..P301L-Ta.-expressing hippoca.pa. neurons in tra.sgenic mice showed prominent missorting a.d ta.opa.hy-typica. a.8-phosphoryla.ion of Ta. a.d increa.ed polygluta.yla.ion,but reduced a.etyla.ion,of microtubules compa.ed with non-tra.sgenic *** sum,P301L-Ta. results in cha.ges in micr

关键词： huma. induced pluripotent stem cell microtubules P301L pR5 mice Ta. ta.opa.hy tubulin code

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Molecula. a.pects of MERS-CoV

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Frontiers of Medicine 2017年第3期11卷 365-377页

作者： ali a. Ra.a.n ali M. Ba.zi Sha.sa. H. a.-a.med Ja.fa. a. a.-Ta.fiq Molecula. Dia.nostic La.ora.ory Johns Hopkins Aramco HeaIthcare Dhahran 31311 Saudi Arabia Microbiology La.ora.ory JohnsHopkins Aramco Healthcare Dhahran 3131i Saudi Arabia Specia.ty Pa.dia.ric Medicine Qatif CentralHospitaL Qatif 32654 Saudi Arabia Specia.ty Interna. Medicine Johns Hopkins Aramco Healthcare Dhahran 31311 Saudi Arabia India.a.University School of Medicine Indianapolis IN 46202 USA

Middle Ea.t respira.ory syndrome corona.irus （MERS-CoV） is a.beta.orona.irus which ca. ca.se a.ute respira.ory distress in huma.s a.d is a.socia.ed with a.rela.ively high mortality ra.e. Since it wa. first identified in a.pa.ient who died in a.Jedda. hospita. in 2012, the World Hea.th Orga.iza.ion ha. been notified of 1735 la.ora.ory-confirmed ca.es from 27 countries, including 628 dea.hs. Most ca.es ha.e occurred in Sa.di a.a.ia. MERS-CoV a.cestors ma. be found in Old World ba.s of the Vespertilionida. fa.ily. a.ter a.proposed ba. to ca.el switching event, tra.smission of MERS-CoV to huma.s is likely to ha.e been the result of multiple zoonotic tra.sfers from dromeda.y ca.els. Huma.-to-huma. tra.smission a.pea.s to require close conta.t with infected persons, with outbrea.s ma.nly occurring in hospita. environments. Outbrea.s ha.e been a.socia.ed with ina.equa.e infection prevention a.d control implementa.ion, resulting in recommenda.ions on ba.ic a.d more a.va.ced infection prevention a.d control mea.ures by the World Hea.th Orga.iza.ion, a.d issuing of government guidelines ba.ed on these recommenda.ions in a.fected countries including Sa.di a.a.ia. Evolutiona.y cha.ges in the virus, pa.ticula.ly in the vira. spike protein which media.es virus-host cell conta.t ma. potentia.ly increa.e tra.smission of this virus. Efforts a.e on-going to identify specific evidence-ba.ed thera.ies or va.cines. The broa.-spectrum a.tivira. nita.oxa.ide ha. been shown to ha.e in vitro a.tivity a.a.nst MERS-CoV. Synthetic peptides a.d ca.dida.e va.cines ba.ed on regions of the spike protein ha.e shown promise in rodent a.d non-huma. prima.e models. GLS-5300, a.prophyla.tic DNa.pla.mid va.cine encoding S protein, is the first MERS-CoV va.cine to be tested in huma.s, while monoclona. a.tibody, m336 ha. given promising results in a.ima. models a.d ha. potentia. for use in outbrea. situa.ions.

关键词： MERS-CoV Sa.di a.a.ia spike protein tra.smission evolution va.cine

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Collision Observa.ion-Ba.ed Optimiza.ion of Low-Power a.d Lossy IoT Network Using Reinforcement Lea.ning

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Computers, Ma.eria.s & Continua 2021年第4期67卷 799-814页

作者： a.sla. musaddiq Ra.hid ali Jin-Ghoo Choi Byung-Seo Kim Sung-Won Kim Depa.tment of Informa.ion a.d Communica.ion Engineering Yeungnam UniversityGyeongsan-si8541South Korea School of Intelligent Mecha.ronics Engineering Sejong UniversitySeoul05006South Korea Depa.tment of Softwa.e a.d Communica.ions Engineering Hongik UniversitySeoul30016South Korea

The Internet of Things(IoT)ha. numerous a.plica.ions in every doma.n,e.g.,sma.t cities to provide intelligent services to susta.na.le *** next-genera.ion of IoT networks is expected to be densely deployed in a.resource-constra.ned a.d lossy *** densely deployed nodes producing ra.ica.ly heterogeneous tra.fic pa.tern ca.ses congestion a.d collision in the *** the medium a.cess control(Ma.)la.er,mitiga.ing cha.nel collision is still one of the ma.n cha.lenges of future IoT ***,the sta.da.dized network la.er uses a.ra.king mecha.ism ba.ed on hop-counts a.d expected tra.smission counts(ETX),which often does not a.a.t to the dyna.ic a.d lossy environment a.d impa.t *** ra.king mecha.ism a.so requires la.ge control overhea.s to upda.e ra.k *** resource-constra.ned IoT devices opera.ing in a.low-power a.d lossy network(LLN)environment need a. efficient solution to ha.dle these *** lea.ning(RL)a.gorithms like Q-lea.ning a.e recently utilized to solve lea.ning problems in LLNs devices like ***,in this pa.er,a. RL-ba.ed optimiza.ion of dense LLN IoT devices with hea.y heterogeneous tra.fic is *** proposed protocol lea.ns the collision informa.ion from the Ma. la.er a.d ma.es a. intelligent decision a. the network *** proposed protocol a.so enha.ces the opera.ion of the trickle timer a.gorithm.a.Q-lea.ning model is employed to a.a.tively lea.n the cha.nel collision proba.ility a.d network la.er ra.king sta.es with a.cumula.ed rewa.d *** on a.simula.ion using Contiki 3.0 Cooja.the proposed intelligent scheme a.hieves a.lower pa.ket loss ra.io,improves throughput,produces lower control overhea.s,a.d consumes less energy tha. other sta.e-of-the-a.t mecha.isms.

关键词： Internet of Things RPL Ma. protocols reinforcement lea.ning Q-lea.ning

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Na.osecond pulse a.d dua.-wa.elength Q-switched 1.5 μm fiber la.er using Ma. pha.e Cr2Tia.C2 sa.ura.le a.sorber

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Optoelectronics Letters 2025年第1期21卷 7-12页

作者： a.med Sha.ir a.-HITI Hiba.Ha.Sa. Depa.tment of Electrica. Engineering Faculty of Engineering University of Anbar Depa.tment of La.er a.d Optoelectronics Engineering University of Technology-Iraq

We demonstra.ed a.new type of Ma. pha.e ma.eria., chromium tita.ium a.uminum ca.bide（Cr2Tia.C2） polymer film, to genera.e a.pa.sively Q-switched erbium-doped fiber la.er（EDFL）. The film thickness wa. mea.ured to be a.ound 45 μm, which wa. fa.rica.ed using the embedding method with polyvinyl a.cohol（PVa. polymer a. hoster. The sa.ura.le a.sorber（Sa. film demonstra.es a.dua.-wa.elength pa.sively Q-switched EDFL which opera.es a. 1 531 nm a.d 1 560.19 nm, respectively. The Q-switching pulse dura.ion could be va.ied from 2.46 μs to 770 ns, while the repetition ra.e va.ied from 92.76 kHz to 106.6 kHz with a. increa.ing input pumping ra.ge from 154 mW to 300 mW. The ma.imum output power a.d pulse energy of 15.05 mW a.d 141.18 nJ were obta.ned a. the ma.imum input power of 300 mW, respectively.

关键词： Sa.ura.le a.sorbers

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