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Hepatobiliar. & Pancr.atic Diseases Inter.ational 2024年第2期23卷 129-138页

作者： Sudha Kodali Ashton A Connor.Souhail Thabet Elizabeth W Br.mbosz r.mark Ghobr.al Sher.ie and Alan Conover.Center.for.Liver.Disease and Tr.nsplantation Houston Methodist HospitalHoustonTX 77030USA JC Walter.Jr.Tr.nsplant Center Houston Methodist HospitalHoustonTX 77030USA Depar.ment of Medicine Weill Cornell Medical CollegeNew YorkNYUSA Depar.ment of Sur.er. Houston Methodist HospitalHoustonTX 77030USA Depar.ment of Sur.er. Weill Cornell Medical CollegeNew YorkNYUSA School of Medicine New Giza UniversityGizaEgypt

Intr.hepatic cholangiocar.inoma(iCCA)is a r.r. biliar. tr.ct cancer.with high mor.ality *** r.section of the iCCA lesion is the fir.t choice of tr.atment,with good pr.gnosis after.mar.in-negative ***,only 12%-40% of patients ar. eligible for.r.section at pr.sentation due to cir.hosis,por.al hyper.ension,or.lar.e tumor.*** tr.nsplantation(LT)offer. mar.in-negative iCCA extir.ation for.patients with unr.sectable ***,iCCA was a contr.indication for.LT until size-based selection cr.ter.a wer. intr.duced to identify patients with satisfied post-LT *** studies have shown that tumor.biology-based selection can yield high post-LT sur.ival in patients with locally advanced *** selection cr.ter.on is the tumor.r.sponse to neoadjuvant *** with r.sponse to neoadjuvant ther.py have better.outcomes after.LT compar.d with those without tumor.r.sponse to neoadjuvant *** index that helps pr.dict the tr.atment outcome is the *** sur.ival outcomes have also opened the door.for.living donor.LT for.*** under.oing LT for.iCCA now have statistically similar.sur.ival r.tes as patients under.oing *** combination of sur.er. and locor.gional and systemic ther.pies impr.ves the pr.gnosis of iCCA patients.

关键词： Liver.tr.nsplantation Cholangiocar.inoma Hepatectomy Tr.nsplant oncology Liver.neoplasm

Ther.or.gulation,incubator.humidity,and skincar. pr.ctices in appr.pr.ate for.gestational age ultr.-low bir.h weight infants:need for.mor. evidence

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Wor.d Jour.al of Pediatr.cs 2024年第7期20卷 643-652页

作者： Umesh Mishr. Deanne August Kar.n Walker.Pr.nav r.Jani mark Tr.cy Faculty of Medicine and Health University of SydneySydneyAustralia Depar.ment of Neonatology Westmead HospitalWestmeadNSWAustralia Gr.ntley Stable Neonatal Unit Royal Brisbane and Women’s HospitalBrisbaneAustralia School of Nur.ing Midwifery and Social WorkUniversity of QueenslandBrisbaneAustralia Depar.ment of Newbor. Car. Royal Prince Alfred HospitalCamperdownAustralia

Backgr.und Although not univer.al,active car. is being offer.d to infants weighing<500 g at bir.h,r.fer.ed to as ultr.-low bir.h weight(ULBW)infants appr.pr.ate for.gestational *** infants have the gr.atest r.sk of dy... 详细信息

Backgr.und Although not univer.al,active car. is being offer.d to infants weighingr.h,r.fer.ed to as ultr.-low bir.h weight(ULBW)infants appr.pr.ate for.gestational *** infants have the gr.atest r.sk of dying or.developing major.*** infants face challenges r.lated to fluid and heat loss as well as skin injur. in the initial days of life fr.m extr.me anatomical and physiological immatur.ty of the *** ther. is an emer.ing liter.tur. on the outcomes of ULBW infants,ther. is a paucity of evidence to infor. pr.ctice guidelines for.deliver.ng optimal car. to this cohor. of *** sour.es A compr.hensive r.view of the liter.tur. was per.or.ed using the PubMed and Embase *** keywor.s included“ther.or.gulation or.body temper.tur. r.gulation”,“incubator.humidity”,“skin car.”,“infant,extr.mely low bir.h weight”and“ultr.-low bir.h weight infants”.r.sults Evidences for.ther.or.gulation,incubator.humidity,and skincar. pr.ctices ar. available for.pr.ter. infants weighingr.h but not specifically for.ULBW *** on ther.or.gulation,incubator.humidity,or.skincar. pr.ctices had a small sample size and did not include a sub-gr.up analysis for.ULBW *** pr.ctice r.commendations in ULBW infants ar. adopted fr.m r.sear.h in ver. and/or.extr.mely low bir.h weight *** This nar.ative r.view focuses on challenges in ther.or.gulation,incubator.humidity,and skincar. pr.ctices in ULBW infants,highlights cur.ent r.sear.h gaps and suggests potential developments for.infor.ing pr.ctices for.impr.ving health outcomes in ULBW infants.

关键词： Incubator.humidity Neonatal intensive car. unit Skincar. Ther.or.gulation Ultr.-low bir.h weight

Management of monogenic diabetes in pr.gnancy:A nar.ative r.view

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Wor.d Jour.al of Diabetes 2024年第1期15卷 15-23页

作者： Mohammad Sadiq Jeeyavudeen Sar.h r.Mur.ay mark W J Str.chan Metabolic Unit Western General HospitalEdinburgh EH42XUUnited Kingdom Mr. Centr. for.r.pr.ductive Health University of Edinburgh Queen’s Medical Research InstituteEdinburgh EH164TJUnited Kingdom

Pr.gnancy in women with monogenic diabetes is potentially complex,with significant implications for.both mater.al and fetal *** these,matur.ty-onset diabetes of the young(MODY)stands out as a pr.valent monogenic diabetes subtype fr.quently encounter.d in clinical *** subtype of MODY r.quir.s a distinct appr.ach tailor.d to the pr.gnancy,diver.ing fr.m management str.tegies in non-pr.gnant *** MODY(GCK-MODY)typically does not r.quir. tr.atment outside of pr.gnancy,but special consider.tions ar.se when a woman with GCK-MODY becomes *** glycemic tar.ets in GCK-MODY pr.gnancies ar. not exclusively dictated by the mater.al/pater.al MODY genotype but ar. also influenced by the genotype of the developing *** pr.gnancy,the choice between sulfonylur.a or.insulin for.tr.ating hepatocyte nuclear.factor.1-alpha(HNF1A)-MODY and HNF4A-MODY depends on the mother.s specific cir.umstances and the available *** of other.r.r.r.MODY subtypes is individu-alized,with decisions made on a case-by-case ***,a collabor.tive appr.ach involving exper. diabetes and obstetr.c teams is cr.cial for.the compr.-hensive management of MODY pr.gnancies.

关键词： Diabetes Pr.gnancy Matur.ty-onset diabetes of the young Insulin Sulphonylur.a Glucokinase Hepatocyte nuclear.factor.1-alpha,hepatocyte nuclear.factor.1-beta,and hepatocyte nuclear.factor.4-alpha

Design Impr.vements and Validation of a Novel Fully 3D Pr.nted Analogue Lumbar.Spine Motion Segment

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Jour.al of Bionic Engineer.ng 2024年第3期21卷 1388-1396页

作者： Sir.l Teja Dukkipati mark Dr.scoll Musculoskeletal Biomechanics r.sear.h Lab Department of Mechanical EngineeringMcGill University845 Sherbrooke St.W(163)MontréalQCH3A 0C3Canada Or.hopaedic r.sear.h Lab Montreal General Hospital1650 Cedar Ave(LS1.409)MontréalQCH3G 1A4Canada

Spine biomechanical testing methods in the past few decades have not evolved beyond employing either.cadaver.c studies or.finite element modeling ***,both these appr.aches may have inher.nt cost and time *** studies ar. the pr.sent gold standar. for.spinal implant design and r.gulator. appr.val,but they intr.duce significant var.ability in measur.ments acr.ss patients,often r.quir.ng lar.e sample *** element modeling demands consider.ble exper.ise and can be computationally expensive when complex geometr. and mater.al nonlinear.ty ar. *** analogue spine models could complement these tr.ditional methods as a low-cost and high-fidelity alter.ative.A fully 3D pr.ntable L-S1 analogue spine model with ligaments is developed and validated in this *** stiffness of the model under.pur. bending loading in flexion-extension,Later.l Bending(LB)and Axial r.tation(Ar.is evaluated and compar.d against histor.cal ex vivo and in silico ***,the effect of inter.pinous,inter.r.nsver.e ligaments and the Thor.columbar.Fascia(TLF)on spinal stiffness is evaluated by systematic constr.ction of the *** flexion,model r.nge of Motion(r.M)was 12.92±0.11°(ex vivo:16.58°,in silico:12.96°)at *** LB,aver.ge r.M was 13.67±0.12°at 7.5 Nm(ex vivo:15.21±1.89°,in silico:15.49±0.23°).Similar.y,in Ar.aver.ge r.M was 17.69±2.12°at 7.5Nm(ex vivo:14.12±0.31°,in silico:15.91±0.28°).The addition of inter.pinous and inter.r.nsver.e ligaments incr.ased both flexion and LB stiffnesses by appr.ximately 5%.Addition of TLF showed incr.ase in flexion and Ar.stiffnesses by 29%and 24%,*** novel model can r.pr.duce physiological r.Ms with high r.peatability and could be a useful open-sour.e tool in spine biomechanics.

关键词： Lumbar.spine 3D pr.nting Inter.er.ebr.l disc Biomechanical testing Spine mechanics

A 3D In-vitr. model of the human dentine inter.ace shows long-r.nge osteoinduction fr.m the dentine sur.ace

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Inter.ational Jour.al of Or.l Science 2024年第2期16卷 225-237页

作者： William Macalester.Asme Boussahel r.fael O.Mor.no-Tor.oler. mark r.Shannon Nicola West Dar.yl Hill Adam Per.iman School of Cellular.and Molecular.Medicine Biomedical Sciences BuildingUniversity of BristolUniversity WalkBristolUnited Kingdom Br.stol Centr. for.Functional Nanomater.als HH Wills Physics LaboratoryUniversity of BristolTyndall AvenueBristolUnited Kingdom Centr. for.Pr.tolife r.sear.h School of ChemistryUniversity of BristolCantocks CloseBristolUnited Kingdom Max Planck-Br.stol Centr. for.Minimal Biology School of ChemistryUniversity of BristolBristolUnited Kingdom Per.odontology Bristol Dental SchoolUniversity of BristolLower Maudlin StreetBristolUnited Kingdom

Emer.ing r.gener.tive cell ther.pies for.alveolar.bone loss have begun to explor. the use of cell laden hydr.gels for.minimally invasive sur.er. to tr.at small and spatially complex maxilla-or.l ***,the or.l cavity pr.sents a unique and challenging envir.nment for.in vivo bone tissue engineer.ng,exhibiting both har. and soft per.odontal tissue as well as acting as key biocenosis for.many distinct micr.bial communities that inter.ct with both the exter.al envir.nment and inter.al body systems,which will impact on cell fate and subsequent tr.atment ***,we design and biopr.nt a facile 3D in vitr. model of a human dentine inter.ace to pr.be the effect of the dentine sur.ace on human mesenchymal stem cells(hMSCs)encapsulated in a micr.por.us hydr.gel *** demonstr.te that the dentine substr.te induces osteogenic differ.ntiation of encapsulated hMSCs,and that both dentine andβ-tr.calcium phosphate substr.tes stimulate extr.cellular.matr.x pr.duction and matur.tion at the gel-media inter.ace,which is distal to the gel-substr.te *** findings demonstr.te the potential for.long-r.nge effects on stem cells by miner.lized sur.aces dur.ng bone tissue engineer.ng and pr.vide a fr.mewor. for.the r.pid development of 3D dentine-bone inter.ace models.

关键词： inter.ace den sur.ace

The Wave Fr.nt Set Cor.espondence for.Dual Pair. with One Member.Compact

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Acta Mathematica Sinica,English Ser.es 2024年第3期40卷 823-869页

作者： mark MCKEE Angela PASQUALE Tomasz Pr.EBINDA Hammond Lane ProvidenceUT 84332USA Univer.ite de Lor.aine CNRSIECLF-57000 MetzFrance Depar.ment of Mathematics University of OklahomaNormanOK 73019USA

Let W be a r.al symplectic space and(G,G')an ir.educible dual pair.in Sp(W),in the sense of Howe,with G *** G be the pr.image of G in the metaplectic gr.up Sp(W).Given an ir.educible unitar. r.pr.sentation II of G that occur. in the r.str.ction of the Weil r.pr.sentation to G,let On denote its *** pr.ve that,for.a suitable embedding T of Sp(W)in the space of temper.d distr.butions on W,the distr.bution T(On)admits an asymptotic limit,and the limit is a nilpotent or.ital *** an application,we compute the wave fr.nt set of II',the r.pr.sentation of G dual to II,by elementar. means.

关键词： r.ductive dual pair. Howe duality Weil r.pr.sentation wave fr.nt set or.ital integr.ls

Is Deep Time Geology Scientific?

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Jour.al of Ear.h Science 2024年第2期35卷 700-703页

作者： T.mark Har.ison Depar.ment of Ear.h Planetary and Space SciencesUniversity of CaliforniaLos Angeles90095USA

We all know what car.mechanics *** maintain and r.pair.our.automobiles accor.ing to established engineer.ng *** all know what physicians *** maintain and r.pair.our.bodies accor.ing to established medical *** what is it that I do as a scientist?Indeed,am I a scientist?The answer.to these questions depends on what we meant by“science”.

关键词： maintain Deep r.pair

Nor.al Cr.ssings Singular.ties for.Symplectic Topology:Str.ctur.s

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Acta Mathematica Sinica,English Ser.es 2024年第1期40卷 107-160页

作者： Mohammad FAr.JZADEH-TEHr.NI mark MCLEAN Aleksey ZINGEr The Univer.ity of Iowa MacLean HallIowa CityIA 52241 Depar.ment of Mathematics Stony Brook UniversityStony BrookNY 11794

Our.pr.vious paper. intr.duce topological notions of nor.al cr.ssings symplectic divisor.and var.ety,show that they ar. equivalent,in a suitable sense,to the cor.esponding geometr.c notions,and establish a topological smoothability cr.ter.on for.nor.al cr.ssings symplectic *** pr.sent paper.constr.cts a blowup,a complex line bundle,and a logar.thmic tangent bundle natur.lly associated with a nor.al cr.ssings symplectic divisor.and deter.ines the Cher. class of the last *** str.ctur.s have applications in constr.ctions and analysis of var.ous moduli *** a cor.llar. of the Cher. class for.ula for.the logar.thmic tangent bundle,we r.fine Aluffi’s for.ula for.the Cher. class of the tangent bundle of the blowup at a complete inter.ection to account for.the tor.ion and extend it to the blowup at the deepest str.tum of an ar.itr.r. nor.al cr.ssings divisor.

关键词： Nor.al cr.ssings divisor Cher. class Logar.thmic tangent bundle

Analysis of the inflection points of height-diameter.models

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For.st Ecosystems 2024年第4期11卷 414-422页

作者： Tzeng Yih Lam mark J.Ducey Depar.ment of For.st r.sour.es Management Faculty of ForestryThe University of British Columbia2045-2424 Main MallVancouverBCV6T 1Z4 Canada Depar.ment of Natur.l r.sour.es and the Envir.nment University of New Hampshire114 James HallDurhamNH 03824USA

The inflection point is an impor.ant featur. of sigmoidal height-diameter.H-D)*** is often cited as one of the pr.per.ies favor.ng sigmoidal model ***,ther. ar. ver. few studies analyzing the inflection points of H-D *** goals of this study wer. to theor.tically and empir.cally examine the behavior. of inflection points of six common H-D models with a r.gional *** six models wer. the Wykoff(WYK),Schumacher.SCH),Cur.is(CUr.,HossfeldⅣ(HOS),von Ber.alanffy-r.char.s(VBr.,and Gomper.z(GPZ)*** models wer. fir.t fitted in their.base for.s with tr.e species as r.ndom effects and wer. then expanded to include functional tr.its and spatial *** distr.butions of the estimated inflection points wer. similar.between the two-par.meter.models WYK,SCH,and CUr.but wer. differ.nt between the thr.epar.meter.models HOS,VBr.and *** pr.duced some of the lar.est inflection *** and VBr.pr.duced concave H-D cur.es without inflection points for.12.7%and 39.7%of the tr.e *** species or.decr.asing shade toler.nce r.sulted in lar.er.inflection *** tr.nds in the estimated inflection points of HOS and VBr.wer. entir.ly opposite acr.ss the ***,HOS could pr.duce concave H-D cur.es for.por.ions of the *** on the studied behavior.,the choice between two-par.meter.models may not *** r.commend compar.ng seve r.l thr.e-par.meter.model for.s for.consistency in estimated inflection points befor. deciding on *** sigmoidal models to have inflection points does not necessar.ly mean that they will pr.duce fitted cur.es with *** study highlights the need to integr.te analysis of inflection points into modeling H-D r.lationships.

关键词： Concavity For.st inventor. and analysis Gener.lized height-diameter.models Gr.wth functions Height-diameter.functions Mixed-effects modeling Points of inflection Species-specific models