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Is There a Link between Circadian Clock Protein PERIOD 3 (PER3) (rs57875989) Variant and the Severity of COVID-19 Infection?

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Current Medical Science 2021年第6期41卷 1075-1080页

作者： Gozde YESIL SAYIN Sacide PEHLIVAN Istemi SERIN Alpay MEDETALIBEYOGLU murat rose Ali AGACFIDAN Naci SENKAL Ummihan ISOGLU-ALKAC Tufan TUKEK Department of Medical Genetics Istanbul Faculty of MedicineIstanbul UniversityIstanbul 34098Turkey Department of Medical Biology Istanbul Faculty of MedicineIstanbul UniversityIstanbul 34098Turkey Department of Hematology Istanbul Training and Research HospitalUniversity of Health SciencesIstanbul 34098Turkey Department of Internal Medicine Istanbul Faculty of MedicineIstanbul UniversityIstanbul 34098Turkey Department of Microbiology Istanbul Faculty of MedicineIstanbul UniversityIstanbul 34098Turkey Department of Physiology Istanbul Faculty of MedicineIstanbul UniversityIstanbul 34098Turkey

Objective:Corona Virus Disease-2019(COVID-19)has been among the major infectious events of the *** today’s literature where COVID-19 and host factor effects are frequently examined,we aimed to examine another factor:Circadian Clock Protein PERIOD 3(PER3).There is a significant correlation between PER3 gene polymorphism and circadian rhythm disturbances and immune system ***:In our study,we recruited 200 patients diagnosed with COVID-19 in our hospital between April-June 2020,and 100 volunteers without known comorbidities to create a healthy control *** comparing the initial gene polymorphisms of the patients with healthy controls,three separate clinical subgroups were *** polymorphism distribution and statistical significance were examined in the formed patient ***:No significant difference was found between the patient group and the healthy controls(P>0.05,for all).When patients were divided into two separate clinical subgroups as exitus/alive according to their last condition during their 28-day follow-up,the 4R/5R genotype was significantly more common in patients with a mortal course(P=0.007).The PER34R75R genotype was found at a significantly higher rate in the group of patients with the need for intensive care(P=0.034).Conclusion:The 4R/5R genotype may be associated with the need for intensive care and mortality in COVID-19 *** important results will be a guide for future studies.

关键词： corona virus disease 2019 circadian rhythm PER3 prognosis

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Comprehensive and personalized approach is a critical area for developing remote cardiac rehabilitation programs

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World Journal of Clinical Cases 2024年第12期12卷 2009-2015页

作者： Garyfallia Pepera Varsamo Antoniou Jing Jing Su rose Lin Ladislav Batalik Clinical Exercise Physiology and Rehabilitation Research Laboratory Department of PhysiotherapyFaculty of Health SciencesUniversity of ThessalyLamia GR35100Greece School of Nursing The Hong Kong Polytechnic UniversityHong Kong 999077China University of Rochester School of Nursing New YorkNY 14602United States Department of Rehabilitation University Hospital BrnoBrno 62500Czech Republic Department of Public Health Faculty of MedicineMasaryk UniversityBrno 62500Czech Republic

In the evolving landscape of cardiac rehabilitation(CR),adopting digital technologies,including synchronous/real-time digital interventions and smart applications,has emerged as a transformative *** technologies offer realtime health data access,continuous vital sign monitoring,and personalized educational enhanced patient self-management and *** their potential benefits,challenges and limitations exist,necessitating careful ***/real-time digital CR involves remote,two-way audiovisual communication,addressing issues of accessibility and promoting home-based *** applications extend beyond traditional healthcare,providing real-time health data and fostering patient *** devices and mobile apps enable continuous monitoring,tracking of rehabilitation outcomes,and facilitate lifestyle modifications crucial for cardiac health *** digital CR progresses,ensuring patient access,equitable implementation,and addressing the digital divide becomes *** intelligence holds promise in the early detection of cardiac events and tailoring patient-specific CR ***,challenges such as digital literacy,data privacy,and security must be addressed to ensure inclusive ***,the shift toward digital CR raises concerns about cost,safety,and potential depersonalization of therapeutic relationships.A transformative shift towards technologically enabled CR necessitates further research,focusing not only on technological advancements but also on customization to meet diverse patient *** challenges related to cost,safety,data security,and potential depersonalization is crucial for the widespread adoption of digital *** studies should explore integrating moral values into digital therapeutic relationships and ensure that digital CR is accessible,equitable,and seamlessly integrated into routine cardiac *** frameworks that accommodate

关键词： Cardiac rehabilitation Digital approaches Remote care Equity in technology access Synchronous/real-time interventions Digital innovation in healthcare

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Applying Earth Observation Technologies to Economic Consequence Modeling:A Case Study of COVID‑19 in Los Angeles County,California

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International Journal of Disaster Risk Science 2024年第1期15卷 18-31页

作者： Fynnwin Prager Marina T.Mendoza Charles K.Huyck Adam rose Paul Amyx Gregory Yetman Kristy F.Tiampo California State University Dominguez HillsCarsonCA 90747USA ImageCat Inc.Long BeachCA 90802USA University of Southern California Los AngelesCA 90015USA CIESIN–Center for International Earth Science Information Network Columbia UniversityPalisadesNY 10964USA Cooperative Institute for Research in Environmental Sciences(CIRES) University of Colorado BoulderBoulderCO 80309USA

Earth observation(EO) technologies,such as very high-resolution optical satellite data available from Maxar,can enhance economic consequence modeling of disasters by capturing the fine-grained and real-time behavioral responses of businesses and the *** investigated this unique approach to economic consequence modeling to determine whether crowd-sourced interpretations of EO data can be used to illuminate key economic behavioral responses that could be used for computable general equilibrium modeling of supply chain repercussions and resilience *** applied our methodology to the COVID-19 pandemic experience in Los Angeles County,California as a case *** also proposed a dynamic adjustment approach to account for the changing character of EO through longer-term disasters in the economic modeling *** found that despite limitations,EO data can increase sectoral and temporal resolution,which leads to significant differences from other data sources in terms of direct and total impact *** findings from this analytical approach have important implications for economic consequence modeling of disasters,as well as providing useful information to policymakers and emergency managers,whose goal is to reduce disaster costs and to improve economic resilience.

关键词： Computable general equilibrium models COVID-19 Disaster economic impacts Earth observation Economic consequence analysis Los Angeles County

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Templated synthesis of transition metal phosphide electrocatalysts for oxygen and hydrogen evolution reactions

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Journal of Energy Chemistry 2024年第2期89卷 646-669,I0014页

作者： rose Anne Acedera Alicia Theresse Dumlao DJ Donn Matienzo Maricor Divinagracia Julie Anne del Rosario Paraggua Po-Ya Abel Chuang Joey Ocon Laboratory of Electrochemical Engineering(LEE) Department of Chemical EngineeringUniversity of the PhilippinesDilimanQuezon City 1101Philippines Mechanical Engineering University of CaliforniaMercedCA 95343USA Energy Engineering Program College of EngineeringUniversity of the PhilippinesDilimanQuezon City 1101Philippines

Transition metal phosphides(TMPs)have been regarded as alternative hydrogen evolution reaction(HER)and oxygen evolution reaction(OER)catalysts owing to their comparable activity to those of noble metal-based *** have been produced in various morphologies,including hollow and porous nanostructures,which are features deemed desirable for electrocatalytic *** synthesis routes are often responsible for such *** paper reviews the latest advances and existing challenges in the synthesis of TMP-based OER and HER catalysts through templated methods.A comprehensive review of the structure-property-performance of TMP-based HER and OER catalysts prepared using different templates is *** discussion proceeds according to application,first by HER and further divided among the types of templates used-from hard templates,sacrificial templates,and soft templates to the emerging dynamic hydrogen bubble *** catalysts are then reviewed and grouped according to their ***,prospective research directions for the synthesis of hollow and porous TMP-based catalysts,such as improvements on both activity and stability of TMPs,design of environmentally benign templates and processes,and analysis of the reaction mechanism through advanced material characterization techniques and theoretical calculations,are suggested.

关键词： OER HER Transition metal phosphide Templated synthesis Electrocatalysts

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光学矫正角膜不规则散光专家共识(2024)

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中华眼视光学与视觉科学杂志 2024年第5期26卷 321-326页

作者：中国眼谷rose K临床研究会中国眼谷rose K临床研究会

角膜不规则散光是一种角膜形态异常导致的散光类型。造成角膜不规则散光的原因主要包括角膜扩张性疾病、角膜营养不良、角膜变性、角膜瘢痕等[1]。过去研究发现, 世界范围内的圆锥角膜患病率为0.05%～0.23%[2], 不同国家地区发病率存在... 详细信息

角膜不规则散光是一种角膜形态异常导致的散光类型。造成角膜不规则散光的原因主要包括角膜扩张性疾病、角膜营养不良、角膜变性、角膜瘢痕等[1]。过去研究发现, 世界范围内的圆锥角膜患病率为0.05%～0.23%[2], 不同国家地区发病率存在差异。早年的文献报道中国圆锥角膜的发病率约为0.9%[3]。随着角膜地形图、角膜断层扫描等检查技术的发展与普及, 眼科医师在疾病发展的早期就可以发现与诊断出角膜不规则散光, 特别是圆锥角膜[4]。

关键词：散光角膜不规则散光光学矫正接触镜共识

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Calcium channels caught in peripheral glia’s tug-of-war on axon regeneration in Drosophila

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Neural Regeneration Research 2025年第2期20卷 475-476页

作者： Jackson Powell Tobias Steinschaden rose Horowitz Yuanquan Song Raymond G.Perelman Center for Cellular and Molecular Therapeutics The Children’s Hospital of PhiladelphiaPhiladelphiaPAUSA The Neuroscience Graduate Group University of PennsylvaniaPhiladelphiaPAUSA Department of Pathology and Laboratory Medicine University of PennsylvaniaPhiladelphiaPAUSA Medical University of Vienna Center for Brain ResearchDepartment of NeuroimmunologyViennaAustria

Neural damage or degeneration is at the crux of many diseases,and treatment of these diseases will require the development of therapeutics to enhance and guide neural *** intrinsic and extrinsic factors dictate a neuron’s ability to regenerate,and the combination of these factors results in the great regenerative capacity of the peripheral nervous system(PNS)and the poor regenerative capacity of the central nervous system(CNS)following *** the core of a neuron’s function is its ability to relay electrochemical signals,and a neuron’s excitability is a key factor in its ability to *** works have focused on the changes in neuronal electrophysiological properties,firing patterns,and ion flux after injury,which differentially activate signaling pathways at the core of *** role of glia in neuron regeneration has long been studied.

关键词： degeneration firing system

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Palaeodepositional environment,implications of Glossopteris flora,and organic matter characteristics from the Lower Permian,Karo Open Cast Mine,East Bokaro Coalfield,Damodar Basin,India

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Journal of Palaeogeography 2024年第3期13卷 528-546页

作者： Sankar Suresh Kumar Pillai rose Ann Sebastian Runcie Paul Mathews Srikanta Murthy Anju Saxena Mrutyunjaya Sahoo Suraj Kumar Sahu Gulshan Kumar Dhingra Birbal Sahni Institute of Palaeosciences 53 University RoadLucknow-226007UPIndia Academy of Scientific and Innovative Research(AcSIR) Ghaziabad-201002India Department of Geology School of Earth Science SystemsCentral University of KeralaKasaragod-671316KeralaIndia Department of Geology Ravenshaw UniversityCuttack-753003OdishaIndia Department of Botany Sri Dev Suman Uttarakhand UniversityUttarakhand-249145India

The present study deals with the Early Permian floral diversity,palaeoenvironment,palaeoclimate and depositional setting using a multiproxy approach that includes morphotaxonomy,palynology,and organic geochemistry of Karo OCM(Open Cast Mine),East Bokaro Coalfield,Damodar Gondwana Basin,*** Permian sediments of Peninsular India are widely regarded as fluvial,along with some marine *** macroplant fossil assemblage exhibits the presence of Glossopteridales,comprising Glossopteris,Gangamopteris,and Vertebraria,as well as Coniferales,which includes *** palynological assemblage encompasses the dominance of the striate bisaccate pollen Faunipollenites *** the subdominance of the non-striate bisaccate pollen Scheuringipollenites *** glossopterid *** megafloral and palynofloral assemblage confirms the biostratigraphical age to be Late Barakar palynoflora of Kungurian *** studied morphological characteristics,including small to large Glossopteris leaves exhibiting a lanceolate shape,acute apices,and acute cuneate or tapering bases,as well as entire margins with narrower lamina and narrow meshes,suggest the existence of a dense forest with the prevalence of a warm and humid climate during their *** organic geochemical characterization based on functional group and biomarker analyses reveals the diagenetic effects on organic *** symmetric(~2865-2855 cm^(-1))and asymmetric stretching(~2930-2910 cm^(-1))peaks are identifiable in coal samples,whereas they are absent in carbonaceous *** A-factor vs.C-factor plot suggests that the kerogen type is type Ⅲ,which can generate mainly gaseous *** vitrinite reflectance studies(R_(r) av.1.1%)show increased maturity of the samples,which is supported by the n-alkane distribution pattern and the absence of hopane *** Indian floral assemblages in contemporary of southern Gondwana continents reveal a stronger inclination/affinity with th

关键词： Glossopteris Palynomorph FTIR GCMS Gondwana Permian Palaeoclimate

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The Role of Impulsivity and Addiction in Gambling Behaviors: How Applied Neuroscience Research Can Help in the Monitoring and Management of Mental Health Issues

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Open Journal of Medical Psychology 2024年第1期13卷 11-24页

作者： Yingzhen Jia Kimberly rose Clark College of Arts and Sciences Boston University Boston MA USA Department of Psychological and Brain Sciences Dartmouth College Hanover NH USA

One in five Americans experience symptoms associated with at least one mental health disorder every year. These include behavioral addictions, which have long been overlooked despite their similar neural bases with substance addictions. Gambling addiction, a type of behavioral addiction, deserves particular attention given the significant negative effects, this addiction has on financial and interpersonal health. The purpose of this paper is to review the available literature concerning the behavioral and neural processes involved in gambling addiction, including: the anticipation of reward, the role of dopamine, and the neural substrates of the decision-making processes involved in gambling addiction. Market research has also identified solutions that integrate applied neuroscience and self-tracking systems to monitor and manage mental health issues associated with gambling addiction. The authors then propose a gambling treatment-focused mobile app solution that addresses outstanding issues with a special design aimed at reversing plasticity in order to relieve the effects of gambling addiction. .

关键词： Applied Neuroscience Gambling Addiction Mental Health Management

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A signaling cascade mediating fruit trait development via phosphorylation-modulated nuclear accumulation of JAZ repressor

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Journal of Integrative Plant Biology 2024年第6期66卷 1106-1125页

作者： Wei Wang Jinyao Ouyang Yating Li Changsheng Zhai Bing He Huahan Si Kunsong Chen Jocelyn K.C.rose Wensuo Jia College of Horticulture China Agricultural UniversityBeijing 100193China College of Agriculture and Biotechnology Zhejiang UniversityZijingang CampusHangzhou 310058China Plant Biology Section School of Integrative Plant ScienceCornell UniversityIthaca14853NYUSA Institute of Horticulture Crops Xinjiang Academy of Agricultural SciencesUrumqi 830000China

It is generally accepted that jasmonate-ZIM domain(JAZ)repressors act to mediate jasmonate(JA)signaling via CORONATINE-INSENSITIVE1(COI1)-mediated ***,we report a cryptic signaling cascade where a JAZ repressor,FvJAZ12,mediates multiple signaling inputs via phosphorylation-modulated subcellular translocation rather than the COI1-mediated degradation mechanism in strawberry(Fragaria vesca).FvJAZ12 acts to regulate flavor metabolism and defense response,and was found to be the target of Fv MPK6,a mitogen-activated protein kinase that is capable of responding to multiple signal ***6 phosphorylates FvJAZ12 at the amino acid residues S179 and T183 adjacent to the PY residues,thereby attenuating its nuclear accumulation and relieving its repression for FvMYC2,which acts to control the expression of lipoxygenase 3(FvLOX3),an important gene involved in JA biosynthesis and a diverse array of cellular *** data reveal a previously unreported mechanism for JA signaling and decipher a signaling cascade that links multiple signaling inputs with fruit trait development.

关键词： defense response JAZ repressor phosphorylation strawberry subcellular translocation

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Will artificial intelligence reach any limit in gastroenterology?

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Artificial Intelligence in Gastroenterology 2024年第2期5卷 1-9页

作者： Joseph Bou Jaoude rose Al Bacha Bassam Abboud Department of Gastroenterology Levant HospitalBeirut 166830Lebanon Department of General Surgery Geitaoui HospitalFaculty of MedicineLebanese UniversityLebanonBeirut 166830Lebanon

Endoscopy is the cornerstone in the management of digestive *** the last few decades,technology has played an important role in the development of this field,helping endoscopists in better detecting and characterizing luminal ***,despite ongoing advancements in endoscopic technology,the incidence of missed pre-neoplastic and neoplastic lesions remains high due to the operator-dependent nature of endoscopy and the challenging learning curve associated with new *** intelligence(AI),an operator-independent field,could be an invaluable *** can serve as a“second observer”,enhancing the performance of endoscopists in detecting and characterizing luminal *** utilizing deep learning(DL),an innovation within machine learning,AI automatically extracts input features from targeted endoscopic *** encompasses both computer-aided detection and computer-aided diagnosis,assisting endoscopists in reducing missed detection rates and predicting the histology of luminal digestive *** applications in clinical gastrointestinal diseases are continuously expanding and evolving the entire digestive *** all published studies,real-time AI assists endoscopists in improving the performance of non-expert gastroenterologists,bringing it to a level comparable to that of *** development of DL may be affected by selection *** have utilized different AI-assisted models,which are *** the future,algorithms need validation through large,randomized ***,AI has no limit to assist endoscopists in increasing the accuracy and the quality of endoscopic ***,practically,we still have a long way to go before standardizing our AI models to be accepted and applied by all gastroenterologists.

关键词： Artificial intelligence Digestive tract Gastroenterology Gastroscopy Coloscopy

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