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The Association between Serum Resistin Levels and Major Adverse Cardiac Events

World Journal of Cardiovascular Diseases 2017年第10期7卷 332-339页

作者： Umit Yasar Sinan Ozge Cetinarslan Veysel Ok.ay Ilk.ur Calpar Yalcin Dalgic Aysem k.ya Alev Arat Ozk.n murat k. ersanli Department of Cardiology Istanbul University Institute of Cardiology Istanbul Turkey Department of Biochemistry Istanbul University Institute of Cardiology Istanbul Turkey

Resistin is a member of the family of cysteine-rich secretary proteins called resistin-lik. molecules (RELMs). It is suggested to be involved in inflammatory conditions and atherosclerosis. We have established a significant correlation between serum resistin levels and coronary artery disease (CAD) in a study was performed between 2011 and 2012 in our institute in two hundred fourteen patients (164 CAD patients and 50 controls). Then the CAD patients were followed up to investigate the relationship between increased serum resistin levels and major adverse cardiac events (MACE) between 2012 and 2016. One hundred fifty-five of 164 patients (95%) were followed up and 9 patients lost to follow up. There were 39 MACE (25%) in four years of follow-up.?There were 16 in-hospital deaths due to cardiac causes, 8 revascularization procedures, and 15 re-hospitalization due to acute coronary syndrome (ACS) or heart failure (HF). The patients with MACE had similar serum resistin level (median: 71.37 pg/ml) compared to patients without MACE (median: 80.23 pg/ml) (p > 0.05).

关键词： Resistin Adipok.ne Atherosclerosis Coronary Artery Disease Major Adverse Cardiac Event

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A predictive score for retinopathy of prematurity by using clinical risk.factors and serum insulin-lik. growth factor-1 levels

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International Journal of Ophthalmology(English edition) 2017年第11期10卷 1722-1727页

作者： Yesim Cosk.n Ceyhun Dalk.n Ozge Yabas Ozlem Onay Demirel Elif Samiye Bayar Sibel Sak.rya Tuba Muftuoglu Dilaver ersanli Nerin Bahceciler ipek.Ak.an Department of Pedialrics Bahcesehir University Medical Faculty Medical Park Goztepe Hospital Istanbul 34732 Turkey Department of Pediatrics Division of Neonatology Near East University Nicosia 99138 North Cyprus Department of Ophtalmotology Bahce~ehir University Medical Faculty Medical Park Goztepe Hospital Istanbul 34732 Turkey Department of Biochemistry Bahcesehir University Medical Faculty Medical Park Goztepe Hospital Istanbul 34732 Turkey Department of Public Health Marmara University Medical Faculty Istanbu 134890 Turkey Department of Biochemistry GATA Haydarpa~a Hospital Istanbul 34668 Turkey Department of Ophtalmotology GATA Haydarpasa Hospital Istanbu134668 Turkey Department of Pediatrics Near East University Nicosia 99138 North Cyprus

AIM：To detect the impact of insulin-lik. growth factor-1（IGF-1）and other risk.factors for the early prediction of retinopathy of prematurity（ROP）and to establish a scoring system for ROP prediction by using clinical criteria and serum IGF-1 ***：The study was conducted with 127 preterm ***-1 levels in the 1st day of life,1st,2nd,3rd and4th week.of life was *** score was established after logistic regression analysis,considering the impact of each variable on the occurrences of any stage ROP.A validation cohort containing 107 preterm infants was included in the study and the predictive ability of ROP score was ***：Birth weights（BW）,gestational week.（GW）and the prevalence of breast milk.consumption were lower,respiratory distress syndrome（RDS）,bronchopulmonarydysplasia（BPD）and necrotizing enterocolitis（NEC）were more frequent,the duration of mechanical ventilation and oxygen supplementation was longer in patients with ROP（P〈0.05）.Initial serum IGF-1 levels tended to be lower in newborns who developed *** regression analysis revealed that low BW（〈1250 g）,presence of intraventricular hemorrhage（IVH）and formula feeding increased the risk.of ***,the scoring system was validated on 107 *** negative predictive values of a score less than 4 were 84.3%,74.7%and 79.8%while positive predictive values were 76.3%,65.5%and71.6%***：In addition to BW〈1250 g and IVH,formula consumption was detected as a risk.factor for the development of *** is important for prevention of ROP in preterm infants.

关键词： ROP A predictive score for retinopathy of prematurity by using clinical risk.factors and serum insulin-lik. growth factor-1 levels IVH IGF

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睫状体扁平部玻璃体切割术对闭合性眼外伤的疗效研究

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世界核心医学期刊文摘（眼科学分册） 2005年第9期1卷 41-42页

作者： ersanli D. Unal M. Aydin A. 张少娟 GATA Haydarpasa Egitim Hastanesi G¨oz Hast. Klinigi Istanbul Turkey Dr.

BACk.ROUNDANDOBJECTIVE: To assess surgical and visual outcomeswith pars plana vitrectomy (PPV) in closed-globe injuries resulting in anterior and posterior segment pathologies and evaluate the factors influencing the prognosis. PATIENTS AND METHODS: Retrospective ob servational study. Fortyseven eyes of 47 consecutive patients who underwent PPV because of closed-globe injury between January 1992 and August 2003 were reviewed. Surgical and visual outcomes and prognostic factors were analyzed according to the Ocular Trauma Classification System. RESULTS: Preoperative visual acuity was less than 4/200 in 49%of eyes, classified as grades IV to V After surgery, this ratio was 23%(P < .05)-. Final visual acuity was statistically significantly better in grade I (P=.0001), grade II (P=.002), and relative afferent pupillary defect-negative (P=.0001) injuries. Maculopathy was the most common adverse outcome influencing final visual acuity (32%), followed by secondary glaucoma (13%) and proliferative vitreoretinopathy (8%). CONCLUSION: PPV is a favorable treatment modality in severe closed-globe injuries. Assessment of injuries with respect to the Ocular Trauma Classification System seemed to predict visual outcomes in this series.

关键词：闭合性眼外伤玻璃体切割术疗效研究眼前节继发性青光眼黄斑病变观察性研究分级系统

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