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Assessment of the correlation between serum prolidase and alpha-fetoprotein levels in patients with hepatocellular carcinoma

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World Journal of Gastroenterology 2015年第22期21卷 6999-7007页

作者： Sevil Uygun Ilikhan Muammer Bilici Hatice Sahin Ayse Semra Demir Akca murat can Ibrahim Ilker Oz Berrak Guven M Cagatay Buyukuysal Yucel Ustundag Department of Internal medicine Bülent Ecevit University Faculty of Medicine Department of Family Medicine Bülent Ecevit University Faculty of Medicine Department of Biochemistry Bülent Ecevit University Faculty of Medicine Department of Radiology Bülent Ecevit University Faculty of Medicine Department of Biostatistic Bülent Ecevit University Faculty of Medicine Bülent Ecevit University Faculty of Medicine Department of Gastroenterology

AIM: To determine the predictive value of increased prolidase activity that reflects increased collagen turnover in patients with hepatocellular carcinoma(HCC).METHODS: Sixty-eight patients with HCC(mean age of 69.1 ± 10.1), 31 cirrhosis patients(mean age of59.3 ± 6.3) and 33 healthy volunteers(mean age of51.4 ± 12.6) were enrolled in this study. Univariate and multivariate analysis were used to evaluate the association of serum α-fetoprotein(AFP) values with HCC clinicopathological features, such as tumor size,number and presence of vascular and macrovascular invasion. The patients with HCC were divided into groups according to tumor size, number and presence of vascular invasion(diameters; ≤ 3 cm, 3-5 cmand ≥ 5 cm, number; 1, 2 and ≥ 3, macrovascular invasion; yes/no). Barcelona-clinic liver cancer(BCLC)criteria were used to stage HCC patients. Serum samples for measurement of prolidase and alphafetoprotein levels were kept at-80 ℃ until *** levels were measured spectrophotometrically and AFP concentrations were determined by a chemiluminescence immunometric commercial diagnostic ***: In patients with HCC, prolidase and AFP values were evaluated according to tumor size, number,presence of macrovascular invasion and BCLC staging classification. Prolidase values were significantly higher in patients with HCC compared with controls(P cantly associated with tumor size and number(P cant difference compared with patients with cirrhosis(P cant correlation(r = 0.616; P< 0.001) between prolidase and AFP values in

关键词： Alpha-fetoprotein Hepatocellular carcinoma Prolidase Cirrhosis Macrovascular invasion

Towards optimum Franson interference recurrence in mode-locked singly-filtered biphoton frequency combs

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光子学研究:英文版 2023年第7期11卷 1175-1184页

作者： KAI-CHI CHANG XIANG CHENG murat can SARIHAN CHEE WEI WONG Fang Lu Mesoscopic Optics and Quantum Electronics Laboratory Department of Electrical and Computer EngineeringUniversity of CaliforniaLos AngelesCalifornia 90095USA

Mode-locked biphoton frequency combs exhibit multiple discrete comblike temporal correlations from the Fourier transform of its phase-coherent frequency *** temporal correlation and Franson interferometry are valuable tools for analyzing the joint properties of biphoton frequency combs,and the latter has proven to be essential for testing the fundamental quantum nature,the time-energy entanglement distribution,and the large-alphabet quantum key ***,the Franson recurrence interference visibility in biphoton frequency combs unavoidably experiences a falloff that deteriorates the quality of time-energy entanglement and channel capacity for longer cavity round *** this paper,we provide a new method to address this problem towards optimum Franson interference *** first observe mode-locked temporal oscillations in a5.03 GHz free-spectral range singly filtered biphoton frequency comb using only commercial ***,we observe similar falloff trend of time-energy entanglement in 15.15 GHz and 5.03 GHz free-spectral range singly filtered biphoton frequency combs,whereas,the optimum central time-bin accidental-subtracted visibility over 97%for both ***,we find that by increasing the cavity finesse F,we can enhance the detection probability in temporal correlations and towards optimum Franson interference recurrence in our singly filtered biphoton frequency *** the first time,via a higher cavity finesse F of 45.92 with a 15.11 GHz free-spectral range singly filtered biphoton frequency comb,we present an experimental≈3.13-fold improvement of the Franson visibility compared to the Franson visibility with a cavity finesse F of 11.14 at the sixth time *** optimum Franson interference recurrence and a time-bin Schmidt number near 16 effective modes in similar free-spectral range cavity are predicted with a finesse F of *** configuration is versatile and robust against changes in cavity parameters that can be d

关键词： optimum filtered visibility

Mitigation of indomethacin-induced gastric mucosal lesions by a potent specific type V phosphodiesterase inhibitor

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World Journal of Gastroenterology 2009年第40期15卷 5091-5096页

作者： Kemal Karakaya Volkan Hanci Sibel Bektas murat can Hamdi B Ucan Ali Ugur Emre Oge Tasc1lar Is1l Ozkocak Turan Mustafa Comert Oktay Irkorucu Guldeniz Karadeniz Cakmak Department of General Surgery Zonguldak Karaelmas UniversityMedical Faculty Department of Anesthe-siology Zonguldak Karaelmas UniversityMedical Faculty Department of Pathology Zonguldak Karaelmas UniversityMedical Faculty Department of Biochemistry Zonguldak Karaelmas UniversityMedical Faculty

AIM: To investigate the gastroprotective effect of vardenafil against indomethacin-induced gastric damage. METHODS: Forty-eight female Wistar albino rats were randomly divided into 6 groups. Group 1 received saline only. Group 2 (indomethacin) received indomethacin. Rats in group 3 and 4 were pretreated with different doses of famotidine. Group 5 and 6 were pretreated with different doses of vardenafil. Rats in groups 3 to 6 received 25 mg/kg indomethacin 30 min after pretreatment. The animals were sacrificed 6 h later and their stomachs were opened. Gastric lesions were counted and measured. The stomach of each animal was divided in two parts for histopathological examinations and nitric oxide (NO) and malondialdehyde (MDA) assays, respectively. RESULTS: There were no gastric mucosal lesion in the saline group but all rats in the indomethacin group had gastric mucosal ulcerations (ulcer count; 6.25 ± 3.49, and mean ulcer area; 21.00 ± 12.35). Ulcer counts werediminished with famotidine 5 mg/kg (4.12 ± 2.47, P > 0.05), 20 mg/kg (2.37 ± 4.43, P cantly higher in indometh-acin group (28.48 ± 14.51), compared to the famotidine 5 mg/kg (6,21 ± 1.88, P cantly increased (P cant. Histopathology revealed dimin-ished gastric damage for pretreatment groups co

关键词： Vardenafil Gastric ulceration Indomethacin Gastroprotection Rats

Note on Lower Triassic Gondolelloid Conodont Rediversifications with Emphasis on the Spathian Recovery

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Journal of Earth Science 2024年第4期35卷 1236-1242页

作者： Ali murat Kilic Department of Geological Engineering Faculty of EngineeringBalikesir UniversityBalikesir99100Turkey

Conodonts,as a biotic group,next to ammonoids,pollen and spores,crustaceans and vertebrates,provide proxy clues for environment and age assessments of the rocks in which they *** are widely used for Triassic marine ***,there are various discussions about their multielement taxonomy and evolutionary lineages(e.g.,generation,speciation).Although first studies reported that most Triassic conodont species were unimembrate,studies carried out in the following years maintained that all Triassic conodonts were *** statistical reconstructions of a number of Triassic apparatuses were attempted,the discovery of fused clusters and natural assemblages has subsequently demonstrated that Triassic conodonts are indeed multimembrate,and all of the elements exist together in the same *** present paper aims to clarify the evolutionary relationship and array of some Lower Triassic *** dagisi *** described.

关键词： Triassic Spathian conodont Columbitella Siberia environmental geology

Highly Improved Creep Resistance in Polypropylene Through Thermally Reduced Graphene Oxide and Its Creep Lifetime Prediction

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Chinese Journal of Polymer Science 2024年第2期42卷 256-266,I0010页

作者： can-can Zhang Jun-Long Yang Ya-Jiang Huang Guang-Xian Li College of Polymer Science and Engineering State Key Laboratory of Polymer Materials Engineering of ChinaSichuan UniversityChengdu610065China

Polypropylene(PP) exhibits suboptimal creep resistance due to the presence of methyl groups on its main chain, leading to irregular chain segment distribution, diminished inter-chain interaction, and crystallinity. This structural feature causes chain slippage in PP under stress,significantly constraining its service lifetime. In this study, thermally reduced graphene oxide(TrGO) nanosheets were incorporated into the PP matrix, yielding a nanocomposite with exceptional creep resistance performance. Results demonstrated that at a stress of 25 MPa, a 2.0 wt% TrGO content could enhance the creep failure lifetime of PP by 21.5 times compared to neat PP. Rheology, transmission electron microscopy(TEM),and scanning electron microscopy(SEM) characterization techniques were employed to analyze the mechanism of TrGO's influence on PP's creep behavior. It was observed that when TrGO content exceeded 1.0 wt%, an effective particle network structure formed within the PP matrix. This homogeneously dispersed TrGO-formed particle network structure restricted the migration and rearrangement of PP molecular chains, enabling prolonged stress resistance without structural failure. By combining the time-strain superposition method with the critical failure strain as a criterion, generalized creep compliance curves for PP and its composites were established, facilitating the prediction of material creep failure lifetimes, with a strong agreement between experimental and predicted lifetime values. This research proposes a novel strategy aimed at developing polypropylene materials and products with enhanced long-term stability and durability, thus extending service life, reducing failure risk, and broadening their potential across various application domains.

关键词： Thermally reduced graphene oxide Polypropylene Creep failure and lifetime prediction

Stereochemical editing:Catalytic racemization of secondary alcohols and amines

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Chinese Chemical Letters 2024年第5期35卷 17-31页

作者： Jun Zhang Zhiyao Zheng can Zhu Department of Chemistry Fudan UniversityShanghai 200438China Department of Organic Chemistry Arrhenius LaboratoryStockholm UniversityStockholm 10691Sweden

Chiral alcohols and amines are important structural units widely existing in pharmaceuticals,agrochemicals,and food *** kinetic resolution(DKR)is an efficient strategy to deliver optically active alcohols and amines from their *** the development of DKR method,racemization catalyst plays as a crucial element with the requirement of compatibility with the kinetic resolution(KR)*** this paper,recent advance in the catalytic racemization of secondary alcohols and amines is summarized based on different types of racemizing intermediates,which are redox racemization via ketone/imine intermediates,racemization via radical intermediates,and racemization via carbocation *** racemization of secondary alcohols and amines is also enclosed.

关键词： Racemization Secondary alcohols Amines Kinetic resolution Dynamic kinetic resolution

Ytterbium modified birnessite MnO_(2) for improving deep oxidation of toluene

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Journal of Rare Earths 2024年第4期42卷 668-675页

作者： Linjiang Sun Yan Cheng Yujie Liu can Yi Faculty of Geosciences and Environmental Engineering Southwest Jiaotong UniversityChengdu611756China

A series of rare earth metals modified birnessite manganese dioxides(RE-Mn)was synthesized by hydrothermal method and their catalytic degradation of toluene was ***-Mn shows the best toluene oxidation activity with the conversion of T50%and T99%at 196 and 226℃,*** physiochemical characterizations identified that the high catalytic performance and excellent stability of Yb-Mn are mainly associated with its higher molar ratios of Mn^(4+)/Mn^(3+),more lattice oxygen(Olatt),and better mobility of surface adsorbed oxygen(O_(ads)).Moreover,it is confirmed that introduction of Yb into birnessite MnO_(2) facilitates the production of acetic acid at lower *** results can aid the design of high-efficiency manganese oxide catalysts for the catalytic combustion of VOCs.

关键词： Manganese oxide Rare earth metal doping Toluene Catalytic combustion

Effect of a cervical collar on optic nerve sheath diameter in trauma patients

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World Journal of Emergency Medicine 2024年第2期15卷 126-130页

作者： Mümin murat Yazici Ozcan Yavasi Department of Emergency Medicine Recep Tayyip Erdogan University Training and Research HospitalRize 53020Türkiye

BACKGROUND:As advocated in advanced trauma life support and prehospital trauma life support protocols,cervical immobilization is applied until cervical spine injury is *** study aimed to show the difference in optic nerve sheath diameter(ONSD)between patients with and without a cervical collar using computed tomography(CT).METHODS:This was a single-center,retrospective study examining trauma patients who presented to the emergency department between January 1,2021,and December 31,*** ONSD on brain CT of the trauma patients was measured and analyzed to determine whether there was a difference between the ONSD with and without the cervical ***:The study population consisted of 169 *** CT imaging of patients with(n=66)and without(n=103)cervical collars,the mean ONSD in the axial plane were 5.43±0.50 mm and 5.04±0.46 mm respectively for the right eye and 5.50±0.52 mm and 5.11±0.46 mm respectively for the left *** results revealed an association between the presence of a cervical collar and the mean ONSD,which was statistically significant(P<0.001)for both the right and left ***:A cervical collar may be associated with increased *** effect of this increase in the ONSD on clinical outcomes needs to be investigated,and the actual need for cervical collar in the emergency department should be evaluated on a case-by-case basis.

关键词： Optic nerve sheath diameter Computed tomography Trauma Emergency medicine

Performance of iron-air battery with iron nanoparticle-encapsulated C-N composite electrode

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Frontiers in Energy 2024年第1期18卷 42-53页

作者： can FANG Xiangmei TANG Jiaoyan WANG Qingfeng YI School of Chemistry and Chemical Engineering Hunan University of Science and TechnologyXiangtan 411201China Hunan Provincial Key Laboratory of Advanced Materials for New Energy Storage and Conversion Xiangtan 411201China

Highly efficient and stable iron electrodes are of great significant to the development of iron-air battery(IAB).In this paper,iron nanoparticle-encapsulated C–N composite(NanoFe@CN)was synthesized by pyrolysis using polyaniline as the C–N *** performance of the NanoFe@CN in different electrolytes(alkaline,neutral,and quasi-neutral)was investigated via cyclic voltammetry(CV).The IAB was assembled with NanoFe@CN as the anode and IrO_(2)+Pt/C as the *** effects of different discharging/charging current densities and electrolytes on the battery performance were also *** K_(2)SO_(4)electrolyte can effectively suppress the passivation of iron electrode,and the battery showed a good cycling stability during 180 charging/discharging *** to the pure nano-iron(NanoFe)battery,the NanoFe@CN battery has a more stable cycling stability either in KOH or NH_(4)Cl+KCl electrolyte.

关键词： energy storage and conversion metallic composites nanocomposites iron-air battery iron anode