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Acceleration of coxarthrosis by an exostosis causing femoroacetabular impingement

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Health 2010年第4期2卷 318-320页

作者： Mahmut Nedim Aytekin Hakan Atalar Burcu Yanik murat arikan 不详

Here we describe a 28-year-old man with a history of right hip pain for the past 11 years and ankylosing spondylitis for the past 6 months. Imaging studies showed an exostosis in the femoral neck causing femoroacetabular imping- ement. The patient was diagnosed with coxar- throsis. This case report suggests that femoro- acetabular impingement may accelerate the degenerative process in the hip joint.

关键词： Femoroacetabular Impingement Exostosis

Inhibition of Ehrlich ascites carcinoma growth by melatonin:Studies with micro-CT

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Oncology Research 2024年第1期32卷 175-185页

作者： SEHER YILMAZ ZÜLEYHA DOĞANYIĞIT MERT OCAK EVRIM SUNA arikan SÖYLEMEZ ASLI OKAN OFLAMAZ SÜMEYYE UÇAR ŞÜKRÜATEŞ AMMAD AHMAD FAROOQI Department of Anatomy Faculty of MedicineYozgat Bozok UniversityYozgatTurkey Department of Mechanical and Aerospace Engineering Case Western Reserve UniversityClevelandOhioUSA Department of Histology and Embriology Faculty of MedicineYozgat Bozok UniversityYozgatTurkey Department of Anatomy Faculty of DentistryAnkara UniversityAnkaraTurkey Department of Medical Biology Faculty of MedicineAfyonkarahisar Health Sciences UniversityAfyonTurkey Department of Anatomy Faculty of MedicineErciyes UniversityKayseriTurkey Department of Molecular Oncology Institute of Biomedical and Genetic Engineering(IBGE)IslamabadPakistan

Melatonin is a versatile indolamine synthesized and secreted by the pineal gland in response to the photoperiodic information received by the retinohypothalamic signaling *** has many benefits,such as organizing circadian rhythms and acting as a powerful *** aimed to show the antitumor effects of melatonin in both in vivo and in vitro models through the mammalian target of rapamycin(mTOR)signaling pathway and the Argyrophilic Nucleolar Regulatory Region(AgNOR),using the Microcomputed Tomography(Micro CT).Ehrlich ascites carcinoma(EAC)cells were administered into the mice by subcutaneous *** with solid tumors were injected intraperitoneally with 50 and 100 mg/kg melatonin for 14 *** measurements for the taken tumors were made with micro-CT imaging,immunohistochemistry(IHC),real-time polymerase chain reaction(PCR)and ***,the tumor tissue volume in the Tumor+100 mg/kg melatonin group was significantly lower than that in the other groups in the data obtained from micro-CT *** the IHC analysis,the groups treated with Tumor+100 mg/kg melatonin were compared when the mTOR signaling pathway and factor 8(F8)expression were compared with the control *** was determined that there was a significant decrease(p<0.05).Significant differences were found in the total AgNOR area/nuclear area(TAA/NA)ratio in the treatment groups(p<0.05).Furthermore,there were significant differences between the amount of mTOR mRNA for the phosphatidylinositol 3-kinase(PI3K),AKT Serine/Threonine Kinase(PKB/AKT)genes(p<0.05).Cell apoptosis was evaluated with Annexin V in an in vitro study with different doses of melatonin;It was observed that 100µg/mL melatonin dose caused an increase in the apoptotic cell *** this study,we have reported anti-tumor effects of melatonin in cell culture studies as well as in mice *** characterization of the melatonin-mediated cancer inhibitory effects will be valuable in advanc

关键词： Signaling pathway Apoptosis Real-time PCR AgNOR

A Retrospective Analysis of Intoxicated Patients Admitted to the Intensive Care Unit: A Single-Institution Assessment in the Post-Pandemic Period

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Journal of Biosciences and Medicines 2024年第3期12卷 159-167页

作者： Müge arikan Abdullah Yeşilkaya Büşra Nur Taşdelen İbrahim Özyiğit Department of Anesthesia and Intensive Care Faculty of Medicine Karabuk University Karabuk Turkey

Background: The aim of this study was to evaluate the clinical and epidemiological characteristics of patients with acute intoxication admitted to the Intensive Care Unit (ICU). Material and Methods: An observational retrospective study was conducted on intoxicated patients who admitted to ICU between January 2022 and January 2024. Data were collected from the patients medical records. The demographic characteristics, causes of intoxications, clinical parameters, the mean stay in the ICU, treatment modalities and prognosis were recorded. Results: A total of 2875 critically ill patients were admitted during the study period, and 109 (3.79%) of them were acute intoxications. Their mean of ages was 38.09 ± 12.29. The female-to-male ratio was 1.37/1. Drugs were found to be the primary cause (62.39%) of intoxications, and analgesics, antidepressants, and antibiotics were the most frequent agents. Suicidal attempts were present in 66 patients, most of them were female (62.13%) and between 17 - 24 years (40.91%). The other common causes of intoxications were carbon monoxide (CO) (22.02%), methyl/ethyl alcohol (8.26%) and mushroom (5.50%). The mean stay in the ICU was 2.69 ± 0.89 days. Mechanical ventilation was applied to 10 of our patients. Renal replacement therapy was required in 6 patients. Despite all treatments, 6 of our patients died, and we found the mortality rate to be 5.50%. Conclusion: Intoxications were more frequent in young female patients and drugs were the most common cause with suicidal intent. Unfortunately, CO poisoning continues to be a very important problem in our city. These findings provided significant information about the characteristics of intoxications in Karabuk.

关键词： Intoxication Intensive Care Unit Suicidal Mortality

Dynamo equation solution using Finite Volume Method for midlatitude ionosphere

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Geodesy and Geodynamics 2018年第6期9卷 425-431页

作者： Feza arikan Umut Sezen Orhan arikan Department of Electrical and Electronics Engineering Hacettepe University Department of Electrical and Electronics Engineering Bilkent University

Ionosphere is the layer of atmosphere which plays an important role both in space based navigation,positioning and communication systems and HF signals. The structure of the electron density is a function of spatio-temporal variables. The electrodynamic medium is also influenced with earth’s magnetic field, atmospheric chemistry and plasma flow and diffusion under earth’s gravitation. Thus, the unified dynamo equation for the ionosphere is a second order partial differential equation for quasi-static electric potential with variable spatial coefficients. In this study, the inhomogeneous and anisotropic nature of ionosphere that can be formulated as a divergence equation is solved numerically using Finite Volume Method for the first time. The ionosphere and the operators are discretized for the midlatitude region and the solution domain is investigated for Dirichlet type boundary conditions that are built in into the diffusion equation. The analysis indicates that FVM can be a powerful tool in obtaining parametric electrostatic potential distribution in ionosphere.

关键词： Ionosphere Finite volume method(FVM) Dynamo equation Electric potential

NVIS HF signal propagation in ionosphere using calculus of variations

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Geodesy and Geodynamics 2019年第1期10卷 72-76页

作者： Umut Sezen Feza arikan Orhan arikan Department of Electrical and Electronics Engineering Hacettepe University Department of Electrical and Electronics Engineering Bilkent University

Modeling Near Vertical Incidence Sounding(NVIS) High Frequency(HF) signal propagation in the ionosphere is important. Because, ionosondes which are special types of radars probing the ionosphere with certain HF frequencies(between 2 and 30 MHz), work mostly in NVIS mode(where elevation angle is between 89 and 90°). In this work, we are going to propose a new method for NVIS wave propagation in the ionosphere by discretizing the NVIS wave propagation path into mediums in which the refractive index changes linearly, where we solve the ray propagation in each medium analytically using calculus of variations and use Snell's Law at medium changes. The main advantage of the proposed solution is the reduced computational complexity and time. This algorithm can be used to simulate and compare the behavior of vertical ionosondes together with other ray tracing algorithms.

关键词： Ionosphere HF propagation Calculus of variations

Spectral investigation of traveling ionospheric disturbances:IONOLAB-FFT

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Geodesy and Geodynamics 2017年第5期8卷 297-304页

作者： Feza arikan Aysenur Yarici Hacettepe University Department of Electrical and Electronics Engineering

Ionosphere is an important layer of atmosphere which is under constant forcing from both below due to gravitational, geomagnetic and seismic activities, and above due to solar wind and galactic radiation. Spatio-temporal variability of ionosphere is made up of two major components that can be listed as spatio-temporal trends and secondary variabilities that are due to disturbances in the geomagnetic field, gravitational waves and coupling of seismic activities into the upper atmosphere and ionosphere. Some of these second order variabilities generate wave-like oscillations in the ionosphere which propagate at a certain frequency, duration and velocity. These oscillations cause major problems for navigation and guidance systems that utilize GNSS （Global Navigation Satellite Systems）. In this study, the frequency and duration of wave-like oscillations are determined using a DFT （Discrete Fourier Transform） based algo- rithm over the STEC （slant total electron content） values estimated from single GPS （Global Positioning System） station. The performance of the developed method, namely IONOLAB-FFT, is first determined using synthetic oscillations with known frequencies and durations. Then, IONOLAB-FFr is applied to STEC data from various midlatitude GPS stations for detection of frequency and duration of both medium and large scale TIDs （traveling ionospheric disturbances）. It is observed that IONOLAB-FFr can estimate TIDs with more than 80% accuracy for the following cases： frequencies from 0.6 mHz to 2.4 mHz and durations longer than 10 min; frequencies from 0.15 mHz to 0.6 mHz and durations longer than 50 min; fre- quencies higher than 0.29 mHz and durations longer than 50 rain.

关键词： IonosphereTID (traveling ionospheric disturbances)GPS (Global Positioning System)TEC (total electron content)IONOLAB-FFF

Inhomogeneous Quantum Invariance Group of Multi-Dimensional Multi-parameter Deformed Boson Algebra

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Chinese Physics Letters 2012年第1期29卷 8-10页

作者： Azmi Ali Altintas Metin Arik Ali Serdar arikan Emre Dil Faculty of Engineering Okan UniversityTuzlaIstanbulTurkey Department of Physics Boğazici UniversityBebekIstanbulTurkey Department of Physics Sakarya UniversityEsentepeSakaryaTurkey

We investigate the inhomogeneous invariance quantum group of the d-dimensional d-parameter deformed boson *** is found that the homogeneous part of this quantum group is given by the𝑑-parameter deformed general linear *** construct the d-matrix which collects all information about the non-commuting structure of the quantum group for the two-dimensional case.

关键词： group. algebra. parameter

Immediate intraocular pressure rise after intravitreal injection of ranibizumab and two doses of triamcinolone acetonide

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International Journal of Ophthalmology(English edition) 2011年第4期4卷 402-405页

作者： Gul arikan Ali Osman Saatci Ferit Hakan Oner Department of Ophthalmology School of Medicine Dokuz Eylul University

AIM: To evaluate prospectively immediate intraocular pressure (IOP) changes after the intravitreal injection of ranibizumab, 2 and 4mg triamcinolone acetonide. METHODS: Patients who underwent intravitreal injection of 0.1mL (4mg) triamcinolone acetonide (TA, Group T4), 0.05mL (2mg) TA (Group T2) and 0.05mL (0.5mg) ranibizumab (Group R) comprised the study population. Overall, 229 eyes of 205 patients were injected. Fifty-four eyes (23.6%) were in Group T4, 69 eyes (30.1%) in Group T2 and 106 eyes (46.3%) in Group R. If IOP was less than 26mmHg immediately after the injection no further measurement was performed. If IOP was ≥26mmHg, IOP was remeasured till the reading was below 26mmHg at 5, 15 and 30 minutes. RESULTS: Immediately after the injection, the IOP of 28 eyes (51.9%) in Group T4, 22 eyes (31.9%) in Group T2 and 51 eyes (48.1%) in Group R were over 25mmHg. At 30 minutes, IOP of one eye (1.9%) in group T4, two eyes (2.9%) in group T2 and two eyes (1.9 %) in Group R were over 25mmHg. Immediate post-injection IOP was significantly higher in Group T4 and Group R when compared to Group T2 (P <0.001 and P <0.001, respectively). IOP was significantly higher in eyes without vitreous reflux when compared to those with vitreous reflux in all groups (P <0.001). CONCLUSION: IOP may remarkably increase immediately after the intravitreal injection of 2 or 4mg triamcinolone acetonide, and 0.5mg ranibizumab. Absence of vitreous reflux is the most important predicting factor for immediate IOP rise after the injection.

关键词： anti-VEGF agents glaucoma intraocular pressure intravitreal injection steroids

Performance of GPS slant total electron content and IRI-Plas-STEC for days with ionospheric disturbance

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Geodesy and Geodynamics 2016年第1期7卷 1-10页

作者： Feza arikan Seymur Shukurov Hakan Tuna Orhan arikan T.L. Gulyaeva Department of Electrical and Electronics Engineering Hacettepe University Beytepe Ankara 06800 Turkey Department of Electrical and Electronics Engineering Bilkent Uniuersity Bilkent Ankara 06800 Turkey IZMIRAN Moscow 142190 Troitsk Russian Federation

Total Electron Content （TEC） is an important observable parameter of the ionosphere which forms the main source of error for space based navigation and positioning systems. Since the deployment of Global Navigation Satellite Systems （GNSS）, cost-effective esti- mation of TEC between the earth based receiver and Global Positioning System （GPS） sat- ellites became the major means of investigation of local and regional disturbance for earthquake precursor and augmentation system studies. International Reference Iono- sphere （IRI） extended to plasmasphere （IRI-Plas） is the most developed ionospheric and plasmaspheric climatic model that provides hourly, monthly median of electron density distribution globally. Recently, IONOLAB group {***） has presented a new online space weather service that can compute slant TEC （STEC） on a desired ray path for a given date and time using IRI-Plas model （IRI-Plas-STEC）. In this study, the performance of the model based STEC is compared with GPS-STEC computed according to the estimation method developed by the IONOLAB group and includes the receiver bias as IONOLAB-BIAS （IONOLAB-STEC）. Using Symmetric Kullback-Leibler Distance （SKLD）, Cross Correlation （CC） coefficient and the metric norm （L2N） to compare IRI-Plas-STEC and IONOLAB-STEC for the month of October 2011 over the Turkish National Permanent GPS Network （TNPGN- Active）, it has been observed that SKLD provides a good indicator of disturbance for both earthquakes and geomagnetic storms.

关键词： IonosphereTotal Electron Content (TEC)GPSIRI-Plas