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NeCAB family of neuronal calcium-binding proteins in health and disease

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Neural Regeneration Research 2025年第5期20卷 1236-1243页

作者： Diones Bueno Michael K.e.Schafer Sudena Wang Michael j.Schmeisser Axel Methner Institute for Molecular Medicine University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Department of Anesthesiology University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Institute of Anatomy University Medical Center of the Johannes Gutenberg-UniversityMainzGermany

The N-terminal eF-hand calcium-binding proteins 1–3(NeCAB1–3) constitute a family of predominantly neuronal proteins characterized by the presence of at least one eF-hand calcium-binding domain and a functionally less well characterized C-terminal antibiotic biosynthesis monooxygenase domain. All three family members were initially discovered due to their interactions with other proteins. NeCAB1 associates with synaptotagmin-1, a critical neuronal protein involved in membrane trafficking and synaptic vesicle exocytosis. NeCAB2 interacts with predominantly striatal G-protein-coupled receptors, while NeCAB3 partners with amyloid-β A4 precursor protein-binding family A members 2 and 3, key regulators of amyloid-β production. This demonstrates the capacity of the family for interactions with various classes of proteins. NeCAB proteins exhibit distinct subcellular localizations: NeCAB1 is found in the nucleus and cytosol, NeCAB2 resides in endosomes and the plasma membrane, and NeCAB3 is present in the endoplasmic reticulum and Golgi apparatus. The antibiotic biosynthesis monooxygenase domain, an evolutionarily ancient component, is akin to atypical heme oxygenases in prokaryotes but is not wellcharacterized in vertebrates. Prokaryotic antibiotic biosynthesis monooxygenase domains typically form dimers, suggesting that calcium-mediated conformational changes in NeCAB proteins may induce antibiotic biosynthesis monooxygenase domain dimerization, potentially activating some enzymatic properties. However, the substrate for this enzymatic activity remains uncertain. Alternatively, calcium-mediated conformational changes might influence protein interactions or the subcellular localization of NeCAB proteins by controlling the availability of protein–protein interaction domains situated between the eF hands and the antibiotic biosynthesis monooxygenase domain. This review summarizes what is known about genomic organization, tissue expression, intracellular localization, interac

关键词： calcium eF hand mitochondria nervous system signal transduction

eLeCTRONIC STRUCTURe OF THe eLeMeNTS

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Chinese Physics C 2016年第10期40卷 124-125页

作者： j.e. Sansonetti NIST

The electronic configurations and the ionization energies are from the NIST database, ＂Ground Levels and Ionization energies for the Neutral Atoms,＂ W.C. Martin, A. Musgrove, S. Kotochigova, and j.e. Sansonetti, http：//*** .gov/pml/data/ion_energy. cfm. The electron configuration for, say, iron indicates an argon electronic core （see argon） plus six 3d electrons and two 4s electrons.

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Two-neutron transfer reactions as a tool to study the interplay between shape coexistence and quantum phase transitions

1000年

作者： (美)安德森(Anderson j.e.)

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Chinese Physics C 2020年第12期44卷 103-113页

作者： j.e.García-Ramos j.M.Arias A.Vitturi Departamento de Ciencias Integradas y Centro de estudios Avanzados en Física Matemática y ComputaciónUniversidad de Huelva21071 HuelvaSpain Instituto Carlos I de Física Teórica y Computacional Universidad de GranadaFuentenueva s/n18071 GranadaSpain Departamento de Física Atómica Molecular y NuclearUniversidad de SevillaApdo.106541080 SevillaSpain Dipartimento di Fisica e Astronomia“Galileo Galilei” Universitádegli Studi di PadovaPadovaItaly

The atomic mass table presents zones where the structure of the states changes rapidly as a function of the neutron or proton *** them,notable examples are the A≈100 Zr region,the Pb region around the neutron midshell(N=104),and the N≈90 rare-earth *** observed phenomena can be understood in terms of either shape coexistence or quantum phase *** objective of this study is to find an observable that can distinguish between both shape coexistence and quantum phase *** an observable to be analyzed,we selected the two-neutron transfer intensity between the 0+states in the parent and daughter *** framework used for this study is the Interacting Boson Model(IBM),including its version with configuration mixing(IBM-CM).To generate wave functions of isotope chains of interest needed for calculating transfer intensities,previous systematic studies using IBM and IBM-CM were used without changing the *** results of two-neutron transfer intensities are presented for Zr,Hg,and Pt isotopic chains using ***,for Zr,Pt,and Sm isotopic chains,the results are presented using IBM with only a single configuration,i.e.,without using configuration *** Zr,the two-neutron transfer intensities between the ground states provide a clear observable,indicating that normal and intruder configurations coexist in the low-lying spectrum and cross at A=98→*** can help clarify whether shape coexistence induces a given quantum phase *** Pt,in which shape coexistence is present and the regular and intruder configurations cross for the ground state,there is almost no impact on the value of the two-neutron transfer *** is the situation with Hg,where the ground state always has a regular *** the Sm isotope chain,which is one of the quantum phase transition paradigms,the value of the two-neutron transfer intensity is affected strongly.

关键词： two nucleon transfer reactions shape coexistence quantum phase transition interacting boson model

Aluminum electroplating on AZ31 Magnesium Alloy with Acetic Anhydride Pretreatment

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Acta Metallurgica Sinica(english Letters) 2022年第12期35卷 1996-2006页

作者： Zelei Zhang Atsushi Kitada Kazuhiro Fukami Kuniaki murase Department of Materials Science and engineering Kyoto UniversityKyoto 606-8501Japan Department of Chemical System engineering The University of TokyoTokyo 113-8656Japan

Magnesium(Mg)alloys for metal electroplating require a surface pretreatment,i.e.,the removal of the spontaneously oxidized surface layer(MgO,Mg(OH)_(2),andMgCO_(3)).However,the use of highly toxic and/or corrosive acids in conventional pretreatment processes has become an *** this study,a facile and less toxic pretreatment is demonstrated and applied in aluminum(Al)*** immersion of the AZ31 Mg alloy into acetic anhydride(Ac_(2)O)removed the spontaneously oxidized surface layer and formed a thin but stable magnesium acetate(Mg(OAc)_(2))layer that protects the metal substrate from further *** Al electroplating bath is a concentrated diglyme(G2)-AlCl_(3)organic solution that can readily dissolve Mg(OAc)_(2)to enable direct plating onto a metal *** as-deposited Al layer has a compact and crack-free morphology that improves the corrosion resistance and hardness(2.7 GPa).Owing to the lack of an interfacial oxidized layer,heat treatment led to the successful diff usion of Mg and Al atoms,which increased the hardness to 4.4 *** Ac_(2)O pretreatment of Mg alloys enables the successful Al electroplating and subsequent heat treatment.

关键词： Magnesium alloy Surface modifi cation electrodeposition Hardness Corrosion resistance

Annealing,solvation,and mirror-plating effects in phosphonium chloroaluminate ionic liquids

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Nano Research 2023年第2期16卷 3348-3357页

The physicochemical properties of a specific ionic liquid(IL)are naturally considered to be constant at a given ***,a series of eutectic melts of trihexyl(tetradecyl)phosphonium chloride([P6,6,6,14]Cl)with aluminum chloride(AlCl3)is an *** viscosity of Al_(2)Cl_(7)−-dominated[P6,6,6,14]Cl–AlCl_(3)ILs(i.e.,AlCl_(3)mole fraction x=0.60–0.67)gradually increased as a function of *** also influenced the ultraviolet–visible spectra,nuclear magnetic resonance spectra,and the glass transition temperature of the *** annealing-induced variations in physicochemical properties were not observed in the AlCl4−-and Cl−-dominated *** particular,the ionic conductivities of the ILs(x=0.60–0.67)were strongly decoupled from their viscosities during *** initio calculations revealed the bending of the long tetradecyl chains in[P6,6,6,14]+coupled with Al_(2)Cl_(7)−,while neither Cl−nor AlCl_(4)−caused *** general,[P6,6,6,14]+-based ILs are recognized as sponge-like structures that consist of nano-scale polar and non-polar *** propose a gradual structurization process in Al_(2)Cl_(7)−-dominated ILs to account for their unusual physicochemical ***,the addition of tetradecane,solvated in the non-polar domains of the ILs,substantially reduced the viscosity of the structured IL with x=*** Al electroplating is possible without a brightener,using the x=0.67 ILs,regardless of annealing or the admixture of tetradecane.

关键词： ionic liquid physicochemical property ab initio calculation electrodeposition

数学分析--在企业管理与经济学中的应用 (下)

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数学分析--在企业管理与经济学中的应用 (下)

作者： (美)j.e.韦伯王昌曜译

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数学分析--在企业管理与经济学中的应用

数学分析--在企业管理与经济学中的应用

Recent Advancements in the Optimization Capacity Configuration and Coordination Operation Strategy of Wind-Solar Hybrid Storage System

作者： (美)j.e.韦伯王昌曜译

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energy engineering 2025年第1期122卷 285-306页

作者： Hongliang Hao Caifeng Wen Feifei Xue HaoQiu Ning Yang Yuwen Zhang Chaoyu Wang edwin e.Nyakilla Department of New energy Storage Peking University Ordos Research Institute of EnergyOrdos017010China School of energy and Power engineering Inner Mongolia University of TechnologyHohhot010080China Key Laboratory of Wind energy and Solar energy Utilization Technology Inner Mongolia University of TechnologyHohhot010051China

Present of wind power is sporadically and cannot be utilized as the only fundamental load of energy *** paper proposes a wind-solar hybrid energy storage system(HeSS)to ensure a stable supply grid for a longer period.A multi-objective genetic algorithm(MOGA)and state of charge(SOC)region division for the batteries are introduced to solve the objective function and configuration of the system capacity,***/Simulink was used for simulation *** optimization results show that for a 0.5 MW wind power and 0.5 MW photovoltaic system,with a combination of a 300 Ah lithium battery,a 200 Ah lead-acid battery,and a water storage tank,the proposed strategy reduces the system construction cost by approximately 18,000 ***,the cycle count of the electrochemical energy storage systemincreases from4515 to 4660,while the depth of discharge decreases from 55.37%to 53.65%,achieving shallow charging and discharging,thereby extending battery life and reducing grid voltage fluctuations *** proposed strategy is a guide for stabilizing the grid connection of wind and solar power generation,capability allocation,and energy management of energy conservation systems.

关键词： electric-thermal hybrid storage modal decomposition multi-objective genetic algorithm capacity optimization allocation operation strategy