根据世界卫生组织(WHO)的数据,2015-2050年,全球60岁以上人口的比例将从12%增加近一倍至22%,这会给医疗和社会系统带来巨大的挑战。衰老与许多慢性疾病有关,例如痴呆、癌症、2型糖尿病和动脉粥样硬化(atherosclerosis)。事实上,返老还童或寻找“青春之泉”(fountain of youth)的想法可能在人类诞生之初就存在了。现在,我们开始对衰老的分子机制有了一定的了解,这不仅可以帮助我扪活得更久,还能帮助我们活得更健康。
PURPOSE: We describe a new technique that endoscopically eradicates rectal stump mucosa after total colectomy for ulcerative colitis. METHODS: Seven patients (5 males; median age, 56 (range, 36- 72) years) underwent a...
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PURPOSE: We describe a new technique that endoscopically eradicates rectal stump mucosa after total colectomy for ulcerative colitis. METHODS: Seven patients (5 males; median age, 56 (range, 36- 72) years) underwent attempted endoscopic transanal rectal mucosal ablation using the 28- French-gauge urologic resectoscope, either at the time of total colectomy and ileostomy for failed medical therapy (5 patients) or as an alternative to completion pro-ctectomy (2 patients) with rectal stump discharge. All had declined restorative proctocolectomy. Clinical, endoscopic, and histologic follow-up was undertaken during a mean of 15 (range, 3- 28) months. RESULTS: The operative technique evolved during these cases; mucosal ablation was successfully performed leaving a denuded muscular rectal tube in situ in six patients. Mean operative time was 45 minutes. Postoperative endoscopic surveillance has not demonstrated any viable rectal mucosa in these six patients, with only granulation tissue detected histologically. Narrowing of the rectal tube has occurred in two patients. Although all patients report insignificant rectal discharge, urinary and sexual function have remained unchanged. CONCLUSIONS: Diathermy ablation of the rectal mucosa via endoscopic transanal rectal mucosal ablation avoids the complications of pelvic dissection and might offer an effective alternative to proctectomy for ulcerative colitis.
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