检索结果-南通市图书馆

Randomized Trial of the Use of Dexmedetomidine vs. Propofol after Regional Blockade in Shoulder Surgery Patients in Beach Chair Position

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Anesthesiology 2015年第8期5卷 187-191页

作者： Piyush Gupta Ofer Wellisch Mark Kronenfeld Jack Choueka Kenneth D. Eichenbaum murali Pagala Peter Homel Dennis E. Feierman Department of Anesthesiology Maimonides Medical Center Brooklyn NY USA Department of Surgery Maimonides Medical Center Brooklyn NY USA Department of Biostatistics Maimonides Medical Center Brooklyn NY USA

Background: Propofol is often the drug of choice for ambulatory orthopedic cases. However, propofol can be associated with apnea or other events requiring airway interventions. Dexmedetomidine (Dex) has the unique pharmacologic profile of providing sedation without respiratory depression. This is particularly relevant in patients with morbid obesity and/or challenging airways. The hypotheses were: 1) Propofol would cause more apnea or require more airway manipulations than dexmedetomidine;2) Propofol would have shorter post anesthesia unit recovery times;and 3) Dexmedetomidine would be associated with more bradycardia and hypotension. Methods: After IRB approval, 50 patients were randomized to receive either propofol or Dex for Total Intravenous anesthesia (TIVA) after interscalene brachial plexus block was performed preoperatively under ultrasound guidance. The main end points that we measured where: airway interventions, intra-operative bradycardia, hypotension, and PACU length of stay. Results: There were more airway interventions in the propofol group compared to the Dex group. Additionally, the Dex group had significantly longer PACU stays. Conclusion: We would recommend that Dex should be preferentially considered for patients predisposed to airway obstruction;however, the standard use of Dex over Propofol needed to reconsider since the use of Dex as the agent for TIVA was associated with longer PACU stays.

关键词： Dexmedetomidine Propofol Beach Chair Regional Block

A Novel Non Radioactive PCR-DNA Probe for the Detection of Aflatoxin Producing <i>Aspergillus</i>Species from Major Food Crops Grown in India

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Advances in Microbiology 2012年第4期2卷 577-586页

作者： S. R. Priyanka M. Venkata Ramana K. Balakrishna H. S. murali H. V. Batra Division of Microbiology Defense Food Research Laboratory Siddarthanagar India

In the present study, a novel non radioactive digoxigenen labelled PCR-DNA probe was developed targeting nor-1 gene to assess the contamination of aflatoxigenic Aspergillus species in food grain samples from Southern parts of India. The sensitivity of developed PCR-DNA probe was determined to be 10 pg of genomic DNA and 1 pg of purified PCR product. The specificity of the DNA probe was validated by testing against an array of Aspergillus, Fusarium and Penicillium spp. A total of 89 Aspergillus isolates were recovered from 152 grain samples of maize, paddy, and groundnut. Among them, maize had the highest (90%) incidence of toxigenic Aspergillus species. When developed PCR-DNA probe was evaluated onto pure cultures of toxigenic and nontoxigenic Aspergillus species, 60 samples were positive for the nor-1 gene probe. DNA probe results unequivocally matched with the HPLC analysis. In conclusion, the novel PCR-DNA probe developed in this study may find its application in rapid detection of aflatoxin-producing Aspergillus isolates from contaminated cereal grains.

关键词： AFB1-Aflatoxin B1 HPLC-High Performance Liquid Chromatography NOR-1 Norsolorinic Acid Synthase PCR-Polymerase Chain Reaction

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

内存产品的金属化技术集成铜工艺

集成电路应用 2008年第7期25卷 26-29页

作者： Niranjan Kumar Kevin Moraes murali Narasimhan Prabu Gopalraja Applied Materials Inc. Santa ClaraCalif.

得益于双重大马士革结构的尺寸不断缩小、低介电常数绝缘材料的引入和铜互连可靠性的提升,逻辑产品的互连技术不断向前发展。随着内存产品由铝工艺转向铜工艺,包括间隙填充在内的多项工艺也面临着更多的挑战。

关键词：内存产品铜工艺技术集成金属化低介电常数大马士革绝缘材料互连技术

Fabrication of Curcumin Encapsulated Chitosan-PVA Silver Nanocomposite Films for Improved Antimicrobial Activity

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Journal of Biomaterials and Nanobiotechnology 2011年第1期2卷 55-64页

作者： K. Vimala murali Mohan Yallapu K. Varaprasad N. Narayana Reddy S. Ravindra N. Sudhakar Naidu K. Mohana Raju 不详

The present study explores the in situ fabrication of chitosan-poly(vinyl alcohol)-silver nanocomposite films in view of their increasing applications as antimicrobial packaging, wound dressing and antibacterial materials. The reduction of silver ions into silver nanoparticles (AgNPs) is achieved in acidic solution of chitosan (C) and poly (vinyl alcohol) (PVA) using their functional groups (-OH, -COOH, -NH2 groups). The presence of silver nanoparticles in the chito-san-PVA film is confirmed by UV-Vis spectroscopy, Fourier Transform Infrared (FTIR) spectroscopy and X-ray Dif-fraction (XRD) analysis. The Scanning Electron Microscopic (SEM) images illustrate the presence of embedded silver nanoparticles throughout the films. In addition, the formed silver nanoparticles have an average particle size of ~ 16.5 nm as observed by Transmission Electron Microscopy (TEM). The anti-microbial and anti-fungal activity of the chitosan-PVA silver nanoparticle films have demonstrated significant effects against Escherichia coli (E. coli), Pseudomonas, Staphylococcus, Micrococcus, Candida albicans, and Pseudomonas aeruginosa (P. aeruginosa). To improve further their therapeutic efficacy as anti-microbial agents, curcumin encapsulated chitosan-PVA silver nanocomposite films are developed which showed enormous growth inhibition of E. coli compared to curcumin and chitosan-PVA silver nanoparticles film alone. Therefore, the present study clearly provides novel antimicrobial films which are potentially useful in preventing/treating infections.

关键词： Silver Nanoparticles Chitosan Poly(Vinyl Alcohol) Curcumin Wound Dressing Hydrogel

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

铁-石墨混合粉末的直接选择性激光烧结

失效分析与预防 2004年第4期25卷 58-64页

作者： K.murali A.N.Chatterjee 潘琰峰沈以赴南京航空航天大学江苏南京210016

本文用脉冲Nd-YAG激光实现了铁-石墨混合粉末(ω分别为99.22%,0.78%)的激光烧结.对微观结构变化进行了观测,和对烧结材料的物理和机械性能进行了测定,结果表明这种激光烧结材料适用于一些专门的应用.

关键词：激光烧结快速成形铁粉

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

细菌碱性蛋白酶的脱毛机理研究

北京皮革（中外鞋讯）（下） 2012年第4期 83-90页

作者： S. Sivasubramanian B. murali Manohar R. Puvanakrishnan 刘兰（编译）不详四川大学制革清洁技术国家工程实验室四川成都610065

在皮革生产的常规脱毛工艺过程中，原料皮都将遭受到强烈的化学处理，而这一强烈的化学处理通常是由于使用了石灰和硫化钠所致。硫化物之所以能够起到脱毛的作用，是由于它能够破坏存在于毛发和表皮中的角蛋白上的双硫健，因此能够使得... 详细信息

在皮革生产的常规脱毛工艺过程中，原料皮都将遭受到强烈的化学处理，而这一强烈的化学处理通常是由于使用了石灰和硫化钠所致。硫化物之所以能够起到脱毛的作用，是由于它能够破坏存在于毛发和表皮中的角蛋白上的双硫健，因此能够使得毛和表皮从生皮上脱落下来。石灰作为一种碱性物质，由于能够清除蛋白聚糖中的大部分粘多糖、皮肤结缔组织间的纤维间质。因此能够起到松散皮纤维的目的。而作为一种町替代常规化学脱毛法的酶脱毛方法，由于其具有环保效益（酶脱毛方法避免了石灰和硫化物的使用），近年来得到了快速的发展。虽然使用石灰和硫化物的化学品脱毛处理与使用酶制剂的酶脱毛处理，其目的都是为了去除非胶原蛋白和蛋白聚糖，以达到松散胶原纤维的目的，然而，两种方法的机理却是截然不同的。任本项研究中，我们对具有保毛脱毛作用的细菌碱性蛋白酶的酶脱毛机理及作用进行了详细的研究，并将具与具有毁毛脱毛作用的化学脱毛法进行了对比。通过对生化成分的定量分析表明，按两种处理方法处理后的脱毛皮中的胶原蛋白含量相当，而酶脱毛皮中的蛋白聚糖含量相比石灰一硫化物脱毛皮中的蛋白聚糖含量有显著的减少。且这一实验结果也通过对脱毛皮的断面使用不同染色泫的组织化学观察和免疫组织化学染色法观察（可检验核心蛋白聚糖的去除情况），得到了进一步的验证。另外，高效液相色谱分析也表明，核心蛋白聚糖已差不多完全被细菌蛋白酶所分解。因此，在本项研究中，我们可以得出这样的结论：在酶脱毛工艺过程中，核心蛋白聚糖的蛋白降解及随之引起的蛋白聚糖的去除对于胶原纤维束的松散具有十分重要的作用。

关键词：皮革蛋白聚糖胶原蛋白核心蛋白聚糖组织学免疫组织化学

Aberrant post-translational protein modifications in the pathogenesis of alcohol-induced liver injury

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2016年第27期22卷 6192-6200页

作者： Natalia A Osna Wayne G Carter murali Ganesan Irina A Kirpich Craig J Mc Clain Dennis R Petersen Colin T Shearn Maria L Tomasi Kusum K Kharbanda Research Service Veterans Affairs Nebraska-Western Iowa Health Care System Omaha NE 68105 United States Department of Internal Medicine 982000 Nebraska Medical Center Omaha NE 68198 United States School of Medicine University of Nottingham Royal Derby Hospital Centre Derby DE22 3DT United Kingdom Division of Gastroenterology Hepatology and Nutrition Department of Medicine Department of Medicine and Pharmacology and Toxicology University of Louisville Louisville KY 40202 United States University of Colorado Denver School of Pharmacy Department of Pharmaceutical Sciences Aurora CO 80045 United States Division of Gastroenterology Department of Medicine Davis research building suite 2096/2035 Cedars-Sinai Medical Center Los Angeles CA 90048 United States Department of Biochemistry and Molecular Biology 985870 Nebraska Medical Center Omaha NE 68198 United States

It is likely that the majority of proteins will undergo post-translational modification, be it enzymatic or non-enzymatic. These modified protein(s) regulate activity, localization and interaction with other cellular molecules thereby maintaining cellular hemostasis. Alcohol exposure significantly alters several of these post-translational modifications leading to impairments of many essential physiological processes. Here, we present new insights into novel modifications following ethanol exposure and their role in the initiation and progression of liver injury. This critical review condenses the proceedings of a symposium at the European Society for the Biomedical Research on Alcoholism Meeting held September 12-15, 2015, in Valencia, Spain.

关键词： Alcohol Acetylation Liver Carbonylation methylation Dysfunction Methylation Glycosylation Phosphoryl

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

心脏外科手术后患儿的未测阴离子

世界核心医学期刊文摘(心脏病学分册) 2007年第6期 59-60页

作者： Murray D Grant D murali N Butt W 赵建峰 Melbourne Paediatric Intensive Care Unit Royal Children’ s Hospital Australia Dr.

目的:心脏外科手术后常常由于未测阴离子水平的升高而引起酸中毒,其意义尚未明确。验证未测阴离子和乳酸预测心脏外科手术后主要不良事件的能力,并测定在低心输出量状

关键词：心脏外科手术不良事件心脏手术阴离子患儿

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

多中心骨巨细胞瘤 30例临床病理分析

骨科动态 2007年第1期3卷 40-48页

作者： BENJAMIN HOCH CARRIE INWARDS murali SUNDARAM ANDREW E. ROSENBERG 胡永成（译） Investigation performed at the Mayo Clinic Rochester Minnesota and Massachusetts General Hospital Boston Massachusetts 天津医院骨肿瘤科 300211

背景：骨巨细胞瘤占原发性骨肿瘤的4％-5％，约1％表现为多发的同时（synchronous）或不同时（metachronous）发生的病变。本研究介绍30例多中心骨巨细胞瘤的临床病理特点。方法：病理确诊为具有2个或2个以上分开部位病灶的骨巨细胞瘤3... 详细信息

背景：骨巨细胞瘤占原发性骨肿瘤的4％-5％，约1％表现为多发的同时（synchronous）或不同时（metachronous）发生的病变。本研究介绍30例多中心骨巨细胞瘤的临床病理特点。方法：病理确诊为具有2个或2个以上分开部位病灶的骨巨细胞瘤30例，回顾分析影像学资料，了解肿瘤的特点及发病部位规律。再次行病理组织学观察，分析组织形态学特点。从病历记录中获得临床和随访资料。结果：男、女比例为1：2，确诊时平均年龄为21岁。59％的患者年龄小于20岁。本研究共有94处肿瘤，每例患者平均有3处肿瘤（范围，2-9处）。大部分肿瘤发生于长骨。6例患者为同时发生的病变累及同侧肢体的股骨远端和胫骨近端。在影像学上，长骨上肿瘤表现为膨胀性溶骨病灶，位于干骺端并向骨骺方向扩展。少部分肿瘤局限在干骺端，表现为纤维骨性或成骨性病变，或者发生在未成年患者较多。次要的病理组织改变包括，纤维组织细胞区反应性骨形成以及动脉瘤样骨囊肿样改变。大部分肿瘤采取刮除术（64％）或切除术（22％）。其复发率与单发骨巨细胞瘤相似。3例发生转移，2例发生恶变。结论：与单发骨巨细胞瘤相比，多中心骨巨细胞瘤更易发生于年轻人，常表现为膝关节周围呈同时发生的病变。由于纤维组织细胞区和反应性骨形成的存在，因此在影像学一些肿瘤表现为成骨性或纤维骨性肿瘤。肿瘤的复发率主要取决于采取的术式。可信水平：治疗性研究，Ⅳ级。进一步可信度参见作者介绍。

关键词：临床病理特点骨巨细胞瘤病理分析多中心原发性骨肿瘤纤维组织细胞病理组织学观察影像学资料