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Clinical Insights:Prevalence of β-Thalassemia Mutations(IVSI-5,FSC8/9,and CD41/42)in the Swat District

Journal of Bio-X Research 2024年第1期7卷 1-7页

作者： Sumaia Saif Shah Lila Gulalai Ghani murad ali rahat Akhtar Rasool Muhammad Israr Department of Forensic Sciences University of SwatKhyber PakhtunkhwaPakistan Centre for Animal Sciences and Fisheries University of SwatKhyber PakhtunkhwaPakistan

Background:Thalassemia is a prevalent condition characterized by decreased production or absence of hemoglobin globin *** are 2 types of thalassemia,alpha thalassemia and beta thalassemia(β-thalassemia),classified according to defects in the alpha or beta protein chain.β-Thalassemia results from a diverse range of mutations in theβsubunit of the hemoglobin gene(HBB).This results in severe reductions in erythrocyte and hemoglobin ***,more than 40,000 babies are born withβ-thalassemia *** are approximately 80 millionβ-thalassemia *** Pakistan,the annual birth rate ofβ-thalassemia major carriers is approximately 6,000,and 50,000 to 100,000 patients suffer from this common inherited ***-1,IVSI-5(G>C),Fr 8/9(+G),Fr 41/42(-TTCT),and del 619 are the 5 most common mutations that account for 90%ofβ-thalassemia cases in *** study aimed to investigate the prevalence ofβ-thalassemia mutations(IVSI-5,Fr 41/42,and Fr 8/9)in the Swat district and to analyze the blood morphology of different mutant thalassemia blood ***:A cross-sectional study was performed at the Forensic Research Lab University of Swat from December 2021 to March *** study included a total of 150 blood *** analysis of blood morphology through microscopy was carried out on samples from patients with differentβ-thalassemia mutations and normal *** DNA extraction was performed according to the Sambrook protocol,and DNA was quantified via agarose gel *** mutations were detected by amplification refractory mutation system(ARMS)-polymerase chain reaction(PCR).The frequencies of differentβ-thalassemia mutations were ***:Thalassemia blood cells were more hypochromic and microcytic than normal blood cells,although no differences were detected in the morphology of IVSI-5,Fr 8/9,or CD41/42 mutant blood *** IVSI-5,Fr 8/9,and CD41/42 mutations were analyzed through agarose ge

关键词： Thalassemia annually Pakistan

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Cloud authorization： exploring techniques and approach towards effective access control framework

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Frontiers of Computer Science 2015年第2期9卷 297-321页

作者： rahat MASOOD Muhammad Awais SHIBLI Yumna GHAZI Ayesha KANWAL Arshad ali School of Electrical Engineering and Computer Science (SEECS) National University of Sciences and Technology (NUST) Islamabad - 44000 Pakistan

Despite the various attractive features that Cloud has to offer, the rate of Cloud migration is rather slow, pri- marily due to the serious security and privacy issues that exist in the paradigm. One of the main problems in this regard is that of authorization in the Cloud environment, which is the focus of our research. In this paper, we present a systematic analysis of the existing authorization solutions in Cloud and evaluate their effectiveness against well-established industrial standards that conform to the unique access control require- ments in the domain. Our analysis can benefit organizations by helping them decide the best authorization technique for deployment in Cloud; a case study along with simulation re- sults is also presented to illustrate the procedure of using our qualitative analysis for the selection of an appropriate tech- nique, as per Cloud consumer requirements. From the results of this evaluation, we derive the general shortcomings of the extant access control techniques that are keeping them from providing successful authorization and, therefore, widely adopted by the Cloud community. To that end, we enumer- ate the features an ideal access control mechanisms for the Cloud should have, and combine them to suggest the ultimate solution to this major security challenge - access control as a service （ACaaS） for the software as a service （SaaS） layer. We conclude that a meticulous research is needed to incorpo- rate the identified authorization features into a generic ACaaS framework that should be adequate for providing high level of extensibility and security by integrating multiple accesscontrol models.

关键词： authorization access control software as a ser-vice extensible access control markup language identity &access management cloud security

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Pharmacotherapeutics and molecular docking studies of alphasynuclein modulators as promising therapeutics for Parkinson’s disease

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BIOCELL 2022年第12期46卷 2681-2694页

作者： rahat ali AFTAB ALAM SATYENDRA K.RAJPUT RAZI AHMAD Department of Medical Elementology and Toxicology Jamia HamdardNew Delhi110062India Centre for Interdisciplinary Research in Basic Sciences Jamia Millia IslamiaNew Delhi110025India Department of Pharmaceutical Sciences Gurukul Kangri UniversityUttarakhand249404India Department of Pharmacology HIMSR Jamia HamdardNew Delhi110062India

Parkinson’s disease(PD)is an age-related neurodegenerative ailment that affects dopamine-producing neurons in a specific area of the brain called the substantia nigra of the ventral *** is clinically characterized by movement disorder and marked with unusual synaptic protein alpha-synuclein accumulation in the *** date,only a few Food and Drug Administration(FDA)approved drugs are available on the market for the treatment of ***,these drugs show parasympathomimetic related adverse events and remarkably higher toxicity;hence,it is important to find more efficacious molecules to treat *** our study,We chosen 22 natural compounds as inhibitors that potentially block the alpha-synuclein clump-the pathological hallmark of PD-and provide new avenues for its *** of these molecules exhibited good pharmacokinetic behaviors,making them decisively favorable drug candidates to cure *** docking studies were performed to investigate the binding interactions between natural compounds and alpha-synuclein as anti-Parkinson drug *** the examined compounds,curcumin and piperine emerged as promising phytochemicals with the highest binding affinity,key residual stable bindings and showed a good inhibitory ***,the present study indicates that curcumin and piperine hold the potential to be developed as treatment options against *** validations are needed for insights into their mechanism of action and potential clinical application.

关键词： Parkinson’s disease(PD) Alpha-synuclein Molecular docking and dynamics Anti-Parkinson drug Curcumin Piperine

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X-Band Power Amplifier for Next Generation Networks Based on MESFET

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China Communications 2017年第4期14卷 11-19页

作者： Muhammad Saad Khan Hongxin Zhang Fan Zhang Sulman Shahzad rahat Ullah Sajid ali Qasim ali Arain Manzoor Ahmed School of Electronic Engineering Beijing University of Posts and Telecommunications (BUPT) Beijing 100876 China Beijing Key Laboratory of Work Safety Intelligent Monitoring Beijing University of Posts and Telecommunications Beijing 100876 china College of Information Science and Electrical Engineering Zhejiang University Hangzhou Zhejiang 310027china Electrical Engineering Department University College of Engineering & Technology Bahauddin Zakariya University Multan Pakistan State Key Laboratory of Information Photonics and Optical Communications Beijing University of Posts and Telecommunications Beijing 100876 China Department of Coxnputer Science D.G. Khan Campus. University of Education Lahore Pakistan Future lnternet & Communication Lab (FIB) Department of Electronic Engineering Tsinghua University Beijing 100084 China

Advanced wireless standards of communication like 3GPP and LTE are becoming more and more efficient and with this evolution of communication systems mobile equipment is also become smaller and smaller. Power amplifier designing has become a very crucial task in this era where efficiency and size are the main concern of any designer. In this paper we have design and analyzed X-band Class E Metal-semiconductor field effect transistor(MESFET) based Power Amplifier. This device targets the devices which use OFDM technique to improve their spectral efficiency for the next generation communication systems. Microstrip lines are used to achieve small size for our design instead of lumped components. Load Pull measurements are used to get MESFET input and output impedances optimum values. For linear and non linear operation small signal mathematical model of the design is used. To reduce thermal losses FR4 substrate is used to increase PA efficiency. Our designs shows small values of input and output return loss of about-22.3d B and-23.716 d B achieving a high gain of about25.6 d B respectively, with PAE of about 30 % having stability factor greater than 1 and 21.894 d Bm of output power.

关键词： MESFET X-band power amplifier advance design system PAE LTE

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In vivo immunomodulatory profile of histamine receptors(H1,H2,H3 and H4):a comparative antagonists study

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Asian Pacific Journal of Tropical Medicine 2010年第6期3卷 465-470页

作者： Trivendra Tripathi Mohammad Shahid Haris M Khan Aijaz Ahmed Khan Mashiatullah Siddiqui rahat ali Khan Department of Biochemistry Faculty of MedicineJawaharlal Nehru Medical College & HospitalAligarh Muslim UniversityAligarh-202002U.P.India Department of Microbiology Faculty of MedicineJawaharlal Nehru Medical College & HospitalAligarh Muslim UniversityAligarh-202002U.P.India Department of Anatomy Faculty of MedicineJawaharlal Nehru Medical College & HospitalAligarh Muslim UniversityAligarh-202002U.P.India Department of Pharmacology Faculty of MedicineJawaharlal Nehru Medical College & HospitalAligarh Muslim UniversityAligarh-202002U.P.India

Objective:To delineate the comparative immunomodulatory roles of H1R-H4R in antibody generation profile in rabbit ***:The cohort comprised of eight groups containing 18(9 male and 9 female) rabbits in each ***Ⅰremained non-immunized and received only vehicle(sterile distilled water,1 mL/kg×b.i.d.) ***Ⅱreceived vehicle (1 mL/kg×b.i.d.) while GroupsⅢ-Ⅶ(drugs-treated) received subcutaneous histamine (100μg/kg×b.i.d.),and intramuscular H1R-antagonist(pheniramine,10 mg/kg×b.i.d.), H2R-antagonist(ranitidine,10 mg/kg×b.i.d.),H3R-antagonist(iodophenpropit,1μg/kg×b.i.d.) and H4R-antagonist(JNJ 7777120,10μg/kg×b.i.d.),and GroupⅧDMSO(1 mL/kg×b.i.d.),respectively for 10 days(starting from day 1).They were subsequendy immunized with intravenous injection of sheep red blood cells(SRBC) at day *** estimation of serum Igs,IgM and IgG were done by ELISA,and observed at day 0(pre-immunization),and 7,14,21,28 and 58(post-immunization).Results:It was shown that histamine and HRs-antagonists could influence a detectable antibody response to SRBC as early as day 7-post-immunization(post-Ⅰ), which lasted until day 58 post-Ⅰ.The results were found statistically significant(P<0.05,). Conclusions:This study suggests that histamine receptors play important roles in modulation of antibody generation in which H1R,H2R and H4R have immunosuppressive roles and conversely, H3R playes an immune enhancing *** findings of this study may have clinical significance and provide the baseline information for future study.

关键词： Histamine receptors Immunomodulation Humoral immune response H3R-antagonist H4R-antagonist

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Cost Effective Scheme for OLT in Next Generation Passive Optical Access Network Based on Noise Free Optical Multi Carrier

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China Communications 2016年第6期13卷 76-87页

作者： rahat Ullah Bo Liu Qi Zhang Qinghua Tian Amjad ali Yousaf Khan Feng Tian M.Azam Zia Haseeb Ahmad Lijia Zhang Xiangjun Xin State Key Laboratory of Information Photonics and Optical Communications.Beijing University of Posts and Telecommunications No.10 Xitucheng RoadBeijingChina100876 School of Electronic Engineering Beijing University of Posts and TelecommunicationsNo.10 Xitucheng RoadBeijingChina100876 Sarhad University of Science and Information technology PeshawarPakistan. Electrical Engineering Department Iqra University PeshawarPakistan. State Key laboratory of Network and Switching Technology Beijing University of Posts and TelecommunicationsNo.10 Xitucheng RoadBeijing100876China

We propos e a cos t-effective multi-carrier generation technique which minimizes the passive optical access network(PON) costs. In this study replacement of laser array with multi-carrier source at optical line terminal(OLT) side in PON is addressed. With 25-GHz frequency spacing, the generated optical multi-carriers exhibit good tone to noise ratio(TNR) i. e. above 20 d B, and least amplitude difference i. e. 1.5d B. At the OLT, multi-carriers signal based multiplexed differential phase shift keying(DPSK) data from all the channels each having 10 Gbps for downlink is transmitted through 25 km single mode fiber. While the transmitted information is retrieved at optical network unit(ONU), part of the downlink signal is re-modulated using intensity modulated(IM) on-off keying(OOK) for upstream transmission at 10-Gbps. Simulation results are in good agreement with the theoretical analysis, showing error free transmission in downlink and uplink with 10 Gbps symmetric data rate at each channel. The receivedpower, both for uplink and downlink transmission, is adequate for all channels at BER of 10-9 with minimum power penalties. Power budget is calculated for different splitting ratios showing excellent system margins for any unseen losses. The proposed setup provides a cost-effective way minimizing transmission losses, and providing greater system's margin in PON architecture.

关键词： differential phase shift keying intensity modulated on-off-keying optical frequency comb generation optical access network

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Colorless WDM-PON Using Single Side Band Carrier Suppressed Signals Mitigating Carrier Rayleigh Backscattering

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China Communications 2016年第12期13卷 150-161页

作者： rahat Ullah Bo Liu Qi Zhang Yousaf Khan Amjad ali Qinghua Tian Feng Tian M.Saad Khan Tabinda Salam Sibghat Ullah Lijia Zhang Xiangjun Xin State Key Laboratory of Information Photonics and Optical Communications Beijing University of Posts and TelecommunicationsNo.10 Xitucheng Road Beijing China 100876 School of Electronic Engineering Beijing University of Posts and Telecommunications No. 10 Xitucheng Road Beijing China 100876 Electrical Engineering Department Iqra University Peshawar Pakistan. Sarhad University Peshawar Pakistan 25000 School of Information and Communication Beijing University of Posts and TelecommunicationsNo. 10 Xitucheng Road Beijing China 100876

A new scheme is offered for minimizing carrier Rayleigh backscattering(CRB) in single feeder fiber based wavelength division multiplexed passive optical network(WDM-PON). The proposed scheme is based on single side band carrier suppressed(SSBCS) signal, both at network and receiver sides, used for the first time at optical line terminal(OLT) and optical network unit(ONU) sides. We use dual-drive Mach-zehnder modulator(DD-MZM) for generating SSB-CS signals, which decreases the expense per bit in full transmission. SSB-CS mitigates CRB, both at OLT and ONU sides, because of having no chance of reflections from the carrier. Since no extra dedicated RF or laser source is used at ONU side, we thus achieve cost effective colorless WDM-PON system. Suppressed signals from four channels, each of 10 Gbps, are multiplexed before injecting into the fiber span of 25 km at OLT. At ONU side, half of the downlink power is used for re-modulating the data signal. The simulation results show an errorfree transmission. Moreover, the detailed power budget calculations show that the proposed scheme can be sought out for splitting ratio up to 128. Hence it offers enough system's margin for unseen losses.

关键词： Carrier Rayleigh backscattering dual drive Mach-zehnder modulator single side band suppress carrier on-off keying

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Identification of potential inhibitors for Sterol C-24 reductase of Leishmania donovani through virtual screening of natural compounds

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BIOCELL 2021年第6期45卷 1601-1610页

作者： FAZLUR RAHMAN SHAMS TABREZ rahat ali SAJJADUL KADIR AKAND MOHAMMED AALAIDAROUS MOHAMMED ALSAWEED BADER MOHAMMED ALSHEHRI SAEED BANAWAS ABDUR RUB ABDUL AZIZ BIN DUKHYIL Infection and Immunity Laboratory(414) Department of BiotechnologyJamia Millia Islamia-A Central UniversityNew Delhi110025India Department of Medical Laboratory Sciences College of Applied Medical SciencesMajmaah UniversityAl Majmaah11952Saudi Arabia Health and Basic Sciences Research Center Majmaah UniversityAl Majmaah11952Saudi Arabia

Leishmaniasis is a vector-borne parasitic neglected tropical disease caused by a group of about 30 different species of the genus *** is transmitted by the bite of female phlebotomies sand *** main clinical manifestations of leishmaniasis include cutaneous,visceral,and mucocutaneous *** leishmaniasis(VL)caused by Leishmania donovani,is an infection of reticuloendothelial system and fatal if ***,a sterol that is prominent in the mammalian cell membranes whereas stigmasterol and ergosterol are more prevalent in plants,yeast,and protozoa,*** which is absent in human being,is an important constituent of parasite *** C-24 reductase(LdSR)enzyme catalyzes the final step in the ergosterol biosynthesis *** inhibition of biosynthesis of ergosterol may lead to decreased cell viability and ***,we performed the molecular docking-based virtual screening of a library of natural ligands against LdSR to identify a potential inhibitor to fight ***,prenyletin,flavan-3-ol,resveratrol,and gingerol showed the top binding affinity towards *** upon ADME properties and bioactivity score,gingerol showed the best lead-likeness and drug-likeness ***,we further annotated its leishmanicidal *** found that gingerol inhibited the growth and proliferation of promastigotes as well as intra-macrophagic *** exerted its antileishmanial action through the induction of reactive oxygen species(ROS)in concentration-dependent *** induced ROS led to ***,this study described that gingerol would act as possible inhibitor to LdSR.

关键词： Leishmania Gingerol Sterol C-24 reductase Molecular docking ROS

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Evaluation of the Genotoxicity of Chlorpyrifos in Common Indus Valley Toad, <i>Bufo stomaticus</i>Using Alkaline Single-Cell Gel Electrophoresis (Comet) Assay

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Agricultural Sciences 2014年第4期5卷 376-382页

作者： Muhammad Ismail Qaiser Mahmood Khan rahat ali Tayyaba ali Ameena Mobeen Department of Zoology Wildlife and Fisheries Government College University Faisalabad Faisalabad Pakistan Environmental Toxicology Laboratory National Institute for Biotechnology and Genetic Engineering (NIBGE) Faisalabad Pakistan

Chlorpyrifos is a commonly used pesticide of organophosphate group, which causes toxicological effects in non-target organisms especially fish and frogs. In the present study, the genotoxicity of sublethal concentrations of chlorpyrifos was observed in the erythrocytes of common Indus valley toad, Bufo stomaticus, using the Alkaline Single-Cell Gel Electrophoresis (Comet) assay. In the first step, acute toxicity of chlorpyrifos was evaluated by exposing the tadpoles to high concentrations of the pesticide. The acute LC50 value of chlorpyrifos, calculated by Trimmed Spearman-Karber (TSK) in static bioassay, was found to be 930.0 μg/L. On the basis of acute LC50 value, the tadpoles were exposed to three sublethal concentrations (155, 233 and 465 μg/L) of chlorpyrifos for 96 h. Blood cells were collected at every 24 h interval and were subjected to the Alkaline Single-Cell Gel Electrophoresis assay. The observed DNA damage was concentration and time-dependent, and those levels of DNA damage in between the tested concentrations and times were significantly different (p alities. It was concluded that chlorpyrifos is a genotoxic pesticide causing DNA damage in Bufo stomaticus.

关键词： Pesticide Chlorpyrifos Tadpoles DNA Damage Comet Assay

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Hybrid Prediction Method for Solar Power Using Different Computational Intelligence Algorithms

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Smart Grid and Renewable Energy 2013年第1期4卷 76-87页

作者： Md rahat Hossain Amanullah Maung Than Oo A. B. M. Shawkat ali Power Engineering Research Group (PERG) Central Queensland University Rockhampton Australia.

Computational Intelligence (CI) holds the key to the development of smart grid to overcome the challenges of planning and optimization through accurate prediction of Renewable Energy Sources (RES). This paper presents an architectural framework for the construction of hybrid intelligent predictor for solar power. This research investigates the applicability of heterogeneous regression algorithms for 6 hour ahead solar power availability forecasting using historical data from Rockhampton, Australia. Real life solar radiation data is collected across six years with hourly resolution from 2005 to 2010. We observe that the hybrid prediction method is suitable for a reliable smart grid energy management. Prediction reliability of the proposed hybrid prediction method is carried out in terms of prediction error performance based on statistical and graphical methods. The experimental results show that the proposed hybrid method achieved acceptable prediction accuracy. This potential hybrid model is applicable as a local predictor for any proposed hybrid method in real life application for 6 hours in advance prediction to ensure constant solar power supply in the smart grid operation.

关键词： Computational Intelligence Heterogeneous Regressions Algorithms Performance Evaluation Hybrid Method Mean Absolute Scaled Error (MASE)

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