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Capecitabine and irinotecan with and without bevacizumab for advanced colorectal cancer patients

World Journal of Gastroenterology 2009年第4期15卷 449-456页

作者： Markus Moehler Martin F Sprinzl murad abdelfattah Carl C Schimanski Bernd Adami Werner Godderz Klaus Majer Dimitri Flieger Andreas Teufel Juergen Siebler Thomas Hoehler Peter R Galle Stephan Kanzler 1st Medical Department Johannes Gutenberg-University Outpatient Clinic Outpatient Clinic of City Hospital Outpatient Clinic of 1st Medical Department Outpatient Clinic of 2nd Medical Department Leopoldina Krankenhaus

AIM:To investigate the efficacy and safety of capecitabine plus irinotecan±bevacizumab in advanced or metastatic colorectal cancer patients. METHODS:Forty six patients with previously untreated,locally-advanced or metastatic colorectal cancer(mCRC) were recruited between 2001-2006 in a prospective open-label phaseⅡtrial,in German community-based outpatient *** received a standard capecitabine plus irinotecan(CAPIRI) or CAPIRI plus bevacizumab(CAPIRI-BEV) regimen every 3 wk. Dose reductions were mandatory from the first cycle in cases of>grade 2 *** treatment choice of bevacizumab was at the discretion of the *** endpoints were response and toxicity and secondary endpoints included progression-free survival and overall survival. RESULTS:In the CAPIRI group vs the CAPRI-Bev group there were more female than male patients(47% vs 24%) ,and more patients had colon as the primary tumor site(58.8%vs 48.2%) with fewer patients having sigmoid colon as primary tumor site(5.9%vs 20.7%) .Grade 3/4 toxicity was higher with CAPIRI than CAPIRI-Bev:82%vs 58.6%.Partial response rates were 29.4%and 34.5%,and tumor control rates were 70.6%and 75.9%,*** complete responses were *** median progression-free survival was 11.4 mo and 12.8 mo for CAPIRI and CAPIRI-Bev,*** median overall survival for CAPIRI was 15 mo(458 d) and for CAPIRI-Bev 24 mo(733 d) .These differences were not statistically *** the CAPIRI-Bev,group,two patients underwent a full secondary tumor resection after treatment,whereas in the CAPIRI group no cases underwent this procedure. CONCLUSION:Both regimens were well tolerated and offered effective tumor growth control in this outpatient *** gastrointestinal toxicities and thromboembolic events were rare and if observed were never fatal.

关键词： First-line therapy Metastatic colorectalcancer Bevacizumab Capecitabine Irinotecan Tumorresponse

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Palaeoenvironmental Reconstruction of the Early to Middle Miocene Sequence in West Central Sinai, Egypt, as Revealed from Fossil Diatoms

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Acta Geologica Sinica(English Edition) 2018年第1期92卷 354-366页

作者： abdelfattah A. ZALAT Department of Geology Faculty of Science Tanta University Tanta 31527 Egypt

A detailed analysis of the diatoms from the sedimentary sequence exposed in Abu Qada basin, west central Sinai, was used to determine the palaeoenvironmental changes during the Lower to Middle Miocene. A total of 85 diatom species and varieties belonging to 37 genera were identified from 154 samples collected throughout the stratigraphic succession. The lithological characters of the studied samples varied between sandstone, silty interbeds, sandy shales, shales, and terminated with anhydrite and limestones. These rock units are included in two lithostratigraphic formations （Rudies and Kareem）, which are separated by a marked unconformity. The distribution and preservation of fossil diatoms in the sedimentary record are examined with the aim of outlining the temporal and spatial variation in the composition of the diatom assemblages, in order to estimate the changes in depositional environments during the Lower to Middle Miocene. The distributional pattern of the recorded diatom taxa distinguished four diatom eco-zones. The environment of each eco-zone is deduced and a proposed paleobathymetric change and depositional history of the Miocene sediments in the studied area are given.

关键词： palaeoenvironment Miocene sequence diatoms west central Sinai Egypt

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Geophysical appraisal of the Abu Madi gas reservoir,Nile Delta Basin,Egypt:Implications for the tectonic effect on the lateral distribution of petrophysical parameters

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Petroleum Research 2022年第4期7卷 511-520页

作者： Mohammad abdelfattah Sarhan Geology Department Faculty of ScienceDamietta UniversityNew Damietta City34517Egypt

The tectonic deformation has a significant influence on the hydrocarbon reservoirs *** effect of this process focuses on the lateral distribution of the petrophysical parameters characterizing the hydrocarbon *** main objective of the current study is to perform a petrophysical examination of the Abu Madi gas reservoir which is the greatest gas-bearing reservoir at Nile Delta Basin in order to examine how far the Messinian tectonics affected the lateral variations of these petrophysical *** petrophysical evaluation was performed based on the wireline log data acquired for five wells,namely,Abu Madi-2,Abu Madi-7,El Qara-3,Nidoco-7,and Nidoco-9 drilled within the Abu Madi *** petrophysical assessment for the most promising zone intervals within the Abu Madi sandstones in the inspected wells show that the total porosity varies between 17%and 22%,the effective porosity ranges from 7%to 19%,the shale volume fluctuates between 16%and 30%,hydrocarbon satu-ration varies from 37%to 76%,and the bulk volume of water varies between 0.02 and *** significant variations in the petrophysical properties of the Abu Madi reservoir are attributed to the tectonic influence during the deposition of the Abu Madi Formation as a part of the Late Miocene synrift megasequence in the Nile Delta *** conclusion confirms that the petrophysical properties of sandstone reservoirs are function of tectonic and structural deformation.

关键词： Abu madi formation Messinian reservoir Nile delta basin Petrophysical parameters Well logging

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New prospective gas plays in pliocene sands, offshore Nile Delta Basin: A case study from Kamose-1 well at North Sinai Concession, Egypt

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Petroleum Research 2022年第3期7卷 329-340页

作者： Mohammad abdelfattah Sarhan Geology Department Facultyof ScienceDamietta UniversityNew Damietta City34517Egypt Center of Space Research and Applications(CSRA) Damietta UniversityNew Damietta CityEgypt

The Pliocene sands in the offshore parts of the Nile Delta Basin represent significant gas *** targets have been recently discovered in different places along the offshore Nile Delta *** present work focuses on the possibility of discovering new natural gas resources at North Sinai Concession through an integrated method between seismic and well logs data interpretations.A case study from Kamose-1 Well at Kamose Field,North Sinai Concession has been *** quantitative explanation for the well log data of Kamose-1 Well has revealed two zones expected to be gas-bearing *** intervals are located between depths;1174–1186 m(zone I)and between 1429 and 1503 m(zone II).The calculated petrophysical parameters for these zones exhibit low water saturation(24–43%),high effective porosity(30–31%),low shale volume(21–26%),high total porosity(37–38%)and low bulk volume of water(0.07–0.12).Zone II(74 m thick)shows a clear bright spot on the seismic profiles covering the study area,while,zone I is beyond seismic resolution(12 m thick).Several seismic bright spots have been outlined on the seismic data nearby Kamose-1 *** comparison between the newly outlined seismic bright spots with the drilled one in Kamose-1 Well exhibited a great ***,these prospects are expected to be new targets for gas exploration in the Pliocene succession at North Sinai Concession.

关键词： Petrophysical evaluation Pliocene sands Seismic bright spot Kamose field Nile delta basin

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Adaptive Control System for Biogas Power Plant Using Model Predictive Control

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Journal of Modern Power Systems and Clean Energy 2021年第5期9卷 1193-1204页

作者： Samaa Fawzy Mohammed Saeed abdelfattah Eladl Magdi El-Saadawi Electrical Engineering Department Mansoura UniversityMansouraEgypt

This paper presents an adaptive control system using model predictive control for a biogas-fueled power *** control scheme is derived from an anaerobic digestion model that includes the concentration of biodegradable volatile solid in the reactor,the concentration of volatile solid in influent,the concentration of acidogens,and the concentration of *** these concentrations are the state variables of model predictive *** whole biogas-fueled power system has been modeled,implemented,and tested in MATLAB/Simulink *** validate the performance of the proposed controller,different operation conditions are studied and *** simulation results prove the effectiveness and the applicability of the proposed control system under different operating conditions.

关键词： Anaerobic digestion micro-turbine model predictive control state space biogas

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Study of the prevalence and association of ocular chlamydial conjunctivitis in women with genital infection by Chlamydia trachomatis, Mycoplasma genitalium and Candida albicans attending outpatient clinic

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International Journal of Ophthalmology(English edition) 2016年第8期9卷 1176-1186页

作者： Rania Abdelmonem Khattab Maha Mohssen abdelfattah Microbiology and Immunology Department Faculty of Pharmacy Cairo University Microbiology and Immunology Department Research Institute of Ophthalmology

AIMTo determine the association between chlamydial conjunctivitis and genital infection by Chlamydia trachomatis, Mycoplasma genitalium and Candida albicans, in addition to the possible relationship between cultured bacterial pathogens and oculogenital chlamydial *** study was performed on 100 (50 symptomatic and 50 asymptomatic) women attending the Gynecological and Obstetric outpatient clinic of Alzahra hospital, Alazhar University. Simultaneously a conjunctival swab was taken from these patients. Polymerase chain reaction (PCR) was done on DNA extracted from both vaginal and conjunctival swab samples. Culture for both vaginal and conjunctival swabs was also *** albicans was the predominant organism isolated by culture in 20% and 40% of conjunctival and vaginal swabs respectively. By the PCR method, ocular Chlamydia trachomatis was present in 60% of symptomatic women, while genital Chlamydia trachomatis infection was present in 30% of symptomatic women. The results of this method also indicated that 25/50 (50%) vaginal swabs were positive with PCR for Candida albicans versus 15/50 (30%) were PCR positive in conjunctival swab. Mycoplasma genitalium was present in only 10% of vaginal swabs. Concomitant oculogenital PCR positive results for Chlamydia trachomatis and Candida albicans were 30% and 28% *** Chlamydia trachomatis was associated with genital Chlamydia trachomatis in a high percentage of women followed by Candida albicans. Cultured bacterial organisms do not play a role in enhancement of Chlamydia trachomatis infection.

关键词： Chlamydia trachomatis Mycoplasma genitalium Candida albicans vaginal swabs polymerase chain reaction

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Galectins dysregulation: A way for cancer cells to invade and pervade

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Oncology Research 2022年第3期30卷 129-135页

作者： MAHMOUD M.abdelfattah REHAM HELWA Molecular Cancer Biology Group Zoology DepartmentFaculty of ScienceAin Shams UniversityCairoEgypt Faculty of Basic Science King Salman International UniversitySouth SinaiEgypt

Galectins are sticky molecules that bind toβ-*** interactions render them essential players in many cellular *** imbalance of galectin expression was reported in many *** cancer,galectins interact with the extracellular matrix,evade the immune system,and potentially have broad interactions with blood *** the last ten years,since 2010,we did focus on galectin research in different cancer ***ﬁndings showed an interaction between cancer cells and erythrocytes via ***,we found that upregulation of galectins was associated with lymph node metastasis in ovarian ***,with this,we shortly review some important aspects of galectins and their potential importance in more profound understanding of cancer progression and theﬁeld of cancer biomarkers.

关键词： Galectins Cancer Metastasis Erythrocytes Invasion

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3D static reservoir modelling of Abu Madi paleo-valley in Baltim Field,Offshore Nile Delta Basin,Egypt

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Petroleum Research 2022年第4期7卷 473-485页

作者： Mohammad abdelfattah Sarhan Tamer Hassan Ahmed Saied Ali Geology Department Faculty of ScienceDamietta University34517Egypt Qarun Petroleum Company(Apache J.V) New MaadiCairo11742Egypt

The 3D static reservoir modelling provides a good understanding for the hydrocarbon reservoir distri-bution and *** study aimed to construct a static model to study the gas-reservoir potentiality of the Messinian Abu Madi Formation in Baltim Field,offshore Nile Delta *** model was constructed based on the interpretation of the thirty-seven 2D seismic sections besides the analysis of well logs data for five drilled wells(Baltim East-2,Baltim East-3,Baltim East-5,Baltim North-1 and Baltim North-2).The seismic interpretation exposed that the Abu Madi incised valley in Baltim Field is oriented NNW-SSE with width ranges from 5 to 8 km and approximately 32 km in *** reservoir modelling revealed a relatively homogeneous reservoir facies qualities for gas production in two different zones within the Abu Madi *** trapping mechanism for these intervals is represented by pinching out in the two sides of the Abu Madi paleo-valley and bounded by two faults in the northern and southern parts of the study area.

关键词： Abu madi reservoir Baltim field Nile Delta Basin Seismic interpretation Static model Well logging

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Physical properties of three short period close binaries:KIC 2715417,KIC 6050116 and KIC 6287172

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Research in Astronomy and Astrophysics 2019年第2期19卷 111-124页

作者： Mahmoud abdelfattah NegmEldin Ahmed Essam Elsayed Shahinaz Mostafa Yousef Astronomy Space Science and Meteorology Department Faculty of Science Cairo University Department of Astronomy National Research Institute of Astronomy and Geophysics(Egypt)

We present the physical parameters of three short period close binaries using data observed from the Kepler Space Telescope. All of these observations were taken in a single bandpass(which approximates the Johnson V-band). Our three systems are KIC 2715417, KIC 6050116 and KIC 6287172. The first system, KIC 2715417, is considered a semi-detached system with the secondary component filling its Roche lobe. The second system, KIC 6050116, is an overcontact system, while the third system, KIC 6287172, belongs to ellipsoidal variables as deduced from the Roche lobe geometry. For photometric analysis, we used the PHOEBE software package, which is based on the Wilson-Devinney code. Due to lack of spectroscopic data, the photometric mass ratios are determined from the analyses of light curves using the q-search method. The absolute parameters are determined using three different methods(Harmanec, Maceroni &Van'tVeer and Gazeas & Niarchos).

关键词： stars:binaries:eclipsing stars:fundamental parameters stars:luminosity function,mass function stars:individual(KIC 2715417,KIC 6050116 and KIC 6287172)

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Direct-fed microbial: Animal nutrition and reproduction responses

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Journal of Integrative Agriculture 2015年第3期14卷 494-496页

作者： abdelfattah Z M Salem Nicolas Di Lorenzo Member of JIA Editorial Board Faculty of Veterinary Medicine and Animal Science Autonomous University of the State of Mexico North Florida Research and Education Center University of Florida Marianna Guest Editor Dr.

Manipulating the gastrointestinal microbial ecosystem to enhance animal performance and reproductive responses has been one of the main goals of animal science researchers and *** restrictions to the use of antimicrobials as growth promoters led researchers to seek alternative practices that can show promise both from the standpoint of efficacy as well as from the practical and economic *** of the alternatives that surfaced as very promising in the last few decades is the use of direct-fed microbials （DFM） as a means to modulate the effects of the gastrointestinal microbiome on the host immune status, health and productivity.

关键词： microbial nutrition reproduction goals promise ecosystem fermentation anaerobic digestion pleased

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