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Systematic Acupuncture Explains Acupuncture at Baihui(GV20) and Fengchi(GB20) Targeting the Inflammatory Response to Regulate Migraine

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Journal of Traditional Chinese Medicine 2025年

作者： MIN Yu ZHENG Meifeng SUN Ju PENG Zetong cao Zhixian HUANG Xiaohua Medical College of Acu-Moxi and Rehabilitation， Guangzhou University of Chinese Medicine Department of Rehabilitation Medicine， the Affiliated Panyu Central Hospital of Guangzhou Medical University

Objective: To take Baihui (GV20) and Fengchi (GB20) targeting inflammatory response to regulate migraine as an example to describe a new method for studying the mechanism of stimulating ***: The target information of Baihui (GV20) and Fengchi (GB20) was retrieved， and after intersection with migraine， Kyoto Encyclopedia of Genes and Genomes (KEGG)， Reactome， and UniProt Keywords were used for functional enrichment. After selecting the main pathway， rats were selected and nitroglycerin was used for modeling， and the behavioral scores， inflammatory factors， heme oxygenase 1 (HMOX1)， protein kinase B (AKT1)， signal transducer and activator of transcription 3 (STAT3)， phosphorylated extracellular signal-regulated kinase 1/2 (P-ERK1/ERK2) and other states of the rats in the acupuncture， twisting， and electroacupuncture groups were ***: A total of 135 Baihui (GV20) targets and 27 Fengchi (GB20) targets were collected. A total of 73 target information were obtained after the intersection of these targets in migraine. These 73 targets have three main pathways: hypoxia-inducible factor 1 (HIF-1) signaling pathway， signaling by interleukins and inflammatory response. The main targets in the pathway were verified and found that interleukin-1 beta (IL-1β)， interleukin-6 (IL-6)， tumor necrosis factor-alpha (TNF-α) and HMOX1， AKT1， STAT3， P-ERK1/ERK2 can be regulated by Baihui (GV20) and Fengchi (GB20).Conclusion: Baihui (GV20) and Fengchi (GB20) can regulate migraine by regulating inflammatory factors and HMOX1， AKT1， STAT3， P-ERK1/ERK2 and other changes in HIF-1 signaling pathway， Signaling by Interleukins and Inflammatory response pathways. Based on systems biology and network pharmacology， and with the model of "acupoint-target-disease"， explore the research methods of systematic acupuncture and moxibustion. We believe this is a usable research direction for exploring the mechanism of acupuncture stimulation.

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日本知识界认知中的五四运动

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河北学刊 2025年第1期45卷 210-217页

作者：曹萌中国社会科学院

五四运动爆发后,日本主流舆论将其定性为“排日运动”,多指责中国青年学生排斥日本,认为英美势力与中国亲英美派政客煽动青年学生促成了“暴动”。部分日本在华媒体人和以吉野作造为代表的日本新知识分子以及大阪报刊《大正日日新闻》... 详细信息

五四运动爆发后,日本主流舆论将其定性为“排日运动”,多指责中国青年学生排斥日本,认为英美势力与中国亲英美派政客煽动青年学生促成了“暴动”。部分日本在华媒体人和以吉野作造为代表的日本新知识分子以及大阪报刊《大正日日新闻》却肯定了五四运动体现出的进步思想,呼吁日本民众理性看待中国的民众运动。其中,《大正日日新闻》1920年新年号连载“中国名士之对日意见”,这些意见集中介绍了五四运动、新思想运动的真义,体现了五四运动后日本知识界对中国新思想的关注,同时也呈现出日本对华观的多面性与复杂性。

关键词：五四运动中日关系吉野作造《大正日日新闻》

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Pomegranate-like C_(60)@cobalt/nitrogen-codoped porous carbon for high-performance oxygen reduction reaction and lithium-sulfur battery

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Nano Research 2021年第8期14卷 2596-2605页

作者： Jianhua Wu Shiyang Wang Zhanwu Lei Runnan Guan muqing Chen Pingwu Du Yalin Lu Ruiguo cao Shangfeng Yang Hefei National Laboratory for Physical Sciences at Microscale CAS Key Laboratory of Materials for Energy ConversionAnhui Laboratory of Advanced Photon Science and TechnologyDepartment of Materials Science and Engineering University of Science and Technology of ChinaHefei 230026China

Porous carbon materials play essential roles in electrocatalysis and electrochemical energy *** is of significant importance to rationally design and tune their porous structure and active sites for achieving high electrochemical activity and ***,we develop a novel approach to tune the morphology of porous carbon materials(PCM)by embedding fullerene C_(60),achieving improved performance of oxygen reduction reaction(ORR)and lithium-sulfur(Li-S)*** to the strong interaction between C_(60)and imidazole moieties,pomegranate-like hybrid of Ow-embedded zeolitic imidazolate framework(ZIF-67)precursor is synthesized,which is further pyrolyzed to form C_(60)-embedded cobalt/nitrogen-codoped porous carbon materials(abbreviated as C_(60)@Co-N-PCM).Remarkably,the unique structure of C_(60)@Co-N-PCM offers excellent ORR electrocatalytic activity and stability in alkaline solutions,outperforming the commercial Pt/C(20 wt.%)***,C_(60)@Co-N-PCM as a novel cathode delivers a high specific capacity of-900 mAh·g^(-1) at 0.2 C rate in Li-S batteries,which is superior to the pristine ZIF-67-derived PCM without embedding C_(60).

关键词： porous carbon materials fullerene zeolitic imidazolate framework(ZIF) oxygen reduction reaction(ORR) lithium-sulfur(Li-S)battery

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不同认知水平的学龄期孤独症谱系障碍儿童体力活动与超重或肥胖的关联性研究

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教育生物学杂志 2020年第1期8卷 12-17页

作者：石碧君曹牧青王馨罗靓尹曾晶晶陈嘉洁静进中山大学公共卫生学院妇幼卫生学系中国广州510080

目的了解不同认知水平的学龄期孤独症谱系障碍(autism spectrum disorder,ASD)儿童体力活动情况,分析其与超重或肥胖的相关性。方法纳入中山大学儿童青少年心理行为发育研究中心2018年7月-2019年5月就诊的ASD儿童45例,采用中文版韦氏智... 详细信息

目的了解不同认知水平的学龄期孤独症谱系障碍(autism spectrum disorder,ASD)儿童体力活动情况,分析其与超重或肥胖的相关性。方法纳入中山大学儿童青少年心理行为发育研究中心2018年7月-2019年5月就诊的ASD儿童45例,采用中文版韦氏智力量表第4版与临床访谈对入组儿童进行认知能力评估,按照有无智力低下分为高功能ASD组(high function ASD,HFA)和低功能ASD组(low function ASD,LFA),采用Actigraph-GT3X三轴加速度计对两组儿童进行客观的体力活动测量,应用标准方法进行体格测量并根据世界卫生组织(World Health Organization,WHO)的体质指数(body mass index,BMI)标准判断超重或肥胖,运用二元Logistic回归模型分析体力活动相关指标与超重或肥胖患病风险的关联。结果入组的ASD儿童中超重者为7人(15.6%),肥胖者为8人(17.8%);平均中高强度体力活动时间为(49.2±20.3)min/d,未达到WHO推荐标准(60 min/d),达标率为26.7%;LFA组的高强度体力活动时间(Z=2.55,P=0.011)和中高强度体力活动时间(Z=1.98,P=0.048)均显著大于HFA组。在HFA组中,控制年龄、性别和平均睡眠时长后,较高水平的中强度、高强度和中高强度体力活动与超重或肥胖低风险有关(依次为OR=0.09,95%CI 0.01~0.94;OR=0.06,95%CI 0.004~0.96;OR=0.06,95%CI 0.005~0.70)。而在LFA组中,未发现相关指标与超重或肥胖有统计学关联。结论学龄期ASD儿童存在体力活动不足及较高超重或肥胖患病率问题,不同认知水平的ASD儿童其体力活动与超重或肥胖之间的关联性有差别,在HFA儿童中两者呈负相关关系,可为进一步的干预提供参考依据。

关键词：孤独症谱系障碍超重肥胖体力活动认知水平

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Multivariate synergy for heightening ionic HOF robustness and proton conductivity

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Science China Chemistry 2025年

作者： Xiang-Tian Bai Li-Hui cao Xu-Yong Chen Jia-Yu Wang Zi-Ye Zhou Shaanxi Key Laboratory of Chemical Additives for Industry College of Chemistry and Chemical EngineeringShaanxi University of Science and Technology

Multicomponent crystalline materials construct more complex and diversified structures with different combinations and modes,which expands the material structure space and application *** this work,we have successfully synthesized two twocomponent ionic hydrogen-bonded organic frameworks （iHOF-32 and iHOF-33） and a three-component iHOF （iHOF-34）.Guanidine hydrochloride which is rich in N and H and has a short chain length strengthens the hydrogen bonding network of iHOF,thereby aiding in the efficient migration of *** rigid architecture of 1,1'-diamino-4,4'-bipyridine diiodide furnishes additional scaffolding for the iHOFs and enhances its robustness under harsh ***-34 accomplishes the combination of the ultra-high proton conductivity of iHOF-32 and the robustness of iHOF-33 by the synergistic interaction among the three components of *** addition,iHOF-34 was fabricated as a composite membrane with a peak proton conductivity of 1.55×10-1S cm-1,which is 3.8 times higher than that of recast Nafion,and has extensive potential in fuel *** self-assembly strategy of multicomponent HOFs opens up new avenues for constructing diverse structures while promising new opportunities for applications in the fields of proton conduction and energy storage.

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孤独症谱系障碍男童皮质醇分泌水平及其相关因素研究

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教育生物学杂志 2020年第1期8卷 18-22页

作者：罗靓尹曹牧青石碧君王馨陈倩刘斯宇静进中山大学公共卫生学院妇幼卫生学系中国广州510080

目的探讨孤独症谱系障碍(autism spectrum disorder,ASD)儿童的皮质醇分泌水平及其相关因素。方法纳入6~12岁男童50名,其中ASD组30名,正常对照组[典型发展(typical development,TD)] 20名。采用儿童焦虑情绪筛查量表-修订版、社交反应... 详细信息

目的探讨孤独症谱系障碍(autism spectrum disorder,ASD)儿童的皮质醇分泌水平及其相关因素。方法纳入6~12岁男童50名,其中ASD组30名,正常对照组[典型发展(typical development,TD)] 20名。采用儿童焦虑情绪筛查量表-修订版、社交反应量表、重复刻板行为检查表-修订版对其焦虑性情绪、社交能力及ASD重复刻板行为等进行评估,随后连续2 d分别于早上起床时、起床后30 min和晚上睡觉前收集唾液并测定皮质醇水平,同时连续记录14 d睡眠日记,分析ASD儿童皮质醇分泌水平及其相关因素。结果 ASD组夜晚皮质醇水平(-0. 13±0. 50) nmo L/L低于TD组(0. 34±0. 34) nmo L/L,差异具有统计学意义。两组儿童在睡眠模式上存在显著差异,表现为ASD组24 h睡眠时长较短且睡眠效率较低。以ASD儿童夜晚皮质醇水平为因变量进行多元线性回归分析显示,其夜晚皮质醇水平与入睡潜伏期呈正相关,与重复刻板行为呈负相关。结论ASD儿童与TD儿童在夜晚皮质醇分泌水平上存在差异,ASD儿童夜晚皮质醇水平与其入睡潜伏期及重复刻板行为有关。

关键词：孤独症谱系障碍皮质醇睡眠重复刻板行为

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Role of the globus pallidus in motor and non-motor symptoms of Parkinson's disease

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Neural Regeneration Research 2025年第6期20卷 1628-1643页

作者： Yimiao Jiang Zengxin Qi Huixian Zhu Kangli Shen Ruiqi Liu Chenxin Fang Weiwei Lou Yifan Jiang Wangrui Yuan Xin cao Liang Chen Qianxing Zhuang Department of Physiology School of MedicineNantong UniversityNantongJiangsu ProvinceChina Department of Neurosurgery Huashan HospitalShanghai Medical CollegeFudan UniversityShanghaiChina National Center for Neurological Disorders ShanghaiChina Shanghai Key Laboratory of Brain Function Restoration and Neural Regeneration ShanghaiChina State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Institute of Brain ScienceFudan UniversityShanghaiChina

The globus pallidus plays a pivotal role in the basal ganglia circuit. Parkinson's disease is characterized by degeneration of dopamine-producing cells in the substantia nigra, which leads to dopamine deficiency in the brain that subsequently manifests as various motor and non-motor symptoms. This review aims to summarize the involvement of the globus pallidus in both motor and non-motor manifestations of Parkinson's disease. The firing activities of parvalbumin neurons in the medial globus pallidus, including both the firing rate and pattern, exhibit strong correlations with the bradykinesia and rigidity associated with Parkinson's disease. Increased beta oscillations, which are highly correlated with bradykinesia and rigidity, are regulated by the lateral globus pallidus. Furthermore,bradykinesia and rigidity are strongly linked to the loss of dopaminergic projections within the cortical-basal ganglia-thalamocortical loop. Resting tremors are attributed to the transmission of pathological signals from the basal ganglia through the motor cortex to the cerebellum-ventral intermediate nucleus circuit. The cortico–striato–pallidal loop is responsible for mediating pallidi-associated sleep disorders. Medication and deep brain stimulation are the primary therapeutic strategies addressing the globus pallidus in Parkinson's disease. Medication is the primary treatment for motor symptoms in the early stages of Parkinson's disease, while deep brain stimulation has been clinically proven to be effective in alleviating symptoms in patients with advanced Parkinson's disease,particularly for the movement disorders caused by levodopa. Deep brain stimulation targeting the globus pallidus internus can improve motor function in patients with tremordominant and non-tremor-dominant Parkinson's disease, while deep brain stimulation targeting the globus pallidus externus can alter the temporal pattern of neural activity throughout the basal ganglia–thalamus network. Therefore, the comp

关键词： anxiety basal ganglia bradykinesia deep brain stimulation depression globus pallidus externus globus pallidus internus lateral globus pallidus medial globus pallidus neural circuit Parkinson's disease

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鄂尔多斯盆地华池地区三叠系长7页岩油储层特征、形成环境及富集模式

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岩性油气藏 2025年第1期37卷 24-40页

作者：梁锋曹哲延长油田股份有限公司吴起采油厂

通过对鄂尔多斯盆地华池地区三叠系长7段钻井岩心进行岩石学特征以及元素地球化学测试分析，采用V/（V+Ni）,Ni/Co,U/Th,Sr/Cu,cao/（MgO*Al2O3）,Sr/Ba,Fe/Mn,Mn/Ti,Babio值和P/Al值等多种判别标准，并结合总有机碳的含量，进行古环境... 详细信息

通过对鄂尔多斯盆地华池地区三叠系长7段钻井岩心进行岩石学特征以及元素地球化学测试分析，采用V/（V+Ni）,Ni/Co,U/Th,Sr/Cu,cao/（MgO*Al2O3）,Sr/Ba,Fe/Mn,Mn/Ti,Babio值和P/Al值等多种判别标准，并结合总有机碳的含量，进行古环境分析，恢复了沉积期的古气候、古盐度和古氧化还原条件等。研究结果表明：（1）鄂尔多斯盆地华池地区三叠系长7段岩石主要为深灰色泥岩、深灰色灰质泥岩及含炭屑的粉砂质泥岩、富含有机质的粉砂质泥岩，黏土矿物晶间孔与粒间孔是主要的孔隙类型，可见少量溶蚀孔和微裂缝。（2）研究区延长组长7沉积时期，有机质生产力强，环境以淡水为主且处于贫氧到缺氧状态，其中长72—长73亚段沉积时期，部分水体较深的区域出现极强的还原条件，主要为温湿气候。整体上为深水环境，长72亚段沉积时位于深水区的边界地带，其水深明显较长71与长73亚段更深，P/Al值以及Babio值总体上变化趋势一致，自下而上具有逐渐增大的趋势。（3）研究区延长组长7段古沉积环境具备适宜的温度和盐度条件，与深水和强还原性特征共同促进了有机质的广泛发育、富集和保存，源岩与储层之间通过裂缝连通，离源岩较近的储层，其捕获原油的数量和效率更高，这种源储配置为页岩油的大规模富集成藏奠定了坚实的基础。

关键词：页岩油储层元素地球化学古环境古生产力有机质富集源储配置长7 三叠系华池地区鄂尔多斯盆地

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Asymmetric interfacial engineering regulated charge distribution on Ru/Ni-N-C sites for efficient hydrogen evolution reaction in alkaline and seawater electrolytes

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Science China Chemistry 2025年

作者： Rui Yu Xi cao Chengyang Zhu Qingqing Chen Ziyi Yan Binbin Jiang Junjie Mao Xianwen Wei Key Laboratory of Electrochemical Clean Energy of Anhui Higher Education Institutes College of Chemistry and Materials ScienceAnhui Normal University Anhui Provincial Key Laboratory of Advanced Catalysis and Energy Materials School of Chemistry and Chemical Engineering Anqing Normal University School of Chemistry and Chemical Engineering Anhui University of Technology

Developing highly efficient and cost-effective electrocatalysts for hydrogen evolution reaction（HER） is grandly challenging in alkaline and alkaline seawater electrolytes. Herein, the asymmetric interfacial active sites with Ru nanoparticles and Ni single atoms in Ru/Ni-N-C were designed through a solvothermal-pyrolysis process. Constructing highly asymmetric interfacial active sites with a strong electron delocalization effect significantly improves HER kinetics. As expected, Ru/Ni-N-C requires low overpotentials with around 20 mV at 10 mA cm-2and robust durability over 48 h in alkaline and alkaline seawater *** at 200 mA cm-2, the overpotentials are close to 100 mV in both above electrolytes for Ru/Ni-N-C. Density function theory calculation results suggest that the asymmetric interface between Ru nanoparticle and Ni-N-C could accelerate the dissociation of water molecules and modulate the hydrogen species, consequently improving the HER performances. This work opens a unique approach for constructing advanced materials for energy conversion.

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企业数字化转型与全球价值链参与

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管理工程学报 2025年第1期39卷 15-31页

作者：李鑫佟岩曹丰北京理工大学管理学院湖南大学工商管理学院

本文立足“逆全球化”时代数字经济发展迅速的现实背景,利用2010年至2016年中国A股上市公司与中国海关数据库的合并数据,实证检验了企业数字化转型对其全球价值链参与的影响。研究表明,数字化转型能够促进企业更好地融入全球价值链,并... 详细信息

本文立足“逆全球化”时代数字经济发展迅速的现实背景,利用2010年至2016年中国A股上市公司与中国海关数据库的合并数据,实证检验了企业数字化转型对其全球价值链参与的影响。研究表明,数字化转型能够促进企业更好地融入全球价值链,并且该结论在经过一系列稳健性检验后依然成立。影响机制检验发现,企业数字化转型对全球价值链嵌入的提升作用主要通过缓解融资约束和提高生产效率来实现。异质性检验结果表明,当数字化转型基础较好、劳动力需求较高以及成本加成较低时,企业数字化转型对全球价值链参与的影响更为凸显。本文丰富和拓展了企业数字化转型影响机制与经济后果的研究框架,为企业更好地融入全球价值链分工体系、实现高质量发展找到了新的经验证据,对于企业数字化相关政策的制定与调整也具有一定的参考价值。

关键词：数字化转型全球价值链嵌入融资约束生产效率

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