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Immune Profile of COVID-19 Survivors and Contacts During 9 Months:A Cohort Study

Infectious Diseases & Immunity 2023年第4期3卷 163-175页

作者： Valentina V.Tatarnikova Natalya O.Kiseleva Valentina I.Dubrovina Vladimir A.Vishnyakov Darya D.bryukhova Anna b.Pyatidesyatnikova Konstantin M.Korytov munko b.sharakshanov Sergey V.balakhonov Irkutsk Antiplague Research Institute of Siberia and Far East of Rospotrebnadzor Irkutsk 664047Russia

background:Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)causes a multi-organ systemic damage that can lead to long-term *** is known about the possible long-term effects of COVID-19 on circulating leukocyte kinetics and functional T-cell activity after *** investigate immune system changes,we designed a cohort ***:Volunteer screening and sample collectionwere performed at the Irkutsk Research Anti-Plague Institute of ***-four volunteers who have had COVID-19(recovered volunteers(RVs))betweenMay 2020 andMay 2021,33 volunteers who had been in contact with COVID-19 patients(contact volunteers(CVs))within the family setting but had not become ill,and 47 healthy volunteers(HVs)participated in the *** performed immunophenotyping of peripheral blood cells using flow *** was tested for SARS-CoV-2 anti-nucleocapsid immunoglobulin G antibodies by enzyme-linked immunosorbent assay(Ab(+),people with specific anti-N antibodies to SARS-CoV-2;Ab(−),people without specific antibodies).Results:There were no serious disturbances in the internal environment of the body in RVs and *** the evaluation of the general state of the immune system,the most informative indicator was the index of the ratio of neutrophils to bloodmonocytes–decreased on the 1st terms of observation(1 and 3 months post-symptom onset(PSO)/post-contact onset(PCO)),on average,1.3 times compared with HVs(8.6%(7.5%–10.5%),Pby the 6th month of *** of the cells responsible for the development of the adaptive immune response was noted only in RVs–increased b-lymphocyte content(HVs,9.1%(6.4%–10.2%))and immunoregulatory index ratio(HVs,1.6%(1.2%–2.1%))due to redistribution of T-helper and cytotoxic T cells throughout the follow-up period by an average of 1.2-fold compared with HVs(Pbodies to SARS-CoV-2 N-protein also had an increased proportion of CD3−CD19+c

关键词： COVID-19 Flow cytometry Immunity Specific IgG T cells b cells

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