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Interfacial activation of alkaline phosphatase induced by hydrophilic metal—organic frameworks

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Nano Research 2024年第11期17卷 9980-9989页

作者： Dongyan Chen Yi Xu Jie Wei munetaka Oyama Quansheng Chen Xiaomei Chen College of Ocean Food and Biological Engineering Jimei University Xiamen 361021 China Department of Material Chemistry Graduate School of Engineering Kyoto University Nishikyo-ku Kyoto 615-8520 Japan Fujian Provincial Key Laboratory of Food Microbiology and Enzyme Engineering Jimei University Xiamen 361021 China

Encapsulating natural enzymes in metal—organic frameworks (MOFs) can maintain the original biological functions of enzymes in harsh environments. However, the nature of interfacial interactions between a MOF and enzyme is currently unclear, rendering effective regulation of the biocatalytic activity of the enzyme@MOF composite difficult. Differences in the hydrophilicity of MOF carriers are closely related to the conformational changes and catalytic properties of the enzyme. In this study, the catalytic activity, stability, and conformational changes of alkaline phosphatase (ALP) encapsulated in hydrophilic zeolite imidazolate framework-90 (ZIF-90) and hydrophobic ZIF-8 were systematically investigated using experimental methods and molecular dynamics simulations. The results demonstrated that hydrophilic ZIF-90-encapsulated ALP exhibited superior stability and was 2.22-fold more retained catalytically active than hydrophobic ALP@ZIF-8 after 20 cycles of utilization. Moreover, the hydrophilic interface provided by ZIF-90 effectively regulated the structure of ALP to maintain the optimal catalytic conformation of its active center. The practical application of highly bioactive ALP@ZIF-90 was demonstrated by employing it in a self-calibrated colorimetric/fluorescence dual-mode sensing method for the efficient, reliable, and accurate detection of methyl paraoxon. This study provides new insights for improving enzyme immobilization strategies and promoting the rapid development of enzyme@MOF composites for catalytic and sensing applications.

关键词： alkaline phosphatase metal—organic frameworks enzyme immobilization hydrophilic molecular dynamics simulations

Polyarteritis nodosa diagnosed by surgically resected jejunal necrosis following acute abdomen

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World Journal of Gastroenterology 2013年第18期19卷 2830-2834页

作者： Yuta Hiraike Makoto Kodaira munetaka Sano Yasuyuki Terazawa Shingo Yamagata Syuzo Terada Masaharu Ohura Ken Kuriki Department of Gastroenterology Yaizu City Hospital Yaizu City Shizuoka 425-8505 Japan Department of Nephrology Yaizu City Hospital Yaizu City Shizuoka 425-8505 Japan Department of Pathology Yaizu City Hospital Yaizu City Shizuoka 425-8505 Japan

The differential diagnosis of acute abdomen is typically extremely broad in range, with vasculitis posing a rare but potentially life-threatening cause of acute abdomen. Here, we report a case of acute abdomen with bowel wall thickening limited to jejunum, accompanied by unexplained renal dysfunction. Later, the patient was diagnosed as having polyarteritis nodosa based on surgically resected jejunal necrosis. Despite aggressive treatment, including the use of steroid pulse therapy and continuous hemodiafiltration, the patient died. Although polyarteritis nodosa is extremely rare in patients with acute abdomen, acute abdomen is relatively common manifestation of that. And it is reported that involvement of small intestine suggests poorer prognosis. Our case highlights the importance of vasculitis as a differential diagnosis of patients with atypical acute abdomen. In this report, we not only review possible clues that might have led to an earlier diagnosis in this case, but also attempt to draw some lessons for treating similar cases in the future.

关键词： Acute abdomen Polyarteritis nodosa Jejunal necrosis

Separation, Recovery, and Recycling MSW with Steam Classification

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Separation, Recovery, and Recycling MSW with Steam Classific...

Bacterial Infection in the Limbs of Patients with Rheumatoid Arthritis during Biological Agent Therapy

7th World Congress on Recovery, Recycling and Re-integration

作者： munetaka Ikeda Global Business Navigation Incorporation 2185 Station Village Way San Diego California 92108 United States of America

Steam Classification is a process for the treatment of commingled municipal solid waste (MSW) with steam under pressure and agitation to transform certain waste components, such as packaging materials, paper products, food waste, into a homogenous cellulosic biomass product. Initial volume reduction of the processed MSW is 50%-70%. The biomass product may be used directly for energy production as combustion or gasification fuel. The biomass may also be further processed to produce clean fiber suitable for recycling into a variety pulp and paper products. The biomass may also be used in the production of medium density fiberboard, plastic lumber, cement and concrete products, asphalt paving, and chemicals. In addition to the biomass, clean recyclable steel and aluminum cans are recovered from the process free of food, labels, and laminates. Recyclable PET plastic bottles are flattened, shrunken, and freed of labels during processing HOPE, LDPE and other plastics are melted during processing and recovered as agglomerates or films suitable for making plastic lumber and pipe. Broken glass, ceramics, rock, ash and dirt may also be recovered and recycled into aggregate for cement, concrete, asphalt and plastic pipe. Textiles may also be recovered and recycled. Other components, generally sterile and inert, may be safely landfilled. The first 500 t/d facility will be in operation in Anaheim, California in January 2005. The patented process has been licensed to World Waste Technologies, Inc., San Diego, California for development in the U.S.A. (***), The Fernwood Group, Ltd., Nottingham, U.K. for development in Europe, and International Waste Processors Inc., San Diego, California for development in the Middle East and in cooperation with Global Business Navigation, Inc., San Diego, California for Asia.

关键词： municipal solid waste, steam classification, recycling, cellulose, biomass

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Open Journal of Rheumatology and Autoimmune Diseases 2012年第3期2卷 47-52页

作者： Hajime Yamanaka Kenichiro Goto munetaka Suzuki Department of Orthopaedic Surgery National Hospital Organization Shimoshizu Hospital Yotsukaido City Japan

Biological therapies in rheumatoid arthritis (RA) are known to increase the risk of serious infections. The present study was performed to evaluate the clinical features of bacterial infections occurring in the limbs during biological therapies in patients with RA. By March 2011, 11 RA patients (14 limbs) treated with biological agents at our institution required hospitalization due to bacterial infections occurring in the limbs. These patients had an average age of 53.7 years old. Infections occurred an average of 19 months after biological treatment. Two limbs in one patient were treated with infliximab, eight limbs in six patients were treated with etanercept, one limb in one patient was treated with adalimumab, and three limbs in three patients were treated with tocilizumab. Cellulitis occurred in 7 limbs, late infections after total knee arthroplasty occurred in two limbs, early infections after orthopedic surgery occurred in three limbs, and septic arthritis occurred in two limbs. Four cases had comorbidities—liver cirrhosis and diabetes mellitus in one and three cases, respectively. All patients were treated using corticosteroid with an average dose of 4.6 mg daily. Seven limbs required surgical treatment. All patients finally recovered. Ten limbs continued treatment with biological agents. Care must be taken regarding bacterial infection in the limbs of RA patients treated by using biological agents, particularly those with comorbidities. Further studies are required to confirm means of preventing such infections in daily practice.

关键词： Bacterial Infection Limbs Rheumatoid Arthritis Biological Agents

Preliminary study of photodynamic diagnosis using 5-aminolevulinic acid in gastric and colorectal tumors

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World Journal of Gastroenterology 2015年第21期21卷 6706-6712页

作者： munetaka Nakamura Jun Nishikawa Kouichi Hamabe Atsushi Goto Junichi Nishimura Hiroaki Shibata Misato Nagao Sho Sasaki Shinichi Hashimoto Takeshi Okamoto Isao Sakaida Department of Gastroenterology and Hepatology Yamaguchi University Graduate School of Medicine

AIM:To investigate the utility of photodynamic diagnosis(PDD) using 5-aminolevulinic acid(5-ALA) to detect gastric/colorectal ***:This prospective single-center study investigated inter-subject variability in patients with early-stage gastric/colorectal tumor indicated for endoscopic *** were patients with gastric or colorectal tumors who had undergone endoscopic resection between November 2012 and November *** criteria included age 20-80 years,either sex,and provision of informed *** were orally administered 20 mg/kg of 5-ALA enteric-coated capsules(SBI ALApromo Co.,Tokyo,Japan).Administration of5-ALA was followed by endoscopic resection of gastric or colorectal tumors,and the resected specimens were examined using a video autofluorescence processor and a fluorescence endoscope(SAFE-3000 and EB-1970 AK,respectively;Pentax,Tokyo,Japan).The primary endpoint was the presence of fluorescence in ***,macroscopic,and histopathologic findings of tumors were *** also evaluated adverse events of the present procedure as a secondary endpoint and examined each patient for the presence of known adverse effects of 5-ALA,namely,hematocytopenia,liver dysfunction,hypotension,nausea,and ***:We enrolled 10 patients(7 men,3 women)(n = 13 lesions:10 gastric/3 colorectal tumors).Fluorescence was detected in 7/13(53.8%) *** significant differences in sex(male:55.6%vs female:50.5%,P = 1.00),age(67.1 ± 1.9 years vs 65.0 ±2.0 years,P= 0.45),tumor color(reddish:60.0%vs discolored:33.3%,P = 0.56),tumor diameter(15.0± 2.1 mm vs 14.2 ± 2.3 mm,P= 0.80),macroscopic type(protruded:70.0%vs depressed 0%,P = 0.07),histologic type(differentiated type:58.3%vs 0%,P = 0.46),invasion depth(mucosal layer:55.6%vs submucosal layer:33.3%,P = 1.00),lymphatic invasion(present:33.3%vs absent:50.0%,P= 1.00),venous invasion(present:0%vs absent:54.5%,P= 1.00) or procedure time of endoscopic resection(36.3 ± 8.3 min v

关键词： Photodynamic diagnosis 5-aminolevulinicacid Protoporphyrin IX, Gastric tumor Colorectaltumor

Electrochemical Characteristics of Indium Tin Oxide Electrodes Modified with Gold Nanoparticles Using a Novel Attachement Approach

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Electrochemical Characteristics of Indium Tin Oxide Electrod...

Novel Method to Attach Gold Nanoparticles on Indium Tin Oxide Surface

2～(nd) Spring Meeting of the International Society of Electrochemistry

作者： Miyako Kambayashi munetaka Oyama Division of Research Initiatives International Innovation Center Kyoto University Sakyo-ku Kyoto 606-8501 Japan Division of Research Initiatives International Innovation Center Kyoto University Sakyo-ku Kyoto 606-8501 Japan

Nanomaterials have unique physical and chemical properties that are not only highly size-dependent but also strongly shape-related. Various nanomaterials such as metal andsemiconductor nanoparticles and carbon nanotubes have been prepared and developed aselectrode materials and their electrochemical characteristics have been extensively introduced.

关键词： MPTMS ITO Electrochemical Characteristics of Indium Tin Oxide Electrodes Modified with Gold Nanoparticles Using a Novel Attachement Approach

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Novel Method to Attach Gold Nanoparticles on Indium Tin Oxid...

The Impact of Footwear on Posture, Gait and Balance

2～(nd) Spring Meeting of the International Society of Electrochemistry

Metal nanoparticles have unique optical, electronic, magnetic, and catalytic properties that areoften different from those of the bulk metals. These properties are currently under intensestudy for potential uses as optoelectronic components, spectroscopic enhancers, biologicaldetection labels, and chemical sensing elements. For electrochemical measurements, muchattention has been devoted to the modification of electrodes with metal nanoparticles, whichis a promising approach to provide nano-structured functional interfaces.

关键词： Novel Method to Attach Gold Nanoparticles on Indium Tin Oxide Surface ITO

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Health 2022年第2期14卷 209-218页

作者： Saori Karasawa munetaka Yamamoto Junko Sakurai Shiori Kawasaki Hiroyuki Kobayashi Department of Hospital Administration Juntendo Graduate School of Medicine Tokyo Japan Patient Safety Management Section Juntendo University Hospital Tokyo Japan Faculty of Health and Nursing Juntendo University Chiba Japan

Background: The objective of this study was to investigate the effects of footwear on posture and balance while walking. The types of footwear investigated in this study were open back shoes, commonly worn by hospitalized patients, and closed back shoes. Previous studies have shown that open back shoes, or slippers, increase the risk of falling (among elderly). We hypothesized that our findings would suggest that open back shoes negatively affect gait mechanics in healthy individuals. Methods: Healthy individuals (n = 12) participated in a walking test while wearing closed back shoes and open back shoes. The explanatory variables in this study were the analysis of gait, posture, and balance before and after walking. The objective variable was footwear (closed back shoes vs. open back shoes). A paired t-test was performed to detect significant differences between the two conditions. Results: Among the test items measured, we found a significant difference in minimum wide tilt angle and left-right differences in step length and intensity while walking between the conditions of closed back shoes and open back shoes. These results suggest that open back shoes could negatively impact posture and balance while walking, even in healthy subjects. Conclusion: It is imperative to improve patient awareness of the risk of falling. We believe that the inclusion of our findings in educational pamphlets and in-house notices could help improve patient awareness and more effectively prevent falls among patients.

关键词： Footwear Posture Walking Test Health Fall

新辅助化疗后行腹腔镜辅助胃切除术治疗晚期胃癌

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中国普通外科杂志 2013年第10期22卷 1238-1242页

作者： Takaki Yoshikawa Takashi Oshima Yasushi Rino munetaka Masuda 日本横滨神奈川癌症中心胃肠外科日本横滨市立大学医学院外科

目前治疗晚期胃癌的方法为开腹胃切除及D2淋巴结清扫并在术后行S-1或卡倍他滨加奥沙利铂辅助化疗。然而III期胃癌患者的预后并不理想。为了提高生存率,需要加大化疗药物的剂量。鉴于患者接受二联或三联化疗的顺应性差,新辅助化疗将是一... 详细信息

目前治疗晚期胃癌的方法为开腹胃切除及D2淋巴结清扫并在术后行S-1或卡倍他滨加奥沙利铂辅助化疗。然而III期胃癌患者的预后并不理想。为了提高生存率,需要加大化疗药物的剂量。鉴于患者接受二联或三联化疗的顺应性差,新辅助化疗将是一个充满前景的方法。目前在东亚国家,正进行多项III期临床试验用于评估新辅助化疗效果。另一方面,手术治疗方法已倾向于行腹腔镜手术。在日本和韩国已经进行了多项III期临床试验评估腹腔镜辅助远端胃切除(LADG)在早期和晚期患者中的疗效。因此,未来标准治疗肿瘤位于中、下1/3晚期胃癌的候选方案由综合治疗组成,包括新辅助化疗及随后的LADG。只要新辅助化疗是按标准实施,随后的腹腔镜胃切除术的可行性、安全性及长期生存率是有保障的。在这个背景下,我们实施了一项随机II期临床试验比较新辅助化疗后LADG和开腹远端胃切除术(ODG)治疗胃癌的疗效。

关键词：胃肿瘤腹腔镜胃切除术新辅助化疗