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Irsogladine maleate and rabeprazole in non-erosive reflux disease: A double-blind, placebo-controlled study

World Journal of Gastroenterology 2015年第16期21卷 5023-5031页

作者： Takayoshi Suzuki Masashi Matsushima Aya Masui Shingo Tsuda Jin Imai Jun Nakamura Yoko Tsukune Tetsufumi Uchida Hiroki Yuhara muneki igarashi Jun Koike Tetsuya Mine Division of Gastroenterology and Hepatology Department of Internal MedicineTokai University School of Medicine

AIM:To evaluate the efficacy of adding irsogladine maleate(IM) to proton-pump inhibitor(PPI) therapy in non-erosive reflux disease(NERD) ***:One hundred patients with NERD were recruited and randomized to receive rabeprazole plus IM(group I) or rabeprazole plus placebo(group P).The efficacy of the treatment was assessed using the Frequency Scale for the Symptoms of Gastroesophageal Reflux Disease(FSSG) and the short form(SF)-36 quality of life questionnaires after four weeks of *** also assessed whether patients with NERD with minimal changes(grade M) had different responses to the therapies compared with patients who did not have minimal changes(grade N).RESULTS:Group I and group P showed significant improvements in their FSSG scores after the treatment(from 17.9 ± 7.9 to 9.0 ± 7.6, and from 17.7 ± 7.3 to 11.2 ± 7.9, respectively, P = 0.0001), but there was no statistically significant difference between the FSSG scores in group I and those in group *** analysis showed that significant improvements in the FSSG scores occurred in the patients in group I who had NERD grade N(modified Los Angeles classification)(7.8 ± 7.4 vs 12.5 ± 9.8, P = 0.041).The SF-36 scores for patients with NERD grade N who had received IM and rabeprazole were significantly improved in relation to their vitality and mental health ***:The addition of IM to rabeprazole significantly improves gastroesophageal reflux diseasesymptoms and the quality of the lives of patients with NERD grade N.

关键词： Irsogladine maleate Rabeprazole Nonerosivereflux disease Randomized controlled trial Frequency scale for the symptoms of gastroesophagealreflux disease Quality of life

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Investigation of the Association of TLR2 and TLR4 Polymorphisms with Susceptibility to <i>Helicobacter pylori</i>-Related Gastrointestinal Diseases

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Open Journal of Internal Medicine 2014年第4期4卷 130-136页

作者： Takayoshi Suzuki Akira Meguro Masashi Matsushima Aya Masui Shingo Tsuda Jun Nakamura Ryoko Nishina Tetsufumi Uchida Hiroki Yuhara muneki igarashi Jun Koike Tetsuya Mine Hidetoshi Inoko Atsushi Takagi Division of Gastroenterology & Hepatology Department of Internal Medicine Tokai University School of Medicine Isehara Japan Division of Molecular Life Science Department of Genetic Information Tokai University School of Medicine Isehara Japan Division of General Internal Medicine Department of Internal Medicine Tokai University School of Medicine Isehara Japan

Background and Aim: Toll-like receptor (TLR) 2 and TLR4 are cell surface signaling receptors that are involved in the recognition of and host response to Helicobacter pylori. Our aim was to investigate the association between TLR gene polymorphisms and susceptibility of Japanese subjects to 4 H. pylori-related gastrointestinal diseases. Methodology: A total of 100 patients with histologically diagnosed gastric cancer, 105 patients with gastric ulcer, 102 with atrophic gastritis, 72 with duodenal ulcer and 428 healthy controls were recruited. A TaqMan assay was used to genotype 7 single nucleotide polymorphisms (SNPs) in TLR2 and 6 SNPs in TLR4. Results: There was a tendency for TLR4 rs10759932 TC/CC genotypes to be associated with a decreased risk of gastric cancer (p = 0.059);however, this did not reach statistical significance. No significant associations were found between polymorphisms in TLR2 or TLR4 and the risks for gastric cancer, gastric ulcer, duodenal ulcer, or atrophic gastritis. Conclusion: The 13 SNPs inTLR2 and TLR4 examined in this study may not be linked with the development of H. pylori-related gastrointestinal diseases. Further studies with larger numbers of subjects are necessary to verify the present findings.

关键词： TLR2 TLR4 Polymorphisms Helicobacter pylori

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Double-balloon endoscopy-diagnosed multiple small intestinal ulcers in a Churg-Strauss syndrome patient

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World Journal of Gastrointestinal Endoscopy 2012年第5期4卷 194-196页

作者： Takayoshi Suzuki Masashi Matsushima Yoshitaka Arase Mia Fujisawa Ichiro Okita muneki igarashi Jun Koike Tetsuya Mine Division of Gastroenterology and Hepatology Department of Internal MedicineTokai University School of MedicineIseharaKanagawa 259-1193Japan

Churg-Strauss syndrome(CSS) is a systemic vascular disorder characterized by severe bronchial asthma hypereosinophilia,and allergic *** intestina ulcers associated with CSS are a relatively rare manifestation that causes gastrointestinal *** deep ulcers with an irregular shape are characteristic of small intestinal involvement of ***-capsuleendoscopy(VCE),double-balloon endoscopy(DBE) and Spirus assisted enteroscopy have been developed recently and enabled observation of the small intestine In this case report,we have described a patient with CSS who had multiple deep ulcers in the jejunum detected by oral *** severe gastrointestinal(GI) involvement has been identified as an independent factor associated with poor outcome,the careful investigation of GI tract must be needed for CSS patients with GI *** describe the usefulness of DBE for diagnosis of small intestinal ulcers in patient with CSS.

关键词： Churg-Strauss syndrome Small intestinal ulcers Double-balloon endoscopy

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Malignant peritoneal mesothelioma presenting umbilical hernia and Sister Mary Joseph's nodule

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World Journal of Gastrointestinal Endoscopy 2013年第8期5卷 407-411页

作者： Kota Tsuruya Masashi Matsushima Takayuki Nakajima Mia Fujisawa Katsuya Shirakura muneki igarashi Jun Koike Takayoshi Suzuki Tetsuya Mine Division of Gastro-enterology Department of Internal Medicine Tokai University School of Medicine

Malignant peritoneal mesothelioma is a rare aggres-sive tumor of the peritoneum. An increasing number of malignant mesothelioma cases have been reported in recent years. We report here a very rare case of malignant peritoneal mesothelioma with both umbilical hernia and umbilical metastasis which is also called Sister Mary Joseph's nodule. We performed laparoscopy which showed specific laparoscopic findings, and the pathological findings of the biopsy specimen led to the diagnosis. This case was associated with umbilical her-nia which could be induced by massive ascites. A newly developed abdominal hernia should be noted as a primary symptom of malignant peritoneal mesothelioma, as shown in the present case.

关键词： Malignant peritoneal mesothelioma Umbili-cal hernia Sister Mary Joseph’s nodule Umbilical me- tastasis Laparoscopy

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Rational Engineering of Secondary Metabolic Pathways in a Heterologous Host to Enable the Biosynthesis of Hibarimicin Derivatives with Enhanced Anti-Melanomic Activity

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Engineering 2024年第7期38卷 113-123页

作者： Xiangyang Liu Fei-Peng Zhao Tian Tian Wei-Chen Wang Zaizhou Liu Qiang Zhou Xian-Feng Hou Jing Wang Wenli Guo Shuangjun Lin Yasuhiro igarashi Gong-Li Tang State Key Laboratory of Chemical Biology Shanghai Institute of Organic ChemistryUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200032China School of Chemistry and Materials Science Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China State Key Laboratory of Microbial Metabolism&Joint International Research Laboratory on Metabolic and Developmental Sciences School of Life Sciences and BiotechnologyShanghai Jiao Tong UniversityShanghai 200240China Biotechnology Research Center Toyama Prefectural UniversityImizu 939-0398Japan

A 61-kb biosynthetic gene cluster(BGC),which is accountable for the biosynthesis of hibarimicin(HBM)B from Microbispora rosea *** TP-A0121,was heterologously expressed in Streptomyces coelicolor M1154,which generated a trace of the target products but accumulated a large amount of shunt *** on rational analysis of the relevant secondary metabolism,directed engineering of the biosynthetic pathways resulted in the high production of HBM B,as well as new HBM derivates with improved antitumor *** results not only establish a biosynthetic system to effectively synthesize HBMs-a class of the largest and most complex Type-Ⅱpolyketides,with a unique pseudo-dimeric structure-but also set the stage for further engineering and deep investigation of this complex biosynthetic pathway toward potent anticancer drugs.

关键词： Hibarimicin Biosynthesis Heterologous expression Biosynthetic gene cluster Rational engineering Type-II polyketide

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Pyronaridine combined with diminazene aceturate inhibits Babesia in vitro and in vivo

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Asian Pacific Journal of Tropical Biomedicine 2024年第3期14卷 93-99页

作者： Shimaa Abd El-Salam El-Sayed Mohamed Z.Sayed-Ahmed Shaimaa Ahmed Awad Ali Nourah Alsadaan Nawazish Alam Mahmoud S.Alkhoudary Ikuo igarashi Mohamed Abdo Rizk National Research Center for Protozoan Diseases Obihiro University of Agriculture and Veterinary MedicineInada-ChoObihiroHokkaido 080-8555Japan Department of Biochemistry and Chemistry of Nutrition Faculty of Veterinary MedicineMansoura UniversityMansoura 35516Egypt Department of Clinical Pharmacy College of PharmacyJazan UniversityJazan 45142Saudi Arabia Medical-Surgical Department College of NursingJouf UniversitySakaka 72388Saudi Arabia Critical Care and Emergency Nursing Faculty of NursingMansoura UniversityEgypt College of Nursing Jouf UniversitySakaka 72388Saudi Arabia Faculty of Pharmacy Mansoura UniversityMansoura 35516DakahliaEgypt Department of Internal Medicine and Infectious Diseases Faculty of Veterinary MedicineMansoura UniversityMansoura 35516Egypt

Objective:To evaluate the combination therapy of pyronaridine tetraphosphate and diminazene aceturate against Babesia in vitro and in ***:Bioinformatic analysis was performed using atom pair *** in vitro combination test was performed against Babesia bovis and Theileria ***,the in vivo chemotherapeutic efficacy of pyronaridine tetraphosphate in combination with diminazene aceturate was investigated against the growth of Babesia microti in mice using a fluorescence inhibitory ***:Pyronaridine tetraphosphate and diminazene aceturate exhibited nearly similar molecular *** in vitro combination of pyronaridine tetraphosphate and diminazene aceturate was synergistic on Babesia bovis and additive on Theileria *** addition,5 mg/kg pyronaridine tetraphosphate combined with 10 mg/kg diminazene aceturate inhibited Babesia microti growth significantly compared with those observed after treatment with 25 mg/kg diminazene aceturate alone from day 6 post treatment to day 12 post *** combination therapy also normalized the hematological parameters of infected ***:An oral dose of pyronaridine tetraphosphate combined with a subcutaneous dose of diminazene aceturate inhibits Babesia in vitro and in mice,suggesting it might be a new paradigm for the treatment of babesiosis.

关键词： Babesia Pyronaridine tetraphosphate Diminazene aceturate Babesiosis Theileria

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寓居自然井原俊之访谈录

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室内设计与装修 2024年第5期 101-102页

作者：井原俊之 COCHI建筑事务所

id+c:请先为我们介绍一下您创立的COCHI建筑事务所。井原俊之:COCHI建筑事务所创立于2014年,目前设有设计部和木工部2个职能部门,并有4名设计师、1名木工和1名财务行政人员。虽然公司规模并不大,但所有员工各司其职,长时间的共同协作,... 详细信息

id+c:请先为我们介绍一下您创立的COCHI建筑事务所。井原俊之:COCHI建筑事务所创立于2014年,目前设有设计部和木工部2个职能部门,并有4名设计师、1名木工和1名财务行政人员。虽然公司规模并不大,但所有员工各司其职,长时间的共同协作,更磨合出彼此之间的融洽和信任。事务所的企业理念是将建筑作为纽带,将自然与人、建筑联系起来,以打造更为丰富多彩的相互关系。

关键词：企业理念建筑事务所自然与人财务行政各司其职木工相互关系

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Computational design of iris folding patterns

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Computational Visual Media 2016年第4期2卷 321-327页

作者： Yuki igarashi Takeo igarashi Jun Mitani Meiji University The University of Tokyo University of Tsukuba

Iris folding is an art-form consisting of layered strips of paper, forming a spiral pattern behind an aperture, which can be used to make cards and gift tags. This paper describes an interactive computational tool to assist in the design and construction of original iris folding patterns. The design of iris folding patterns is formulated as the calculation of a circumscribed polygonal sequence around a seed polygon. While it is possible to compute the positions of vertices analytically for a regular polygon, it is not straightforward to do so for irregular polygons. We give a numerical method for irregular polygons, which can be applied to arbitrary convex seed polygons. The user can quickly experiment with various patterns using the system prior to constructing the art-form.

关键词： craft pattern fabrication user interface novice users

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Lateral load performance and seismic demand of unbonded scrap tire rubber pad base isolators

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Earthquake Engineering and Engineering Vibration 2021年第3期20卷 803-821页

作者： M.B.Zisan A.igarashi Department of Urban Management Kyoto UniversityKyoto 615-8540Japan Disaster Prevention Research Institute Kyoto UniversityKyoto 611-0011Japan

The scrap tire rubber pad(STRP)made by natural or synthetic rubber and high strength reinforcing cords exhibits substantial vertical stiffness and horizontal flexibility,and these properties can be regarded as suitable for seismic isolators for *** use of environmentally burdensome scrap tires as STRP isolators might be convenient as an efficient and low-cost solution for the implementation of aseismic design philosophy for low-to-medium rise buildings,especially in developing *** element analyses of unbonded square and strip-shaped STRP isolators subjected to a combination of axial and lateral loads are conducted to investigate its lateral deformation performance under seismic *** rubber of the isolator is modelled with Mooney-Rivlin hyperelastic and Prony viscoelastic materials,including the Mullins material damage *** influence of the length-to-width ratio and bearing height on the isolator performance is assessed in terms of the force-displacement relationship,horizontal stiffness,damping,and isolation *** is shown that the dependence of stiffness on the length-to-width ratio is significant in the longitudinal direction and minor in the transverse *** STRP isolators following the proposed design criteria are shown to satisfy the performance requirement at different levels of seismic demand specified by the ASCE/SEI 7-2010 seismic provisions.

关键词： lateral load STRP isolator length-to-width ratio height unbonded application performance-based design FEM

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一种单向隔离型谐振开关电容变换器

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电工技术学报 2024年第15期39卷 4668-4681,4717页

作者：刘妍杨晓峰谭海霞郑琼林五十岚征辉北京交通大学电气工程学院北京100044 富士电机株式会社东京141-0032

作为隔离型单向直流变换器常用的整流器件之一,二极管结电容易与变压器漏感发生谐振,导致严重的电压尖峰问题。为此,提出一种基于二次侧移相的单向隔离型谐振开关电容变换器(UI-RSCC)拓扑,其二次侧整流单元由一个开关半桥和二极管半桥组... 详细信息

作为隔离型单向直流变换器常用的整流器件之一,二极管结电容易与变压器漏感发生谐振,导致严重的电压尖峰问题。为此,提出一种基于二次侧移相的单向隔离型谐振开关电容变换器(UI-RSCC)拓扑,其二次侧整流单元由一个开关半桥和二极管半桥组成,避免了二次侧二极管振荡的产生,可实现所有开关器件的零电压软开关(ZVS)。该文在分析UI-RSCC拓扑的基础上,研究了其输入直流电容的电压均衡机制,提出了相应的输出电压控制策略及其软开关条件。结果表明,UI-RSCC可实现输入直流电容电压的自动均衡,降低了开关器件的电压应力;通过复用部分开关,减少了所需的开关器件数量;使用电容滤波即可实现所有开关器件的软开关,且无需额外的钳位电路。最后,通过仿真及实验结果验证了理论分析的正确性。

关键词：直流变换器谐振开关电容变换器自动均压软开关电压应力

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