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Use of Cryopreserved Osteogenic Matrix Cell Sheets for Bone Reconstruction

Stem Cell Discovery 2016年第1期6卷 13-23页

作者： Tomohiko Kura Manabu Akahane Takamasa Shimizu Yoshinobu Uchihara Yasuaki Tohma Yusuke Morita munehisa koizumi Kenji Kawate Yasuhito Tanaka Department of Orthopedic Surgery Nara Medical University School of Medicine Kashihara Japan Department of Public Health Health Management and Policy Nara Medical University School of Medicine Kashihara Japan Departmentof Biomedical Engineering Doshisha University Kyotanabe Japan Department of Artificial Joint and Regenerative Medicine Nara Medical University Kashihara Japan

Skeletal diseases, such as nonunion and osteonecrosis, are now treatable with tissue engineering techniques. Single cell sheets called osteogenic matrix cell sheets (OMCSs) grown from cultured bone marrow-derived mesenchymal stem cells show high osteogenic potential;however, long preparation times currently limit their clinical application. Here, we report a cryopreservation OMCS transplantation method that shortens OMCS preparation time. Cryopreserved rat OMCSs were prepared using slow- and rapid-freezing methods, thawed, and subsequently injected scaffold-free into subcutaneous sites. Rapid- and slow-frozen OMCSs were also transplanted directly to the femur bone at sites of injury. Slow-freezing resulted in higher cell viability than rapid freezing, yet all two cryopreservation methods yielded OMCSs that survived and formed bone tissue. In the rapid- and slow-freezing groups, cortical gaps were repaired and bone continuity was observed within 6 weeks of OMCS transplantation. Moreover, while no significant difference was found in osteocalcin expression between the three experimental groups, the biomechanical strength of femurs treated with slow-frozen OMCSs was significantly greater than those of non-transplant at 6 weeks post-injury. Collectively, these data suggest that slow-frozen OMCSs have superior osteogenic potential and are better suited to produce a mineralized matrix and repair sites of bone injury.

关键词： Bone Marrow Stromal Cell Cryopreservation Cell Sheet Injectable Bone Bone Reconstruction

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Proposal of a Method to Easily Understand Rainfall Infiltration in Railway Embankments

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Journal of Civil Engineering and Architecture 2024年第6期18卷 261-268页

作者： Takashi Nakayama Tadashi Hara Keigo koizumi C.S.Inspector Co. Ltd.2-7-2 Nambanaka Naniwa-Ku Osaka-ShiOsaka-Fu 556-0011Japan Research and Education Faculty Kochi University2-5-1 Akebonocho Kochi-ShiKochi-Ken 780-8072Japan Earth Watch Institute Inc.8-10 Toyotsucho Suita-ShiOsaka-Fu 564-0051Japan

Slope failures due to heavy or prolonged rain have been occurring frequently in Japan in recent *** railway embankments,even small-scale surface collapse can result in track ***,train operation during rainy periods is regulated according to empirical rules based on rainfall and disaster ***,the validity of operation regulations is lacking because the rainfall infiltration circumstances inside the slope are *** have been attempting to understand rainfall infiltration in railway embankments by applying a method of predicting surface collapse from observations of volumetric water content in the *** used previous field monitoring and model experiments to propose a method for easily understanding the state of rainfall infiltration in the surface layer of an embankment using the relative history of volumetric water content at different *** this study,we applied this simple determination method to railway embankments with different topography and geological environments to demonstrate the versatility of the method.

关键词： Railway embankments field monitoring volumetric water content

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Effects of elafibranor on liver fibrosis and gut barrier function in a mouse model of alcohol-associated liver disease

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World Journal of Gastroenterology 2024年第28期30卷 3428-3446页

作者： Aritoshi koizumi Kosuke Kaji Norihisa Nishimura Shohei Asada Takuya Matsuda Misako Tanaka Nobuyuki Yorioka Yuki Tsuji Koh Kitagawa Shinya Sato Tadashi Namisaki Takemi Akahane Hitoshi Yoshiji Department of Gastroenterology Nara Medical UniversityKashihara 634-8521Japan

BACKGROUND Alcohol-associated liver disease(ALD)is a leading cause of liver-related morbidity and mortality,but there are no therapeutic targets and modalities to prevent ALD-related liver *** proliferator activated receptor(PPAR)α and δ play a key role in lipid metabolism and intestinal barrier homeostasis,which are major contributors to the pathological progression of ***,elafibranor(EFN),which is a dual PPARαand PPARδagonist,has reached a phase III clinical trial for the treatment of metabolic dysfunctionassociated steatotic liver disease and primary biliary ***,the benefits of EFN for ALD treatment is *** To evaluate the inhibitory effects of EFN on liver fibrosis and gut-intestinal barrier dysfunction in an ALD mouse *** ALD-related liver fibrosis was induced in female C57BL/6J mice by feeding a 2.5% ethanol(EtOH)-containing Lieber-DeCarli liquid diet and intraperitoneally injecting carbon tetrachloride thrice weekly(1 mL/kg)for 8 ***(3 and 10 mg/kg/day)was orally administered during the experimental *** and molecular analyses were performed to assess the effect of EFN on steatohepatitis,fibrosis,and intestinal barrier *** EFN effects on HepG2 lipotoxicity and Caco-2 barrier function were evaluated by cell-based *** The hepatic steatosis,apoptosis,and fibrosis in the ALD mice model were significantly attenuated by EFN *** promoted lipolysis and β-oxidation and enhanced autophagic and antioxidant capacities in EtOH-stimulated HepG2 cells,primarily through PPARα***,EFN inhibited the Kupffer cell-mediated inflammatory response,with blunted hepatic exposure to lipopolysaccharide(LPS)and toll like receptor 4(TLR4)/nuclear factor kappa B(NF-κB)*** improved intestinal hyperpermeability by restoring tight junction proteins and autophagy and by inhibiting apoptosis and proinflammatory *** protective effect on intestinal bar

关键词： Liver fibrosis Ethanol Gut barrier function Apoptosis Autophagy Peroxisome proliferator activated receptor

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Tumor size discrepancy between endoscopic and pathological evaluations in colorectal endoscopic submucosal dissection

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World Journal of Gastrointestinal Endoscopy 2024年第3期16卷 136-147页

作者： Takeshi Onda Osamu Goto Toshiaki Otsuka Yoshiaki Hayasaka Shun Nakagome Tsugumi Habu Yumiko Ishikawa Kumiko Kirita Eriko koizumi Hiroto Noda Kazutoshi Higuchi Jun Omori Naohiko Akimoto Katsuhiko Iwakiri Department of Gastroenterology Nippon Medical SchoolGraduate School of MedicineBunkyo-ku 113-8603TokyoJapan Endoscopy Center Nippon Medical School HospitalBunkyo-ku 113-8603TokyoJapan Department of Hygiene and Public Health Nippon Medical SchoolBunkyoku 113-8603TokyoJapan Center for Medical Education Nippon Medical SchoolBunkyo-ku 113-8603TokyoJapan

BACKGROUND Tumor size impacts the technical difficulty and histological curability of colorectal endoscopic submucosal dissection(ESD);however,the preoperative evaluation of tumor size is often different from histological *** influential factors on failure to obtain an accurate tumor size evaluation could help prepare optimal conditions for safer and more reliable *** This was a retrospective study conducted at a single institution.A total of 377 lesions removed by colorectal ESD at our hospital between April 2018 and March 2022 were *** first assessed the difference in size with an absolute per-centage of the scaling ***,we compared the clinicopatho-logical characteristics of the correct scaling group(>-33%and33%),which was further subdivided into the underscaling group(-33%or less of the discrepancy)and overscaling group(33%or more of the discrepancy),*** secondary outcome measures,parameters on size estimation were compared between the underscaling and correct scaling groups,as well as between the overscaling and correct scaling ***,multivariate analysis was performed in terms of the following relevant parameters on size estimation:Pathological size,location,and possible influential factors(P<0.1)in the univariate *** The mean of absolute percentage in the scaling discordance was 21%,and 91 lesions were considered to be incorrectly estimated in *** incorrect scaling was significantly remarkable in larger lesions(40 mm vs 28 mm;P<0.001)and less experience(P<0.001),and these two factors were influential on the underscaling(75 lesions;P<0.001).Conversely,compared with the correct scaling group,16 lesions in the overscaling group were significantly small(20 mm vs 28 mm;P<0.001),and the small lesion size was influential on the overscaling(P=0.002).CONCLUSION Lesions indicated for colorectal ESD tended to be underestimate

关键词： Endoscopic submucosal dissection Colorectal tumor Tumor size Size estimation Size discrepancy

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PROFESSOR BRITTON CHANCE AND THE EARLY TIMES HE LIVED

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Journal of Innovative Optical Health Sciences 2011年第3期4卷 215-219页

作者： HIDEAKI koizumi Hitachi Ltd.

*** Professor Britton Chance passed away on November 16,*** on July 24,1913,he was 97 years old when he died.I was honored to have had the opportunity to meet Professor Chance and have friendly conversation at the ear... 详细信息

关键词： Chance passed conversation

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Development and Practical Applications of Blue Light-Emitting Diodes

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Engineering 2015年第2期1卷 167-168页

作者： Hideaki koizumi Hitachi Ltd. Engineering Academy of Japan(EAJ)

The practical application of semiconductor-based high-efficiency white-light sources, also known as light-emitting diodes, or LEDs, is a recent development of Japanese engineering. This development could be a game-changer for lighting worldwide, given that current power consumption for lighting accounts for 16% of the total electricity consumption in Japan.

关键词： salinity gradient energy pressure-retarded osmosis reverses electrodialysis

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Engineering for Human Security and Well-Being

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Engineering 2015年第3期1卷 282-287页

作者： Hideaki koizumi Hitachi Ltd. Engineering Academy of Japan(EAJ)

For some time,I have been studying the combined concept of'human security and well-being,'which addresses people’s daily lives as a top priority,as well as the concept of'societal innovation.'The concept of'human sec... 详细信息

关键词：人类安全工程健康全球变暖流行病

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Seasonal change in sexual differences in nestling size and survival： a framework to evaluate sex-dependent environmental sensitivity in the wild

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Avian Research 2018年第2期9卷 136-143页

作者： Daisuke Nomi Teru Yuta Itsuro koizumi Graduate School of Environmental Science Hokkaido University Sapporo Hokkaido Japan Center for Toki and Ecological Restoration Niigata University Sado Niigata Japan Faculty of Environmental Earth Science Hokkaido University Sapporo Hokkaido Japan

Background: Sexual size dimorphism(SSD) occurs in a wide range of species in birds and other animals, but the magnitude of SSD often varies with environmental conditions. In general, in the developmental stages, the larger sex is more vulnerable to adverse environmental conditions because the larger sex requires more energy than the smaller sex. However, this may not hold true for birds with large brood sizes; the larger sex can acquire more food by suppressing the smaller sex. In addition, most previous studies have been experimental, such as by manipulating clutch size and ectoparasites, which may not reflect natural ***: In the present study, we propose a general framework to assess sexual differences in environmental sensitivity in natural populations. Because environmental conditions change throughout the breeding season, seasonal changes of nestling SSD and sex ratio should reflect sexual differences in environmental sensitivity. We applied this approach to a large dataset(1555 nestlings over 5 years) of Japanese Tits(Parus minor). In this population, the male nestling is generally larger than the female(5% SSD in body weight).Results: We found that the magnitude of SSD(weight, tarsus, wing) and fledgling sex ratio increased both in the beginning and the end of the breeding ***: Our study suggested that female nestlings are more valuable to poor environmental conditions in the relatively fecund species. This study underscores the importance of brood size on sexual differences in environmental stochasticity and our framework encourages comparative analysis among different bird species.

关键词： Brood size Japanese tit Parus minor Seasonal change Sexual size dimorphism

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Substantiality:A Construct Indicating Research Excellence to Measure University Research Performance

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Journal of Data and Information Science 2021年第4期6卷 76-89页

作者： Masashi Shirabe Amane koizumi Institute for Liberal Arts Tokyo Institute of TechnologyOookayama 2-12-1 W9-77MeguroTokyo 152-8550Japan Center for Novel Science Initiatives National Institutes of Natural Sciences2nd FloorHulic Kamiyacho Building 4-3-13ToranomonMinatoTokyo 105-0001Japan

Purpose:The adequacy of research performance of universities or research institutes have often been evaluated and understood in two axes:“quantity”(*** or volume)and“quality”(*** we define here as a measure of excellence that is considered theoretically independent of size or volume,such as clarity in diamond grading).The purpose of this article is,however,to introduce a third construct named“substantiality”(“ATSUMI”in Japanese)of research performance and to demonstrate its importance in evaluating/understanding research ***/methodology/approach:We take a two-step approach to demonstrate the effectiveness of the proposed construct by showing that(1)some characteristics of research universities are not well captured by the conventional constructs(“quantity”and“quality”)-based indicators,and(2)the“substantiality”indicators can capture ***,by suggesting that“substantiality”indicators appear linked to the reputation that appeared in university reputation rankings by simple statistical analysis,we reveal additional benefits of the ***:We propose a new construct named“substantiality”for measuring research *** show that indicators based on“substantiality”can capture important characteristics of research institutes.“Substantiality”indicators demonstrate their“predictive powers”on research *** limitations:The concept of“substantiality”originated from IGO game;therefore the ease/difficulty of accepting the concept is culturally *** other words,while it is easily accepted by people from Japan and other East Asian countries and regions,it might be difficult for researchers from other cultural regions to accept *** implications:There is no simple solution to the challenge of evaluating research universities’research *** is vital to combine different types of indicators to understand the excellence of research *** indicators could be part of such a c

关键词： Substantiality Research excellence University research performance Accumulation of excellent players

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Isothermal γ →ε phase transformation behavior in a Co-Cr-Mo alloy depending on thermal history during electron beam powder-bed additive manufacturing

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Journal of Materials Science & Technology 2020年第15期47卷 162-170页

作者： Yufan Zhao Yuichiro koizumi Kenta Aoyagi Kenta Yamanaka Akihiko Chiba Department of Materials Processing Graduate School of EngineeringTohoku UniversityAoba-yama 02Aoba-kuSendai980-8579Japan Institute for Materials Research Tohoku University2-1-J KatahiraAoba-kuSendai980-8577Japan

Powder bed fusion with electron beam(PBF-EB),allows Co-Cr-Mo(CCM) implants with patientcustomization to be fabricated with high quality and complex ***,the variability in the properties of PBF-EB-built CCM alloy,mainly due to the lack of understanding of the mechanisms that govern microstructural heterogeneity,brings limitations in extensive *** this study,the microstructural heterogeneity regarding the γ-fcc→ε-hcp phase transformation was *** phase transformation during PBF-EB was analyzed depending on the thermal history that was elucidated by the numerical *** revealed that isothermal γ→ε transformation occurred during the ***,the difference in γ/ε phase distribution was a result of the thermal history determining which method phase transformation was taking place,which can be influenced by the PBF-EB process *** the sample with a low energy input(Earea=2.6 J/mm2),the martensitic transformation was *** the building height increased from the bottom,the e phase fraction *** the other hand,in the sample with a higher energy input(Earea=4.4 J/mm2),the ε phase fo rmed via diffusional-massive transformation and only appea red in a short range of the lower part away from the bottom.

关键词： Powder bed fusion with electron beam Phase transformation Thermal history Numerical simulation

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