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Coconut oil as a therapeutic treatment for Alzheimer’s disease:a review

journal of Future Foods 2022年第1期2卷 41-52页

作者： Poorni Sandupama Dilusha munasinghe Madhura jayasinghe Department of Food Science and Technology Faculty of Applied SciencesUniversity of Sri JayewardenepuraNugegoda 10250Sri Lanka

The coconut tree(Cocos nucifera)which is also known as the“Tree of life”has its own values in each part of the tree and coconut oil is more prestigious among *** present,the consumption of coconut oil is booming all around the world owing to its tremendous health *** unique chemical composition of coconut oil enriched with medium chain fatty acids(MCFAs)has led to the exploration of these nutritional and therapeutic *** the long chain fatty acids(LCFAs),the MCFAs generated from the digestion of medium chain triglycerides(MCTs)has a specific pathway for the metabolism,as it bypasses the lymphatic system and enter the liver directly through the portal *** to such distinct attributes in absorption and metabolism,MCTs are readily capable of forming ketone bodies than other *** ketone bodies are a competent energy source for the brains,especially those having cognitive impairments like Alzheimer's disease(AD).AD is a neurodegenerative disease characterized clinically by accelerating shortfalls in memory and behavioral *** principal biochemical hallmarks behind the pathogenesis of AD are the development of extracellular amyloidβplaques and the accumulation of intracellular neurofibrillary *** of Cardiovascular diseases(CVD)with elevated LDL levels,hypertension,Type 2 diabetes,obesity,and insulin resistance are some key risk factors that are responsible for the increasing prevalence and incidence of *** is sufficient evidence to prove that MCTs in coconut oil are metabolized and absorbed in such a way that retards the severity of these physiological risk ***,coconut oil is endowed with many polyphenolic compounds that are serving as antioxidants by combating oxidative stress and inflammation,which in turn downregulates the etiology of *** depending on the different processing conditions applied in extraction techniques of coconut oil,variations in antioxidant capacity can take place.

关键词： Alzheimer's disease Coconut oil Medium chain triglycerides Ketone bodies

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基于二氧化碳、水、太阳能的绿色化工精炼（英文）

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化工学报 2015年第8期66卷 3225-3232页

作者：俞坚 Pradeep munasinghe 康世民夏威夷大学马诺阿分校

化石资源为人类提供了不可或缺的化学品、材料以及燃料，但也造成了大量二氧化碳排放。生物质是可以生产低碳化工产品的可再生资源，但要占用有限的可耕地资源。提出了直接以二氧化碳、水和太阳能为原料的绿色化工精炼。采用光电板收集... 详细信息

化石资源为人类提供了不可或缺的化学品、材料以及燃料，但也造成了大量二氧化碳排放。生物质是可以生产低碳化工产品的可再生资源，但要占用有限的可耕地资源。提出了直接以二氧化碳、水和太阳能为原料的绿色化工精炼。采用光电板收集太阳能并转化为电能，电能通过膜式水电解池产生氢气，氢气通入新型生物反应器并在自养菌的作用下把二氧化碳还原为聚三羟基丁酸酯（PHB）。此新型生物反应器解决了因气体溶解性低而影响传质速度的关键技术，微生物干重产出达0.18 g·L-1·h-1，其中PHB质量分数约50%。PHB不仅是优良的可生物降解塑料，也是可用于生产 C3～C4有机低分子和芳香烃的平台化合物。在磷酸催化作用下，PHB 可转化为与汽油相当热值和元素组成的C4～C16燃料油。分离PHB后的细菌生物质残渣可水热分解获得生物油和富氮水相产物。此生物油具有比植物生物油更高的热值，而水相产物可作为营养物用于培养微生物。

关键词：绿色化工生物反应器二氧化碳微生物固碳生物基产物

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Prediction of chemical composition for callus production in Gyrinops walla Gaetner through machine learning

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Information Processing in Agriculture 2020年第4期7卷 511-522页

作者： Sachithri P.munasinghe Seneviratnege Somaratne Shyama R.Weerakoon Chandani Ranasinghe Department of Botany The Open University of Sri LankaP.O.Box 21NawalaNugegoda 10250Sri Lanka Department of Chemistry The Open University of Sri LankaP.O.Box 21NawalaNugegoda 10250Sri Lanka

Developing new tissue culture protocols and optimization of plant media composition for particular plant species are precluded by the higher labor,time and *** usage of machine learning becomes rewarding tools for efficient,cost-effective method of optimization of growth media composition for desires growth *** are often encountered in determination of media composition for raising calli from explants of woody Gyrinops *** paper provides the finding of the study performed on modeling and optimization of chemical composition of culture media for raising callus from explants of *** of experiments were conducted to raise calli from sterilized leaf and node explants with varying concentrations of 1-Naphthaleneacetic acid(NAA),6-Benzylaminopurine(BAP)and coconut water in Murashige and Skoog medium(MSM)and Woody plant medium(WPM)were *** Neural Networks(ANNs)were developed to predict the best media composition on callus weight(CW),callus induction percentage(CIP)and days taken to initiate callus(DC).Callus formation was observed in all the experiments except for *** ANN models were developed to predict the best media composition for CW,CIP and *** results of ANN models predict optimum media composition during the training,validation and testing with satisfactory levels of *** R2 values of the best ANN models;CWnet,CIPnet and DCnet were 0.95,0.95 and 0.88 *** mean sums of square errors(RMSRs)of CWnet,CIPnet and DCnet were 0.1410,0.1391 and 0.1961 and mean residual(MRs)were 0.0199,0.0194 and *** corrected Akaike information criterion(AICc)of the models was331.431,254.926 and210.777,and Schwarz Bayesian information criterion(SBC)were490.495,454.229 and*** predicted best media consisting MSM+3.0 mg/l NAA+0.5 mg/l BAP and MSM+1.5 mg/l NAA+0.5 mg/l BAP were the optimum combination for leaves and nodal explants *** AICc and SBC of CWnet indicated

关键词： Gyrinops walla Gaetner Tissue culture Coconut water Woody plant Artificial neural network

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固定低剂量三联抗高血压药物与常规治疗对斯里兰卡轻度至中度高血压患者血压控制的疗效差异:一项随机临床试验

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中华高血压杂志 2018年第12期26卷 1130-1130页

作者： Web-ster R Salam A de Silva HA Selak V Stepien S Rajapakse S Amarasekara S Amarasena N Billot L de Silva AP Fernando M Guggilla R jan S jayawardena j Maulik PK Mendis S munasinghe j Naik N Prabhakaran D Ranasinghe G Thom S Tisserra N Senaratne V Wijekoon S Wijeyasingam S Rodgers A Patel A 刘莉叶鹏

控制不良的高血压是全球领先的公共卫生问题,需要新的治疗策略。该研究评估低剂量三联抗高血压药物治疗是否能达到比常规治疗更好的血压控制。研究者纳入2016年2月至2017年5月在斯里兰卡11所城市医院诊所就诊的需要开始抗高血压治疗(未... 详细信息

控制不良的高血压是全球领先的公共卫生问题,需要新的治疗策略。该研究评估低剂量三联抗高血压药物治疗是否能达到比常规治疗更好的血压控制。研究者纳入2016年2月至2017年5月在斯里兰卡11所城市医院诊所就诊的需要开始抗高血压治疗(未治疗的患者)或接受单药治疗的患者,进行低剂量三联降压与常规治疗比较的随机、开放性试验,随访至2017年10月。

关键词：高血压患者随机临床试验抗高血压药物常规治疗血压控制斯里兰卡低剂量疗效差异

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The first laboratory-confirmed neonatal Mpox infection in Sri Lanka

Infectious Medicine

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Infectious Medicine 2023年第3期2卷 237-240页

作者： Thulani Thivanshika Pattiyakumbura Denagama Vitharanage Rishan Geeth Ruwan jinadari Maduwanthi munasinghe Gamage Don Diluk Chathuranga janaki Indira Abeynayake Department of Virology Medical Research InstituteNo-527Dr Danister De Silva MawathaColombo 08Colombo 00800Sri Lanka

In 2022-2023,a global outbreak of Mpox was reported especially in nonendemic *** report the first laboratory-confirmed neonatal case of Mpox infection complicated by bronchopneumonia in Sri Lanka.

关键词： Mpox Neonatal case of Mpox infection Sri Lanka Global outbreak 2022-2023

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