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Soluble Human Leukocyte Antigen-G Expression in Pregnancy Success and Early Pregnancy Loss in Korle-Bu Teaching Hospital

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Open Journal of Immunology 2016年第1期6卷 1-6页

作者： Abdul-Rahman Mubarak Irene Sitsofe Blebu kareem mumuni Yao Tettey Richard Kwasi Gyasi Andrew Anthony Adjei Michael Ofori Department of Pathology School of Biomedical and Allied Health Sciences University of Ghana Accra Ghana Department of Obstetrics and Gynaecology School of Medicine and Dentistry University of Ghana Accra Ghana Department of Immunology Noguchi Memorial Institute of Medical Research Accra Ghana

Introduction: Human leukocyte antigen G (HLA-G) is a non-classical major histocompatibility complex (MHC) class Ib antigen characterized by a limited polymorphism. The expression of HLA-G at immune privileged sites and its ability to inhibit the effectors functions of immune cells has set HLA-G as a molecule of immune tolerance. This expression pattern is unique among HLA genes and suggests that HLA-G may be involved in interactions that are critical in establishing and/or maintaining pregnancy. Methods: Soluble HLA-G (sHLA-G) levels were measured using a BioVendor sHLA-G ELISA kit following the manufacturer’s protocol. The study participants include women undergoing spontaneous abortion, non-pregnant women, males and an archive sample of women who had normal vaginal deliveries without any complications and any history of malaria infection from gestation to delivery. Results: Soluble HLA-G levels were higher among women undergoing spontaneous abortion as compared to women who had normal vaginal delivery and non-pregnant women. Soluble HLA-G levels were also higher in second trimester as compared to first trimester in both women who had spontaneous abortions and women who had normal delivery. Conclusion: Although sHLA-G levels were higher among women undergoing spontaneous abortion as compared to non-pregnant women and women who had normal delivery, this may be playing a role in the maintenance of maternal immune tolerance to fetal antigen, since plasma sHLA-G levels increased with increasing trimester in both women who had normal delivery and women undergoing spontaneous abortion.

关键词： Soluble Human Leukocyte Antigen G (sHLA-G) Spontaneous Abortion Maternal Immune Tolerance Implantation

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Intraligamentary Pregnancy with Recurrent Urine Retention: Case Report

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Open Journal of Obstetrics and Gynecology 2021年第5期11卷 516-522页

作者： Salma Abdi Mahmoud Adam Munkaila Ali M. Ussi Chukwuma J. Okafor Gumanga Solomon mumuni kareem Ali Said Yussuf Osman Saia Department of Obstetrics and Gynaecology School of Health and Medical Sciences The State University of Zanzibar Zanzibar Tanzania Department of Obstetrics and Gynaecology University for Development Study Tamale Teaching Hospital Tamale Ghana Department of Natural Sciences The State University of Zanzibar Zanzibar Tanzania Department of Pathology and Biochemistry School of Health and Medical Sciences The State University of Zanzibar Zanzibar Tanzania Department of Anaesthesia Tamale Teaching Hospital Tamale Ghana

An intraligamentary pregnancy is an extremely rare form of ectopic pregnancy, with only a few cases reported. We report a 20-year-old woman who had an ongoing pregnancy at about 22 weeks gestation, consulted for recurrent urinary retention and severe lower abdominal pain of two days duration. Pelvic ultrasonography revealed an extrauterine gestation of 19 weeks and four days on the left adnexal region. Exploratory laparotomy was performed that found left intraligamentary pregnancy (unruptured) measured 20 - 25 cm across, attached posteriorly to the bowel (sigmoid colon) and extended to the pouch of douglas impinging on the bladder base. Resection of ectopic pregnancy was successfully performed, urine retention resolved, and the patient was discharged with no postoperative complications. Early recognition of this rare form of ectopic gestation is of considerable importance because of the risk of a life-threatening haemorrhagic complication necessitating emergency surgical intervention.

关键词： Intraligamentary Pregnancy Urine Retention Ultrasonography

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