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Going only half the way:cell cycle exit after the G1 restriction point

Signal Transduction and Targeted Therapy 2024年第1期9卷 1-2页

作者： Lisa muller Tony Gutschner mechthild Hatzfeld Department of Pathobiochemistry Institute of Molecular MedicineMartin Luther University Halle-WittenbergCharles Tanford Protein Research CenterHalleGermany Department of RNA Biology and Pathogenesis Institute of Molecular MedicineMartin Luther University Halle-WittenbergCharles Tanford Protein Research CenterHalleGermany

In a recent article published in Nature,James *** et *** that cyclin A2 levels determine whether cells will make an entrance into mitosis or whether cells will leave the cell cycle after having passed the G1/restriction(R)-point implicating that the decision is fully reversible(Fig.1).This ground-breaking study could impact future approaches for cancer treatment by targeting the mitotic clock.

关键词： point cycle

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Feature selection for energy system modeling: Identification of relevant time series information

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能源与人工智能(英文) 2021年第2期4卷 16-29页

作者： Inga m.muller Chair of Renewable and Sustainable Energy Systems Technical University of MunichAccisstrasse 21Munich 80333Germany

Heuristic or clustering based time series aggregation methods are often used to reduce temporal complexity of energy system models by selecting representative ***,these methods potentially neglect relevant information of time series(e.g.,distribution parameters).To identify relevant time series parameters,feature selection algorithms can be *** present research contributes by(a)developing a new feature selection approach based on clustering,nested modeling and regression(CNR)which is designed for applications requiring high selectivity and using different data sets,(b)comparing and evaluating CNR with feature selection methods available from the literature(e.g.,LASSO)and(c)identifying relevant information of the time series applied in energy system models,in particular those of demand,photovoltaic and *** show that CNR achieves on average up to 101%lower mean absolute errors when methods are directly ***,CNR better identifies relevant information when the number of selected features is *** disadvantage of CNR,however,is its high computational effort.A potential remedy to counter this is the combination with another method(e.g.,as pre-feature selection).In terms of relevant information,energy systems including photovoltaic are mainly characterized by the correlation between demand and photovoltaic time series as well as the range and the 35%quantile of *** energy systems include wind power,the minimum and mean of wind as well as the correlation between demand and wind time series are relevant *** implications of these findings are discussed.

关键词： Energy system modeling Feature selection Time series analysis Nested modeling Clustering Regression Intermittent renewable energies

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Liver transplantation as an alternative for the treatment of neuroendocrine liver metastasis: Appraisal of the current evidence

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Hepatobiliary & Pancreatic Diseases International 2024年第2期23卷 146-153页

作者： Philip C.muller matthias Pfister Dilmurodjon Eshmuminov Kuno Lehmann Department of Surgery and Transplantation University Hospital ZurichRämistrasse 100Zurich CH-8091Switzerland

Background:Liver transplantation(LT)for neuroendocrine liver metastases(NELm)is still in *** comparing LT with liver resection(LR)for NELm are scarce,as patient selection is heterogeneous and experience is *** goal of this review was to provide a critical analysis of the evidence on LT versus LR in the treatment of *** sources:A scoping literature search on LT and LR for NELm was performed with Pubmed,including English articles up to march ***:International guidelines recommend LR for NELm in resectable,well-differentiated tumors in the absence of extrahepatic metastatic disease with superior results of LR compared to systemic or liver-directed *** liver surgery has extended resectability criteria whilst entailing increased perioperative risk and short disease-free *** highly selected patients(based on the milan criteria)with unresectable NELm,oncologic results of LT are *** factors include tumor biology(G1/G2)and burden,waiting time for LT,patient age and extrahepatic *** on low-level evi-dence,LT for low-grade NELm within the milan criteria resulted in improved disease-free survival and overall survival compared to *** benefits of LT were lost in patients beyond the milan ***:With adherence to strict selection criteria especially tumor biology,LT for NELm is becoming a valuable option providing oncologic benefits compared to *** evidence suggests even stricter selection criteria with regard to tumor biology.

关键词： Liver transplantation Neuroendocrine liver metastases Liver resection Selection criteria Tumor biology

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Excess dietary Lys reduces feed intake, stimulates jejunal CCK secretion and alters essential and non‑essential blood AA profile in pigs

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Journal of Animal Science and Biotechnology 2024年第3期15卷 1336-1346页

作者： maximiliano muller Elout Van Liefferinge Alan Tilbrook Robert van Barneveld Eugeni Roura Centre for Nutrition and Food Sciences Queensland Alliance for Agriculture and Food InnovationThe University of QueenslandBrisbaneQueensland 4072Australia Laboratory of Animal Nutrition and Animal Product Quality(LANUPRO) Department of Animal Sciences and Aquatic EcologyGhent University339000 GhentFlandersBelgium Centre for Animal Science Queensland Alliance for Agriculture and Food Innovation and the School of Veterinary ScienceThe University of QueenslandBrisbaneQueensland 4072Australia SunPork Group BrisbaneQueensland 4009Australia

Background Commercial diets are frequently formulated to meet or exceed nutrient levels including those of lim-iting essential amino acids(AA)covering potential individual variations within the ***,the provision of dietary excess of AA,such as Lys,may lead to reduced appetite and growth in *** mechanisms modulat-ing these responses have not been extensively *** study evaluated the effect of Lys dietary excesses on performance and satiety biomarkers in post weaning *** Twenty-four pigs aged 21 d and weighing 6.81±0.12kg(mean±SEm)were individually housed and offered 1 of 4 dietary treatments for 3weeks:a diet containing a standardized ileal digestible Lys reaching 100%(T0),120%(T1),150%(T2)or 200%(T3)of the NRC(2012)*** the end of the experiment,blood samples from the cephalic vein of the T0 and T3 groups were obtained for AA *** addition,primary intestinal cultures from T0 pigs were used,following their humane killing,to evaluate the effect of Lys on gut hormone secretion and AA sensors gene expression under ex vivo *** Feed intake was linearly reduced(Pmetabotropic glutamate receptor 1 and the solute carrier family 7 member 2(Pmal jejunum tissues incubated with Lys at 20mmol/L when compared to the control(Lys 0mmol/L).Plasma Lys and Glu(Pmpared to T0 *** contrast,plasma levels of His,Val,Thr,Leu(Pm that excess dietary Lys inhibits hunger in ***,the results provide evidence of pre-and post-absorptive mechanisms modulating these *** dietary excesses should be nar-rowed,when possible,to avoid negative effects of

关键词： Amino acid Blood Cholecystokinin Feed intake Lysine Pig Satiety

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Energy Dissipation of P- and S-Waves in Fluid-Saturated Rocks: An Overview Focusing on Hydraulically Connected Fractures

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Journal of Earth Science 2015年第6期26卷 785-790页

作者： J.German Rubino Beatriz Quintal Tobias m.muller Luis Guarracino Ralf Janicke Holger Steeb Klaus Holliger Applied and Environmental Geophysics Group Institute of Earth Sciences University of Lausanne Energy Flagship Commonwealth Scientific and Industrial Research Organization CONICET Facultad de Ciencias Astronomicasy Geofisicas Universidad Nacional de La Plata Institute of mechanics University of Bochum

An important characteristic of fractured rocks is their high seismic attenuation, which so far has been mainly attributed to wave-induced fluid flow（WIFF） between the fractures and the embedding matrix. The influence of fracture connectivity on seismic attenuation has, however, recently, only been investigated. Numerical compressibility and shear tests based on Biot＇s quasi-static poro-elastic equations illustrate that an important manifestation of WIFF arises in the presence of fracture connectivity. The corresponding energy loss, which can be significant for both P- and S-waves, is mainly due to fluid flow within the connected fractures and is sensitive to the permeabilities as well as the lengths and intersection angles of the fractures. Correspondingly, this phenomenon contains valuable information on the governing hydraulic properties of fractured rocks and hence should be accounted for whenever realistic seismic models of such media are needed.

关键词： fractured rocks seismic attenuation WIFF fracture connectivity embedding matrix Biot’s theory

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A cross-sectional analysis of the effectiveness of a nutritional support programme for people with tuberculosis in Southern madagascar using secondary data from a non-governmental organisation

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Infectious Diseases of Poverty 2024年第1期13卷 101-102页

作者： mara Anna Franke Julius Valentin Emmrich Fierenantsoa Ranjaharinony Onja GbrilleRavololohanitra Harizaka Emmanuel Andriamasy Samuel Knauss Nadine muller Global Digital Health Lab at Charité Center for Global Health Charité – Universitätsmedizin Berlin Berlin Germany London School of Hygiene and Tropical medicine London UK Ärzte Für madagaskar E.V. Leipzig Germany Heidelberg Institute of Global Health Heidelberg University Heidelberg Germany Berlin Institute of Health at Charité - Universitätsmedizin Berlin Berlin Germany Doctors for madagascar Antananarivo Madagascar Speciality Network: Infectious Diseases and Respiratory medicine Charité - Universitätsmedizin Berlin Berlin Germany

Background There is a strong,bi-directional link between tuberculosis(TB)and undernutrition:TB often causes undernutrition,and undernourished people are more likely to contract TB and experience worse ***,several TB nutritional support programmes exist;however,evidence on their effectiveness is limited and *** study evaluates the effect of a nutritional support programme implemented for people with TB in the Atsimo-Andrefana region,madagascar in *** this programme,undernourished people with TB[with a body mass index(BmI)ofm]receive 0.6 L of vegetable oil and 6.0 kg of a soy-wheat blend per month throughout their TB *** We analysed secondary non-governmental organisation data collected between January and Novem-ber 2022 in the Atsimo-Andrefana region,Southern madagascar,including information on an individual's medical conditions(e.g.,type of TB,treatment outcomes)and nutritional status measured prior to,during,and after comple-tion of treatment(e.g.,height,weight,mid-upper arm circumference).We conducted descriptive analyses of patient baseline characteristics and outcomes to assess the impact of the provided nutritional support on the BmI of people With *** A total of 1310 people with TB were included in the study[9.9%(130)children under the age of 5,32.1%(420)children between 5 and 18 years,58.0%(760)adults].55.4% of children under 5,28.1% of children between ages 5 and 18,and 81.3%of adults were undernourished at treatment initiation.42.3%(55/130)of children under 5 experi-enced severe acute malnutrition at treatment *** the average Bml of adults with TB receiving food support increased over time,from 17.1 kg/m^(2)(interquartile range:15.8-18.3,range:10.3-22.5)to 17.9 kg/m^(2)(interquartile range:16.6-19.1,range:11.9-24.1),most adults remained undernourished even after completing TB *** The current TB nutritional support programme falls short of sufficiently increasing the Bm

关键词： Tuberculosis Sub-Saharan Africa Undernutrition Nutritional support

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《德语语言大纲》

《德语语言大纲》

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作者： muller,m. L.Wertenshlag

＜正＞出版社:德国Langenscheidt出版社出版时间:2002年第一版/2005年第二版《德语语言大纲》是欧洲首次以某一欧洲语言的教学为例对欧洲语言共同参考框架中统一衡量外语能力的标准进行具体阐释、补充和创新,实施并发展了欧洲语言共同...

＜正＞出版社:德国Langenscheidt出版社出版时间:2002年第一版/2005年第二版《德语语言大纲》是欧洲首次以某一欧洲语言的教学为例对欧洲语言共同参考框架中统一衡量外语能力的标准进行具体阐释、补充和创新,实施并发展了欧洲语言共同参考框架。该书针对德语语言教学制定,使语言教授者针对学习者不同的需求制定学习目标,归纳语言表达手段,确定教学用书和考试要求,并为教学提供实例,启发教学思路。《大纲》将理解、表达、互动和语言中介四种能力与A1—C2六个

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Ecological impact of land reclamation on Jiangsu coast(China):A novel ecotope assessment for Tongzhou Bay

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Water Science and Engineering 2020年第1期13卷 57-64页

作者： Jos R.m.muller Yong-ping Chen Stefan G.J.Aarninkhof Ying-Chi Chan Theunis Piersma Dirk S.van maren Jian-feng Tao Zheng Bing Wang Zheng Gong Faculty of Civil Engineering and Geosciences Delft University of TechnologyDelft 2600 GAthe Netherlands Baggermaatschappij Boskalis BV Papendrecht 3350 AEthe Netherlands College of Harbor Coastal and Offshore EngineeringHohai UniversityNanjing 210098China Groningen Institute for Evolutionary Life Sciences(GELIFES) University of GroningenGroningen 9700 CCthe Netherlands Department of Coastal Systems NIOZ Royal Netherlands Institute for Sea Research and Utrecht UniversityDen Burg 1790 ABthe Netherlands Unit of marine and Coastal Systems DeltaresDelft 2600 MHthe Netherlands

China’s continuous and rapid economic growth has led to the reclamation of large sections of the intertidal mud coast in combination with port construction,such as that of the proposed Tongzhou Bay port on the Jiangsu *** reclamations threaten the local ecosystem *** ecotope distribution map was created and a hydrodynamic numerical model of Tongzhou Bay was set up to quantify the impacts of reclamation on the *** on the field data and model results,several abiotic features were classified into 11 ecotopes and visualized in an ecotope map of the Tongzhou Bay *** with spatial distributions of two threatened shorebird species(bar-tailed godwit and great knot) showed confirmation with the mid-range and low-range littoral zones(inundated from 40% to 100% of a tidal cycle),indicating the importance of the areas with these conditions to these *** the ecotope map with recent and proposed land reclamation schemes revealed a loss of ecotopes,composed of the high-range(42%),mid-range(48%),and low-range(38%) littoral habitats,corresponding to a 44%-45% loss of the most important ecotopes for bar-tailed godwit and great knot(mid-range and low-range littoral zones).These results confirm the applicability of the novel ecotope assessment approach in practice.