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NURBS Modeling and Curve Interpolation Optimization of 3D Graphics

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Computers, Materials & Continua 2021年第2期66卷 1799-1811页

作者： Hao Zhu mulan wang Kun Liu Weiye Xu School of Information and Communication Engineering Nanjing Institute of TechnologyNanjing211167China Jiangsu Key Laboratory of Advanced Numerical Control Technology Nanjing Institute of TechnologyNanjing211167China Department of informatics University of LeicesterLeicesterLE17RHUK

In order to solve the problem of complicated Non-Uniform Rational B-Splines(NURBS)modeling and improve the real-time performance of the high-order derivative of the curve interpolation process,the method of NURBS modeling based on the slicing and layering of triangular mesh is *** research and design of NURBS curve interpolation are carried out from the two aspects of software algorithm and hardware *** on the analysis of the characteristics of traditional computing methods with Taylor series expansion,the Adams formula and the Runge-Kutta formula are used in the NURBS curve interpolation process,and the process is then optimized according to the characteristics of NURBS *** can ensure accuracy,and avoid the calculation of higher-order ***,the hardware modules for the Adams and Runge-Kutta formulas are designed by using the parallel hardware construction technology of Field Programmable Gate Array(FPGA)*** parallel computing process using FPGA is compared with the traditional serial computing process using *** and experimental results show that this scheme can improve the computational speed of the system and that the algorithm is feasible.

关键词： NURBS modeling interpolation Adams Runge-Kutta FPGA

Postmarketing studies on safety of Dengfeng~ shenmai injection

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Journal of Traditional Chinese Medicine 2013年第6期33卷 827-831页

作者： Lianxin wang Wen Zhang Yanming Xie Yang Bai mulan wang Qinghua Ai Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical Sciences Marketing Department Research Department of Chiatai Qingchunbao Pharmaceutical Company Ltd.

OBJECTIVE: To systematically research the postmarketing safety of Dengfeng shenmai injection, identify potential risk factors, and ensure its clinical safety. METHODS: We investigated a comprehensive series of studies on the production process, quality standards, pharmacology, postmarketing clinical studies, and safety evaluation of Shenmai injection, including literature analysis of adverse drug reaction(ADR) case analysis and systematic review. Data from the hospital information system(HIS) and spontaneous reporting system(SRS) were also analyzed. RESULTS: The approximate dosage leading to death in dogs is 45.0-67.5 g raw drug/kg and the toxic reactions are restlessness, skin irritation, salivation, and vomiting. The results of chronic toxicity tests in mice and dogs, and the other tests such as 6-month toxicity, drug safety, genetic toxicity, and reproductive toxicity of rats and dogs, were positive or qualified. Patient ADR history and ADR family history were closely associated with itching based on the data analysis from SRS. There was no damage to renal function from Shenmai injection use at a dosage and a treatment course outside the recommended dosage and treatment course as specified based on data analysis from HIS. The most common ADR from Shenmai injection are difficulty breathing, facial flushing, nausea, vomiting, chest tightness, skin itching, rash, and back pain. CONCLUSION: This study includes complete information on Shenmai injection ADR incidence rate. We found that Shenmai injection is safe and this study can provide clinical, research, and production institutions with an objective, reliable, and scientific basis for use of Shenmai injection.

关键词： Product surveillance, postmarketing Medicine, Chinese traditional Safety Shenmai in-jection

基于滑模干扰观测器的直线伺服系统滑模速度控制仿真研究

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机械设计与制造工程 2024年第6期53卷 34-38页

作者：余卓周磊汪木兰卜又亮南京工程学院江苏省先进数控技术重点实验室江苏南京211167 南京工程学院工业中心江苏南京211167 南京工程学院自动化学院江苏南京211167

为了减小永磁同步直线电机伺服系统的速度跟踪误差,提出了一种基于滑模干扰观测器的滑模控制方法。首先,建立直线电机的数学模型。其次,针对直线电机具有参数时变、内部状态耦合的非线性特性,设计了滑模控制器。然后,考虑到直线电机伺... 详细信息

为了减小永磁同步直线电机伺服系统的速度跟踪误差,提出了一种基于滑模干扰观测器的滑模控制方法。首先,建立直线电机的数学模型。其次,针对直线电机具有参数时变、内部状态耦合的非线性特性,设计了滑模控制器。然后,考虑到直线电机伺服系统存在的多种扰动,设计了滑模干扰观测器用于估计扰动,并将观测器的扰动估计值作为速度控制器的前馈补偿,以消除扰动对系统的影响。最后的仿真结果表明,所提出的控制方法能提高直线电机速度控制系统的静态性能和抗干扰性。

关键词：直线电机滑模控制滑模干扰观测器速度控制

Submergence induced changes of molecular species in membrane lipids in Arabidopsis thaliana

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Plant Diversity 2016年第3期38卷 156-162页

作者： mulan wang Yunmei Shen Faqing Tao Shengchao Yang Weiqi Li Yunnan Research Center on Good Agricultural Practice for Dominant Chinese Medicinal Materials Yunnan Agriculture University Kunming 650201 China Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of Botany Chinese Academy of Sciences Kunming 650201 China Department of Biology Honghe University Mengzi 661100 China Germplasm Bank of Wild Species Kunming Institute of Botany Chinese Academy of Sciences Kunming 650201 China

The composition of membrane lipids is sensitive to environmental *** is a type of stress often encountered by ***,how the molecular species of membrane lipids respond to submergence has not yet been *** this study,we used a lipidomic approach to profile the molecular species of membrane lipids in whole plants of Arabidopsis thaliana that were completely submerged for three *** plants survived one day of submergence,after which,we found that the total membrane lipids were only subtly decreased,showing significant decreases of monogalactosyldiacylglycerol(MGDG)and phosphatidylcholine(PC)and an increase of phosphatidic acid(PA);however,the basic lipid composition was *** contrast,three days of submergence caused plants to die,and the membranes deteriorated via the rapid loss of 96% of lipid content together with a 229% increase in *** turnover of molecular species from PG and MGDG to PA indicated that submergenceinduced lipid changes occurred through PA-mediated *** addition,molecular species of extraplastidic PG degraded sooner than plastidic ones,lyso-phospholipids exhibited various patterns of change,and the double-bond index(DBI)remained unchanged until membrane *** results revealed the unique changes of membrane lipids upon submergence and suggested that the major cause of the massive lipid degradation could be anoxia.

关键词： Submergence Anoxia stress Membrane lipids Lipidomics Arabidopsis thaliana

Spatiotemporal variation in snow cover and its effects on grassland phenology on the Mongolian Plateau

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Journal of Arid Land 2021年第4期13卷 332-349页

作者： SA Chula MENG Fanhao LUO Min LI Chenhao wang mulan ADIYA Saruulzaya BAO Yuhai College of Geographical Science Inner Mongolia Normal UniversityHohhot 010022China Inner Mongolia Key Laboratory of Remote Sensing and Geographic Information System Inner Mongolia Normal UniversityHohhot 010022China Institute of Geography and Geoecology Mongolian Academy of ScienceUlaanbaatar 15170Mongolia

Snow cover is an important water source for vegetation growth in arid and semi-arid areas,and grassland phenology provides valuable information on the response of terrestrial ecosystems to climate *** Mongolian Plateau features both abundant snow cover resources and typical grassland *** recent years,with the intensification of global climate change,the snow cover on the Mongolian Plateau has changed correspondingly,with resulting effects on vegetation *** this study,using MOD10A1 snow cover data and MOD13A1 Normalized Difference Vegetation Index(NDVI)data combined with remote sensing(RS)and geographic information system(GIS)techniques,we analyzed the spatiotemporal changes in snow cover and grassland phenology on the Mongolian Plateau from 2001 to *** correlation analysis and grey relation analysis were used to determine the influence of snow cover parameters(snow cover fraction(SCF),snow cover duration(SCD),snow cover onset date(SCOD),and snow cover end date(SCED))on different types of grassland *** results showed wide snow cover areas,an early start time,a late end time,and a long duration of snow cover over the northern Mongolian ***,a late start,an early end,and a short duration were observed for grassland phenology,but the southern area showed the opposite *** SCF decreased at an annual rate of 0.33%.The SCD was shortened at an annual rate of 0.57 *** SCOD and SCED in more than half of the study area advanced at annual rates of 5.33 and 5.74 DOY(day of year),*** grassland phenology,the start of the growing season(SOS)advanced at an annual rate of 0.03 DOY,the end of the growing season(EOS)was delayed at an annual rate of 0.14 DOY,and the length of the growing season(LOS)was prolonged at an annual rate of 0.17 *** SCF,SCD,and SCED in the snow season were significantly positively correlated with the SOS and negatively correlated with the EOS and *** SCOD was significantly negative

关键词： snow cover fraction snow cover phenology vegetation phenology grey relation grade climate change Mongolian Plateau

白头翁皂苷B4对大鼠局灶节段性肾小球硬化的保护作用及机制研究

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江西中医药 2024年第9期55卷 60-65,71页

作者：李俊左沙沙何北兰王木兰龚琴江西中医药大学药学院南昌330006 中药固体制剂制造技术国家工程研究中心南昌330006

目的:通过单侧肾摘除联合多柔比星(ADR)诱导建立大鼠局灶节段性肾小球硬化(FSGS)模型,探讨白头翁皂苷B4对大鼠局灶节段性肾小球硬化的保护作用及其机制。方法:采用单侧肾摘除联合尾静脉注射ADR诱导建立FSGS模型;造模14 d后,白头翁皂苷B... 详细信息

目的:通过单侧肾摘除联合多柔比星(ADR)诱导建立大鼠局灶节段性肾小球硬化(FSGS)模型,探讨白头翁皂苷B4对大鼠局灶节段性肾小球硬化的保护作用及其机制。方法:采用单侧肾摘除联合尾静脉注射ADR诱导建立FSGS模型;造模14 d后,白头翁皂苷B4连续给药28 d,每周测定血清尿素氮(BUN)、血肌酐(Cre)、血清总蛋白(TP)、血清白蛋白(ALB)、尿蛋白含量;糖原染色(PAS)及马松染色(Masson)检查肾脏病理学变化;免疫组化检测肾脏caspas-3表达情况;Western Blot法检测肾脏组织中nephrin、podocin、p53、Bcl-2、Bax、caspase-3及尿液中nephrin和podocin蛋白表达水平。结果:白头翁皂苷B4可以升高FSGS大鼠血清中TP和ALB的水平(P<0.05),降低Cre、BUN含量,改善肾脏组织病理变化,减轻FSGS肾小球基底膜不规则增厚及肾小管损伤等病变;降低FSGS大鼠尿液中nephrin、podocin蛋白表达(P<0.01,P<0.05),提高肾脏nephrin、podocin蛋白表达(P<0.01,P<0.05);降低肾脏组织中caspasse-3、p53蛋白表达,上调Bcl-2/Bax蛋白比值(P<0.01,P<0.05)。结论:白头翁皂苷B4对ADR所致的FSGS具有显著保护作用,其作用机制可能通过改善肾小球足细胞nephrin、podocin的表达,抑制肾脏细胞凋亡实现。

关键词：白头翁皂苷B4 局灶节段性肾小球硬化肾小球足细胞凋亡

特发性肺纤维化的发病机制及中药调节作用研究进展

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中国实验方剂学杂志 2024年第10期30卷 280-289页

作者：邹恩国黄天宇王木兰查晨亮龚琴朱卫丰冯育林刘良徛李俊江西中医药大学南昌330006 江西中医药大学中药固体制剂制造技术国家工程研究中心南昌330006 江西中医药大学附属医院南昌330006

特发性肺纤维化(IPF)作为一种肺部进行性疾病,预后不佳,目前尚无可靠手段进行根治。当下治疗IPF以器官移植和给予化学药为主,但效果欠佳且不良反应颇多,无法满足目前的临床需求。因此,开发更安全、有效的药物已成为亟需解决的问题,而研... 详细信息

特发性肺纤维化(IPF)作为一种肺部进行性疾病,预后不佳,目前尚无可靠手段进行根治。当下治疗IPF以器官移植和给予化学药为主,但效果欠佳且不良反应颇多,无法满足目前的临床需求。因此,开发更安全、有效的药物已成为亟需解决的问题,而研究IPF的发病机制将有助于新药的开发。现阶段关于IPF发病机制的研究主要集中在巨噬细胞极化、上皮-间质转化(EMT)、氧化应激和自噬作用等方面,但对于系统说明各发病机制原理及揭示各机制存在的联系尚未有研究报道。中医理论认为“气虚血瘀”“气阳虚弱”是IPF的关键病机,故临床常采用益气活血、温阳补气和祛瘀化痰类等中药或复方治疗IPF。现代药理学研究表明,此类中药在抑制巨噬细胞极化、改善氧化还原平衡、抑制EMT和调节细胞自噬等方面可发挥积极作用,但针对中药如何调节相关通路而治疗IPF,目前尚无系统的报道。该文通过总结国内外最新文献,将逐一并系统的阐述IPF的发病机制,同时更全面的概述中药中有效成分或复方调节IPF的作用机制。针对IPF的发病机制,结合中药的调节作用,着重挖掘系统治疗IPF的方案,以期为IPF的深入研究及相关药物研发提供新的思路。

关键词：特发性肺纤维化(IPF) 发病机制中药作用机制巨噬细胞极化上皮-间质转化(EMT) 氧化应激自噬

温肺化纤颗粒通过调控TGF-β1/Smad信号通路改善肺纤维化

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中国医院药学杂志 2024年第12期44卷 1398-1404页

作者：李俊黄天宇王木兰龚琴查晨亮冯育林朱卫丰刘良徛熊磊江西中医药大学药学院江西南昌330006 江西中医药大学中药固体制剂制造技术国家工程研究中心江西南昌330006 江西中医药大学附属医院江西南昌330006 江西省药品认证审评中心江西南昌330006

目的:探究温肺化纤颗粒抗博来霉素诱导小鼠肺纤维化的作用及其机制。方法:将C57BL/6J雄性小鼠随机分为Control组、Model组、WFHX-low-dose(12.5 g·kg^(–1))组、WFHX-high-dose(50 g·kg^(–1))组以及吡非尼酮(Pirfenidone,180 mg·kg^(–1))组,采用气管插管法灌注博来霉素(0.75 mg·kg^(–1))建立肺纤维化模型。自造模第2天起灌胃给药干预,持续给药28 d。HE和Masson染色法检测肺组织肺泡炎及纤维化程度;RT-qPCR法检测肺组织白细胞介素-6(IL-6)、肿瘤坏死因子α(TNF-α)、胶原蛋白Ⅰ(collagenⅠ)以及上皮间质转化(epithelial-mesenchymal transition,EMT)相关标志物的mRNA表达;Western blot法检测肺组织IL-6、TNF-α、CollagenⅠ、EMT相关标志物以及转化生长因子β1(transforming growth factorβ1,TGF-β1)/Smad信号通路相关蛋白表达;免疫组织化学染色法(IHC)检测p-Smad3、Smad7表达。结果:与Control组比较,Model组的组织纤维化评分显著升高,IL-6、TNF-α、collagenⅠ以及间质标志物纤维连接蛋白(fibronectin,Fn)、波形蛋白(vimentin)、α-平滑肌肌动蛋白(α-SMA)的mRNA及蛋白表达水平显著上调(P<0.01),上皮标志物钙黏蛋白E(E-cadherin)显著下调(P<0.05)。同时,TGF-β1与p-Smad2、p-Smad3蛋白表达增加,Smad7表达减少;与Model组比较,给药干预后显著降低了肺组织纤维化程度,并且WFHX给药组均在不同程度上改善上述因子的表达,显著抑制炎症因子IL-6、TNF-α释放,减轻肺组织炎症反应,减少collagenⅠ的分泌,改善EMT,减少TGF-β1生成并抑制Smad2、Smad3磷酸化,上调Smad7的表达。结论:温肺化纤颗粒可通过减轻炎症反应,抑制EMT,抑制TGF-β1/Smad信号通路发挥抗纤维化作用。

关键词：肺纤维化温肺化纤颗粒转化生长因子-β1/Smad 上皮-间质转化细胞外基质

Identification of bioactive anti-angiogenic components targeting tumor endothelial cells in Shenmai injection using multidimensional pharmacokinetics

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Acta Pharmaceutica Sinica B 2020年第9期10卷 1694-1708页

作者： Chongjin Zhong Chao Jiang Suiying Ni Qizhi wang Lingge Cheng Huan wang Qixiang Zhang Wenyue Liu Jingwei Zhang Jiali Liu mulan wang Min Jin Peiqiang Shen Xuequan Yao Guangji wang Fang Zhou Key Laboratory of Drug Metabolism and Pharmacokinetics State Key Laboratory of Natural MedicinesChina Pharmaceutical UniversityNanjing 210009China Department of Digestive Tumor Surgery Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210029China Chiatai Qingchunbao Pharmaceutical Co. Ltd.Hangzhou 310023China

Shenmai injection(SMI)is a well-defined herbal preparation that is widely and clinically used as an adjuvant therapy for ***,we found that SMI synergistically enhanced the activity of chemotherapy on colorectal cancer by promoting the distribution of drugs in xenograft ***,the underlying mechanisms and bioactive constituents remained *** the present work,the regulatory effects of SMI on tumor vasculature were determined,and the potential anti-angiogenic components targeting tumor endothelial cells(TECs)were *** pharmacokinetic profiles of ginsenosides in plasma,subcutaneous tumors,and TECs were *** results showed that the concentrations of protopanaxadiol-type(PPD)ginsenosides(Rb1,Rb2/Rb3,Rc,and Rd)in both plasma and tumors,were higher than those of protopanaxatriol-type(Rg1 and Re)and oleanane-type(Ro)*** PPD-type ginsenosides,Rd exhibited the greatest concentrations in tumors and TECs after repeated *** vivo bioactivity results showed that Rd suppressed neovascularization in tumors,normalized the structure of tumor vessels,and improved the anti-tumor effect of 5-fluorouracil(5 FU)in xenograft ***,Rd inhibited the migration and tube formation capacity of endothelial cells in *** conclusion,Rd may be an important active form to exert the anti-angiogenic effect on tumor after SMI treatment.

关键词： Shenmai injection Ginsenoside Rd Multidimensional pharmacokinetics Anti-angiogenic Tumor endothelial cell