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Anti-endothelial cell antibody rich sera from rheumatic heart disease patients induces proinflammatory phenotype and methylation alteration in endothelial cells

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Genes & Diseases 2018年第3期5卷 275-289页

作者： mukul rastogi Subendu Sarkar Ankita Makol Rana Sandip Singh Uma Nahar Saikia Dibyajyoti Banerjee Seema Chopra Anuradha Chakraborti Department of Experimental Medicine and Biotechnology Postgraduate Institute of Medical Education and ResearchChandigarh160012India Department of Cardiothoracic and Vascular Surgery Postgraduate Institute of Medical Education and ResearchChandigarh160012India Department of Histopathology Postgraduate Institute of Medical Education and ResearchChandigarh160012India Department of Obstetrics and Gynaecology Postgraduate Institute of Medical Education and ResearchChandigarh160012India

Rheumatic heart disease(RHD)is a major cause of cardiovascular morbidity and mortality in developing nations like *** commonly affects the mitral valve which is lined by a single layer of endothelial cells(ECs).The role of ECs in mitral valve damage during RHD is not well *** here,anti-endothelial cell antibody from RHD patients has been used to stimulate the ECs(HUVECs and HMVECs).ECs proinflammatory phenotype with increased expression of TNFa,IL-6,IL-8,IFNg,IL-1b,ICAM1,VCAM1,E-selectin,laminin B,and vimentin was documented in both *** promoter hypomethylation of various key inflammatory cytokines(TNFa,IL-6,and IL-8),integrin(ICAM1)associated with leukocyte transendothelial migration,and extracellular matrix genes(vimentin,and laminin)were also ***,the in-vitro data was in accordance with ex-vivo observations which correlated significantly with the etiological factors such as smoking,socioeconomic status,and ***,the study sheds light on the role of ECs in RHD which is a step forward in the elucidation of disease pathogenesis.

关键词： Anti-Endothelial cell antibodies DNA methylation Endothelial cells Inflammation Rheumatic heart disease

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