检索结果-南通市图书馆

Coagonist of glucagon-like peptide-1 and glucagon receptors ameliorates kidney injury in murine models of obesity and diabetes mellitus

引用

World Journal of Diabetes 2018年第6期9卷 80-91页

作者： Vishal J Patel Amit A Joharapurkar Samadhan G Kshirsagar Brijesh K Sutariya Maulik S Patel Hiren M Patel Dheerendra K Pandey rajesh H Bahekar mukul r jain Department of Pharmacology and Toxicology Zydus Research CentreCadila Healthcare Limited

AIM To investigate the role of glucagon-like peptide-1(GLP-1)/glucagon receptors coagonist on renal dysfunction associated with diabetes and obesity. METHODS Chronic high-fat diet fed C57 BL/6 J mice, streptozotocintreated high-fat diet fed C57 BL/6 J mice and diabeticC57 BLKS/J db/db mice were used as models of diabetes-induced renal dysfunction. The streptozotocintreated high-fat diet fed mice and db/db mice were treated with the GLP-1 and glucagon receptors coagonist(Aib2 C24 Chimera2, 150 μg/kg, sc) for twelve weeks, while in chronic high-fat diet fed mice, coagonist(Aib2 C24 Chimera2, 150 μg/kg, sc) treatment was continued for forty weeks. Kidney function, histology, fibrosis, inflammation, and plasma biochemistry were assessed at the end of the treatment. rESULTS Coagonist treatment decreased body weight, plasma lipids, insulin resistance, creatinine, blood urea nitrogen, urinary albumin excretion rate and renal lipids. In kidney, expression of lipogenic genes(SrEBP-1 C, FAS, and SCD-1) was decreased, and expression of genes involved in β-oxidation(CPT-1 and PPAr-α) was increased due to coagonist treatment. In plasma, coagonist treatment increased adiponectin and FGF21 and decreased IL-6 and TNF-?. Coagonist treatment reduced expression of inflammatory(TNF-α, MCP-1, and MMP-9) and pro-fibrotic(TGF-β, COL1 A1, and α-SMA) genes and also improved histological derangement in renal *** Coagonist of GLP-1 and glucagon receptors alleviated diabetes and obesity-induced renal dysfunction by reducing glucose intolerance, obesity, and hyperlipidemia.

关键词： Coagonist Glucagon renal dysfunction Glucagon-like peptide-1 Insulin sensitivity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A review on re-emerging bacteriophage therapy in the era of XDr

引用

生物细胞(英文) 2023年第9期47卷 1915-1930页

作者： POOJA BHADOrIYA rICHA SHArMA rEKHA MEHrOTrA SIMrAN KAUr ISHA SrIVASTAVA mukul jain PrASHANT KAUSHIK Department of Microbiology Shaheed Rajguru College of Applied Sciences for WomenUniversity of DelhiVasundhara EnclaveNew Delhi110096India Lab-209 Cell&Developmental biology labCenter of Research for DevelopmentParul UniversityVadodara391760GujaratIndia Instituto de Conservacióny Mejora de la Agrodiversidad Valenciana Universitat Politècnica de ValènciaValencia46022Spain

In the present medicine world antibiotic resistance is one of the key threats to universal health *** continue to work hard to combat this global health *** therapy,an age-old practice during the early twentieth century,was outshined by the discovery of *** the advent of widespread antibiotic resistance,phage therapy has again redeemed itself as a potential alternative owing to its adeptness to target bacteria *** side effects,the ability to migrate to different body organs,a distinct mode of action,and proliferation at the infection site,make phages a profitable candidate to replace conventional *** progressive outcome of numerous in vitro studies and case reports has validated the clinical efficacy of phage *** bright perspective of using phages to treat bacterial infections has fueled enormous medical research to exploit their potential as *** gaps in the information about phages and the lack of consent for clinical trials is major hurdle for consideration of phage *** phage therapy as a reality in medicine requires a coordinated effort from different *** this review,we aim to emphasize the importance of phage therapy in modern *** review explains their historical journey,basic phage biology,cross-talk with the host immunity,obstacles with phage therapy,and their possible *** data on the various significant clinical trials of phage therapy has been *** evaluated the efficacy of antibiotics and phage therapy in part and in combination,along with recent progress and future perspectives of phage therapy.

关键词： Bacteriophages Antibiotic resistance Phage biology Phage therapy Phage therapy clinical trials Phage therapy in India

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A six months old neglected anterior shoulder dislocation managed by closed reduction and Latarjet procedure

引用

Chinese Journal of Traumatology 2016年第5期19卷 295-297页

作者： Deepak Chaudhary Deepak Joshi Vineet jain mukul Mohindra Nitin Mehta Sports Injury Center Safdarjung Hospital and VMM College New Delhi India

忽视的肩膀脱臼是一个更稀罕的实体，仅仅很少案例在文学被报导。肩膀的前面的脱臼很少在诱拐和外部旋转作为与手足在场的病人被错过，对整形外科的外科医生很熟悉的态度。当时，偶尔，如此的案例被错过他们与近似肱骨的骨折在场或当他... 详细信息

忽视的肩膀脱臼是一个更稀罕的实体，仅仅很少案例在文学被报导。肩膀的前面的脱臼很少在诱拐和外部旋转作为与手足在场的病人被错过，对整形外科的外科医生很熟悉的态度。当时，偶尔，如此的案例被错过他们与近似肱骨的骨折在场或当他们从通常在农村区域练习的全然的专业人员接受治疗时。由于很少的报告，有文学的少量，没有标准治疗协议为肩膀的忽视的前面的脱臼存在，尽管最如此的长期的案例被开的减小管理。这份案例报告与重要的山 Sachs 损害描述六个月旧的忽视的前面的脱臼，它被关上的减小和 Latarjet 过程管理。

关键词：肩膀脱臼肱骨的破裂 Latarjet 过程

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Probiotics:A new tool to combat against COVID-19 disease

引用

Asian Toxicology Tesearch 2022年第1期4卷 1-6页

作者： Patil Nil mukul jain Parul Institute of Applied Sciences Parul UniversityVadodaraGujaratIndia Lab 209 cell&development biology labCentre of Research for DevelopmentParul UniversityVadodaraGujaratIndia

During this COVID-19 pandemic’s,scientists and researchers are developing vaccines and with help of country's health ministry and *** try to reach out vaccination throughout the country but this process should take some ***,until vaccination can done we have to protect our immune *** the year,2021 people may also get an infection of the third wave of COVID,which is a chance to ***,protecting our immunity and decreasing the severity of infection is the priority for that developing a new approach is ***,probiotics(Lactobacillus plantarum&Bifidobacterium breve)are good option for the person having post Covid Symptoms without side *** probiotics can help people for developing immunity against COVID-19 *** probiotics dosages are useful to patient because these probiotics are easily available,easy to administrate and it is useful in severe condition as well as in mild condition.

关键词： COVID-19 Probiotic Lactobacillus plantarum Bifidobacterium breve Cytokine Chemokine

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：