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Nonalcoholic Fatty Liver Disease after Liver Transplant

Journal of Clinical and Translational Hepatology 2021年第3期9卷 428-435页

作者： Akshay Shetty Fanny Giron mukul K.divatia Muhammad I.Ahmad Sudha Kodali David Victor Department of Medicine Sherrie and Alan Conover Center for Liver Disease and TransplantationHouston Methodist HospitalHoustonTXUSA Department of Medicine Houston Methodist HospitalHoustonTXUSA Department of Pathology and Genomic Medicine Weill Cornell Medical CollegeHouston Methodist HospitalHoustonTXUSA

Nonalcoholic fatty liver disease(NAFLD)is one of the most common causes of chronic liver disease in the *** rising prevalence of nonalcoholic steatohepatitis(NASH)has led to a 170%increase in NASH cirrhosis as the listing indication for liver transplantation from 2004 to *** of 2018,NASH has overtaken hepatitis C as an indication for liver transplantation in the *** liver transplantation,the allograft often develops recurrent NAFLD among patients with known NASH *** addition to recurrent disease,de novo NAFLD has been reported in patients with other indications for liver *** this review,we will discuss the risk factors associated with recurrent and de novo NAFLD,natural course of the disease,and management strategies after liver transplantation.

关键词： Nonalcoholic fatty liver disease Nonalcoholic steatohepatitis Posttransplant Recurrent NAFLD De novo NAFLD Recurrent NASH De novo NASH

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Renal cell carcinoma: Evolving and emerging subtypes

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World Journal of Clinical Cases 2013年第9期1卷 262-275页

作者： Suzanne M Crumley mukul divatia Luan Truong Steven Shen Alberto G Ayala Jae Y Ro Department of Pathology and Genomic Medicine Houston Methodist Hospital Weill Cornell Medical College of Cornell University

Our knowledge of renal cell carcinoma(RCC) is rapidly expanding. For those who diagnose and treat RCC, it is important to understand the new developments. In recent years, many new renal tumors have been described and defined, and our understanding of the biology and clinical correlates of these tumors is changing. Evolving concepts in Xp11 translocation carcinoma, mucinous tubular and spindle cell carcinoma, multilocular cystic clear cell RCC, and carcinoma associated with neuroblastoma are addressed within this review. Tubulocystic carcinoma, thyroid-like follicular carcinoma of kidney, acquired cystic disease-associated RCC, and clear cell papillary RCC are also described. Finally, candidate entities, including RCC with t(6;11) translocation, hybrid oncocytoma/chromophobe RCC, hereditary leiomyomatosis and RCC syndrome, and renal angiomyoadenomatous tumor are reviewed. Knowledge of these new entities is important for diagnosis, treatment and subsequent prognosis. This review provides a targeted summary of new developments in RCC.

关键词： Renal cell carcinoma Subtypes Xp11 translocation Mucinous tubular and spindle cell Multilocular cystic clear cell Carcinoma associated with neuroblastoma recently described entities Clear cell papillary renal cell carcinoma Acquired cystic kidney disease Hereditary leiomyomatosis Candidate entities Renal cell carcinoma with t(6 11)translocation

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Adenoid cystic carcinoma of breast: Recent advances

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World Journal of Clinical Cases 2014年第12期2卷 732-741页

作者： Kosuke Miyai Mary R Schwartz mukul K divatia Rose C Anton Yong Wook Park Alberto G Ayala Jae Y Ro Department of Pathology and Genomic Medicine Houston Methodist Hospital Weill Medical College of Cornell UniversityHouston TX 77030 United States Department of Basic Pathology National Defense Medical College Saitama 359-0042 Japan Department of Pathology Hanyang University Guri Hospital 153 Gyeongchun-ro Guri Gyeonggi-do 471-701 South Korea

Adenoid cystic carcinoma(ACC) of the breast is a rare special subtype of breast cancer characterized by the presence of a dual cell population of luminal and basaloid cells arranged in specific growth patterns. Most breast cancers with triple-negative, basal-like breast features(i.e., tumors that are devoid of estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 expression, and express basal cell markers) are generally high-grade tumors with an aggressive clinical course. Conversely, while ACCs also display a triple-negative, basal-like phenotype, they are usually low-grade and exhibit an indolent clinical behavior. Many discoveries regarding the molecular and genetic features of the ACC, including a specific chromosomal translocation t(6;9) that results in a MYB-NFIB fusion gene, have been made in recent years. This comprehensive review provides our experience with ACC of the breast, as well as an overview of clinical, histopathological, and molecular genetic features.

关键词： Adenoid cystic carcinoma Breast Triplenegative and basal-like phenotype Histology Molecular genetic features

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