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In Vitro Propagation and Artificial Seed Production of Fritillaria cirrhosa D. Don, an Endangered medicinal Plant

Phyton-International Journal of Experimental Botany 2024年第6期93卷 1297-1310页

作者： Qian Tao Guiqi Han Bujin ma Hongmei Jia Can Zhao Wenshang Li Zhuyun Yan Chengdu University of Traditional Chinese medicine State Key Laboratory of Characteristic Chinese Medicine Resources in Southwest ChinaChengdu610000China

Fritillaria cirrhosa ***(Liliaceae)is an endangered perennial bulbous plant and its dry bulb is a valuable med-icinal material with antitussive and expectorant ***,lack of resources and expensive prices make it difﬁcult to meet clinical *** study presents a regeneration system a.med at overcoming the challenge of inadequate supply in ***,focusing on:(1)callus induction,(2)bulblets and adventitious bud induction,and(3)artiﬁcial seed *** development was achieved in 84.93%on Murashige and Skoog(MS)medium fortiﬁed with 1.0 mg·L^(-1) *** optimal medium for callus differentiation into regenerated bulb-lets was MS medium supplemented with 1.0 mg·L^(-1)6-benzyladenine(6-BA)and 0.2 mg·L^(-1)α-naphthaleneacetic acid(NAA).Subsequently,bulblets and adventitious buds were induced from regenerated bulblet sections cul-tured on MS medium fortiﬁed with 0.3 mg·L^(-1)6-BA+1.0 mg·L^(-1)2,4-dichlorophenoxyacetic acid(2,4-D),2.0 mg·L^(-1)6-BA+0.5 mg·L^(-1),and the induction rates were 88.17%and 84.24%,*** regenerated bulblets were transplanted into a substrate of humus soil,river sand,and pearlite(1:1:1)after low-temperature *** germination rate was 42.80%after culture for 30 *** bulblets were used for encap-sulations in liquid MS medium containing 3%sucrose(w/v)+0.5 mg·L^(-1) NAA+2.0 mg·L^(-1)6-BA+3%sodium alginate(w/v)with a 10 min exposure to 2%CaCl_(2).Under non-aseptic conditions,the germination rate reached 81.67%,while the rooting rate was 20.56%after 45 *** capsule added 1.0 g·L^(-1) carbendazim and 1.0 g·L^(-1) activated carbon was the best component of artiﬁcial *** study successfully established an efﬁcient regen-eration system for the rapid propagation of ***,involving in vitro bulblet regeneration and artiﬁcial seed *** method introduces a novel approach for efﬁcient breeding and germplasm preservation,making it suitable for large-scale industrial resou

关键词： Artiﬁcial seed callus induction Fritillaria cirrhosa organogenesis plant propagation

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Experimental Study on Corrosion of Stainless Steel in Low Temperature Multi effect Seawater Desalination

Frontiers of Metallurgical Industry

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Frontiers of Metallurgical Industry 2024年第2期2卷 25-31页

作者： Shiyi Zhang Xinggang ma Baowu Group Shanxi Taigang Stainless Steel Co. Ltd.Cold Rolling Plant

Starting from the corrosion mechanism,this paper analyzes the characteristics of various types of stainless steel and selects the best performance composite plate composite plate stainless *** and select the most suitable corrosion detection method based on specific practical multi working conditions,discuss the interference factors that affect metal corrosion during experimental simulation,and the advantages of newly developed sheet *** new development of composite board panels,with the substrate and composite materials applying their respective capabilities for med,will bring breakthrough progress to the scientific research and engineering applica-tion of composite boards.

关键词： seawater desalination corrosion mechanism of stainless steel composite board lamination corrosion rate

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Impact of calcification on the diagnostic accuracy of quantitative flow fraction based on coronary CT angiography

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China.medical Abstracts(Internal medicine) 2024年第1期41卷 1-2页

作者：马文珊 Sch med Imaging Binzhou Med UnivYantai 264003

Objective To investigate the effect of calcification on the diagnostic accuracy of the quantitative flow fraction (CT-QFR) derived from coronary CT angiography(CCTA).Methods A total of 244 patients (471 coronary arteries) who underwent both CCTA and invasive coronary angiography(ICA) for suspected coronary artery disease between 2019 and 2021 were included in the *** analyses were conducted at the vessel level using CCTA and ICA images.

关键词： coronary angiography arteries

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Combination of AAV-delivered tumor suppressor PTEN with anti-PD-1 loaded depot gel for enhanced antitumor immunity

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Acta Pharmaceutica Sinica B 2024年第1期14卷 350-364页

作者： Yongshun Zhang Lan Yang Yangsen Ou Rui Hu Guangsheng Du Shuang Luo Fuhua Wu Hairui Wang Zhiqiang Xie Yu Zhang Chunting He Cheng ma Tao Gong Ling Zhang Zhirong Zhang Xun Sun Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial TechnologyWest China School of PharmacySichuan UniversityChengdu 610041China med-X Center for materials College of Polymer Science and EngineeringSichuan UniversityChengdu 610065China

Recent clinical studies have shown that mutation of phosphatase and tensin homolog deleted on chromosome 10(PTEN)gene in cancer cells may be associated with immunosuppressive tumor microenvironment(TME)and poor response to immune checkpoint blockade(ICB)***,efficiently restoring PTEN gene expression in cancer cells is critical to improving the responding rate to ICB ***,we screened an adeno-associated virus(AAV)capsid for efficient PTEN gene delivery into B16F10 tumor *** demonstrated that intratumorally injected AAV6-PTEN successfully restored the tumor cell PTEN gene expression and effectively inhibited tumor progression by inducing tumor cell immunogenic cell death(ICD)and increasing immune cell ***,we developed an anti-PD-1 loaded phospholipid-based phase separation gel(PPSG),which formed an in situ depot and sustainably release anti-PD-1 drugs within 42 days in *** order to effectively inhibit the recurrence of melanoma,we further applied a triple therapy based on AAV6-PTEN,PPSG^(@anti-PD-1)and CpG,and showed that this triple therapy strategy enhanced the synergistic antitumor immune effect and also induced robust immune memory,which completely rejected tumor *** anticipate that this triple therapy could be used as a new tumor combination therapy with stronger immune activation capacity and tumor inhibition efficacy.

关键词： Triple therapy Adeno-associated virus PTEN PPSG@anti-PD-1 CpG Immunogenic cell death Antitumor immune response Immune memory

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改性赤泥负载Pt催化剂催化氧化甲苯的性能

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中国环境科学 2024年第3期44卷 1244-1252页

作者：方宏萍梁文俊马琛马连刚李桂贤贵州理工学院资源与环境工程学院贵州贵阳550003 北京工业大学环境与生命学部区域大气复合污染防治北京市重点实验室北京100124

以改性赤泥为载体,采用浸渍方法制备低成本改性赤泥(MRM)负载Pt催化剂,并探究Pt含量对Pt/MRM催化剂催化氧化甲苯活性影响.结果表明0.4Pt/MRM表现出最佳的催化活性,在230℃时甲苯转化率为100%.当空速高达120000h^(-1)时0.4Pt/MRM催化剂... 详细信息

以改性赤泥为载体,采用浸渍方法制备低成本改性赤泥(MRM)负载Pt催化剂,并探究Pt含量对Pt/MRM催化剂催化氧化甲苯活性影响.结果表明0.4Pt/MRM表现出最佳的催化活性,在230℃时甲苯转化率为100%.当空速高达120000h^(-1)时0.4Pt/MRM催化剂依然能保持着较高的催化活性.当甲苯进口浓度为5000mg/m3时仍可以有效氧化甲苯.采用XRD、FT-IR、BET、H2-TPR和O2-TPD等手段进行表征测试分析发现,MRM的比表面积较RM大幅度提高,使MRM能够更好分散活性组分Pt,成为合适的活性组分Pt的催化剂载体.同时所制备的x Pt/MRM催化剂具有较高的比表面积和良好的孔结构.改性赤泥中Fe_(2)O_(3)与活性组分Pt物种相互作用,使催化剂的总氧解吸量增大,提高了催化剂表面氧的迁移率,从而提高了催化效率.

关键词：改性赤泥 Pt 催化燃烧甲苯

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Analysis of clinical phenotype and genotype of PAX2 mutation in Chinese children

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China.medical Abstracts(Internal medicine) 2024年第2期41卷 113-114页

作者：马雪晴 Nephrol Div Dept PediatrTongji HospTongji Med CollHuazhong Univ Sci&TechnolWuhan 430030

Objective To analyze and summarize the clinical,genotypic and pathological characteristics of children with PAX2 gene mutation in China,and to provide information for the monitoring,treatment and prognosis of the *** It was a case series analysis *** clinical data of children with PAX2 gene mutation in Pediatric Nephrology Department,TongijHi ospital Affiliatedd toTongji medicalCollege,HIuazhong University of Science and Technology from January 2014 to December 2022 were collected,and peripheral blood gene DNA was extracted and sequenced for whole exome *** clinical,pathological and genotypic characteristics of PAX2 gene variation of children in China were summarized by searching Pubmed,medline,China National Knowledge Infrastructure and Wanfang database and compared with the cases in this single *** Among the 13 children with PAX2 gene mutation,there were 9 males and 4 females,12 patients with abnormal urine tests,7 patients with small kidney volume by imaging examination,and 5 patients with renal *** clinical phenotypes were congenital renal and urinary tract malformations in 8 cases,renal coloboma syndrome in 1case,and hematuriaor proteinuria in 3 *** patients underwent renal biopsies,showing focal segmental glomerulosclerosis and C33glomerulopathy in1 case,focal segmental glomerulosclerosis in 1 case,thin basement membrane lesion in 1 case,and IgA nephropathy in 2 cases.

关键词： PAX2 clinical urine

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Serum ECM1 is a promising biomarker for staging and monitoring fibrosis in patients with chronic hepatitis B

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Science China Life Sciences 2024年

作者： Lian Liu Danyan Zhang Rong Fan Shipeng Cheng Jichao Yang Liyan ma Zhiyang Ling Yaguang Zhang Jinlin Hou Xiaomei Wang Bing Sun Junqi Niu Shanghai Institute of Biochemistry and Cell Biology Centre for Excellence in Molecular Cell Science Chinese Academy of Sciences University of Chinese Academy of Sciences School of Life Science and Technology ShanghaiTech University Department of Infectious Disease Nanfang Hospital Southern Medical University med-X Institute Centre for Immunological and Metabolic Diseases The First Affiliated Hospital of Xi'an Jiaotong University Xi'an Jiaotong University Hepatology Department Centre of Infectious Diseases and Pathogen Biology First Hospital of Jilin University

It is critical to assess the extent and progression of liver fibrosis for patients to receive suitable treatments, but its diagnostic methods remain unmet. Extracellular matrix protein 1（ECM1） has previously been reported to be a key factor in the induction and progression of liver fibrosis. However, little is known about the use of ECM1 as a biomarker to evaluate fibrosis. In a CCl4-induced mouse model of liver fibrosis, the present study demonstrated that ECM1 decreased with gradually increasing fibrosis. Using biopsy as a reference, the serum ECM1 levels decreased with increasing fibrosis stage in 247 patients with liver fibrosis, but there were no significant changes between fibrosis stage 2 and stage 0–1. To improve the performance of ECM1, age, platelet count, and ECM1 concentration were combined to calculate an EPA（ECM1-platelet-age） score（ranging from 0 to 10）. The areas under the receiver operating characteristic curve of the EPA scores for the detection of F≥2, F≥3, and F4 were 0.6801, 0.7377, and 0.8083, respectively, which showed a comparable or significantly greater diagnostic performance for assessing fibrosis than that of the AST/ALT ratio, APRI score, or FIB-4 score. In HBV patients following antiviral treatment, the dynamics of the EPA score depended on the status of liver fibrosis development. The accuracy of the EPA score in predicting fibrosis regression and progression was 66.00% and 71.43%, respectively, while that of the LSM, another useful method for monitoring hepatic fibrosis changes during treatment, was only 52.00% and 7.14%, respectively. Compared with healthy controls, there were lower levels of serum ECM1 in HBV patients and individuals with HCV infection, maFLD, ALD, PBC, and DILI. These findings suggested that individuals with reduced ECM1 levels may have a risk of developing liver injury, and further examinations or medical care are *** conclusion, the ECM1-containing EPA score is a valuable noninvasive test for staging fibros

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Analysis and optimal synthesis of single loop spatial mechanisms

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2011年第9期12卷 665-679页

作者： med Amine LARIBI Lotfi ROMDHANE Sad ZEGHLOUL Laboratoire de Génie Mécanique LAB-MA-05 Ecole Nationale d'Ingénieurs de Sousse Institut Pprime-UPR 3346 CNRS-Université de Poitiers-ENSMA Département Génie Mécanique et Systémes Complexes SP2MIBP30179 86962 Futuroscope France

In this work, a systematic approach is presented to obtain the input-output equations of a single loop 4-bar spatial mechanisms. The dialytic method along with Denavit-Hartenberg parameters can be used to obtain these equations efficiently. A genetic algorithm （GA） has been used to solve the problem of spatial mechanisms synthesis. Two types of mechanisms, e.g., RSCR and RSPC （R： revolute; S： spherical; C： cylindrical; P： prismatic）, have illustrated the application of the GA to solve the problem of function generation and path generation. In some cases, the GA method becomes trapped in a local minimum. A combined GA-fuzzy logic （GA-FL） method is then used to improve the final result. The results show that GAs, combined with an adequate description of the mechanism, are well suited for spatial mechanism synthesis problems and have neither difficulties inherent to the choice of the initial feasible guess, nor a problem of convergence, as it is the case for deterministic methods.

关键词： Spatial mechanisms Genetic algorithm-fuzzy logic (GA-FL) method Denevit-Hartenberg parameters Mechanism synthesis

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Research progress of severe acute respiratory syndrome coronavirus 2 on aerosol collection and detection

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Chinese Chemical Letters 2024年第1期35卷 108-115页

作者： Xinyu Zhang Yuting Chen Yueying Pan Xinye ma Gui Hu Song Li Yan Deng Zhu Chen Hui Chen Yanqi Wu Zhihong Jiang Zhiyang Li Hunan Key Laboratory of Biomedical Nanomaterials and Devices Hunan University of TechnologyZhuzhou 412007China State Key Laboratory of Quality Research in Chinese medicine Macao University of Science and TechnologyMacao 999078China Shenzhen Lemniscare med Technol Co.Ltd. Shenzhen 518000China Department of Clinical Laboratory the Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjing 210008China

The outbreak of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)in late 2019 has negatively affected people's lives and *** the mode of transmission of SARS-CoV-2 is of great concern,this review discusses the sources of virus aerosols and possible transmission ***,we discuss virus aerosol collection methods,including natural sedimentation,solid impact,liquid impact,centrifugal,cyclone and electrostatic adsorption ***,we review common virus aerosol detection methods,including virus culture,metabolic detection,nucleic acid-based detection and immunology-based detection ***,possible solutions for the detection of SARS-CoV-2 aerosols are ***-of-care testing has long been a focus of *** the near future,the development of an instrument that integrates sampling and output results will enable the real-time,automatic monitoring of patients.

关键词： Virus aerosol Aerosol transmission Aerosol collection Aerosol detection Protective measure

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合成生物学赋能:从学科发展到产业转化

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中国科学院院刊 2024年第5期39卷 851-861页

作者：熊燕马雪晴陈大明刘晓赵国屏中国科学院上海营养与健康研究所上海生命科学信息中心上海200031 中国科学院大学北京100049 中国科学院上海营养与健康研究所生物医学大数据中心上海200031 中国科学院分子植物科学卓越创新中心上海200032

合成生物学通过引入工程科学“自下而上”认识生命体系的理念,在生命科学研究中采用“设计—构建—测试—学习”迭代的研究范式,并在基因组和系统生物学的基础上,构建工程化的新生命体系,为生命科学提供了“从创造到理解”的新途径,不... 详细信息

合成生物学通过引入工程科学“自下而上”认识生命体系的理念,在生命科学研究中采用“设计—构建—测试—学习”迭代的研究范式,并在基因组和系统生物学的基础上,构建工程化的新生命体系,为生命科学提供了“从创造到理解”的新途径,不仅颠覆了从整体到局部的“格物致知—还原论”的传统研究策略,还开启了理解生命本质的“建物致知”新文化。同时,合成生物学将生物技术由“模拟自然过程”和“遗传工程改造”上升至“定量理性设计”和“标准化构建测试”的高度,推动生物工程和代谢工程朝着对标生命过程的高效率、普适性的工程化“重编程”,甚至是“从头构建”的新高度,以实现“建物致用”的目标。文章梳理了合成生物学近年来在生命科学基础研究中“建物致知”方面的重要进展,列举了其在化工、医药、食品、环境等应用领域中“建物致用”的具体案例,展现了合成生物学对人类社会全面发展正在发挥的重大影响,强调了为确保合成生物学的健康、快速发展,构建会聚生态系统与治理体系的重要性。

关键词：合成生物学赋能会聚创新生态系统

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