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A review of neglected tropical diseases:filariasis

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Asian Pacific Journal of Tropical Medicine 2011年第7期4卷 581-586页

作者： Anish Chandy Alok singh Thakur mukesh Pratap singh Ashish Manigauha School of Pharmacy Chouksey Engineering CollegeBilaspurChattishgarhIndia NRI College of Pharmacy BhopalIndia

Filariasis is result of parasitic infection caused by three specific kinds of round *** filariasis is found in under developed region of South America,Central Africa,pacific and *** has been found for centuries,with main symptoms as elephant like swelling of the arms,legs and *** is estimate that 120 millions peoples in the world have lymphatic *** spread of diseases and the challenge encountered in its management are discussed along with a review on drugs against filariasis in this *** on clinical effect of drugs on the infection,safety profile,status in clinical practices and drug resistances are also covered.

关键词： Filariasis Parasite Treatment Pathophysiology Drugs Ivermectin

Monitoring and modeling of urban sprawl through remote sensing and GIS in Kuala Lumpur, Malaysia

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Ecological Processes 2015年第1期4卷 165-174页

作者： mukesh singh Boori Maik Netzband Komal Choudhary Vít Voženílek Palacky University Olomouc 17.listopadu 5077146 OlomoucCzech Republic Geographical Institute Ruhr University BochumBochumGermany Samara State Aerospace University SamaraRussia

Introduction:Kuala Lumpur is currently experiencing a large-scale urban *** study explores a multi-buffer ring method to investigate the spatial and temporal dynamics of urban growth in the Kuala Lumpur metropolitan area by using Geographical Information Systems(GIS)and remote sensing imageries from1989 to ***:The first Landsat images from 1989,2001,and 2014 were classified with maximum likelihood classification to produce land cover maps and identify four types of land cover:urban/built-up,agriculture,forest,and ***,the area coverage for all the land use types at different points in time were measured and combined with distance from the city *** on,urbanization densities from the city center to the outside for every 1-km distance from 1 to 50 km are ***:City density on the distance of 5,8,15,20,and 30 km was very high in the years 1989 and ***,urban expansion shows fast and slow growth stages with high-speed growth shifting to the east side of the ***:In general,the population,traffic conditions,industrialization,and policy are the major factors thatinfluenced the urban expansion.

关键词： Urbanization Landsat Change detection Remote Sensing GIS

Banach Λ-Frames for Operator Spaces

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Advances in Pure Mathematics 2014年第8期4卷 373-380页

作者： mukesh singh Renu Chugh Department of Mathematics Goverment College Bahadurgarh India Department of Mathematics Maharishi Dayanand University Rohtak India

The Banach frame for a Banach space X can reconstruct each vector in X by the pre-frame operator or the reconstruction operator. The Banach Λ-frame for operator spaces was introduced by Kaushik, Vashisht and Khattar [Reconstruction Property and Frames in Banach Spaces, Palestine Journal of Mathematics, 3(1), 2014, 11-26]. In this paper we give necessary and sufficient conditions for the existence of the Banach Λ-frames. A Paley-Wiener type stability theorem for Λ-Banach frames is discussed.

关键词： Frames Banach Frames Reconstruction Property Perturbation

Liquid Metal Grid Patterned Thin Film Devices Toward Absorption‑Dominant and Strain‑Tunable Electromagnetic Interference Shielding

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Nano-Micro Letters 2024年第11期16卷 541-553页

作者： Yuwen Wei Priyanuj Bhuyan Suk Jin Kwon Sihyun Kim Yejin Bae mukesh singh Duy Thanh Tran Minjeong Ha Kwang‑Un Jeong Xing Ma Byeongjin Park Sungjune Park Department of Polymer‑Nano Science and Technology Department of Nano Convergence EngineeringJeonbuk National UniversityJeonju 54896Republic of Korea School of Chemical Engineering Sungkyunkwan University(SKKU)Suwon 16419Republic of Korea Composites Research Division Korea Institute of Materials ScienceChangwon 51508Republic of Korea School of Materials Science and Engineering Gwangju Institute of Science and TechnologyGwangju 61005Republic of Korea School of Materials Science and Engineering and Sauvage Laboratory for Smart MaterialsHarbin Institute of Technology(Shenzhen)ShenzhenGuangdong 518055People’s Republic of China

The demand of high-performance thin-film-shaped deformable electromagnetic interference(EMI)shielding devices is increasing for the next generation of wearable and miniaturized soft *** highly reflective conductive materials can effectively shield EMI,they prevent deformation of the devices owing to rigidity and generate secondary electromagnetic pollution ***,soft and stretchable EMI shielding thin film devices with absorption-dominant EMI shielding behavior is *** devices consist of liquid metal(LM)layer and LM grid-patterned layer separated by a thin elastomeric film,fabricated by leveraging superior adhesion of aerosol-deposited LM on *** devices demonstrate high electromagnetic shielding effectiveness(SE)(SE_(T) of up to 75 dB)with low reflectance(SER of 1.5 dB at the resonant frequency)owing to EMI absorption induced by multiple internal reflection generated in the LM grid ***,the excellent stretchability of the LM-based devices facilitates tunable EMI shielding abilities through grid space adjustment upon strain(resonant frequency shift from 81.3 to 71.3 GHz@33%strain)and is also capable of retaining shielding effectiveness even after multiple strain *** newly explored device presents an advanced paradigm for powerful EMI shielding performance for next-generation smart electronics.

关键词： Absorption-dominant electromagnetic interference shielding Liquid metals Soft and stretchable electronics Thin film devices Tunable electromagnetic interference shielding

Grand Unified Database Model

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Grand Unified Database Model

Effect of random movement and cooperative hunting in the prey-predator system:A dynamical approach

2011 Third Pacific-Asia Conference on Circuits, Communications and System

作者： Shilp Dixit mukesh Kumar singh BTA Deloitte Consulting LLP.

currently there exists no single model to represent a database and it ancillary systems. One has to resort to a number of conceptual models to depict the system based on requirements. Through this paper we present the alternate ways of viewing and visualizing a database in its entirety making use of the thickness of the screen as an additional dimension. One of our prime motives is also to inculcate an additional methodology for imbibing database knowledge among beginners. The alternate view of the conceptual model described in this paper can also be used to find relationships, distinguishing features and other points of interest among database tables, views, warehouses, schema and transformations.

关键词： Databases Database technologies database modeling three dimensional database design

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International Journal of Biomathematics 2024年第3期17卷 211-240页

作者： Shivam Teekam singh mukesh Kumar Department of Mathematics Graphic Era Deemed to be University 566/6 Bell RoadSociety AreaClenent Town DehradunUttarakhand 248002India Department of Computer Science and Engineering Graphic Era Deemed to be University 566/6 Bell RoadSociety AreaClement Town DehradunUttarakhand 248002India

Self-diffusion prerequisite is obtained as the spreading approach of biological *** hunting is a common behavior in predator populations that promotes predation and the coexistence of the prey-predator *** the other side,the Allee effect among prey may cause the system to become *** this paper,a difusive prey predator system with cooperative hunting and the weak Allee effect in prey populations is *** linear stability and Hopf-bifurcation analysis had been used to examine the system's *** the spatial stability of the system,the conditions for Turing instability have been *** multiple-scale analysis has been used to derive the amplitude equations of the *** stability analysis of these amplitude equations leads to the formation of Turing ***,numerical simulations are used to analyze spatial patterns forming in 1-D and *** studies indicate that the model can generate a complex pattern structure and that self-diffusion has a drastic impacton species distribution.

关键词： Prey predator system hunting cooperation Allee effect Hopf-bifurcation diffusive instability amplitudeequation

Trigonometric tension B-spline collocation approximations for time fractional Burgers’equation

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Journal of Ocean Engineering and Science 2024年第5期9卷 508-516页

作者： Brajesh Kumar singh mukesh Gupta School of Physical and Decision Sciences Department of MathematicsBabasaheb Bhimrao Ambedkar University Lucknow 226025(UP)INDIA

This manuscript’s aim is to form and examine the numerical simulation of Caputo-time fractional nonlinear Burgers’equation via collocation approach with trigonometric tension B-splines as base ***,L 1 discretization formula is utilized for the time fractional derivative and after linearizing the nonlinear term,the trigonometric tension B-spline interpolants are utilized to get a system of simultaneous linear equations that are solved via Gauss elimination ***,numerical approximation at the desired time level is *** is demonstrated via von-Neumann approach that proposed scheme produces stable *** results of six different test examples having their analytical solutions are compared with the results in the literature to validate the accuracy and efficiency of the scheme.

关键词： Fractional Burgers’equation Trigonometric tension B-spline Collocation scheme Gauss elimination method

Meta-QTL analysis for mining of candidate genes and constitutive gene network development for fungal disease resistance in maize(Zea mays L.)

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The Crop Journal 2023年第2期11卷 511-522页

作者： Mamta Gupta mukesh Choudhary Alla singh Seema Sheoran Deepak Singla Sujay Rakshit ICAR-Indian Institute of Maize Research LudhianaPunjab 141004India School of Agriculture and Environment The University of Western AustraliaPerthWA 6009Australia The UWA Institute of Agriculture The University of Western AustraliaPerthWA 6009Australia School of Agricultural Biotechnology Punjab Agricultural UniversityLudhianaPunjab 141004India

The development of resistant maize cultivars is the most effective and sustainable approach to combat fungal *** the last three decades,many quantitative trait loci(QTL)mapping studies reported numerous QTL for fungal disease resistance(FDR)in ***,different genetic backgrounds of germplasm and differing QTL analysis algorithms limit the use of identified QTL for comparative *** meta-QTL(MQTL)analysis is the meta-analysis of multiple QTL experiments,which entails broader allelic coverage and helps in the combined analysis of diverse QTL mapping studies revealing common genomic regions for target *** the present study,128(33.59%)out of 381 reported QTL(from 82 studies)for FDR could be projected on the maize genome through MQTL *** revealed 38 MQTL for FDR(12 diseases)on all chromosomes except chromosome *** MQTL namely 1_4,2_4,3_2,3_4,and 5_4 were linked with multiple *** of 1910 candidate genes were identified for all the MQTL regions,with protein kinase gene families,TFs,pathogenesis-related,and disease-responsive proteins directly or indirectly associated with *** comparison of physical positions of marker-traits association(MTAs)from genome-wide association studies with genes underlying MQTL interval verified the presence of QTL/candidate genes for particular *** linked markers to MQTL and putative candidate genes underlying identified MQTL can be further validated in the germplasm through marker screening and expression *** study also attempted to unravel the underlying mechanism for FDR resistance by analyzing the constitutive gene network,which will be a useful resource to understand the molecular mechanism of defense-response of a particular disease and multiple FDR in maize.

关键词： Meta-QTL Maize genome Fungal disease resistance Candidate gene Constitutive genes Gene network

Structural characterization of monoterpene indole alkaloids in ethanolic extracts of Rauwolfia species by liquid chromatography with quadrupole time-of-flight mass spectrometry

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Journal of Pharmaceutical Analysis 2016年第6期6卷 363-373页

作者： Sunil Kumar Awantika singh Vikas Bajpai mukesh Srivastava Bhim Pratap singh Brijesh Kumar Sophisticated Analytical Instrument Facility CSIR-Central Drug Research Institute Lucknow 226031 Uttar Pradesh India Academy of Scientific and Innovative Research (AcSIR) New Delhi 110025 India Biometry and Statistics Division CSIR-Central Drug Research Institute Lucknow 226031 Uttar Pradesh India Department of Biotechnology Mizoram University Tanharil 796004 Aizawl Mizoram India

Rauwolfia species(Apocynaceae) are medicinal plants well known worldwide due to its potent bioactive monoterpene indole alkaloids(MIAs) such as reserpine,ajmalicine,ajmaline,serpentine and ***,ajmalicine and ajmaline are powerful antihypertensive,tranquilizing agents used in *** is an aphrodisiac used in dietary *** there is no report on the comparative and comprehensive phytochemical investigation of the roots of Rauwolfia species,we have developed an efficient and reliable liquid chromatography-tandem mass spectrometry(LC–MS/MS) method for ethanolic root extract of Rauwolfia species to elucidate the fragmentation pathways for dereplication of bioactive MIAs using highperformance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry(HPLC–ESI–QTOF–MS/MS) in positive ion *** identified and established diagnostic fragment ions and fragmentation pathways using reserpine,ajmalicine,ajmaline,serpentine and *** MS/MS spectra of reserpine,ajmalicine,and ajmaline showed C-ring-cleavage whereas E-ring cleavage was observed in serpentine via Retro Diels Alder(RDA).A total of 47 bioactive MIAs were identified and characterized on the basis of their molecular formula,exact mass measurements and MS/MS ***,ajmalicine,ajmaline,serpentine and yohimbine were unambiguously identified by comparison with their authentic standards and other 42 MIAs were tentatively identified and characterized from the roots of Rauwolfia hookeri,Rauwolfia micrantha,Rauwolfia serpentina,Rauwolfia verticillata,Rauwolfia tetraphylla and Rauwolfia *** of LC–MS followed by principal component analysis(PCA) has been successfully used to discriminate among six Rauwolfia species.

关键词： Rauwolfia species Monoterpene indole alkaloids (MIAs) HPLC–ESI–QTOF–MS/MS Principal component analysis (PCA)