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Journal of Central South University 2015年第10期22卷 3738-3744页

作者： mukesh C.sharma Division of Drug Design & Medicinal Chemistry Research Lab School of Pharmacy Devi Ahilya University Takshila Campus

A quantitative structure–activity relationship(QSAR) was performed to analyze antimalarial activities against the D10 strains of Plasmodium falciparum of triazole-linked chalcone and dienone hybrid derivatives using partial least squares regression coupled with stepwise forward–backward variable selection method. QSAR analyses were performed on the available IC50 D10 strains of Plasmodium falciparum data based on theoretical molecular descriptors. The QSAR model developed gave good predictive correlation coefficient(r2) of 0.8994, significant cross validated correlation coefficient(q2) of 0.7689, r2 for external test set)(2predr of 0.8256, coefficient of correlation of predicted data set)(2sepred,r of 0.3276. The model shows that antimalarial activity is greatly affected by donor and electron-withdrawing substituents. The study implicates that chalcone and dienone rings should have strong donor and electron-withdrawing substituents as they increase the activity of chalcone. Results show that the predictive ability of the model is satisfactory, and it can be used for designing similar group of antimalarial compounds. The findings derived from this analysis along with other molecular modeling studies will be helpful in designing of the new potent antimalarial activity of clinical utility.

关键词： quantitative structure–activity relationship(QSAR) chalcone antimalarial Plasmodium falciparum stepwise forward–backward partial least squares

Pulsatile blood flow through stenosed artery with axial translation

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International Journal of Biomathematics 2015年第3期8卷 1-21页

作者： mukesh Kumar sharma P. R. sharma Vinay Nasha Department of MathematicsGuru Jambheshwar University of Science and Technology Hisar 125001 Haryana India Department of MathematicsUniversity of Rajasthan Jaipur 302029 Rajasthan India

The study of pulsatile blood flow through axisymmetric stenosed artery subject to an axial translation has been attempted with hematocrit concentration-dependent blood viscosity. The heart contraction and subsequent relaxation generate periodic pressure gradient in blood flow and translation in the artery can be represented by Fourier series. Numerical data required for computing Fourier harmonics for the pressure gradient and acceleration in the artery has been simulated from pressure waveform graph and biplanar angiogram. Velocity field has been obtained by solving governing equation using variational Ritz method. The hemodynamic indicators WSS, AWSS, OSI, RRT are derived and computed numerically. The effects of thickness of stenosis, and hematocrit concentration index on these indicators are computed and analyzed through graphs.

关键词： Stenosis hematocrit pulsatile WSS oscillatory shear index relative residence time

Plastic scintillator detector for qualitative and quantitative measurements of gamma radiation

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Radiation Detection Technology and Methods 2023年第4期7卷 578-588页

作者： Vaishali M.Thakur Nitin Bhosale Amit Jain mukesh sharma L.M.Chaudhari Probal Chaudhury Radiation Safety Systems Division Bhabha Atomic Research CentreTrombayMumbai400085India Department of Physics Nowrosjee Wadia CollegePune411001India

Background Plastic scintillator detectors are rugged and easily manufactured in desired shape,sizes and response time to gamma radiation is prompt as compared with any other scintillator *** popular these detectors are used in radiation monitors one of the application to restrict radioactive material *** are used in gross counting mode to know the presence of *** secondary survey is required to know the nature of the *** The feasibility study of Cylindrical Plastic Scintillator Detector(CPSD)was carried out for the qualitative and quantitative assessment of gamma emitting *** In this work limited gamma spectrometry was carried out using NE110 equivalent cylindrical plastic scintillating material of 5.1 cm diameter and 100 cm *** is optically coupled to photomultiplier tube(PMT).The detector signal is processed using preamplifier,shaping amplifier and further analysed by a multi channel analyser(MCA).CPSD gamma spectrum consists of Compton continuum and Gaussian shaped Compton edge energy(λ_(e))appearing as Compton maxima energy(λ_(max)).Photon transport simulation is used to characterizeλ_(max) as a signature for radionuclides emitting gamma energy/*** case of unresolved gamma energies,it appears as weighted effective Compton maxima *** prominent gamma energies observed across nuclear industries are in the energy range 0.03–3 *** is grouped as low energy,intermediate energy,high energy and ultra-high energy *** simulated spectrum is obtained suing Gaussian broadening parameters deduced from experimentally measured *** efficiency response function is developed from simulated response of detector to standard gamma sources under known source detector *** The mono energetic gamma emitting radioisotopes are identified againstλ_(max) from data *** analysis of spectrum is used to discriminate artificial radioactive materi

关键词： Plastic scintillator detector Gaussian broadening Compton edge Compton maxima Weighted effective Compton maxima Gamma spectrum Multi-channel analyzer

Mediative Sugeno’s-TSK Fuzzy Logic Based Screening Analysis to Diagnosis of Heart Disease

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Applied Mathematics 2019年第6期10卷 448-467页

作者： Nitesh Dhiman mukesh Kumar sharma Department of Mathematics C.C.S. University Meerut India

Fuzzy logic is an approach which deals with the incomplete information to handle the imperfect knowledge. In the present research paper we have proposed a new approach that can handle the imperfect knowledge, in a broader way that we will consider the unfavourable case also as the intuitionistic fuzzy logic does. The mediative fuzzy logic is an extensive approach of intuitionistic fuzzy logic, which provides a solution, when there is a contradiction in the expert knowledge for favourable as well as unfavourable cases. The purpose of the present paper is to design a mediative fuzzy inference system based Sugeno-TSK model for the diagnosis of heart disease. Our proposed method is the extension of Sugeno-TSK fuzzy logic controller in the form of Sugeno-TSK mediative fuzzy logic controller.

关键词： Fuzzy Logic Intuitionistic Fuzzy Logic Mediative Fuzzy Logic Sugeno’s Fuzzy Controller Fuzzy Rule Firing Level Heart Disease

A Study for Analyzing the Effect of Overlapping Stenosis and Dilatation on Non-Newtonian Blood Flow in an Inclined Artery

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Journal of Biomedical Science and Engineering 2016年第12期9卷 576-596页

作者： mukesh Kumar sharma Vinay Nasha P. R. sharma Department of Mathematics Guru Jambheshwar University of Science & Technology Hisar India Department of Mathematics University of Rajasthan Jaipur India

The stenosis in the artery, which reduces the flow passage to blood, is a common cardiovascular disease that is responsible even for cardiac arrest sometimes. The hemodynaics reveals that the severe blockage in an artery due to stenosis generates pressure tangential stress that impacts adversely on the arterial wall downstream to stenosis and weakens the arterial wall. The site of weakened wall in the artery generates post stenotic dilatation. The objective of this paper is to study flow of blood, of non-Newtonian in nature described by Herschel-Bulkley model, in a diseased artery suffering with partly overlapped two stenoses and a dilatation distal to the stenoses. A mathematical model, describing the blood flow, has been derived using Navier-Stokes equations along with the prescribed geometry of the diseased artery. The expressions of velocity profile, resistive impedance to flow and wall shear stress (skin-friction) are derived. The effect of inclination of the vessel on the resistive impedance to flow is discussed along with the effect of rheological and geometrical parameters on the resistive impedance to flow and skin friction.

关键词： Stenotic Artery Overlapped Stenoses Dilatation Herschel-Bulkley Blood Yield Stress Resistive Impedance

Pulsatile MHD Flow in an Inclined Catheterized Stenosed Artery with Slip on the Wall

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Journal of Biomedical Science and Engineering 2014年第4期7卷 194-207页

作者： mukesh Kumar sharma Kuldip Singh Seema Bansal Department of Mathematics Guru Jambheshwar University of Science & Technology Hisar India

Catheter is commonly used by the surgeons for various reasons in the treatment of a patient suffering with cardiovascular diseases. Catheterization increases the mean flow resistance in the arterial blood flow and many other complications are associated with the presence of catheter in the artery. Effects of catheter in stenosed artery can be estimated non-invasively by means of hemo-dynamic indicator-WSS, WSSG, volume flow rate and impedance. The effect of slip at the arterial wall, inclination of the artery and magnetic field on the hemodynamic indicators and flow profiles are computed, presented and discussed through graphs.

关键词： Stenosed Artery Wall Shear Stress Wall Shear Stress Gradient Impedance Catheter

Intuitionistic Neuro-Fuzzy Optimization in the Management of Medical Diagnosis

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Applied Mathematics 2021年第11期12卷 993-1020页

作者： Nivedita Seema Agrawal Dhanpal Singh mukesh Kumar sharma Department of Mathematics S. S. V. (P. G.) College Hapur India Department of Mathematics Keshav Mahavidyalaya University of Delhi New Delhi India Department of Mathematics Chaudhary Charan Singh University Meerut India

Diabetes has become a major concern nowadays and its complications are affecting various organs of a diabetic patient. Therefore, a multi-dimensional technique including all parameters is required to detect the cause, its proper diagnostic procedure and its prevention. In this present work, a technique has been introduced that seeks to build an implementation for the intelligence system based on neural networks. Moreover, it has been described that how the proposed technique can be used to determine the membership together with the non-membership functions in the intuitionistic environment. The dataset has been obtained from Pima Indians Diabetes Database (PIDD). In this work, a complete diagnostic procedure of diabetes has been introduced with seven layered structural frameworks of an Intuitionistic Neuro Sugeno Fuzzy System (INSFS). The first layer is the input, in which six factors have been taken as an input variable. Subsequently, a neural network framework has been developed by constructing IFN for all the six input variables, and then this input has been fuzzified by using triangular intuitionistic fuzzy numbers. In this work, we have introduced a novel optimization technique for the parameters involved in the INSFS. Moreover, an inference system has also been framed for the neural network known as INFS. The results have also been given in the form of tables, which describe each concluding factor.

关键词： Intuitionistic Fuzzy Set Neural Network Neuro-Fuzzy System Intuitionistic Neuro-Fuzzy System Optimization Medical Diagnosis

Radiative Effect on Flow and Heat Transfer over a Vertically Oscillating Porous Flat Plate Embedded in Porous Medium with Oscillating Surface Temperature

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Open Journal of Fluid Dynamics 2016年第2期6卷 119-129页

作者： Monika Miglani Net Ram Garg mukesh Kumar sharma Department of Mathematics Haryana College of Technology & Management Kaithal India Department of Mathematics Maharshi Dayanand University Rohtak India Department of Mathematics Guru Jambheshwer University of Science & Technology Hisar India

The effect of radiation on flow and heat transfer over a vertically oscillating porous flat plate embedded in porous medium with oscillating surface temperature is investigated. The analytic solutions of momentum and energy equations are obtained. The velocity and temperature profiles are computed. The frictional force at the plate due to viscosity of fluid is estimated in terms of non dimensional skin friction coefficient and heat convection at the plate is estimated in the form of Nusselt number. The effects of physical parameters Prandtl number Pr, Grashof number Gr, Suction parameter S and radiative parameter R on velocity and temperature profiles are analyzed through graphs. The effects of oscillation on the velocity and temperature profiles are shown through 3-D surface plot.

关键词： Radiation Suction Heat Flux Oscillating Porous Plate

Fixed Point Approximation for Suzuki Generalized Nonexpansive Mapping Using B(δ, μ) Condition

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Applied Mathematics 2022年第2期13卷 215-227页

作者： Kamal Kumar Laxmi Rathour mukesh Kumar sharma Vishnu Narayan Mishra Department of Mathematics Government College Faridabad India Ward Number-16 Anuppur Madhya Pradesh India Department of Mathematics Chaudhary Charan Singh University Meerut India Department of Mathematics Indira Gandhi National Tribal University Anuppur India

In this paper, we introduce AK' iteration scheme to approximate fixed point for Suzuki generalized nonexpansive mapping satisfying B(δ, μ) condition in the framework of Banach spaces. Also, an example is given to confirm the efficiency of AK' iteration scheme. Our results are generalizations in the existing literature of fixed points in Banach spaces.

关键词： AK' Iterative Scheme B(δ μ) Condition Suzuki Genertalized Nonexpansive Mappings Banach Spaces

Assessment of long-term climate variability and its impact on the decadal growth of horticultural crops in central India

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Ecological Processes 2022年第1期11卷 862-889页

作者： Gaurav sharma Amita sharma Nishant Kumar Sinha Om Prakash sharma Ashutosh Singh Ajai Kumar Pandey Abhishek Kumar Sudhir Kumar Trivedi Bharti Sao mukesh Kumar Sahu College of Horticulture and Forestry Rani Lakshmi Bai Central Agricultural UniversityJhansiUttar Pradesh 284003India Department of Environmental Science Rajmata Vijayaraje Scindia Krishi VishwavidyalayaGwaliorMadhya Pradesh 474002India Division of Soil Physics Indian Institute of Soil ScienceBhopalMadhya Pradesh 462038India Department of Floriculture and Landscape Architecture Indira Gandhi Krishi VishwavidyalayaRaipurChhattisgarh 492012India

Background:The impact of climate change on horticultural production is of utmost concern *** such vulnerable region of horticultural importance is the Madhya Pradesh state in the central part of *** is crucial to analyse the long-term trend in climatic variations and its effect on horticultural crop ***,this study focuses on detecting trends in mean annual precipitation and temperature of 115 years for the 15 districts covering all the regions of the state as well as projections of all the Representative Concentration Pathway(RCP)climatic scenarios for 2050 and 2080 of Madhya Pradesh *** decadal(2010–2020)insight into the area and production of horticultural crops is undertaken which will help forecasting the future growth *** a better insight,case study on four horticultural crops is undertaken to assess their decadal growth trend vis-à-vis climate parameters in these 15 ***:The Mann–Kendall test for 1901–2016 and Sen’s slope indicated a non-significant change in long-term trend for precipitation except for increasing change in Khargone and decreasing change in Rewa ***-cant increasing trend of average temperature is obtained for Hoshangabad,Jabalpur,Sagar and Rewa *** Sen’s slope indicated an increase of 0.005 to 0.009℃for maximum temperature and 0.005 to 0.012℃for minimum temperature *** projections of all the RCP climate scenarios for the years 2050 and 2080 indicated non-significant variation in precipitation but an increase in maximum(1.4 to 4.1℃)and minimum(1.45 to 4.65℃)annual *** increasing trend in area and production for horticultural crops is also observed in central India for the study *** is yield increase in all the crops selected in case study except for potato,which recorded a decreased yield between the years 2010–***:The Mann–Kendall test and projections indicate towards climate change with a temperature *** the decad

关键词： Climate change Horticulture Madhya Pradesh Precipitation Temperature Trend analysis