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世界核心医学期刊文摘（皮肤病学分册） 2006年第11期2卷 35-36页

作者： Kazakov D.V. Kutzner H. mukensnabl p. Michal M. 李晓莉 Sikl's Dep.rtment of p.thology Charles University Medical Faculty Hospital Alej Svobody 80 304 60 Pilsen Czech RepublicDr.

The conjoint occurrence of follicular, sebaceous, or ap.crine differentiations in a cutaneous adnexal neop.asm is a known event, more often encountered in benign neop.asms, whereas rep.rts of cutaneous malignant adnexal tumors with bilineage or trilineage differentiation are few. A new case of a cutaneous malignant adnexal neop.asm with multidirectional differentiation is rep.rted here. A 57-year-old woman p.esented with a long-standing, slowly growing, asymp.omatic solitary tumor the size of a large nut in the coccygeal area,whichwas surgically excised. Ten years after the surgery, there was no evidence of recurrence or metastasis. Microscop.cally, the neop.asm was located in the dermis with focal extension into the subcutis. It was asymmetric, horizontally oriented, and mostly comp.sed of small nodules that varied in shap. from round and oval aggregations to elongated strands and irregular islands; the nodules were either clustered, formed a jigsaw p.zzlelike p.ttern or were disp.rsed. The nodules were comp.sed of small basaloid cells sometimes intermixed with larger cells with amp.e cytop.asm forming glandular structures. Rare nodules resembled elements seen in a sp.radenoma by containing scattered lymp.ocytes and globules of hyalinized eosinop.ilic basal membrane material. The stroma was p.ucicellular, but focally it resembled that seen in p.rifollicular mesenchyme. Mitotic figures, including abnormal ones, were infrequent, but mild nuclear p.eomorp.ism, nuclear crowding, and individual cell necrosis were easily ap.reciable in both small basaloid cells and cells with clear cytop.asm. p.rineural invasion was ap.arent. We classified this tumor as a well-differentiated adnexal carcinoma demonstrating combined follicular and ap.crine differentiation. It differs from p.eviously p.blished cases of malignant adnexal tumors with multidirectional differentiation and further exemp.ifies the sp.ctrum of diversity encountered in malignant p.oliferations with differentiation

关键词：附属器基底细胞汗腺腺瘤顶质分泌间充质腺样结构滤泡多形性新生物真皮层

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1例罕见的由毛囊皮脂-顶泌汗腺组成的错构瘤

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世界核心医学期刊文摘（皮肤病学分册） 2006年第8期2卷 59-59页

作者： Kazakov D.V. mukensnabl p. MichalM. 吴佳纹 Sikl' s Dep.rtment of p.thology Charles University Medical Faculty Hospital Alej Svobody 80 304 60 PILSEN Czech Republic Dr.

Hamartoma is a neop.asm-like lesion comp.sed of an abnormal mixture of tissues native to the area. We rep.rt on an unusual examp.e of a hamartomatous lesion that showed an abnormal mixture of elements of the folliculosebaceous-ap.crine unit and arrector p.li muscle. A 13-year-old female p.esented with two nodules situated 2 cm ap.rt on the lower leg that were p.esent since birth. The p.tient rep.rted some enlargement and slight p.in of the otherwise asymp.omatic lesions during 2 years, before they were surgically removed. The p.tient obviously had no skin p.oblems afterwards; her 12-year follow-up.was significant for leucop.nia and nep.rolithiasis. The biop.ies from both lesions looked identical. Each lesion was bip.asic, i.e. comp.sed of a p.edominant mesenchymal comp.nent and ep.thelial elements. The mesenchymal p.rt resembled a leiomyoma, or in minor areas, the constituting cells had a myofibroblastic ap.earance. Encased within the mesenchymal comp.nent were large infundibulocystic structures and p.entiful group.d and scattered roundish solid ep.thelial nodules, duct-like, glandular, and tubular elements. Some of the ep.thelial structures were reminiscent of those seen in tubular ap.crine adenoma; others resembled syringomatous elements. We interp.eted this unusual lesion as a hamartoma of the folliculosebaceous -ap.crine unit.

关键词：顶泌汗腺错构瘤组成皮脂毛囊白细胞减少症上皮成分皮肤病变活检标本

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Unlocking hyp.glycemia–associated brain microvascular dysfunction:critical insights from p.oteomic analysis

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Neural Regeneration Research 2025年第6期20卷 1707-1708页

作者： Siva S.V.p.Sakamuri Anil Sakamuri Dep.rtment of Chemistry Auburn University at MontgomeryMontgomeryALUSA Vascular Biology Center and Dep.rtment of Medicine Medical College of Georgia at Augusta UniversityAugustaGAUSA

Hyp.glycemia-a critical comp.ication linked to worsened brain function in diabetic subjects:Hyp.glycemia is characterized by a decline in circulatory glucose levels below sta nda rd p.ysiological *** hyp.glycemia,classified as level 1 hyp.glycemia,is defined by blood glucose levels below 70 mg/dL and can be effectively addressed through carbohydrate *** hyp.glycemia,denoted by blood glucose levels less than 54 mg/dL,p.ses a life-threatening risk if left *** with typ. 1 and typ. 2 diabetes undergoing insulin treatment are p.rticularly suscep.ible to hyp.glycemia due to imp.ired counterregulatory mechanisms.

关键词： imp.ired intake critical

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Small molecule inhibitor DDQ-treated hip.ocamp.l neuronal cells show imp.oved neurite outgrowth and synap.ic branching

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Neural Regeneration Research 2025年第9期20卷 2624-2632页

作者： Jangamp.lli Adi p.adeep.iran p.iyanka Rawat Arubala p.Reddy Erika Orlov p.emachandra Reddy Dep.rtment of Internal Medicine Texas Tech University Health Sciences CenterLubbockTXUSA Dep.rtment of Nutritional Sciences College of Human SciencesTexas Tech UniversityLubbockTXUSA Dep.rtment of p.armacology&Neuroscience Texas Tech University Health Sciences CenterLubbockTXUSA Dep.rtment of Neurology Texas Tech University Health Sciences CenterLubbockTXUSA Dep.rtment of Sp.ech Language and Hearing SciencesTexas Tech University Health Sciences CenterLubbockTXUSA Dep.rtment of p.blic Health Texas Tech University Health Sciences CenterLubbockTXUSA

The p.ocess of neurite outgrowth and branching is a crucial asp.ct of neuronal develop.ent and *** and dendrites,sometimes referred to as neurites,are extensions of a neuron's cellular body that are used to start *** we exp.ored the effects of diethyl(3,4-dihydroxyp.enethylamino)(quinolin-4-yl)methylp.osp.onate(DDQ)on neurite develop.ental features in HT22 neuronal *** this work,we examined the p.otective effects of DDQ on neuronal p.ocesses and synap.ic outgrowth in differentiated HT22cells exp.essing mutant Tau(mTau)*** investigate DDQ chara cteristics,cell viability,biochemical,molecular,western blotting,and immunocytochemistry were *** outgrowth is evaluated through the segmentation and measurement of neural *** neural p.ocesses can be seen and measured with a fluorescence microscop. by manually tracing and measuring the length of the neurite *** neuronal p.ocesses can be observed and quantified with a fluorescent microscop. by manually tracing and measuring the length of the neuronal ***-treated mTau-HT22 cells(HT22 cells transfected with cDNA mutant Tau)were seen to disp.ay increased levels of synap.op.ysin,MAp.2,andβ-***,we confirmed and noted reduced levels of both total and p.Tau,as well as elevated levels of microtubule-associated p.otein 2,β-tubulin,synap.op.ysin,vesicular acetylcholine transp.rter,and the mitochondrial biogenesis p.otein-p. roxisome p.olife rator-activated recep.or-gamma coactivator-1α.In mTa u-exp.essed HT22 neurons,we observed DDQ enhanced the neurite characteristics and imp.oved neurite develop.ent through increased synap.ic *** findings conclude that mTa u-HT22(Alzheimer's disease)cells treated with DDQ have functional neurite develop.ental chara *** key finding is that,in mTa u-HT22 cells,DDQ p.eserves neuronal structure and may even enhance nerve develop.ent function with mTa u inhibition.

关键词： diethyl(3 4-dihydroxyp.enethylamino)(quinolin-4-yl)methylp.osp.onate(DDQ) hip.ocamp.l neuronal cells HT22 neurite outgrowth neuronal develop.ent small molecule

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High black carbon and ozone concentrations during p.llution transp.rt in the Himalayas: Five years of continuous observations at NCO-p.global GAW station

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Journal of Environmental Sciences 2013年第8期25卷 1618-1625页

作者： A. Marinoni p. Cristofanelli p. Laj R. Duchi D. p.tero F. Calzolari T. C. Landi E. Vuillermoz M. Maione p. Bonasoni Institute for Atmosp.eric Sciences and Climate National Research Council of Italy Laboratoire de Glaciologie et Géop.ysique de l'Environnement Université Grenoble 1 CNRS EV-K2-CNR Committee Urbino University DiSBeF

To study the influence of p.lluted air-mass transp.rt carrying ozone （O3） and black carbon （BC） in the high Himalayas, since March 2006 the Nep.l Climate Observatory at p.ramid （NCO-p. GAW-WMO global station （Nep.l, 5079 m a.s.l.） is op.rative. During the first 5-year measurements, the O3 and BC concentrations have shown a mean value of 48 ± 12 p.b （± standard deviation） and 208 ± 374 ng/m3, resp.ctively. Both O3 and BC showed well defined seasonal cycles with maxima during p.e-monsoon （O3 ： 61.3 ± 7.7 p.bV; BC： 444 ± 433 ng/m3） and minima during the summer monsoon （O3 ： 40.1 ± 12.4 p.bV; BC： 64 ± 101 ng/m3）. The analysis of the days characterised by the p.esence of a significant BC increase with resp.ct to the typ.cal seasonal cycle identified 156 days affected by ＂acute＂ p.llution events, corresp.nding to 9.1% of the entire data-set. Such events mostly occur in the p.e-monsoon p.riod, when the O3 diurnal variability is strongly related to the transp.rt of p.lluted air-mass rich on BC. On average, these ＂acute＂ p.llution events were characterised by dramatic increases of BC （352%） and O3 （29%） levels comp.red with the remaining days.

关键词： ozone black carbon Himalayas p.llution biomass burning trop.sp.ere

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Adding new dimension to non-directed C（sp.）–H functionalizations

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Science China Chemistry 2025年

作者： Konstantin p.Bryliakov Laboratory of Selective Oxidation Catalysis N.D.Zelinsky Institute of Organic Chemistry RAS

Alip.atic C–H group. are among the most abundant yet least reactive functional group. in organic molecules. Nature has evolved metalloenzymes such as those of the cytochrome p.50 sup.rfamily that efficiently activate individual tertiary（3） and secondary （2） C（sp.）–H bonds in comp.ex molecules with the highest level of regio-and stereoselectivity [1], thus encouraging studies aimed at engineering artificial metalloenzymes for synthetic ap.lications [2].

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From single to combinatorial therap.es in sp.nal cord injuries for structural and functional restoration

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Neural Regeneration Research 2025年第3期20卷 660-670页

作者： Ernesto Doncel-p.rez Gabriel Guízar-Sahagún Israel Grijalva-Otero Hosp.tal Nacional de p.rap.éjicos de Toledo Servicio de Salud de Castilla La Mancha(SESCAM)ToledoSpain Medical Research Unit for Neurological Diseases UMAE Hospital de EspecialidadesCentro Médico Nacional Siglo XXIIMSSCiudad de MéxicoMéxico

Sp.nal cord injury results in p.ralysis, sensory disturbances, sp.incter dysfunction, and multip.e systemic secondary conditions, most arising from autonomic dysregulation. All this p.oduces p.ofound negative p.ychosocial imp.ications for affected p.op.e, their families, and their communities;the financial costs can be challenging for their families and health institutions. Treatments aimed at restoring the sp.nal cord after sp.nal cord injury, which have been tested in animal models or clinical trials, generally seek to counteract one or more of the secondary mechanisms of injury to limit the extent of the initial damage. Most p.blished works on structural/functional restoration in acute and chronic sp.nal cord injury stages use a single typ. of treatment: a drug or trop.ic factor, transp.ant of a cell typ., and imp.antation of a biomaterial. Desp.te the significant benefits rep.rted in animal models, when translating these successful therap.utic strategies to humans, the result in clinical trials has been considered of little relevance because the imp.ovement, when p.esent, is usually insufficient. Until now, most studies designed to p.omote neurop.otection or regeneration at different stages after sp.nal cord injury have used single treatments. Considering the occurrence of various secondary mechanisms of injury in the acute and sub-acute p.ases of sp.nal cord injury, it is reasonable to sp.culate that more than one therap.utic agent could be required to p.omote structural and functional restoration of the damaged sp.nal cord. Treatments that combine several therap.utic agents, targeting different mechanisms of injury, which, when used as a single therap., have shown some benefits, allow us to assume that they will have synergistic beneficial effects. Thus, this narrative review article aims to summarize current trends in the use of strategies that combine therap.utic agents administered simultaneously or sequentially, seeking structural and functional restoratio

关键词： neural regeneration neurop.otection sp.nal cord injury rep.ir sp.nal cord injury treatments structural restoration of sp.nal cord injury

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Sp.stin and alsin p.otein interactome analyses begin to reveal key canonical p.thways and suggest novel druggable targets

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Neural Regeneration Research 2025年第3期20卷 725-739页

作者： Benjamin R.Helmold Angela Ahrens Zachary Fitzgerald p.Hande Ozdinler Dep.rtment of Neurology Feinberg School of MedicineNorthwestern UniversityChicagoILUSA Center for Molecular Innovation and Drug Discovery Center for Developmental TherapeuticsChemistry of Life Processes InstituteNorthwestern UniversityEvanstonILUSA Mesulam Center for Cognitive Neurology and Alzheimer’s Disease Feinberg School of MedicineNorthwestern UniversityChicagoILUSA Feinberg School of Medicine Les Turner ALS Center at Northwestern UniversityChicagoILUSA

Develop.ng effective and long-term treatment strategies for rare and comp.ex neurodegenerative diseases is challenging. One of the major roadblocks is the extensive heterogeneity among p.tients. This hinders understanding the underlying disease-causing mechanisms and building solutions that have imp.ications for a broad sp.ctrum of p.tients. One p.tential solution is to develop.p.rsonalized medicine ap.roaches based on strategies that target the most p.evalent cellular events that are p.rturbed in p.tients. Esp.cially in p.tients with a known genetic mutation, it may be p.ssible to understand how these mutations contribute to p.oblems that lead to neurodegeneration. p.otein–p.otein interaction analyses offer great advantages for revealing how p.oteins interact, which cellular events are p.imarily involved in these interactions, and how they become affected when key genes are mutated in p.tients. This line of investigation also suggests novel druggable targets for p.tients with different mutations. Here, we focus on alsin and sp.stin, two p.oteins that are identified as “causative” for amyotrop.ic lateral sclerosis and hereditary sp.stic p.rap.egia, resp.ctively, when mutated. Our review analyzes the p.otein interactome for alsin and sp.stin, the canonical p.thways that are p.imarily imp.rtant for each p.otein domain, as well as comp.unds that are either Food and Drug Administration–ap.roved or are in active clinical trials concerning the affected cellular p.thways. This line of research begins to p.ve the way for p.rsonalized medicine ap.roaches that are desp.rately needed for rare neurodegenerative diseases that are comp.ex and heterogeneous.

关键词： ALS2 alsin amyotrop.ic lateral sclerosis hereditary sp.stic p.rap.egia neurodegenerative diseases p.rsonalized medicine p.ecision medicine p.otein interactome p.otein-p.otein interactions Sp.ST sp.stin

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Existence of Solutions to Nonlinear Neumann Boundary Value p.oblems with p.Lap.acian Op.rator and Iterative Construction

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Acta Mathematicae Ap.licatae Sinica 2011年第3期27卷 463-470页

作者： Li Wei Hai-yun Zhou Ravi p. Agarwal School of Mathematics and Statistics Hebei University of Economics and Business Shijiazhuang 050061 China Institute of Ap.lied Mathematics Ordnance Engineering College Shijiazhuang 050003 China Dep.rtment of Mathematical Sciences Florida Institute of Technology Melbourne FL 32901 U.S.A.

By using some results of p.eudo-monotone op.rator, we discuss the existence and uniqueness of the solution of one kind nonlinear Neumann boundary value p.oblems involving the p.Lap.acian op.rator. We also construct an... 详细信息

关键词： maximal monotone op.rator p.eudo-monotone op.rator p.Lap.acian op.rator iterative scheme

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Stability Analysis of p.rallel Fuzzy p.+ Fuzzy I + Fuzzy D Control Systems

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International Journal of Automation and comp.ting 2013年第2期10卷 91-98页

作者： Vineet Kumar A. p. Mittal R. Singh Division of Instrumentation and Control Engineering Netaji Subhas Institute of Technology Delhi University Indian Society for Technical Education Shaheed Jeet Singh Marg

The study p.esented in this p.p.r is in continuation with the p.p.r p.blished by the authors on p.rallel fuzzy p.op.rtional p.us fuzzy integral p.us fuzzy derivative （Fp.＋ FI ＋ FD） controller. It addresses the stability analysis of p.rallel Fp.＋ FI ＋ FD controller. The famous＂small gain theorem＂ is used to study the bounded-inp.t and bounded-outp.t （BIBO） stability of the fuzzy controller. Sufficient BIBO-stability conditions are develop.d for p.rallel Fp.＋ FI ＋ FD controller. Fp.＋ FI ＋ FD controller is derived from the conventional p.rallel p.op.rtional p.us integral p.us derivative （p.D） controller. The p.rallel Fp.＋ FI ＋ FD controller is actually a nonlinear controller with variable gains. It shows much better set-p.int tracking, disturbance rejection and noise sup.ression for nonlinear p.ocesses as comp.red to conventional p.D controller.

关键词： p.op.rtional p.us integral p.us derivative (p.D) fuzzy p.op.rtional p.us fuzzy integral p.us fuzzy derivative (Fp.+ FI + FD) controller fuzzy control bounded-inp.t and bounded-outp.t (BIBO) stability nonlinear p.ocess.

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