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Effects of Interferon Alpha 2b on VEGFR-2, VEGFA, MAPK-1 and ERK-1 Gene Expression in Corneal Neovascularization Models

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Open Journal of Ophthalmology 2018年第2期8卷 97-105页

作者： mujdat karabulut Harun Cakmak Gokay Bozkurt Sinem karabulut Department of Ophthalmology Faculty of Medicine Sitki Kocman University Mugla Turkey Department of Ophthalmology Faculty of Medicine Adnan Menderes University Aydin Turkey Department of Medical Genetic Faculty of Medicine Adnan Menderes University Aydin Turkey

AIM: To investigate effects of interferon alpha 2b on vascular endothelial growth factor receptor-2 (VEGFR-2), vascular endothelial growth factor-A (VEGFA), mitogen activated protein kinase-1 (MAPK-1) and extracellular signal regulated kinase (ERK 1) gene expression in corneal neovascularization (CNV) modelsbyreal time polymerase chain reaction (PCR). METHODS: Thirty Wistar-Albino male rats were divided into three groups of ten rats each, and two corneas were obtained from each rat. CNV was induced by application of silver nitrate. In the first group one million IU/ml, in the second group three million IU/ml interferon-alfa 2b and in the third (control) group isotonic saline was applied to both eyes two times a day for two weeks. Rats were sacrificed by cervical dislocation and corneas were used for real time polymerase chain reaction. RESULTS: MAPK-1 gene expression levels were significantly higher in both first and second groups compared to the control group (p = 0.014 and p = 0.008, respectively). VEGFR-2 gene expression levels were found to be significantly higher in the second group than the control group (p = 0.028). VEGFA gene expression levels were also significantly higher in the second group than the control group, and there was no difference between the control and first group and between first and second groups (p > 0.05). ERK gene expression levels did not differ among all groups (p = 0.545). CONCLUSION: At the end of the study, it was shown that interferon-alfa 2b does not inhibit VEGFR-2, VEGFA, MAPK-1 or ERK 1 gene expression in CNV models despite its known anti-VEGF activities.

关键词： Corneal Neovascularization Vascular Endothelial Growth Factor Interferon-Alfa2b Real Time Polymerase Chain Reaction

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Is the Treatment of Attention Deficit Hyperactivity Disorder a New Cause of Cataract?

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Open Journal of Ophthalmology 2018年第1期8卷 26-30页

作者： mujdat karabulut Sinem karabulut Tolga Kocatürk Seyhan Bahar Ozkan Department of Ophthalmology Sitki Kocman University Mugla Turkey Department of Ophthalmology Adnan Menderes University Aydin Turkey

Attention deficit hyperactivity disorder (ADHD) is the most common behavioral disorder of childhood and it has 5% prevalence among children worldwide [1]. In the treatment of ADHD stimulant medications are recommended as the first choice of pharmacotherapy [2]. Methylphenidate-HCl is a sympathomimetic amine derivative pharmacological agent;and it is widely used in the treatment of ADHD. Although there are some articles showing that oral methylphenidate increases the risk of glaucoma [3], to the best of our knowledge, there is only one case report that indicates a possible relation of methylphenidate treatment and cataract formation [4].

关键词： Attention Deficit Hyperactivity Disorder Methylphenidate Cataract

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Geochemistry and Provenance of Maastrichtian Clastic Rocks in the Dikmendede Formation of Orhaniye in Kazan-Ankara-Turkey Region

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Acta Geologica Sinica(English Edition) 2011年第5期85卷 1067-1081+1083+1082页

作者： Ali mujdat OZKAN Ayla AYAZ-BOZDAG Department of Geological Engineering Faculty of EngineeringSelcuk University

An integrated petrographic and geochemical study of the sandstones of the Maastrichtianaged in the Orhaniye（Kazan-Ankara-Turkey） was carried out to obtain more information on their provenance,sedimentological history and tectonic *** on their matrix and mineralogical content,the Maastrichtian sandstones are identified as lithic arenite/*** Dikmendede sandstones derived from types of provenances,the recycled orogen and recycled *** chemical characteristics of the Dikmendede sandstones,i.e.,fairly uniform compositions,high Th/U ratios（>3.0）,negative Eu anomalies（Eu/Eu* 0.72-0.99） and Th/Sc ratios （mostly less than 1.0）,favor the OUC（old upper continental crust） provenance for the Dikmendede *** SiO2/Al2O3,Th/Sc（mostly<1.0） and La/Sc（<4.0） ratios are;however,slightly lower than typical OUC,and these ratios may suggest a minor contribution of young arc-derived material. The rare earth element（REE） pattern,and La/Sc versus Th/Co plot suggests that these sediments were mainly derived from felsic source *** Dikmendede sandstones have high Cr（123-294 ppm） and Ni（52-212 ppm） concentrations,Cr/Ni ratio of 1.93,and a medium correlation coefficient between Cr and Ni and corresponding medium to high correlation of both（Cr and Ni,respectively） elements with *** relationships indicate a significant contribution of detritus from ophiolitic *** rare earth element data are available for the Dikmendede sandstones,the Eu/Eu*is compared with LaN/YbN. Samples plot in the area of overlapping between continental collision,strike-slip and continental arc *** predominantly felsic composition of the Dikmendede sandstones is supported by the REE plots,which show enriched light REE,negative Eu anomaly and flat or uniform heavy *** Dikmendede sandstones have compositions similar to those of the average upper continental crust and post-Archean Australian *** feature indicates that the sediments were derived mainly from

关键词： Orhaniye Dikmendede sandstone flysch provenans

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Pectoral muscular twitching： a rare manifestation of spontaneous twiddler syndrome

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Journal of Geriatric Cardiology 2017年第8期14卷 532-533页

作者： Serdar Bozyel Tolga Aksu Tumer Erdem Guler Kaznn Serhan Ozcan mujdat Aktas Derince Training and Research Hospital Department of Cardiology Kocaeli Turkey Eregli State Hospital Department of Cardiology Zonguldak Turkey

The twiddler syndrome is an uncommon cause of pacemaker malfunction, in which twisting or rotating of the device in its pocket results in lead retraction or coiling and subsequent malfunction of an implanted devices s... 详细信息

关键词：综合征心脏起搏器抽搐肌肉胸鳍植入式转动副 ICD

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Rare multiple fistulas with large saccular aneurysms originating from left anterior descending artery and left main coronary artery

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World Journal of Clinical Cases 2014年第12期2卷 927-929页

作者： Ender Emre mujdat Aktas Tayfun Sahin Ertan Ural Dilek Ural Department of Cardiology Faculty of Medicine Kocaeli University Kocaeli 41060 Turkey

A 49-year-old female patient consulted us for a cardiac evaluation before undergoing colon adenocarcinoma surgery. Three years prior, the patient underwent coronary angiography for dyspnea. The coronary angiography examination revealed a fistula originating from the left anterior descending artery and left main coronary artery, which had soft aneurysmal sacs and most likely drained into the pulmonary artery. Parasternal short axis echocardiography revealed a color flow that could be related to the fistula, but the other echocardiographic findings were normal. The patient did not accept the proposed examination and invasive treatment.

关键词： Left main coronary artery Left anterior descending Fistula Swinging aneurysmal sacs

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Preface

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Acta Geologica Sinica(English Edition) 2011年第2期85卷 I0001-I0002页

作者： Ali mujdat OZKAN Ayla AYAZ-BOZDAG Department of Geological Engineering Faculty of EngineeringSelcuk University

To establish and consummate the international stratigraphic chart is one of the important missions of the International Commission on Stratigraphy （ICS） and it is also an important basic research of the Earth Sciences. The basic research project ＂research on standard sections and some global standard stratotype-section and points （GSSPs） in China＂ is financially supported by the Ministry of Science and Technology of China and assumed by Institute of Geology, Chinese Academy of Geological Sciences.

关键词： Orhaniye Dikmendede sandstone flysch provenans

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