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食药同源健脾开胃物质及其成方制剂研究与应用进展

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中草药 2024年第6期55卷 2101-2112页

作者：田琦汤旗陈钧 wong LISOO 刘立丽吕正兵鲍康德浙江理工大学生命科学与医药学院浙江杭州310018 浙江省家蚕生物反应器和生物医药重点实验室浙江杭州310063 浙江国邦药业有限公司药物研究所浙江绍兴312369

传统中医认为“百病皆由脾胃衰而生”,现代社会因饮食不节、嗜烟好酒、作息无序及工作和生活压力等诸多因素,造成“脾失健运”。中医药学研究结果显示,健脾开胃的食品疗法因其耐受性及依从性好,被中医医家及患者广泛接受。通过对健脾开... 详细信息

传统中医认为“百病皆由脾胃衰而生”,现代社会因饮食不节、嗜烟好酒、作息无序及工作和生活压力等诸多因素,造成“脾失健运”。中医药学研究结果显示,健脾开胃的食品疗法因其耐受性及依从性好,被中医医家及患者广泛接受。通过对健脾开胃中药成方制剂、食药同源中药材及饮片和国内外食药同源政策进行综述,以促进食药物质在普通食品领域的开发,为健脾开胃类保健食品、特医食品等的研发提供理论依据。

关键词：食药同源健脾开胃食品疗法保健临床应用

Unsynchronized butyrophilin molecules dictate cancer cell evasion of Vγ9Vδ2 T-cell killing

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Cellular & Molecular Immunology 2024年第4期21卷 362-373页

作者： Zeguang Wu Qiezhong Lamao Meichao Gu Xuanxuan Jin Ying Liu Feng Tian Ying Yu Pengfei Yuan Shuaixin Gao Thomas S.Fulford Adam P.Uldrich Catherine C.L wong Wensheng Wei Biomedical Pioneering Innovation Center Peking-Tsinghua Center for Life SciencesPeking University Genome Editing Research CenterState Key Laboratory of Protein and Plant Gene ResearchSchool of Life SciencesPeking University100871BeijingChina EdiGene Inc. Life Science ParkChangping District102206BeijingChina Center for Precision Medicine Multi-Omics Research Peking University Health Science CenterPeking University100191BeijingChina Department of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity The University of MelbourneParkvilleVIC3010Australia Cancer Immunology Program Peter MacCallum Cancer CentreMelbourneVICAustralia State Key Laboratory for Complex Severe and Rare DiseasesClinical Research InstitutePeking Union Medical College HospitalChinese Academy of Medical Science&Peking Union Medical CollegePeking-Tsinghua Center for Life Sciences100871BeijingChina

Vγ9Vδ2 T cells are specialized effector cells that have gained prominence as immunotherapy agents due to their ability to target and kill cells with altered pyrophosphate *** our effort to understand how cancer cells evade the cell-killing activity of Vγ9Vδ2 T cells,we performed a comprehensive genome-scale CRISPR screening of cancer *** found that four molecules belonging to the butyrophilin(BTN)family,specifically BTN2A1,BTN3A1,BTN3A2,and BTN3A3,are critically important and play unique,nonoverlapping roles in facilitating the destruction of cancer cells by primary Vγ9Vδ2 T *** coordinated function of these BTN molecules was driven by synchronized gene expression,which was regulated by IFN-γsignaling and the RFX ***,an enzyme called QPCTL was shown to play a key role in modifying the N-terminal glutamine of these BTN proteins and was found to be a crucial factor in Vγ9Vδ2 T cell killing of cancer *** our research,we offer a detailed overview of the functional genomic mechanisms that underlie how cancer cells escape Vγ9Vδ2 T ***,our findings shed light on the importance of the harmonized expression and function of gene family members in modulating T-cell activity.

关键词： Butyrophilin Vγ9Vδ2 T-cell Cancer-specific immune evasion Glutaminyl-peptide cyclotransferase-like Pyrophosphate metabolite Immunotherapy

IgG4 Coronary Arteritis Presenting as a Cardiac Pseudo-Tumour

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Case Reports in Clinical Medicine 2024年第9期13卷 345-352页

作者： Elaine Mo-Chee Chau Catherine Yuet-Hung wong Raymond Hin-Suen Liang Cardiology Centre Hong Kong Sanatorium & Hospital Hong Kong SAR China Nuclear Medicine Department Hong Kong Sanatorium & Hospital Hong Kong SAR China Comprehensive Oncology Centre Hong Kong Sanatorium & Hospital Hong Kong SAR China

We report on an unusual case presenting with a cardiac pseudo-tumour on echocardiogram, which corresponded to a large soft tissue mural thickening around the mid-right coronary artery. There were similar but not as thick mural lesions around other parts of the coronary arteries. The so-called “pigs-in-a-blanket” sign on computed tomography (CT) scan was pathognomonic of IgG4 coronary arteritis. The IgG4 level was grossly elevated at more than 10 times the upper limit of normal. Positron emission tomography (PET)-CT scans with 18F-fluoro-deoxy-glucose (FDG) and 68Ga-Fibroblast Activation Protein Inhibitor (FAPI) were performed to assess the extent of organ involvement of the IgG4-related disease. The patient was treated with 8 injections of rituximab with good serological response. However, the coronary arteritis findings on CT scan remained unchanged.

关键词： IgG4-Related Disease Coronary Arteritis Cardiac Pseudo-Tumour “Pigs-in-a-Blanket” Sign

Effectiveness of post-COVID-19 primary care attendance in improving survival in very old patients with multimorbidity:a territory-wide target trial emulation

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Family Medicine and Community Health 2024年第3期12卷 25-35页

作者： Cuiling Wei Vincent Ka Chun Yan Camille Maringe Wenxin Tian Rachel Yui Ki Chu Wenlong Liu Boyan Liu Yuqi Hu Lingyue Zhou Celine Sze Ling Chui Xue Li Eric Yuk Fai Wan Ching Lung Cheung Esther Wai Yin Chan William Chi Wai wong Ian Chi Kei wong Francisco Tsz Tsun Lai Centre for Safe Medication Practice and Research Department of Pharmacology and PharmacyLi Ka Shing Faculty of MedicineThe University of Hong KongHong KongHong Kong Department of Health Services Research and Policy Faculty of Public Health and PolicyLondon School of Hygiene and Tropical MedicineLondonUK School of Nursing Li Ka Shing Faculty of MedicineThe University of Hong KongHong KongHong Kong School of Public Health Li Ka Shing Faculty of MedicineThe University of Hong KongHong KongHong Kong Laboratory of Data Discovery for Health(D24H) Hong KongHong Kong Advanced Data Analytics for Medical Science(ADAMS)Limited Hong KongHong Kong Department of Medicine School of Clinical MedicineLi Ka Shing Faculty of MedicineThe University of Hong KongHong KongHong Kong Department of Family Medicine and Primary Care School of Clinical MedicineLi Ka Shing Faculty of MedicineThe University of Hong KongHong KongHong Kong Department of Pharmacy The University of Hong Kong-Shenzhen HospitalShenzhenPeople's Republic of China Aston Pharmacy School Aston UniversityBirminghamUK School of Pharmacy Macao University of Science and TechnologyTaipaMacao

Objectives Older individuals with multimorbidity are at an elevated risk of infection and complications from *** of post-COVID-19 interventions or care models in reducing subsequent adverse outcomes in these individuals have rarely been *** study aims to examine the effectiveness of attending general outpatient within 30 days after discharge from COVID-19 on 1-year survival among older adults aged 85 years or above with *** Retrospective cohort study emulating a randomised target trial using electronic health *** We used data from the Hospital Authority and the Department of Health in Hong Kong,which provided comprehensive electronic health records,COVID-19 confirmed case data,population-based vaccination records and other individual characteristics for the *** Adults aged 85 years or above with multimorbidity who were discharged after hospitalisation for COVID-19 between January 2020 and August *** Attending a general outpatient within 30 days of last COVID-19 discharge defined the exposure,compared to no outpatient *** outcome measures Primary outcome was all-cause mortality within one *** outcomes included mortality from respiratory,cardiovascular and cancer *** A total of 6183 eligible COVID-19 survivors were included in the *** all-cause mortality rate following COVID-19 hospitalisation was lower in the general outpatient visit group(17.1 deaths per 100 person-year)compared with non-visit group(42.8 deaths per 100 person-year).After adjustment,primary care consultations within 30 days after discharge were associated with a significantly greater 1-year survival(difference in 1-year survival:11.2%,95%CI 8.1%to 14.4%).We also observed significantly better survival from respiratory diseases in the general outpatient visit group(difference in 1-year survival:6.3%,95%CI 3.5%to 8.9%).In a sensitivity analysis for different grace period lengths

关键词： morbidity visit records

Overview of Jute Fibre as Thermoplastic Matrix Polymer Reinforcement

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Journal of Renewable Materials 2024年第3期12卷 457-483页

作者： Tezara Cionita Mohammad Hazim Mohamad Hamdan Januar Parlaungan Siregar Deni Fajar Fitriyana Ramli Junid wong Ling Shing Jamiluddin Jaafar Agustinus Purna Irawan Teuku Rihayat Rifky Ismail Athanasius Priharyoto Bayuseno Emilianus Jehadus Faculty of Engineering and Quantity Surveying INTI International UniversityNilaiNegeri Sembilan71800Malaysia Technical Department Dyna Forming Engineering Technology(DFETECH)SDN.BHD.SerembanNegeri Sembilan70300Malaysia Faculty of Mechanical and Automotive Engineering Technology UniversitiMalaysia Pahang Al-Sultan Abdullah(UMPSA)PekanPahang26600Malaysia Automotive Engineering Center(AEC) UniversitiMalaysia Pahang Al-Sultan Abdullah(UMPSA)PekanPahang26600Malaysia Department of Mechanical Engineering Universitas Negeri SemarangKampus SekaranGunungpatiSemarang50229Indonesia Faculty of Manufacturing and Mechatronic Engineering Technology Universiti Malaysia Pahang Al-Sultan AbdullahPekanPahang26600Malaysia Faculty of Health and Life Sciences INTI International UniversityNilai71800Malaysia Faculty of Mechanical and Manufacturing Engineering Universiti Tun Hussein Onn MalaysiaParit RajaBatu PahatJohor86400Malaysia Faculty of Engineering Universitas TarumanagaraJakarta Barat11440Indonesia Department of Chemical Engineering Politeknik Negeri LhokseumaweLhokseumawe24301Indonesia Department of Mechanical Engineering Faculty of EngineeringDiponegoro UniversitySemarang50275Indonesia Department of Mathematics Education Universitas Katolik Indonesia Santu Paulus RutengNusa Tenggara Timur8651Indonesia

Recent decades have seen a substantial increase in interest in research on natural fibres that is aligned with sustainable development goals(SDGs).Due to their renewable resources and biodegradability,natural fiberreinforced composites have been investigated as a sustainable alternative to synthetic materials to reduce the usage of hazardous waste and environmental *** the natural fibre,jute fibre obtained from a bast plant has an increasing trend in the application,especially as a reinforcement *** research works have been performed on jute fibre with regard to reinforced thermoset and thermoplastic ***,current demands on sustainable materials have required new developments in thermoplastic *** this paper,the author reviews jute plants as reinforcement materials for thermoplastic matrix *** review provides an overview of the sustainability of jute plants as reinforcement material for thermoplastic matrix *** overview on jute based thermoplastic composites focused on the thermal behavior and mechanical *** from physical,chemical,and mechanical properties,the study also covers the current and perspectives for future research challenges faced by the researchers on jute fibre reinforced thermoplastic composites.

关键词： Jute fibre sustainable development goals(SDGs) natural fibre thermoplastic composite sustainable manufacturing

Temperate Stutzerimonas Phage Encoding Toxin-Antitoxin System Genes Represents a Novel Genus

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Journal of Ocean University of China 2024年第4期23卷 1087-1101页

作者： ZHANG Hong GUO Ruizhe GAO Chen ZHENG Kaiyang XIONG Yao DONG Yue LIU yundan WANG Ziyue CHEN Ying WANG Hongmin SHAO Hongbing SUNG Yeong Yik MOK Wen Jye wong Li Lian MCMINN Andrew WANG Min LIANG Yantao College of Marine Life Sciences Institute of Evolution and Marine BiodiversityMOE Laboratory of Evolution and Marine BiodiversityFrontiers Science Center for Deep Ocean Multispheres and Earth SystemCenter for Ocean Carbon NeutralityOcean University of ChinaQingdao 266003China UMT-OUC Joint Center for Marine Studies Qingdao 266003China Institute of Marine Biotechnology Universiti Malaysia Terengganu21030 Kuala TerengganuMalaysia Institute for Marine and Antarctic Studies University of TasmaniaHobartTAS 7001Australia Haide College Ocean University of ChinaQingdao 266100China The Affiliated Hospital of Qingdao University Qingdao 266001China

Stutzerimonas have been extensively studied due to their remarkable metabolic and physiological ***,research on its phages is currently *** this study,we isolated a novel double-stranded DNA(dsDNA)phage,vB_SstM-PG1,from the marine environment that infects Stutzerimonas stutzeri *** dsDNA genome is 37204 bp long with a G/C content of 64.14%and encodes 54 open reading *** phage possesses a tail packaging structure that is different from known Stutzerimonas stutzeri phages and exhibits structural protein characteristics similar to those of temperate *** addition,two genes of toxin-antitoxin system,including YdaS_antitoxin and HEPN_SAV_6107,were found in the vB_SstM-PG1 genome and play important roles in regulating host growth and *** phylogenetic tree and comparative genomic analysis,it has been determined that vB_SstM-PG1 is not closely related to any phages previously identified in the GenBank ***,it has a connection with enigmatic,uncultured ***,the vB_SstM-PG1 virus exhibits an average nucleotide identity of over 70%with six uncultivated viruses identified in the IMG/VR v4 *** significant finding has resulted in the identification of a novel viral genus known as Metabovirus.

关键词： Stutzerimonas vB_SstM-PG1 Metabovirus temperate phage genomic and phylogenetic analysis

Electron-beam-driven anomalous Doppler effects in Smith–Purcell radiation

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Photonics Research 2024年第1期12卷 78-84页

作者： XIAOQIUYAN ZHANG TIANYU ZHANG ZHUOCHENG ZHANG XINGXING XU DIWEI LIU ZHAOyun DUAN YANYU WEI YUBIN GONG LIANG JIE wong MIN HU Terahertz Research Center School of Electronic Science and EngineeringUniversity of Electronic Science and Technology of ChinaChengdu 610054China Key Laboratory of Terahertz Technology Ministry of EducationChengdu 610054China School of Electrical and Electronic Engineering Nanyang Technological UniversitySingapore 639798Singapore

The interaction between electrons and matter is an effective means of light emission,through mechanisms including Cherenkov radiation and Smith–Purcell radiation(SPR).In this study,we show that the superlight inverse Doppler effects can be realized in reverse Smith–Purcell radiation excited by a free electron beam with a homogeneous *** particular,we find that two types of anomalous SPR exist in the homogenous substrate:special SPR and reverse *** results reveal that the electron velocity can be tuned to simultaneously excite different combinations of normal SPR,special SPR,and reverse *** proposed manifold light radiation mechanism can offer greater versatility in controlling and shaping SPR.

关键词： anomalous beam Electron

Immunoregulatory and Anti-cancer Activities of Combination Treatment of Novel Four-Herb Formula and Doxorubicin in 4T1-Breast Cancer Bearing Mice

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Chinese Journal of Integrative Medicine 2024年第4期30卷 311-321页

作者： Lea Ling-Yu Kan Ben Chung-Lap Chan Grace Gar-Lee Yue LI Pei-ting Sharon Sze-Man Hon HUANG Dan-qi Miranda Sin-Man Tsang Clara Bik-San Lau Ping-Chung Leung Chun-Kwok wong Institute of Chinese Medicine The Chinese University of Hong KongHong Kong SARChina State Key Laboratory of Research on Bioactivities and Clinical Applications of Medicinal Plants The Chinese University of Hong KongHong KongChina Department of Chemical Pathology The Chinese University of Hong KongHong Kong SARChina China-Australia International Research Centre for Chinese Medicine School of Health and Biomedical SciencesSTEM CollegeRMIT UniversityBundooraVictoriaAustralia Li Dak Sum Yip Yio Chin R&D Centre for Chinese Medicine The Chinese University of Hong Kong SARHong KongChina

Objective To investigate the in vivo immunomodulatory and anti-tumor mechanisms of the combined treatment of novel Four-Herb formula(4HF)and doxorubicin in triple-negative breast cancer(TNBC).Methods Murine-derived triple-negative mammary carcinoma cell line,4T1 cells,was cultured and inoculated into mouse mammary ***-six mice were randomly assigned into 6 groups(n=11 in ench):naive,control,LD 4HF(low dose 4HF),HD 4HF(high dose 4HF),LD 4HF+D(low dose and doxorubicin),and D(doxorubicin).Apart from the naive group,each mouse received subcutaneous inoculation with 5×10^(5)4T1 cells resuspended in 100µL of normal saline in the mammary fat *** from the day of tumor cell inoculation,tumors were grown for 6 *** LD and HD groups received daily oral gavage of 658 and 2,630 mg/kg 4HF,*** LD 4HF+D group received daily oral gavage of 658 mg/kg 4HF and weekly intraperitoneal injection of doxorubicin(5 mg/kg).The D group received weekly intraperitoneal injections of doxorubicin(5 mg/kg).The treatment naive mice received daily oral gavage of 0.2 mL double distilled water and 0.1 mL normal saline via intraperitoneal injection once a *** control group received daily oral gavage of 0.2 mL double-distilled *** treatment period was 30 *** the end of treatment,mice organs were harvested to analyze immunological activities via immunophenotyping,gene and multiplex analysis,histological staining,and gut microbiota *** Mice treated with the combination of 4HF and doxorubicin resulted in significantly reduced tumor and spleen burdens(P<0.05),altered the hypoxia and overall immune lymphocyte landscape,and manipulated gut microbiota to favor the anti-tumor immunological ***,immunosuppressive genes,cytokines,and chemokines such as C-C motif chemokine 2 and interleukin-10 of tumors were significantly downregulated(P<0.05).4HF-doxorubicin combination treatment demonstrated synergetic activities and was most effective

关键词： adjunctivetherapy breast cancer cytokines Chinese medicine tumor microenvironment

Recent advances in optical techniques for dynamically probing cellular mechanobiology

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Biomedical Engineering Communications 2024年第3期3卷 3-11页

作者： Fengqi Wang Qin Zhang Mo Yang Bohan Yin Siu Hong Dexter wong School of Medicine and Pharmacy Ocean University of ChinaQingdao 266003China Laboratory for Marine Drugs and Bioproducts Qingdao Marine Science and Technology CenterQingdao 266237China Department of Biomedical Engineering The Hong Kong Polytechnic UniversityHong Kong 999077China.

Cellular mechanotransduction characterized by the transformation of mechanical stimuli into biochemical signals,represents a pivotal and complex process underpinning a multitude of cellular *** process is integral to diverse biological phenomena,including embryonic development,cell migration,tissue regeneration,and disease pathology,particularly in the context of cancer metastasis and cardiovascular *** the profound biological and clinical significance of mechanotransduction,our understanding of this complex process remains *** recent development of advanced optical techniques enables in-situ force measurement and subcellular manipulation from the outer cell membrane to the organelles inside a *** this review,we delved into the current state-of-the-art techniques utilized to probe cellular mechanobiology,their principles,applications,and *** mainly examined optical methodologies to quantitatively measure the mechanical properties of cells during intracellular transport,cell adhesion,and *** provided an introductory overview of various conventional and optical-based techniques for probing cellular *** techniques have provided into the dynamics of mechanobiology,their potential to unravel mechanistic intricacies and implications for therapeutic intervention.

关键词： mechanobiology cell adhesion optical techniques live cell imaging cell fates