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国际眼科杂志 2017年第2期17卷 209-212页

作者： Umit Calli Taha Ayyildiz Genc Selim Eren Goktas muhammed nurullah bulut Umraniye研究培训医院眼科土耳其伊斯坦布尔34766 Haydarpasa Numune研究培训医院眼科土耳其伊斯坦布尔34668 Kanal Dr.L.Kirdar研究培训医院眼科土耳其伊斯坦布尔34890

目的:研究后囊膜混浊(posterior capsular opacity,PCO)及其治疗对使用谱域光学相干断层扫描(spectral domain optical coherence tomography,SD-OCT)测量视网膜神经纤维层(retinal nerve fiber layer,RNFL)厚度的影响。方法:使用SD-OCT测量50例接受Nd:YAG激光后囊膜切开术患者术前和术后RNFL厚度。通过信噪比(signal to noise ratio,SNR)等级,将患者分为组1(SNR 3和4)、组2(SNR 5和6)及组3(SNR 7和8)。对侧眼作为对照组。结果:接受了Nd:YAG激光后囊膜切开术的眼BCVA、SNR和RNFL均值显著增加。组1和组2激光治疗前后BCVA、SNR和RNFL均值显著不同。尽管组3中患者治疗前后BCVA和SNR均值显著不同,RNFL厚度在治疗前后没有显著差异。结论:PCO对OCT图像质量有影响。所有接受后囊膜切开术的患者,术后SNR较术前有所改善。治疗前SNR7在以下的患者中,RNFL厚度在患者接受Nd:YAG激光后囊膜切开术后显著提高。

关键词：囊膜混浊神经纤维激光固态光学相干断层成像后囊膜切开术

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Six high-intensity interval training sessions over 5 days increases maximal oxygen uptake,endurance capacity,and sub-maximal exercise fat oxidation as much as 6 high-intensity interval training sessions over 2 weeks

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Journal of Sport and Health Science 2021年第4期10卷 478-487页

作者： muhammed M.Atakan Yasemin Guzel Suleyman bulut Sukran N.Kosar Glenn K.McConell Huseyin H.Turnagol Division of Nutrition and Metabolism in Exercise Faculty of Sport SciencesHacettepe UniversityAnkara 06690Turkey Institute for Health and Sport Victoria UniversityMelbourneVIA 3011Australia

Background:High-intensity interval training(HIIT)induces similar or even superior adaptations compared to continuous endurance ***,just 6 HIIT sessions over 2 weeks significantly improves maximal oxygen uptake(VO_(2max)),submaximal exercise fat oxidation,and endurance *** even faster adaptations can be achieved with HIIT is not ***,we aimed to determine whether 2 sessions of HIIT per day,separated by 3 h,every other day for 5 days(double HIIT(HIIT-D),n=15)could increase VO_(2max),submaximal exercise fat oxidation,and endurance capacity as effectively as 6 sessions of HIIT over 2 weeks(single HIIT(HIIT-S),n=13).Methods:Each training session consisted of 10×60 s of cycling at 100%of VO_(2max)interspersed with 75 s of low-intensity cycling at 60 watt(W).Pre-and post-training assessments included VO_(2max),time to exhaustion at-80%of VO_(2max),and 60-min cycling trials at-67%of VO_(2max).Results:Similar increases(p0.05)and endurance capacity(HIIT-D:80.1%***-S:79.2%,p>0.05)were *** exercise carbohydrate oxidation was reduced in the 2 groups after exercise training(HIIT-D:9.2%,p=0.014 ***-S:18.8%,p=0.012)while submaximal exercise fat oxidation was significantly increased in HIIT-D(15.5%,p=0.048)but not in HIIT-S(9.3%,p=0.290).Conclusion:Six HIIT sessions over 5 days was as effective in increasing VO_(2max)and endurance capacity and was more effective in improving submaximal exercise fat oxidation than 6 HIIT sessions over 2 weeks.

关键词： Double interval training Exercise metabolism Performance Substrate oxidation

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Is exon mutation analysis needed for adjuvant treatment of gastrointestinal stromal tumor?

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World Journal of Gastroenterology 2013年第1期19卷 144-146页

作者： Mehmet Ali Nahit Sendur Nuriye Yildirim zdemir muhammed Bülent Akinci Dogan Uncu nurullah Zengin Sercan Aksoy Department of Medical Oncology Ankara Numune Education and Research HospitalAnkara 06100Turkey Department of Medical Oncology Hacettepe University Institute of OncologyAnkara 06100Turkey

Gastrointestinal stromal tumors(GISTs) are the most common soft tissue sarcoma of the gastrointestinal tract,resulting from an activating mutation of stem cell factor receptor(KIT),and an activating mutation of the homologous platelet-derived growth factor receptor alpha(PDGFRA) *** GISTs(90%-95%) are *** 5% of GISTs are truly negative for KIT *** have been documented to resistant conventional *** to the KIT activation that occurs in the majority of the cases,KIT inhibition is the primary treatment approach in the adjuvant treatment of metastatic *** mesylate is an oral agent that is a selective protein tyrosine kinase inhibitor of the KIT protein tyrosine kinase,and it has demonstrated clinical benefit and objective tumor responses in most GIST patients in phase Ⅱ and Ⅲ *** presence and the type of KIT or PDGFRA mutation are predictive of response to imatinib therapy in patients with advanced and metastatic *** analysis in phaseⅠ-Ⅱ trials revealed significant differences in objective response,progression-free survival,and overall survival between GISTs with different kinase *** aim of this letter is to touch on the need for exon mutation analysis for adjuvant treatment with imatinib in GIST patients.

关键词： Imatinib Gastrointestinal stromal tumor Activating mutation Stem cell factor receptor Platelet-derived growth factor receptor alpha Mutation analysis

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