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Endoscopic ultrasound-guided drainage of pelvic abscess: A case series of 8 patients

World Journal of Gastrointestinal Endoscopy 2014年第8期6卷 373-378页

作者： muhammed hadithi Marco J Bruno Department of Gastroenterology Maass-tad Hospital 3079 DZ Rotterdam The Netherlands Department of Gastroenterology and Hepatology Erasmus MC University Medical Center 3015 CE Rotterdam The Netherlands

AIM: To show the safety and effectiveness of endo-scopic ultrasound(EUS)-guided drainage of pelvic ab-scess that were inaccessible for percutaneous drainage. METHODS: Eight consecutive patients with pelvic abscess that were not amenable to drainage under computed tomography(CT) guidance were referred for EUS-guided drainage. The underlying cause of the abscesses included diverticulitis in 4, postsurgical surgi-cal complications in 2, iatrogenic after enema in 1, and Crohn's disease in 1 patient. Abscesses were all drained under EUS guidance via a transrectal or transsigmoidal approach. RESULTS: EUS-guided placement of one or two 7 Fr pigtail stents was technically successful and uneventful in all 8 patients(100%). The abscess was perisigmoidal in 2 and was multilocular in 4 patients. All procedures were performed under conscious sedation and without fluoroscopic monitoring. Fluid samples were success-fully retrieved for microbiological studies in all cases and antibiotic policy was adjusted according to cultureresults in 5 patients. Follow-up CT showed complete re-covery and disappearance of abscess. The stents were retrieved by sigmoidoscopy in only two patients and had spontaneously migrated to outside in six patients. All drainage procedures resulted in a favourable clinical outcome. All patients became afebrile within 24 h after drainage and the mean duration of the postprocedure hospital stay was 8 d(range 4-14). Within a median follow up period of 38 mo(range 12-52) no recurrence was reported. CONCLUSION: We conclude that EUS-guided drain-age of pelvic abscesses without fluoroscopic monitoring is a minimally invasive, safe and effective approach that should be considered in selected patients.

关键词： Pelvic abscess Endoscopic ultrasoundguided drainage

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Abdominal computed tomography in refractory coeliac disease and enteropathy associated T-cell lymphoma

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World Journal of Gastroenterology 2007年第11期13卷 1696-1700页

作者： Maarten Mallant muhammed hadithi Abdul-Baqi Al-Toma Matthijs Kater Maarten Jacobs Radu Manoliu Chris Mulder Jan Hein van Waesberghe Departement of Radiology VU University Medical Center Amsterdam The Netherlands Departement of Gastroenterology Small Bowel Unit VU University Medical Center Amsterdam The Netherlands

AIM： To evaluate computed tomography （CT） findings, useful to suggest the presence of refractory celiac disease （RCD） and enteropathy associated T cell lymphoma （EATL）. METHODS： Coeliac disease （CD） patients were divided into two groups. Group Ⅰ ： uncomplicated CD （n = 14） and RCD type Ⅰ （n = 10）. Group Ⅱ ： RCD type Ⅱ （n = 15） and EATL （n = 7）. RESULTS： Both groups showed classic signs of CD on CT. Intussusception was seen in 1 patient in group Ⅰ vs 5 in group Ⅱ （P = 0.06）. Lymphadenopathy was seen in 5 patients in group Ⅱ vs no patients in group Ⅰ （P = 0.01）. Increased number of small mesenteric vessels was noted in 20 patients in group Ⅰ vs Ⅱ in group 11 （P = 0.02）. Eleven patients （50%） in group 11 had a splenic volume 〈 122 cm^3 vs 4 in group Ⅰ （14%）, 10 patients in group Ⅰ had a splenic volume 〉 196 cm^3 （66.7%） vs 5 in group Ⅱ （33.3%） P = 0.028. CONCLUSION： CT scan is a useful tool in discriminating between CD and （Pre） EATL. RCD Ⅱ and EATL showed more bowel wall thickening, lymphadenopathy and intussusception, less increase in number of small mesenteric vessels and a smaller splenic volume compared with CD and RCD Ⅰ.

关键词： Coeliac disease Refractory coeliac disease Enteropathy associated T-cell lymphoma Computed tomography Bowel wall thickening Lymphadenopathy, Intussusception Splenic volume

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Effect of B vitamin supplementation on plasma homocysteine levels in celiac disease

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World Journal of Gastroenterology 2009年第8期15卷 955-960页

作者： muhammed hadithi Chris JJ Mulder Frank Stam Joshan Azizi J Bart A Crusius Amado Salvador Pea Coen DA Stehouwer Yvo M Smulders Department of Gastroenterology VUmc University Medical Center Amsterdam PO Box 7057 Amsterdam 1007 MB The Netherlands Department of Internal Medicine VUmc University Medical Center Amsterdam PO Box 7057 Amsterdam 1007 MB The Netherlands Laboratory of Immunogenetics Department of Pathology VUmc University Medical Center Amsterdam PO Box 7057 Amsterdam 1007 MB The Netherlands Department of Internal Medicine Academic Hospital Maastricht P. Debyelaan 25 6229 HX Maastricht The Netherlands

AIM: To investigate the effect of vitamin supplements on homocysteine levels in patients with celiac disease. METHODS: Vitamin B6, folate, vitamin B12, and fasting plasma homocysteine levels were measured in 51 consecutive adults with celiac disease [median (range) age 56 (18-63) years; 40% men, 26 (51%) had villous atrophy, and 25 (49%) used B-vitamin supplements] and 50 healthy control individuals matched for age and sex. Finally, the C677T polymorphism of 5,10-methylene tetrahydrofolate reductase (MTHFR) was evaluated in 46 patients with celiac disease and all control individuals. RESULTS: Patients with celiac disease and using vitamin supplements had higher serum vitamin B6 (P = 0.003),folate (P < 0.001), and vitamin B12 (P = 0.012) levels than patients who did not or healthy controls (P = 0.035, P < 0.001, P = 0.007, for vitamin B6, folate, and vitamin B12, respectively). Lower plasma homocysteine levels were found in patients using vitamin supplements than in patients who did not (P = 0.001) or healthy controls (P = 0.003). However, vitamin B6 and folate, not vitamin B12, were significantly and independently associated with homocysteine levels. Twenty-four (48%) of 50 controls and 23 (50%) of 46 patients with celiac disease carried the MTHFR thermolabile variant T-allele (P = 0.89). CONCLUSION: Homocysteine levels are dependent on Marsh classification and the regular use of B-vitamin supplements is effective in reduction of homocysteine levels in patients with celiac disease and should be considered in disease management.

关键词： Celiac disease Homocysteine Vitamin supplements

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Coeliac disease in Dutch patients with Hashimoto’s thyroiditis and vice versa

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World Journal of Gastroenterology 2007年第11期13卷 1715-1722页

作者： muhammed hadithi Hans de Boer Jos WR Meijer Frans Willekens Jo A Kerckhaert Roel Heijmans Amado Salvador Pea Coen DA Stehouwer Chris JJ Mulder Department of Gastroenterology Rijnstate Hospital PO Box 9555 6800 TA Arnhem The Netherlands Department of Endocrinology Rijnstate Hospital PO Box 9555 6800 TA Arnhem The Netherlands Department of Pathology Rijnstate Hospital PO Box 9555 6800 TA Arnhem The Netherlands Laboratory of Biochemistry Rijnstate Hospital PO Box 9555 6800 TA Arnhem The Netherlands Laboratory of Biochemistry Immunology Rijnstate Hospital PO Box 9555 6800 TA Arnhem The Netherlands Laboratory of Immunogenetics VU University Medical Center Amsterdam PO Box 7057 1007 MB Amsterdam The Netherlands Department of Internal Medicine University Hospital Maastricht P. Debyelaan 25 6229 HX Maastricht The Netherlands

AIM: To define the association between Hashimoto’s thyroiditis and coeliac disease in Dutch patients. METHODS: A total of 104 consecutive patients with Hashimoto’s thyroiditis underwent coeliac serological tests (antigliadins, transglutaminase and endomysium antibodies) and HLA-DQ typing. Small intestinal biopsy was performed when any of coeliac serological tests was positive. On the other hand, 184 patients with coeliac disease were subjected to thyroid biochemical (thyroid stimulating hormone and free thyroxine) and thyroid serological tests (thyroglobulin and thyroid peroxidase antibodies). RESULTS: Of 104 patients with Hashimoto’s thyroiditis, sixteen (15%) were positive for coeliac serology and five patients with documented villous atrophy were diagnosed with coeliac disease (4.8%; 95% CI 0.7-8.9). HLA-DQ2 (and/or -DQ8) was present in all the five and 53 patients with Hashimoto’s thyroiditis (50%; 95% CI 43-62). Of 184 patients with coeliac disease, 39 (21%) were positive for thyroid serology. Based on thyroid biochemistry, the 39 patients were subclassified into euthyroidism in ten (5%; 95% CI 2-9), subclinicalhypothyroidism in seven (3.8%; 95% CI 1.8-7.6), and overt hypothyroidism (Hashimoto’s thyroiditis) in 22 (12%; 95% CI 8-16). Moreover, four patients with coeliac disease had Graves’ disease (2%; 95% CI 0.8-5) and one patient had post-partum thyroiditis. CONCLUSION: The data from a Dutch population confirm the association between Hashimoto’s thyroiditis and coeliac disease. Screening patients with Hashimoto’s thyroiditis for coeliac disease and vice versa is recom- mended.

关键词： Autoimmune disease Coeliac disease Hashimoto's thyroiditis

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Retrospective analysis of old-age colitis in the Dutch inflammatory bowel disease population

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World Journal of Gastroenterology 2008年第20期14卷 3183-3187页

作者： muhammed hadithi Marcel Cazemier Gerrit A Meijer Elisabeth Bloemena Richel J Felt-Bersma Chris J Mulder Stephan GM Meuwissen Amado Salvador Pea Adriaan A van Bodegraven Department of Gastroenterology VUmcUniversity Medical Center Department of Pathology VUmc University MedicalCenter

AIM： To describe the characteristics of Dutch patients with *** bowel disease （IBD） first diagnosed above 60 years of age-a disease also known as old-age colitis （OAC） and to highlight a condition that has a similar appearance to IBD, namely segmen- tal colitis associated with diverticular disease （SCAD）. METHODS： A retrospective longitudinal survey of patient demographic and clinical characteristics, disease characteristics, diagnostic methods, management and course of disease was performed. The median follow-up period was 10 years. RESULTS： Of a total of 1100 IBD patients attending the Department of Gastroenterology, 59 （50） [median age 82 years （range 64-101）; 25 male （42%）] were identified. These patients were diagnosed with ulcerative colitis （n = 37, 61%）, Crohn＇s disease （n = 14, 24%）, and indeterminate colitis （n = 8, 15%）. Remission was induced in 40 （68%） patients within a median interval of 6 mo （range 1-21） and immunosuppressive therapy was well tolerated. Histological evaluation based on many biopsy samples and the course of the disease led to other diagnosis, namely SCAD instead of IBD in five （8%） patients. CONCLUSION： OAC is not an infrequent problem for the gastroenterologist, and should be considered in the evaluation of older patients with clinical features suggestive of IBD. Extra awareness and extensive biopsy sampling are required in order to avoid an erroneous diagnosis purely based on histological mimicry of changes seen in SCAD, when diagnosing IBD in the presence of diverticulosis coli.

关键词： Inflammatory bowel disease Old-age colitis Segmental colitis

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Expanding role of antibodies in kidney transplantation

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World Journal of Transplantation 2025年第1期15卷 57-71页

作者： Khawar Abbas muhammed Mubarak Department of Transplant Immunology Sindh Institute of Urology&TransplantationKarachi 74200SindhPakistan Javed I.Kazi Department of Histopathology Sindh Institute of Urology&TransplantationKarachi 74200SindhPakistan

The role of antibodies in kidney transplant(KT)has evolved significantly over the past few *** role of antibodies in KT is multifaceted,encompassing both the challenges they pose in terms of antibody-mediated rejection(AMR)and the opportunities for improving transplant outcomes through better detection,prevention,and treatment *** our understanding of the immunological mechanisms continues to evolve,so too will the approaches to managing and harnessing the power of antibodies in KT,ultimately leading to improved patient and graft *** narrative review explores the multifaceted roles of antibodies in KT,including their involvement in rejection mechanisms,advancements in desensitization protocols,AMR treatments,and their potential role in monitoring and improving graft survival.

关键词： Antibodies Humoral theory Kidney transplantation Rejection

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Abrasive wear behavior of functionally graded Al_(3)Ti reinforced aluminum matrix composite

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China Foundry 2025年第1期22卷 45-54页

作者： Eylül Tuğçe Yaman Yildiz Ömer Savaş muhammed Soner Başer Engin Kocaman Ince Shipping Group 34724IstanbulTurkey Yildiz Technical University Faculty of Naval Architecture and Maritime34349IstanbulTurkey Ministry of Transport and Infrastructure General Directorate of Marine Affairs06338AnkaraTurkey Zonguldak Bulent Ecevit University Faculty of EngineeringDepartment of Aerospace Engineering67100ZonguldakTurkey

Aluminum alloys are widely used in industry due to their light *** alloys are generally exposed to abrasive wear,which diminishes their effective *** wear resistance of these alloys is enhanced by adding various reinforcements,however,this enhancement comes at the cost of reduced fracture *** paradox of increased wear resistance versus decreased fracture toughness in aluminum alloys can be resolved by using functionally graded materials (FGMs).This study focuses on the abrasive wear behavior of functional graded aluminum matrix composites reinforced with Al_(3)Ti *** wear properties of the composites were investigated by considering the characteristics of the composite such as matrix type and various composite zones,as well as the wear parameters such as abrasive particle diameter,load,sliding speed and *** method was used in the abrasive wear tests in order to get more reliable results in a timeefficient *** recipes were created based on the L_(27)(3^(6)) orthogonal *** a result of the study,it is observed that the wear resistance of the composites increases with an increase in Al_(3)Ti reinforcement content and hardness of the *** addition,the size of abrasive particles and the applied load are significant factors affecting abrasive wear.

关键词： functionally graded Al_(3)Ti Taguchi abrasive wear

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Addressing social function in the treatment of depression:A call for holistic approaches

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World Journal of Psychiatry 2025年第2期15卷 279-282页

作者： muhammed Fatih Tabara Department of Psychiatry Firat University School of MedicineElazig 23200Türkiye

This article discusses the importance of addressing social functioning impairment in patients with residual depressive symptoms,as highlighted in the study by Liao et *** authors showed that social dysfunction persists in many patients despite symptom *** observation calls for a shift in depression treatment strategies,with an emphasis on integrating social functioning as a key treatment *** article suggests targeted interventions that focus on both symptomatic relief and the restoration of social function.

关键词： Social function Depression Residual symptoms Treatment Psychotherapy Cognitive-behavioural therapy

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Phase-plane analysis of test particle orbits in regular black holes

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Communications in Theoretical Physics 2020年第1期72卷 111-117页

作者： muhammed Amir Astrophysics and Cosmology Research Unit School of MathematicsStatistics and Computer ScienceUniversity of KwaZulu-NatalPrivate Bag X54001Durban 4000South Africa

We investigate phase-plane analysis of general relativistic orbits in a gravitational field of the Reissner–Nordstr?m-type regular black hole *** employ phase-plane analysis to obtain different phase-plane diagrams of the test particle orbits by varying charge q and dimensionless parameterβ,whereβcontains angular momentum of the test *** compute numerical values of radii for the innermost stable orbits and corresponding values of energy required to place the test particle in *** on,we employ similar analysis on an Ayón–Beato–García(ABG)regular black hole and a comparison regarding key results is also included.

关键词： black holes modified gravity phase-plane diagrams

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Rule Based Collector Station Selection Scheme for Lossless Data Transmission in Underground Sensor Networks

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China Communications 2019年第12期16卷 72-83页

作者： muhammed Enes Bayrakdar Computer Engineering Department Duzce University

There are fundamentally two different communication media in wireless underground sensor networks. The first of these is a solid medium where the sensor nodes are buried underground and wirelessly transmit data from underground to aboveground. The second is an underground medium such as tunnel, cave etc. and the data is transmitted from underground to the aboveground through partially solid medium. The quality of communication is greatly influenced by the humidity of the soil in both environments. The placement of wireless underground sensor nodes at hard-to-reach locations makes energy efficient work compulsory. In this paper, rule based collector station selection scheme is proposed for lossless data transmission in underground sensor networks. In order for sensor nodes to transmit energy-efficient lossless data, rulebased selection operations are carried out with the help of fuzzy logic. The proposed wireless underground sensor network is simulated using Riverbed software, and fuzzy logic-based selection scheme is implemented utilizing Matlab software. In order to evaluate the performance of the sensor network;the parameters of delay, throughput and energy consumption are investigated. Examining performance evaluation results, it is seen that average delay and maximum throughput are accomplished in the proposed underground sensor network. Under these conditions, it has been shown that the most appropriate collector station selection decision is made with the aim of minimizing energy consumption.

关键词： sensor network fuzzy rule based underground collector station

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