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A Multilevel Deep Feature Selection Framework for Diabetic Retinopathy Image Classification

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Computers, Materials & Continua 2022年第2期70卷 2261-2276页

作者： Farrukh Zia Isma Irum Nadia Nawaz Qadri Yunyoung Nam Kiran Khurshid muhammad Ali Imran ashraf muhammad Attique Khan Department of ECE COMSATS University IslamabadWah Campus47040Pakistan Department of Computer Science and Engineering Soonchunhyang UniversityAsanKorea Department of Electrical Engineering NUMLRawalpindiPakistan Department of Computer Science HITEC University TaxilaTaxilaPakistan

Diabetes or Diabetes Mellitus(DM)is the upset that happens due to high glucose level within the *** the passage of time,this polygenic disease creates eye deficiency referred to as Diabetic Retinopathy(DR)which can cause a major loss of *** symptoms typically originate within the retinal space square in the form of enlarged veins,liquid dribble,exudates,haemorrhages and small scale *** current therapeutic science,pictures are the key device for an exact finding of patients’***,an assessment of new medicinal symbolisms stays ***,Computer Vision(CV)with deep neural networks can train models with high *** thought behind this paper is to propose a computerized learning model to distinguish the key precursors of Dimensionality Reduction(DR).The proposed deep learning framework utilizes the strength of selected models(VGG and Inception V3)by fusing the extracated *** select the most discriminant features from a pool of features,an entropy concept is employed before the classification *** deep learning models are fit for measuring the highlights as veins,liquid dribble,exudates,haemorrhages and miniaturized scale aneurysms into various *** model will ascertain the loads,which give the seriousness level of the patient’s *** model will be useful to distinguish the correct class of seriousness of diabetic retinopathy pictures.

关键词： Deep neural network diabetic retinopathy retina features extraction classification

Genome-wide association analysis for stripe rust resistance in spring wheat(Triticum aestivum L.) germplasm

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Journal of Integrative Agriculture 2020年第8期19卷 2035-2043页

作者： Sher muhammad muhammad SAJJAD Sultan Habibullah KHAN muhammad SHAHID muhammad ZUBAIR Faisal Saeed AWAN Azeem iqbal KHAN muhammad Salman MUBARAK Ayesha TAHIR muhammad UMER Rumana KEYANI muhammad InamAFZAL irfan MANZOOR Javed Iqbal WATTOO Aziz-ur REHMAN Department of Bioinformatics and Biotechnology GC UniversityFaisalabad 38090Pakistan Department of Biosciences COMSATS University Islamabad(CUI)Islamabad 45550Pakistan Centre of Agricultural Biochemistry and Biotechnology(CABB) University of AgricultureFaisalabad 38000Pakistan Department of Plant Breeding and Genetics University of AgricultureFaisalabad 38000Pakistan Department of Biotechnology Faculty of Life SciencesUniversity of Central PunjabLahore 54000Pakistan Wheat Research Institute Ayub Agricultural Research Institute(AARI)Faisalabad 38950Pakistan

Stripe rust is a continuous threat to wheat crop all over the *** causes considerable yield losses in wheat crop every *** deployment of adult plant resistance(APR)genes in newly developing wheat cultivars is the most judicious strategy to combat this ***,we dissected the genetics underpinning stripe rust resistance in Pakistani wheat *** association panel of 94 spring wheat genotypes was phenotyped for two years to score the infestation of stripe rust on each accession and was scanned with 203 polymorphic *** on D’measure,linkage disequilibrium(LD)exhibited between loci distant up to 45 c ***-trait associations(MTAs)were determined using mixed linear model(MLM).Total 31 quantitative trait loci(QTLs)were observed on all 21 wheat *** QTLs were newly discovered as well as 19 QTLs and 35 previously reported Yr genes were validated in Pakistani wheat *** major QTLs were ***.2 AL and ***.3 BS(PVE,11.9%).Dissection of genes from the newly observed QTLs can provide new APR genes to improve genetic resources for APR resistance in wheat crop.

关键词： wheat Puccinia striiformis LD GWAS MTA PCoA

Ontological Model for Cohesive Smart Health Services Management

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Computers, Materials & Continua 2023年第2期74卷 3679-3695页

作者： muhammad Raza Naqvi muhammad Waseem Iqbal Syed Khuram Shahzad M.Usman ashraf Khalid Alsubhi Hani Moaiteq Aljahdali Le Laboratoire Génie de Production de l’École Nationale d’Ingénieurs de Tarbes(LGP-INP-ENIT) Universitéde ToulouseCEDEXTarbes65016France Department of Software Engineering Superior UniversityLahore53700Pakistan Department of Informatics&Systems University of Management&TechnologyLahore54000Pakistan Department of Computer Science University of Management and TechnologySialkot51310Pakistan Department of Computer Science King Abdul-Aziz UniversityJeddah21577Saudi Arabia Faculty of Computing and Information Technology King Abdulaziz UniversityJeddah21577Saudi Arabia

Health care has become an essential social-economic concern for all stakeholders(e.g.,patients,doctors,hospitals etc.),health needs,private care and the elderly class of *** massive increase in the usage of health care Internet of things(IoT)applications has great technological evolvement in human *** are various smart health care services like remote patient monitoring,diagnostic,disease-specific remote treatments and *** applications are available in a split fashion and provide solutions for variant diseases,medical resources and remote service *** main objective of this research is to provide a management platform where all these services work as a single unit to facilitate the *** ontological model of integrated healthcare services is proposed by getting requirements from various existing healthcare *** were 26 smart health care services and 26 smart health care services to classify the knowledge-based ontological *** proposed ontological model is derived from different classes,relationships,and constraints to integrate health care *** model is developed using Protégébased on each interrelated/correlated health care service having different *** querying SPARQL protocol and RDF query language(SPARQL)were used for knowledge *** Pellet Reasoner is used to check the validity and relations coherency of the proposed ontology *** to other smart health care services integration systems,the proposed ontological model provides more cohesiveness.

关键词： Ontology internet of things smart health services integration

Corrigendum to“The effective transfection of a low dose of negatively charged drug-loaded DNA-nanocarriers into cancer cells via scavenger receptors”[Journal of Pharmaceutical Analysis volume 11(2021)174e182]

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Journal of Pharmaceutical Analysis 2022年第4期12卷 698-700页

作者： Mirza muhammad Faran ashraf Baig Chengfei Zhang muhammad Furqan Akhtar Ammara Saleem Jahanzeb Mudassir Laboratory of Biomedical&Pharmaceutical Engineering of Stem Cells Research Restorative Dental SciencesFaculty of DentistryThe University of Hong KongHong Kong999077PR China State Key Laboratory of Analytical Chemistry for Life Sciences School of Chemistry and Chemical EngineeringNanjing UniversityNanjing210023PR China Faculty of Pharmacy Bahauddin Zakariya UniversityMultan 60000Pakistan Riphah Institute of Pharmaceutical Sciences Riphah International UniversityLahorePakistan Department of Pharmacology Faculty of Pharmaceutical SciencesGovernment College University FaisalabadFaisalabadPakistan

The authors regret to inform that Figs.4,6,and 7 in the original article were wrongly *** corrected figures appear below:The authors would like to apologize for any inconvenience caused.

关键词： Cor loaded cancer

Modeling the Dynamics of Tuberculosis with Vaccination,Treatment,and Environmental Impact:Fractional Order Modeling

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Computer Modeling in Engineering & Sciences 2024年第11期141卷 1365-1394页

作者： muhammad Altaf Khan Mahmoud H.DarAssi irfan Ahmad Noha Mohammad Seyam Ebraheem Alzahrani Faculty of Natural and Agricultural Sciences University of the Free StateBleomfontein9300South Africa Department of Basic Sciences Princess Sumaya University for TechnologyAmman11941Jordan Department of Clinical Laboratory Sciences College of Applied Medical ScienceKing Khalid UniversityAbha62529Saudi Arabia Mathematical Sciences Department College of Applied SciencesUmm Al-Qura UniversityMakkah24381Saudi Arabia Department of Mathematics Faculty of ScienceKing Abdulaziz UniversityP.O.Box 80203Jeddah21589Saudi Arabia

A mathematical model is designed to investigate Tuberculosis(TB)disease under the vaccination,treatment,andenvironmental impact with real ***,we introduce the model formulation in non-integer order derivativeand then,extend the model into fractional order *** fractional system’s existence,uniqueness,andother relevant properties are ***,we study the stability analysis of the equilibrium *** disease-free equilibrium(DFE)D_(0)is locally asymptotically stable(LAS)when R_(v)1 and D_(0)for R_(v)≤*** existenceof bifurcation analysis in the model is investigated,and it is shown the system possesses the forward *** analysis has been performed to determine the sensitive parameters that impact R_(v).Weconsider the real TB statistics from Khyber Pakhtunkhwa in Pakistan and parameterized the *** computedbasic reproduction number obtained using the real cases is R0≈*** numerical results regardingdisease elimination of the sensitive parameters are shown graphically.

关键词： Tuberculosis real data stability analysis parameter estimations discussion

Overexpression of the phytochrome B gene from Arabidopsis thaliana increases plant growth and yield of cotton (Gossypium hirsutum)

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2011年第4期12卷 326-334页

作者： Abdul Qayyum RAO muhammad irfan Zafar SALEEM Idrees Ahmad NASIR Sheikh RIAZUDDIN Tayyab HUSNAIN National Centre of Excellence in Molecular Biology

The phytochrome B (PHYB) gene of Arabidopsis thaliana was introduced into cotton through Agrobacterium *** and expression of PHYB gene in cotton plants were confirmed by molecular *** RNA (mRNA) expression in one of the transgenic lines,QCC11,was much higher than those of control and other transgenic *** cotton plants showed more than a two-fold increase in photosynthetic rate and more than a four-fold increase in transpiration rate and stomatal *** increase in photosynthetic rate led to a 46% increase in relative growth rate and an 18% increase in net assimilation *** recorded up to two generations,both in the greenhouse and in the field,revealed that overexpression of Arabidopsis thaliana PHYB gene in transgenic cotton plants resulted in an increase in the production of cotton by improving the cotton plant growth,with 35% more ***,the presence of the Arabidopsis thaliana PHYB gene caused pleiotropic effects like semi-dwarfism,decrease in apical dominance,and increase in boll size.

关键词： Transformation Gossypium hirsutum Phytochrome B Overexpression Plant growth Yield

The Spherical q-Linear Diophantine Fuzzy Multiple-Criteria Group Decision-Making Based on Differential Measure

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Computer Modeling in Engineering & Sciences 2024年第2期138卷 1925-1950页

作者： Huzaira Razzaque Shahzaib ashraf muhammad Naeem Yu-Ming Chu Institute of Mathematics Khwaja Fareed University of Engineering&Information TechnologyRahim Yar Khan64200Pakistan Department of Mathematics Deanship of Applied SciencesUmm Al-Qura UniversityMeccaSaudi Arabia Department of Mathematics Huzhou UniversityHuzhou313000China

Spherical q-linearDiophantine fuzzy sets(Sq-LDFSs)provedmore effective for handling uncertainty and vagueness in multi-criteria decision-making(MADM).It does not only cover the data in two variable parameters but is also beneficial for three parametric *** Pythagorean fuzzy sets,the difference is calculated only between two parameters(membership and non-membership).According to human thoughts,fuzzy data can be found in three parameters(membership uncertainty,and non-membership).So,to make a compromise decision,comparing Sq-LDFSs is *** measures of different fuzzy sets do,however,can have several flaws that can lead to counterintuitive *** instance,they treat any increase or decrease in the membership degree as the same as the non-membership degree because the uncertainty does not change,even though each parameter has a different *** the Sq-LDFSs comparison,this research develops the differentialmeasure(DFM).Themain goal of the DFM is to cover the unfair arguments that come from treating different types of FSs opposing criteria *** to their relative positions in the attribute space and the similarity of their membership and non-membership degrees,two Sq-LDFSs formthis preference connectionwhen the uncertainty remains same in both *** to the degree of superiority or inferiority,two Sq-LDFSs are shown as identical,equivalent,superior,or inferior over one *** suggested DFM’s fundamental characteristics are *** on the newly developed DFM,a unique approach tomultiple criterion group decision-making is *** suggestedmethod verifies the novel way of calculating the expert weights for Sq-LDFSS as in *** proposed technique in three parameters is applied to evaluate solid-state drives and choose the optimum photovoltaic cell in two applications by taking uncertainty parameter *** method’s applicability and validity shown by the findings are contrasted with those obtained using various

关键词： Multi-criteria group decision-making spherical q-linear Diophantine fuzzy sets differencemeasures photovoltaic cells medical diagnosis

Anti-obesity effect and UHPLC-QTOF-MS/MS based metabolite profiling of Solanum nigrum leaf extract

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Asian Pacific Journal of Tropical Biomedicine 2022年第4期12卷 164-174页

作者： Zain Ul Aabideen muhammad Waseem Mumtaz muhammad Tayyab Akhtar muhammad Asam Raza Hamid Mukhtar Ahmad irfan Syed Ali Raza muhammad Nadeem Yee Soon Ling Department of Chemistry University of GujratGujratPakistan Institute of Industrial Biotechnology GC University LahoreLahorePakistan Department of Chemistry College of ScienceKing Khalid UniversityP.O.Box 9004Abha 61413Saudi Arabia Research Center for Advanced Materials Science King Khalid UniversityP.O.Box 9004Abha 61413Saudi Arabia Department of Chemistry GC University LahoreLahorePakistan Sabah Occupational Safety Health and Environment AssociationLot331st FloorBlock EIramanis CenterJalanLinatas88450Kota KinabaluSabahMalaysia

Objective:To evaluate the antioxidant potential and pancreatic lipase inhibitory action of optimized hydroethanolic extracts of Solanum ***:Optimized extraction for maximum recovery of metabolites was performed using a combination of freeze-drying and ultrasonication followed by determination of antioxidant and antiobesity *** ultra-high performance liquid chromatography equipped with mass spectrometry was used to analyze metabolite profiling of Solanum *** studies were performed using molecular docking and electrostatic potential analysis for individual *** hypolipidemic potential of the most potent extract was assessed in the obese mice fed on fat rich ***:The 80%hydroethanolic extract exhibited the highest extract yield,total phenolic contents,total flavonoid contents along with the strongest 2,2-diphenyl-1-picrylhydrazyl scavenging activity,total antioxidant power,and pancreatic lipase inhibitory *** 80%hydroethanolic extract not only regulated the lipid profile of obese mice but also restricted the weight gain in the liver,kidney,and *** 80%hydroethanolic extract also reduced alanine transaminase and aspartate transaminase concentrations in *** effects of plant extract at 300 mg/kg body weight were quite comparable with the standard drug ***:Solanum nigrum is proved as an excellent and potent source of secondary metabolites that might be responsible for obesity mitigation.

关键词： Solanum nigrum Ultrasonication Metabolite profiling Total phenolic contents Total flavonoid content Antioxidant DPPH Total antioxidant power Pancreatic lipase UHPLC-QTOF-MS/MS Antiobesity Mice Hypolipidemic Molecular docking

Computational Analysis of the Oscillatory Mixed Convection Flow along a Horizontal Circular Cylinder in Thermally Stratified Medium

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Computers, Materials & Continua 2020年第10期65卷 109-123页

作者： Zia Ullah muhammad ashraf Saqib Zia Yuming Chu Ilyas Khan Kottakkaran Sooppy Nisar Department of Mathematics Faculty of ScienceUniversity of SargodhaSargodhaPakistan Department of Mathematics COMSATS University IslamabadIslamabad44000Pakistan Department of Mathematics Huzhou UniversityHuzhou313000China Hunan Provincial Key Laboratory of Mathematical Modeling and Analysis in Engineering Changsha University of Science&TechnologyChangsha410114China Faculty of Mathematics and Statistics Ton Duc Thang UniversityHo Chi Minh72915Vietnam Department of Mathematics College of Arts and SciencesPrince Sattam bin Abdulaziz UniversityWadi Aldawaser11991Saudi Arabia

The present work emphasizes the significance of oscillatory mixed convection stratified fluid and heat transfer characteristics at different stations of non-conducting horizontally circular cylinder in the presence of thermally stratified *** remove the difficulties in illustrating the coupled PDE’s,the finite-difference scheme with efficient primitive-variable formulation is proposed to transform dimensionless *** numerical simulations of coupled non-dimensional equations are computed in terms velocity of fluid,temperature and magnetic field which are computed to examine the fluctuating components of skin friction,heat transfer and current density for various emerging *** governing parameters namely,thermally stratification parameter𝑆𝑆𝑡𝑡,mixed-convection parameter𝜆𝜆,Prandtl number Pr,magnetic force parameter𝜉𝜉and magnetic-Prandtl number𝛾𝛾are displayed graphically at selected values for velocity and heat transfer *** is computed that heat transfer attains maximum amplitude and good variations in the presence of thermally stratified parameter at each position𝛼𝛼=𝜋𝜋6⁄,𝛼𝛼=𝜋𝜋3⁄and𝛼𝛼=𝜋𝜋around the surface of non-conducting horizontally *** velocity of fluid attains certain height at station𝛼𝛼=𝜋𝜋6⁄for higher value of stratification *** is also found that the temperature gradient decreases with stratification parameter𝑆𝑆𝑡𝑡,but it increases after a certain distance𝑌𝑌from the *** novelty of the current work is that due to non-conducting phenomena the magnetic effects are strongly observed far from the surface but exact at the surface are zero for each position.

关键词： Mixed-convection oscillatory stratified flow non-conducting cylinder thermal stratification heat transfer.