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Formulating etoposide in a nanoemulsion containing polyunsaturated fatty acids potentiates its anti-proliferation and anti-invasion activities against the ovarian cancer cells

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BIOCELL 2021年第3期45卷 695-703页

作者： MAYSON H.alkhatib SalWA M.al-HASHEMI HANA M.GASHLAN Department of Biochemistry Faculty of ScienceKing Abdulaziz UniversityJeddahSaudi Arabia Regenerative Medicine Unit King Fahd Center for Medical ResearchKing Abdulaziz UniversityJeddahSaudi Arabia

Inorporation of etoposide(ETP)into nanoemulsion(NE)containing polyunsaturated faty adids(PUFAS)may potentially augment its antiproliferation efet on the cancer cll The current study aimed to examine the in vitro antitumor activity of a novel formulation(ETP-BC/EP-NE)produced by combining the anticancer drug(ETP)with NE(BCEP-NE)consisting of the blasck currant seed and organic ewening primrose *** produced formulas were physically charaterized using 2etasizer *** ceytotoxkc efect was testfied at concentrations ranges from 0.0001 to 5μM using *** and ant-invasion efects were evaluated using the assays of mitochondrtal membrane potental,annexin V-FITC double *** fragmentation,and collagen-based cell *** to the zetasizer charaterization,the nano-suspensions of ETP-BC/EP-NE have z-average diameters of 87.63土3.30 nm with an average surface zeta potential of-0.605土0.003 mV.A reduction of 50%in the growth of SK-OV-3 cells was found at a distinetly lower concentration of ETP-BCEP-NE(IlCso=0.04土0.2μM)than that of ETP(ICsu=4.75土0.1μM).Resuts indicated that FTP-BCIEP-NE had a greater apoptotic ffect than FTP on SK-OV-3 cllsl which was attibuted to the larger amount of late apoptotic cells(41.9土1.05%)higher loss of mitochondrial membrane potential,and more intensive fragmented DNA The ETP-BC/EP-NE treatment suppressed the cllular invasion by 55%,whereas EIP impeded the ellular invasion by only 3%,Formulting ETP with PUFAs in NE had ameliorated the efcacy of ETP.

关键词： Black currant seed oil Organic evening primrose oil Chemotherapeutic agent Cellular growth Apoptosis

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Prevalence and risk factors of Blastocystis infection among underprivileged communities in rural Malaysia

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Asian Pacific Journal of Tropical Medicine 2017年第5期10卷 467-473页

作者： Nabilah Amelia Mohammad Hesham M.al-Mekhlafi Norhayati Moktar Tengku Shahrul Anuar Centre of Medical Laboratory Technology Faculty of Health SciencesUniversiti Teknologi MARAPuncak Alam Campus Endemic and Tropical Disease Unit Medical Research CenterJazan University Department of Parasitology Faculty of Medicine and Health SciencesSana’a University Department of Pre-Clinical Sciences Faculty of Medicine and Health SciencesUniversiti Tunku Abdul RahmanSungai Long Campus Integrative Pharmacogenomics Institute Universiti Teknologi MARAPuncak Alam Campus

Objective:To determine the prevalence and risk factors of Blastocystis among underprivileged communities living in rural Malaysia. Methods:This cross-sectional study was conducted among 253 participants aged between 1 and 85 years. Stool samples were examined using Wheatley's trichrome stain after in-vitro cultivation in Jones' medium to detect the presence of Blastocystis. Information pertaining to the demography,socioeconomic and environment were collected using pre-validated questionnaires. Results:The total prevalence of Blastocystis infection was 40.7%. The multiple logistic regression analysis revealed that age ≥15 years(OR = 2.72; 95%CI = 1.47-5.04) and presence of infected family members(OR = 8.56; 95%CI = 4.47-16.38) were the significant risk factors associated with blastocystosis in these communities. Conclusions:Blastocystosis is revealed through this study to be still prevalent among Orang Asli communities in rural Malaysia. The two main approaches that should be implemented by the public health authority in battling this infection would be the screening of other family members and giving treatment to the infected individuals. Moreover,it is imperative for health education on good personal and food hygiene practices are provided in order to reduce the morbidity and transmission of Blastocystis infection among the Orang Asli in their communities meaningfully.

关键词： Blastocystis Prevalence Risk factors Malaysia

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Application of Electrodynamic Theory on Quantum Hall Effect

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World Journal of Condensed Matter Physics 2016年第2期6卷 87-94页

作者： Saleem Iqbal muhammad Zafar Farhana Sarwar Syed Mohsin Raza muhammad Afzal Rana Department of Mathematics University of Balochistan Quetta Pakistan Department of Basic Sciences Riphah International University Islamabad Pakistan Department of Mathematics F. G. Girls Degree College Quetta Pakistan Department of Physics University of Balochistan Quetta Pakistan

The quantum electrodynamic (QED) behaviour is studied for quantum Hall effect (QHE). Quantum theory with conjecture of fractional charge quantization (quantum dipole moment), eigenfunctions for fractional charge quantization at the surface of a twisted and twigged electron quanta and above its surface, fractional Fourier transform and Hermite function for fractional charge quantization is developed. With energy eigen value equation for QHE and with energy operator on an eigenfunction of a twisted and twigged electron quanta, the corresponding eigenfunctions are normalized with Schrodinger’s quantum wave mechanical equation for electric scalar and magnetic potentials, respectively (QED behavior). The fractional electric and magnetic fields with their corresponding potentials for the quantized fractional states in semiconducting hereto structures are theoretically calculated. Such mathematical expressions are in good agreement with experimental results of Nobel Prize winning scientists Klitzing, Haroche, Peter and Gruebber. Our results can also explain the hybridized states of orbits with emphasis on sigma and pi bonding and their corresponding antibonding orbitals as a manifestation of electrophilic and nucleophilic chemical reactions.

关键词： Fractional Charge Quantization Fractional Fourier Transform Quantum Hall Effect Quantum Electrodynamics Electron Quanta String Twisted and Twigged Electron Quanta

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A Quantum Spatial Graph Convolutional Network for Text Classification

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Computer Systems Science & Engineering 2021年第2期36卷 369-382页

作者： Syed Mustajar Ahmad Shah Hongwei Ge Sami Ahmed Haider muhammad Irshad Sohail M.Noman Jehangir Arshad Asfandeyar Ahmad Talha Younas College of Computer Science and Technology Dalian University of TechnologyDalian116024China Department of Computing University of WorcesterUK Department of Information Engineering Chang’an UniversityXi’an710054China Department of Cell Biology and Genetics Shantou University Medical CollegeShantou515041China Electrical and Computer Engineering Department COMSATS University IslamabadLahore CampusPakistan School of Information&Communication Engineering Dalian University of Technology Dalian116024China Electrical and Computer Engineering Department COMSATS University IslamabadSahiwal CampusPakistan

The data generated from non-Euclidean domains and its graphical representation(with complex-relationship object interdependence)applications has observed an exponential *** sophistication of graph data has posed consequential obstacles to the existing machine learning *** this study,we have considered a revamped version of a semi-supervised learning algorithm for graph-structured data to address the issue of expanding deep learning approaches to represent the graph ***,the quantum information theory has been applied through Graph Neural Networks(GNNs)to generate Riemannian metrics in closed-form of several graph *** further,to pre-process the adjacency matrix of graphs,a new formulation is established to incorporate high order *** proposed scheme has shown outstanding improvements to overcome the deficiencies in Graph Convolutional Network(GCN),particularly,the information loss and imprecise information representation with acceptable computational ***,the proposed Quantum Graph Convolutional Network(QGCN)has significantly strengthened the GCN on semi-supervised node classification *** parallel,it expands the generalization process with a significant difference by making small random perturbationsG of the graph during the training *** evaluation results are provided on three benchmark datasets,including Citeseer,Cora,and PubMed,that distinctly delineate the superiority of the proposed model in terms of computational accuracy against state-of-the-art GCN and three other methods based on the same algorithms in the existing literature.

关键词： Text classiﬁcation deep learning graph convolutional networks semi-supervised learning GPUs performance improvements

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The microbiology of infected pancreatic necrosis

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Hepatobiliary & Pancreatic Diseases International 2018年第5期17卷 456-460页

作者： Nicholas G.Mowbray Bassam Ben-Ismaeil Mohammed Hammoda Guy Shingler Bilal al-Sarireh Swansea University Medical School Singleton Park Campus Abertawe Bro-Morgannwg University Health Board Public Health Wales Microbiology ABM Morriston Hospital Abertawe Bro-Morgannwg University Health Board Department of Surgery Morriston Hospital

Background: Acute pancreatitis(AP) continues to cause significant morbidity and mortality, especially when it leads to infected pancreatic necrosis(IPN). Modern treatment of IPN frequently involves prolonged courses of antibiotics in combination with minimally invasive therapies. This study aimed to update the existing evidence base by identifying the pathogens causing IPN and therefore aid future selection of empirical antibiotics. Methods: Clinical data, including microbiology results, of consecutive patients with IPN undergoing minimally invasive necrosectomy at our institution between January 2009 and July 2016 were retrospectively reviewed. Results: The results of 40 patients(22 males and 18 females, median age 60 years) with IPN were reviewed. The etiology of AP was gallstones, alcohol, dyslipidemia and unknown in 31, 2, 2 and 5 patients, respectively. The most frequently identified microbes in microbiology cultures were Enterococcus faecalis and faecium(22.5% and 20.0%) and Escherichia coli(20.0%). In 19 cases the cultures grew multiple organisms. The antibiotics with the least resistance amongst the microbiota were teicoplanin(5.0%), linezolid(5.6%), ertapenem(6.5%), and meropenem(7.4%). Conclusion: The carbapenem antibiotics, ertapenem and meropenem provide good antimicrobial cover against the common, mainly enteral, microorganisms causing IPN. Culture and sensitivity results of acquired samples should be regularly reviewed to adjust prescribing and monitor for emergence of resistance.

关键词： Acute pancreatitis Pancreatic abscess Pancreatic necrosis Infected pancreatic necrosis Antibiotics Intra-abdominal infection

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Waste Heat Recovery from a Drier Receiver of an A/C Unit Using Thermoelectric Generators

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Energy Engineering 2023年第8期120卷 1729-1746页

作者： ali Jaber Abdulhamed Aws al-Akam Ahmed A.Abduljabbar Mohammed H.alkhafaji Energy Engineering Department Faculty of Engineering/AL-MussayibUniversity of BabylonHillaBabylonIraq Construction and Projects Department Al Iraqia UniversityBaghdadIraq Department of Electrical Engineering University of TechnologyBaghdadIraq

Thermoelectric generators(TEGs)are considered promising devices for waste heat recovery from various *** Seebeck effect can be utilized to generate power using the residual heat emitted by the filter dryer receiver(FDR)of an air conditioning(A/C)system,which would otherwise go to *** study aims to build a set of thermoelectric generators(TEG)to collect the waste heat of the FDR and generate low-power electricity.A novel electrical circuit with two transformers is designed and fabricated to produce a more stable voltage for operation and *** thermoelectric generator(TEGs)was installed on the FDR of the A/C *** test showed that climate conditions have a significant impact on the output power generated from the *** results showed that the peak voltage recorded in the current study is 5.2 V per day(wet,cold,and wind weather)with an output power of 0.2 *** values are acceptable for powering the load and charging a single battery with 3.5 V as the voltage increases battery 0.1 V/20 min charge.A case study of operating the emergency signs in a building was *** current heat recovery system is deemed to be easily installed and can be connected to a network of TEGs to produce more power.

关键词： Thermoelectric generator waste heat filter dryer receiver air conditioning heat recovery

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Energy efficient indoor localisation for narrowband internet of things

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CAAI Transactions on Intelligence Technology 2023年第4期8卷 1150-1163页

作者： Ismail Keshta Mukesh Soni Mohammed Wasim Bhatt Azeem Irshad ali Rizwan Shakir Khan Renato RMaaliw III Arsalan muhammad Soomar Mohammad Shabaz Computer Science and Information Systems Department College of Applied SciencesAlMaarefa UniversityRiyadhSaudi Arabia Department of CSE University Centre for Research and Development Chandigarh UniversityMohaliPunjabIndia Department of Computer Science and Engineering National Institute of TechnologySrinagarIndia Asghar Mall College Rawalpindi Higher Education Department(HED)Govt.of the PunjabRawalpindiPakistan Department of Industrial Engineering Faculty of EngineeringKing Abdulaziz UniversityJeddahSaudi Arabia College of Computer and Information Sciences Imam Mohammad Ibn Saud Islamic University(IMSIU)RiyadhSaudi Arabia College of Engineering Southern Luzon State UniversityLucbanQuezonPhilippines Department of Automation Electronics and Electrical EngineeringGdansk University of TechnologyGdańskPoland Arba Minch University Arba MinchEthiopia

There are an increasing number of Narrow Band IoT devices being manufactured as the technology behind them develops *** high co‐channel interference and signal attenuation seen in edge Narrow Band IoT devices make it challenging to guarantee the service quality of these *** maximise the data rate fairness of Narrow Band IoT devices,a multi‐dimensional indoor localisation model is devised,consisting of transmission power,data scheduling,and time slot scheduling,based on a network model that employs non‐orthogonal multiple access via a *** on this network model,the optimisation goal of Narrow Band IoT device data rate ratio fairness is first established by the authors,while taking into account the Narrow Band IoT network:The multidimensional indoor localisation optimisation model of equipment tends to minimize data rate,energy constraints and EH relay energy and data buffer constraints,data scheduling and time slot *** a result,each Narrow Band IoT device's data rate needs are met while the network's overall performance is *** investigate the model's potential for convex optimisation and offer an algorithm for optimising the distribution of multiple resources using the KKT *** current work primarily considers the NOMA Narrow Band IoT network under a single EH ***,the growth of Narrow Band IoT devices also leads to a rise in co‐channel interference,which impacts NOMA's performance *** simulation,the proposed approach is successfully *** improvements have boosted the network's energy efficiency by 44.1%,data rate proportional fairness by 11.9%,and spectrum efficiency by 55.4%.

关键词： artificial inteligence detection of moving objects internet of things

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Splenic injuries secondary to colonoscopy:Rare but serious complication

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World Journal of Gastrointestinal Surgery 2020年第2期12卷 55-67页

作者： Waqas Ullah Mamoon Ur Rashid Asif Mehmood Yousaf Zafar Ishtiaq Hussain Deepika Sarvepalli muhammad Khalid Hasan Department of Internal Medicine Abington HospitalAbingtonPA 19001United States Department of Internal Medicine Advent Health HospitalOrlandoFL 32804United States Department of Internal Medicine Geisinger Medical CenterDanvillePA 17822United States Department of Internal Medicine UMKC5100 Rockhill RdKansas CityMO 64110United States Department of Gastroenterology Cleveland ClinicWestonFL 33331United States Department of Gastroenterology Advent Health HospitalOrlandoFL 32804United States

BACKGROUND Colonoscopy is a safe and routine diagnostic and therapeutic procedure for evaluation of large bowel *** common procedure related complications include bleeding and perforation but rarely a splenic *** To investigate the reason for colonoscopy,presentation of patient with spleen injury,types of injury,diagnosis,management and outcomes of patients METHODS A structured search on four databases was done and 45 articles with 68 patients were *** reason for colonoscopy,presentation of patient with spleen injury,types of injury,diagnosis,management and outcomes of patients were identified and analyzed using *** The mean age of the patients was 62.7 years with 64%*** two percent had a complete splenic rupture with colonoscopy while 63%had subcapsular hematoma,spleen laceration and spleen *** most common reason for colonoscopy was screening(46%)followed by diagnostic colonoscopy(28%).Eighty seven percent of patients presented with abdominal *** with spleen rupture mostly required splenectomy(47%),while minor spleen hematomas and lacerations were managed conservatively(38%).Six percent of the patients were managed with proximal splenic artery splenic embolization and 4%were managed with laparoscopic *** overall mortality was 10%while 77%had complete *** reason of colonoscopy against presentation specifically,abdominal pain showed no statistical significance P=*** indication of colonoscopy had no significant impact on incidence of splenic injury(P=0.89).Majority of the patients(47%)were managed with splenectomy while the rest were managed conservatively(P=0.04).This association was moderately strong at a cramer’s V test(0.34).The Fisher exact test showed a higher mortality with spleen rupture(P=0.028).CONCLUSION Spleen rupture due to colonoscopy is a significant concern and is associated with high *** management of the patients can be individualized based on clinical pre

关键词： Colonoscopy Spleen Splenic rupture Systematic review Splenic injuries

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Corrected Statistical Energy Analysis Model in a Non-Reverberant Acoustic Space

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Sound & Vibration 2021年第3期55卷 203-219页

作者： al Munawir Azma Putra Iwan Prasetiyo Wan Mohd Farid Wan Mohamad Safarudin Herawan Jurusan Teknik Mesin Universitas Teuku UmarMeulaboh23615Indonesia Fakulti Kejuruteraan Mekanikal Universiti Teknikal Malaysia MelakaMelaka76100Malaysia Acoustic Laboratory Department of Engineering PhysicsInstitut Teknologi BandungBandung40132Indonesia Department of Industrial Engineering Bina Nusantara UniversityJakarta11480Indonesia

Statistical Energy Analysis(SEA)is a well-known method to analyze the flow of acoustic and vibration energy in a complex *** study investigates the application of the corrected SEA model in a non-reverberant acoustic space where the direct field component from the sound source dominates the total sound field rather than a diffuse field in a reverberant space which the classical SEA model assumption is based on.A corrected SEA model is proposed where the direct field component in the energy is removed and the power injected in the subsystem considers only the remaining power after the loss at first *** was conducted in a box divided into two rooms separated by a partition with an opening where the condition of reverberant and non-reverberant can conveniently be *** the case of a non-reverberant space where acoustic material was installed inside the wall of the experimental box,the signals are corrected by eliminating the direct field component in the measured impulse *** the corrected SEA model,comparison of the coupling loss factor(CLF)and damping loss factor(DLF)with the theory shows good agreement.

关键词： Statistical Energy Analysis(SEA) non-reverberant space coupling loss factor(CLF) damping loss factor(DLF) room acoustics

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COVID-19-associated diarrhea

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World Journal of Gastroenterology 2021年第23期27卷 3208-3222页

作者： Klara Megyeri Áron Dernovics Zaid I I al-Luhaibi András Rosztóczy Department of Medical Microbiology and Immunobiology University of SzegedSzeged 6720CsongradHungary Division of Gastroenterology Department of Internal MedicineUniversity of SzegedSzeged 6720CsongradHungary

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)recently emerged as a highly virulent respiratory pathogen that is known as the causative agent of coronavirus disease 2019(COVID-19).Diarrhea is a common early symptom in a significant proportion of patients with SARS-CoV-2 ***-CoV-2 can infect and replicate in esophageal cells and enterocytes,leading to direct damage to the intestinal *** infection decreases the level of angiotensinconverting enzyme 2 receptors,thereby altering the composition of the gut ***-CoV-2 elicits a cytokine storm,which contributes to gastrointestinal *** direct cytopathic effects of SARS-CoV-2,gut dysbiosis,and aberrant immune response result in increased intestinal permeability,which may exacerbate existing symptoms and worsen the *** exploring the elements of pathogenesis,several therapeutic options have emerged for the treatment of COVID-19 patients,such as biologics and biotherapeutic ***,the presence of SARS-CoV-2 in the feces may facilitate the spread of COVID-19 through fecal-oral transmission and contaminate the *** gastrointestinal SARS-CoV-2 infection has important epidemiological *** development of new therapeutic and preventive options is necessary to treat and restrict the spread of this severe and widespread infection more ***,we summarize the key elements involved in the pathogenesis and the epidemiology of COVID-19-associated diarrhea.

关键词： COVID-19 Diarrhea Ionic imbalance Viroporin Angiotensin-converting enzyme type 2 Leaky gut

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