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National guidelines for the diagnosis and treatment of hilar cholangiocarcinoma

World Journal of Gastroenterology 2024年第9期30卷 1018-1042页

作者： Faisal Saud Dar Zaigham Abbas Irfan Ahmed muhammad Atique Usman iqbal Aujla muhammad Azeemuddin Zeba Aziz Abu Bakar Hafeez Bhatti Tariq Ali Bangash Amna Subhan Butt Osama Tariq Butt Abdul Wahab Dogar Javed iqbal Farooqi Faisal Hanif Jahanzaib Haider Siraj Haider Syed Mujahid Hassan Adnan Abdul Jabbar Aman Nawaz Khan muhammad Shoaib Khan muhammad Yasir Khan Amer Latif Nasir Hassan Luck Ahmad Karim Malik Kamran Rashid Sohail Rashid Mohammad Salih Abdullah Saeed Amjad Salamat Ghias-un-Nabi tayyab Aasim Yusuf Haseeb Haider Zia Ammara Naveed Department of Hepatopancreatic Biliary Surgery&Liver Transplant Pakistan Kidney and Liver Institute&Research CentreLahore 54000Pakistan Department of Hepatogastroenterology and Liver Transplantation Dr.Ziauddin University HospitalKarachi 75600SindhPakistan University of Aberdeen Aberdeen B243FXUnited Kingdom Department of Pathology Pakistan Kidney and Liver Institute&Research CentreLahore 54000Pakistan Department of Gastroenterology&Hepatology Pakistan Kidney and Liver Institute&Research CentreLahore 54000Pakistan Department of Radiology Aga Khan UniversityKarachi 74800Pakistan Department of Oncology Hameed Latif HospitalLahore 54000Pakistan Division of Hepatopancreatic Biliary Surgery&Liver Transplantation Shifa International HospitalIslamabad 44000Pakistan Department of Hepatopancreatic Biliary Surgery&Liver Transplant Shaikh Zayed Hospital and Post Graduate Medical InstituteLahore 54000Pakistan Department of Medicine Aga Khan University HospitalKarachi 74800Pakistan Department of Liver Transplant Pir Abdul Qadir Shah Jeelani Institute of Medical SciencesGambat 66020Pakistan Department of Medicine&Gastroenterology Lifecare Hospital and Research CentrePeshawar 25000Khyber PakhtunkhwaPakistan Department of Hepatopancreatobiliary&Liver Transplant Bahria International HospitalLahore 54000Pakistan Department of Surgery Hepatopancreatobiliary&Liver TransplantDow University of Health SciencesKarachi 74800Pakistan Department of Gastroenterology Hepatology&NutritionPir Abdul Qadir Shah Jeelani Institute of Medical SciencesGambat 66020Pakistan Department of Oncology Dr.Ziauddin HospitalKarachi 74800Pakistan Department of Radiology Rehman Medical InstitutePeshawar 25000Pakistan Army Liver Transplant Unit Pak Emirates Military HospitalRawalpindi 46000Pakistan Department of Gastroenterology Sindh Institute of Urology and TransplantationKarachi 75500Pakistan Rashid Nursing Home and Cancer Clinic Rashid Nursing Home and Cancer ClinicRawalpindi 46000Pakistan Department of Gastroentero

A consensus meeting of national experts from all major national hepatobiliary centres in the country was held on May 26,2023,at the Pakistan Kidney and Liver Institute&Research Centre(PKLI&RC)after initial consultations with the *** Pakistan Society for the Study of Liver Diseases(PSSLD)and PKLI&RC jointly organised this *** effort was based on a comprehensive literature review to establish national practice guidelines for hilar cholangiocarcinoma(hCCA).The consensus was that hCCA is a complex disease and requires a multidisciplinary team approach to best manage these *** coordinated effort can minimise delays and give patients a chance for curative treatment and effective *** diagnostic and staging workup includes high-quality computed tomography,magnetic resonance imaging,and magnetic resonance *** cytology or biopsy utilizing endoscopic retrograde cholangiopancreatography is a mainstay for ***,histopathologic confirmation is not always required before *** ultrasound with fine needle aspiration of regional lymph nodes and positron emission tomography scan are valuable adjuncts for *** only curative treatment is the surgical resection of the biliary tree based on the Bismuth-Corlette *** patients with unresectable hCCA can be considered for liver *** chemotherapy should be offered to patients with a high risk of *** use of preoperative biliary drainage and the need for portal vein embolisation should be based on local multidisciplinary *** with acute cholangitis can be drained with endoscopic or percutaneous biliary *** chemotherapy with cisplatin and gemcitabine has shown improved survival in patients with irresectable and recurrent hCCA.

关键词： Hilar cholangiocarcinoma Bismuth-Corlette classification Memorial Sloan Kettering Cancer Centre Staging Preoperative biliary drainage Portal vein embolisation Surgical resection Hepatectomy

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Evaluation of Various Mango Varieties against the Infection Dynamics of Powdery Mildew (<i>Oidium mangiferae</i>Bert.)

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American Journal of Plant Sciences 2014年第15期5卷 2372-2377页

作者： Syed Atif Hasan Naqvi Rashida Perveen Syed Amir Manzoor Hafiz muhammad Imran Umar muhammad tayyab iqbal Fatima Liaquat Taha Majid Ahsan Irshad Department of Forestry FAST Bahauddin Zakariya University Multan Pakistan Department of Plant Breeding & Genetics FAST Bahauddin Zakariya University Multan Pakistan Department of Plant Pathology FAST Bahauddin Zakariya University Multan Pakistan Department of Soil Science FAST Bahauddin Zakariya University Multan Pakistan

Mango (Mangifera indica L: Anacardiaceae) is regarded as the most liked fruit in tropical and sub-tropical regions of the world. Powdery mildew of mango caused by Oidium mangiferae Bert. is one of the major plant pathological constraints in growing healthy mango orchards. The apparent symptoms of the disease occurred on young tissues of all parts of flowers, leaves and fruits. Severe blossom infection could result in complete damage to fruit;flower failed to open and drop off from the inflorescence. The inflorescence revealed a pattern of disease from tip to downward and showed itself by the emergence of wefts of white mycelium on the affected parts. Twenty-five mango varieties i.e. Langra, Dusehri, Ratole No.12, Fajri, Sindhri, Chaunsa Samar Bahisht, Anwar ratole, Neelam, Yakta, Tota Pari, Sensation, Saroli, Malda, Ghulab e Khas, Chaunsa Black, Chaunsa white, Anmol, Almas, Shan e Ali, Shan e Mustafa, Mahmood Khan, Armughan, Zafaran, Malda Late and Early Gold were evaluated through the observation of symptoms on young inflorescence to determine the disease incidence, disease severity index and average yield of fruit. The study was carried out in a randomized compete block design with twenty-five treatments and three replications. The mango varieties presented different performance in relation to powdery mildew incidence and could be categorized into eight groups. Maximum disease incidence was observed (33.33%, 26.66% and 26.66%, 26.66%) on Dusehri, Chaunsa Samar Bahisht, Malda and Ratole No.12 respectively and minimum disease incidence was (3.66% and 3.66%) noted on Almas and Sensation. These two varieties showed to be tolerant against the disease. It might be concluded that the presence or absence of symptoms caused by the powdery mildew had no such effect on the fruit yield of the mango cultivars.

关键词： Powdery Mildew Oidium mangiferae Bert. Infection Varieties RCBD

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Gene Action Studies in the Inheritance of Economic Traits in Diallel Cross of Lentil (Lens culinaris Medik)

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American Journal of Plant Sciences 2016年第6期7卷 756-768页

作者： Fahim Abbas Asim Riaz Tanzeela Zafar muhammad Hassan Hafiz muhammad Imran Umar Javed Hassan Waseem Alam Saleh muhammad Mudassir Mahmood Hamza Sohail Usman Ali Tiwana muhammad tayyab iqbal muhammad Bilal Nanjing Agriculture University Nanjing China Department of Pharmacy Health and Well-Being University of Sunderland Sunderland UK Centre of Agricultural Biochemistry and Biotechnology Faculty of Agriculture University of Agriculture Faisalabad Pakistan Department of Plant Breeding & Genetics Bahauddin Zakariya University Multan Pakistan Department of Entomology Bahauddin Zakariya University Multan Pakistan Department of Horticulture Bahauddin Zakariya University Multan Pakistan Arid Zone Research Institute Bahawalpur Pakistan Department of Plant Breeding & Genetics PMAS-UAA Rawalpindi Pakistan

The present study was conducted in 4 × 4 half diallel cross fashion using the genotypes named as NL-2002, NL-2006, Punjab Masoor-2009 and Markaz-2009 for the evaluation of gene action in the inheritance of economic traits of lentil by following the Griffing (1956) Method of analysis. Minirap 13.1 Copyright© 2000, Minitab inc. Method II, Model I was used for the analysis and gene action was computed by variance component analysis using Mixed Model with GLM (general linear model) procedure. The F1 direct crosses along with the parental genotypes were then evaluated by framing the experiment in RCBD in 3 replications. The data were recorded for the characters which are under the study are, plant height (cm), number of primary branches, number of secondary branches, number of pods per plant, number of seed per pod, seed yield per plant, biomass (gram), 100 seeds weight (gram), harvest index (%), yield per plant. The simple ANOVA for all the characters revealed that difference among genotypes was highly significant. As significant differences were present between the genotypes, it permitted subsequent analysis of the data. The Combining Ability (CA) results showed that value of variance for GCA (General Combining Ability) was significantly higher than that of those of the values of variance of SCA (Specific Combining Ability). Hence current results clearly depicted the role of additive type of gene action governing the characters under study.

关键词： Lentil Diallel Gene Action Studies

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Economic and Social Impact Assessment of Chronic Diseases Among the Low-Income Population in Southern Punjab,Pakistan

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Proceedings of Anticancer Research 2024年第4期8卷 67-74页

作者： Mehran Khan muhammad Arbab Nasir muhammad Umar Asadullah Faiz Mirza muhammad Abdul Bari Ayesha Saeed Fiza Nazeer Khan Saliha Mehboob Malik Akashah Usama tayyab Bahawalpur College of Pharmacy BMDC Complex63100BahawalpurPunjabPakistan

Introduction:Chronic diseases are becoming more prevalent *** effects of chronic illnesses are disastrous not only for the diagnosed person but also for their entire *** study explores chronic diseases’social and economic impact on low-income *** study aims to determine the economic and social implications of various chronic diseases and the loss of income due to these conditions among low-income individuals in Southern Punjab,***:A sample of 424 patients was selected from different areas of Southern *** were collected using a questionnaire that included questions about economic status,self-reported health status,social status,management strategies,and health insurance,among other ***:The mean monthly income of the respondents was found to be 57,097.6 Pakistani rupee(PKR),and the mean monthly expenses for treatment were 8,256.1 *** loss of income was calculated at 15%.Additionally,62%of patients spent more than 10%of their monthly income on managing their *** 85%of the respondents reported that chronic diseases affected their social ***,80%of patients lacked health ***:Chronic diseases impose significant economic and social burdens on patients and their families in Southern *** reduce the burden of chronic diseases,the government should enhance healthcare services in this region and provide health insurance to low-income families.

关键词： Chronic diseases Low-income families Economic impact Punjab Pakistan

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Risk factors and outcomes of peptic ulcer bleed in a Pakistani population:A single-center observational study

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2024年第3期15卷 1-9页

作者： Nazish Butt muhammad tayyab Usmani Nimrah Mehak Saba Mughal Fakhar Ali Qazi-Arisar Ghulam Mohiuddin Gulzar Khan Department of Gastroenterology Jinnah Postgraduate Medical CentreKarachi 75505SindhPakistan National Institute of Liver&GI Diseases Dow University of Health SciencesKarachi 75330SindhPakistan School of Public Health Dow University of Health SciencesKarachi 75330SindhPakistan

BACKGROUND Peptic ulcer disease(PUD)remains a significant healthcare burden,contributing to morbidity and mortality *** advancements in therapies,its prevalence persists,particularly in regions with widespread nonsteroidal antiinflammatory drugs(NSAIDs)use and Helicobacter pylori *** To comprehensively analyse the risk factors and outcomes of PUD-related upper gastrointestinal(GI)bleeding in Pakistani *** This retrospective cohort study included 142 patients with peptic ulcer bleeding who underwent upper GI endoscopy from January to December *** on demographics,symptoms,length of stay,mortality,re-bleed,and Forrest classification was *** The mean age of patients was 53 years,and the majority was men(68.3%).Hematemesis(82.4%)and epigastric pain(75.4%)were the most common presenting *** patients(73.2%)were discharged within five *** mortality rates at one week and one month were 10.6%and 14.8%,***-bleed within 24 h and seven days occurred in 14.1%and 18.3%of patients,*** ulcers were Forrest class(FC)Ⅲ(72.5%).Antiplatelet use was associated with higher mortality at 7 and 30 d,while alternative medications were linked to higher 24-hour re-bleed *** use was associated with more FCⅢ***-bleed at 24 h and 7 d was strongly associated with one-week or one-month *** Antiplatelet use and rebleeding increase the risk of early mortality in PUD-related upper GI bleeding,while alternative medicines are associated with early rebleeding.

关键词： Non variceal bleed Mortality Re-bleed Forrest classification Antiplatelets Alternative medicines

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Visual News Ticker Surveillance Approach from Arabic Broadcast Streams

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Computers, Materials & Continua 2023年第3期74卷 6177-6193页

作者： Moeen tayyab Ayyaz Hussain Usama Mir M.Aqeel iqbal muhammad Haneef Department of Computer Science and Software Engineering International Islamic UniversityIslamabad44000Pakistan Department of Computer Science Quaid-i-Azam UniversityIslamabad44000Pakistan Department of Computer Science Senior Member IEEEUniversity of WindsorN9B 3P4Canada Department of Software Engineering Foundation University IslamabadIslamabad44000Pakistan Department of Electrical Engineering Foundation University IslamabadIslamabad44000Pakistan

The news ticker is a common feature of many different news networks that display headlines and other *** ticker recognition applications are highly valuable in e-business and news surveillance for media regulatory *** this paper,we focus on the automatic Arabic Ticker Recognition system for the Al-Ekhbariya news *** primary emphasis of this research is on ticker recognition methods and storage *** that end,the research is aimed at character-wise explicit segmentation using a semantic segmentation technique and words identification *** proposed learning architecture considers the grouping of homogeneousshaped *** incorporates linguistic taxonomy in a unified manner to address the imbalance in data distribution which leads to individual ***,experiments with a novel ArabicNews Ticker(Al-ENT)dataset that provides accurate character-level and character components-level labeling to evaluate the effectiveness of the suggested *** proposed method attains 96.5%,outperforming the current state-of-the-art technique by 8.5%.The study reveals that our strategy improves the performance of lowrepresentation correlated character classes.

关键词： Arabic text recognition optical character recognition deep convolutional network SegNet LeNet

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Unfolding the structural features of NASICON materials for sodium-ion full cells

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Carbon Energy 2022年第5期4卷 776-819页

作者： muhammad tayyab Ahsan Zeeshan Ali muhammad Usman Yanglong Hou School of Materials Science and Engineering Peking UniversityBeijingChina School of Chemical and Materials Engineering National University of Sciences and Technology(NUST)IslamabadPakistan Beijing Key Laboratory for Magnetoelectric Materials and Devices(BKL-MMD) School of Materials Science and EngineeringPeking UniversityBeijingChina

Sodium-ion batteries(SIBs)are potential candidates for the replacement of lithium-ion batteries to meet the increasing demands of electrical storage systems due to the low cost and high abundance of *** superionic conductor(NASICON)structured materials have attracted enormous interest in recent years as electrode materials for safer and long-term performance of SIBs for electric energy storage smart *** materials have a threedimensional robust framework,high redox potential,thermal stability,and a fast Na^(+)-ion diffusion ***,NASICON has low intrinsic electronic conductivity,which limits the electrochemical *** review describes the structural features of NASICONs to illustrate the ion storage mechanism and electrochemical performance of *** of the NASICON crystal structure,the affiliated Na^(+)-ion diffusion mechanism,morphology,and electrochemical performance of these materials in sodiumion half-cells as well as full cells are *** addition to the application as electrode materials,the use of NASICONs as solid electrolytes is also elaborated in solid-state *** on these aspects,we have provided more perspectives in terms of the commercialization of SIBs and strategies to overcome the limitations of ***,this review is expected to provide the researchers of energy storage with an in-depth understanding of NASICON materials with the knowledge of structural features,which will provide a new avenue on the practicality of SIBs.

关键词： cathode materials electrical storage systems full cells NASICON materials sodium-ion batteries

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Deep Learning-Enhanced Brain Tumor Prediction via Entropy-Coded BPSO in CIELAB Color Space

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Computers, Materials & Continua 2023年第11期77卷 2031-2047页

作者： Mudassir Khalil muhammad Imran Sharif Ahmed Naeem muhammad Umar Chaudhry Hafiz tayyab Rauf Adham E.Ragab Department of Computer Engineering Bahauddin Zakariya UniversityMultan60000Pakistan Department of Computer Science Kansas State UniversityManhattanKS66506USA Department of Computer Science University of Management and TechnologyLahore54000Pakistan Centre for Smart Systems AI and CybersecurityStaffordshire UniversityStoke-on-TrentST42DEUK Industrial Engineering Department Collage of EngineeringKing Saud UniversityPO Box 800Riyadh11421Saudi Arabia

Early detection of brain tumors is critical for effective treatment *** tumors in their nascent stages can significantly enhance the chances of patient *** there are various types of brain tumors,each with unique characteristics and treatment protocols,tumors are often minuscule during their initial stages,making manual diagnosis challenging,time-consuming,and potentially *** techniques predominantly used in hospitals involve manual detection via MRI scans,which can be costly,error-prone,and *** automated system for detecting brain tumors could be pivotal in identifying the disease in its earliest *** research applies several data augmentation techniques to enhance the dataset for diagnosis,including rotations of 90 and 180 degrees and inverting along vertical and horizontal *** CIELAB color space is employed for tumor image selection and ROI *** deep learning models,such as DarkNet-53 and AlexNet,are applied to extract features from the fully connected layers,following the feature selection using entropy-coded Particle Swarm Optimization(PSO).The selected features are further processed through multiple SVM kernels for *** study furthers medical imaging with its automated approach to brain tumor detection,significantly minimizing the time and cost of a manual *** method heightens the possibilities of an earlier tumor identification,creating an avenue for more successful treatment planning and better overall patient outcomes.

关键词： Brain tumor deep learning feature extraction feature selection feature fusion transfer learning

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Anti-obesity effect and UHPLC-QTOF-MS/MS based metabolite profiling of Solanum nigrum leaf extract

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Asian Pacific Journal of Tropical Biomedicine 2022年第4期12卷 164-174页

作者： Zain Ul Aabideen muhammad Waseem Mumtaz muhammad tayyab Akhtar muhammad Asam Raza Hamid Mukhtar Ahmad Irfan Syed Ali Raza muhammad Nadeem Yee Soon Ling Department of Chemistry University of GujratGujratPakistan Institute of Industrial Biotechnology GC University LahoreLahorePakistan Department of Chemistry College of ScienceKing Khalid UniversityP.O.Box 9004Abha 61413Saudi Arabia Research Center for Advanced Materials Science King Khalid UniversityP.O.Box 9004Abha 61413Saudi Arabia Department of Chemistry GC University LahoreLahorePakistan Sabah Occupational Safety Health and Environment AssociationLot331st FloorBlock EIramanis CenterJalanLinatas88450Kota KinabaluSabahMalaysia

Objective:To evaluate the antioxidant potential and pancreatic lipase inhibitory action of optimized hydroethanolic extracts of Solanum ***:Optimized extraction for maximum recovery of metabolites was performed using a combination of freeze-drying and ultrasonication followed by determination of antioxidant and antiobesity *** ultra-high performance liquid chromatography equipped with mass spectrometry was used to analyze metabolite profiling of Solanum *** studies were performed using molecular docking and electrostatic potential analysis for individual *** hypolipidemic potential of the most potent extract was assessed in the obese mice fed on fat rich ***:The 80%hydroethanolic extract exhibited the highest extract yield,total phenolic contents,total flavonoid contents along with the strongest 2,2-diphenyl-1-picrylhydrazyl scavenging activity,total antioxidant power,and pancreatic lipase inhibitory *** 80%hydroethanolic extract not only regulated the lipid profile of obese mice but also restricted the weight gain in the liver,kidney,and *** 80%hydroethanolic extract also reduced alanine transaminase and aspartate transaminase concentrations in *** effects of plant extract at 300 mg/kg body weight were quite comparable with the standard drug ***:Solanum nigrum is proved as an excellent and potent source of secondary metabolites that might be responsible for obesity mitigation.

关键词： Solanum nigrum Ultrasonication Metabolite profiling Total phenolic contents Total flavonoid content Antioxidant DPPH Total antioxidant power Pancreatic lipase UHPLC-QTOF-MS/MS Antiobesity Mice Hypolipidemic Molecular docking

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Risk factor profiles for gastric cancer prediction with respect to Helicobacter pylori:A study of a tertiary care hospital in Pakistan

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Artificial Intelligence in Gastroenterology 2023年第1期4卷 10-27页

作者： Shahid Aziz Simone König muhammad Umer tayyab Saeed Akhter Shafqat iqbal Maryum Ibrar Tofeeq Ur-Rehman Tanvir Ahmad Alfizah Hanafiah Rabaab Zahra Faisal Rasheed Patients Diagnostic Lab Isotope Application DivisionPakistan Institute of Nuclear Science and TechnologyIslamabad 44000Pakistan Department of Microbiology Quaid-i-Azam UniversityIslamabad 45320Pakistan Interdisciplinary Center for Clinical Research Core Unit ProteomicsUniversity of MünsterMünster 48149Germany Management Information System Division Pakistan Institute of Nuclear Science and TechnologyIslamabad 44000Pakistan Centre for Liver and Digestive Diseases Holy Family HospitalRawalpindi 46300Pakistan Pakistan Scientific and Technological Information Centre Quaid-i-Azam UniversityIslamabad 45320Pakistan Department of Pharmacy Quaid-i-Azam UniversityIslamabad 45320Pakistan Faculty of Medicine Department of Medical Microbiology and ImmunologyUniversiti Kebangsan MalaysiaCherasKuala Lumpur 56000Malaysia

BACKGROUND Gastric cancer(GC)is the fourth leading cause of cancer-related deaths *** relies on histopathology and the number of endoscopies is *** pylori(***)infection is a major risk *** To develop an in-silico GC prediction model to reduce the number of diagnostic surgical *** meta-data of patients with gastroduodenal symptoms,risk factors associated with GC,and *** infection status from Holy Family Hospital Rawalpindi,Pakistan,were used with machine *** A cohort of 341 patients was divided into three groups[normal gastric mucosa(NGM),gastroduodenal diseases(GDD),and GC].Information associated with socioeconomic and demographic conditions and GC risk factors was collected using a *** infection status was determined based on urea breath *** association of these factors and histopathological grades was assessed statistically.K-Nearest Neighbors and Random Forest(RF)machine learning models were *** This study reported an overall frequency of 64.2%(219/341)of *** infection among enrolled *** was higher in GC(74.2%,23/31)as compared to NGM and GDD and higher in males(54.3%,119/219)as compared to *** abdominal pain(72.4%,247/341)was observed than other clinical symptoms including vomiting,bloating,acid reflux and *** majority of the GC patients experienced symptoms of vomiting(91%,20/22)with abdominal pain(100%,22/22).The multinomial logistic regression model was statistically significant and correctly classified 80%of the GDD/GC ***,income level,vomiting,bloating and medication had significant association with GDD and GC.A dynamic RF GC-predictive model was developed,which achieved>80%test *** GC risk factors were incorporated into a computer model to predict the likelihood of developing GC with high sensitivity and *** model is dynamic and will be further improved and validated by including n

关键词： Gastric cancer Gastritis Machine learning Prediction model Helicobacter pylori

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