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Reciprocal impact of host factors and Helicobacter pylori genotypes on gastric diseases

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World Journal of Gastroenterology 2015年第31期21卷 9317-9327页

作者： Sahar Honarmand-Jahromy Farideh Siavoshi Reza Malekzadeh taher Nejad Sattari Saeid Latifi-Navid Department of Biology Tehran Science and Research BranchIslamic Azad University Department of Microbiology School of BiologyUniversity College of SciencesUniversity of Tehran Digestive Disease Research Institute Tehran University of Medical Sciences Department of Biology Faculty of SciencesUniversity of Mohaghegh Ardabili

AIM: To assess the impact of Helicobacter pylori(H. pylori) genotypes and patient age and sex on the development of gastric ***: H. pylori-infected patients(n = 233) referred to the endoscopy unit at Tehran University of Medical Sciences(Tehran,Iran) were diagnosed with chronic gastritis(CG),gastric ulcer(GU),or duodenal ulcer(DU). Brucella blood agar was used for biopsy cultures and H. pylori isolation under microaerobic conditions. H. pylori isolates were confirmed with biochemical tests and through amplification of the 16 S r RNA gene. DNA was extracted from fresh cultures of the H. pylori isolates and used for amplification of vac A alleles and the cag A gene. Statistical analysis was performed to determine the association between H. pylori genotypes,age( 40 years) and sex of the patient,and gastric ***: CG was the most prevalent gastric disease(113/233; 48.5%),compared to GU(64/233; 27.5%)and DU(56/233; 24%). More patients were male,and gastric diseases were more frequent in patients > 40 years(P 40 years was more common in females(18.5%) than males(11.6%)(P = 0.05),whereas a diagnosis of GU or DU in patients > 40 years was more frequent in males(14.6% vs 10.7% and 12.4% vs 4.3%,respectively). Overall,genotyping of the H. pylori isolates revealed that the vac A s1(82%),vac A m2(70%),and cag A+(72.5%) alleles were more frequent than vac A s2(18%),vac A m1(29.2%),and cag A-(all P < 0.05). The vac A s1m2 cag A+ genotype was the most prevalent within the three disease groups. vac A s1m2 frequency was 56.2% with a similar occurrence in all diagnoses,while vac A s1m1 appeared more often in DU patients(33.9%). A genotype of vac A s2m2 occurred in 15% of isolates and was more common in CG patients(21.2%); vac A s2m1 was the leas

关键词： Age Gastric disease Gender Genotype Helicobacter p

CD5 expression promotes IL-10 production through activation of the MAPK/Erk pathway and upregulation of TRPC1 channels in B lymphocytes

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Cellular & Molecular Immunology 2018年第2期15卷 158-170页

作者： Soizic Garaud taher E taher Marjolaine Debant Miguel Burgos Sarra Melayah Christian Berthou Kaushal Parikh Jacques-Olivier Pers Damien Luque-Paz Gilles Chiocchia Maikel Peppelenbosch David A Isenberg Pierre Youinou Olivier Mignen Yves Renaudineau Rizgar A Mageed INSERM ERI29/EA2216 réseau epigenetique and réseau canaux ioniques du Cancéropôle Grand OuestBrest University Medical SchoolBrest29609France Centre for Experimental Medicine and Rheumatology William Harvey Research InstituteBarts and the London School of Medicine and DentistryQueen Mary University of LondonLondonEC1M 6BQUK Canalopathy and Calcium Signaling INSERM UMR1078Brest29238France Centre for Experimental and Molecular Medicine Academic Medical CenterMeibergdreef 9Amsterdam1105 AZThe Netherlands Laboratory of Immunology and Immunotherapy CHU MorvanBrest29609France Institut Cochin INSERM U567Paris75014France Department of Gastroenterology and Hepatology Erasmus MCGravendijkwal 230Rotterdam015 CERotterdamThe Netherlands Centre for Rheumatology University College LondonLondonWC1E 6JFUK

CD5 is constitutively expressed on T cells and a subset of mature normal and leukemic B cells in patients with chronic lymphocytic leukemia(CLL).Important functional properties are associated with CD5 expression in B cells,including signal transducer and activator of transcription 3 activation,IL-10 production and the promotion of B-lymphocyte survival and ***,the pathway(s)by which CD5 influences the biology of B cells and its dependence on B-cell receptor(BCR)co-signaling remain *** this study,we show that CD5 expression activates a number of important signaling pathways,including Erk1/2,leading to IL-10 production through a novel pathway independent of BCR *** pathway is dependent on extracellular calcium(Ca2+)entry facilitated by upregulation of the transient receptor potential channel 1(TRPC1)*** also show that Erk1/2 activation in a subgroup of CLL patients is associated with TRPC1 *** this subgroup of CLL patients,small inhibitory RNA(siRNA)for CD5 reduces TRPC1 ***,siRNAs for CD5 or for TRPC1 inhibit IL-10 *** findings provide new insights into the role of CD5 in B-cell biology in health and disease and could pave the way for new treatment strategies for patients with B-CLL.

关键词： B cells calcium CD5 MAPK/Erk TRPC1

Facile cathodic electrosynthesis and characterization of iron oxide nano-particles

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Progress in Natural Science:Materials International 2013年第1期23卷 51-54页

作者： taher Yousefi Reza Davarkhah Ahmad Nozad Golikand Mohammad Hossein Mashhadizadeh Ahmad Abhari NFCRS Nuclear Science and Technology Research InstituteP.O.Box 11365/8486TehranIran Materials Research School NSTRIP.O.Box:14395-836 TehranIran 3. Department of ChemistryTarbiat Moallem UniversityP.O.Box:31979-37551 TehranIran 4. NFCRSNuclear Science and Technology Research InstituteP.O.Box 11365/8486TehranIranx

Fe2O3 nano-particles have been synthesized by simple cathodic electrodeposition from the low-temperature nitrate *** morphology and crystal structure of the obtained oxide powder were analyzed by means of scanning and transmission microscopy(SEM and TEM),X-ray diffraction(XRD) and Fourier transform infrared(FTIR) *** behavior and phase transformation during the heat treatment of as-deposited sample were investigated by differential scanning calorimetry(DSC) and thermogramimetric analysis(TGA).The results showed that the deposited Fe2O3 was composed of the nanoparticles with grain size of approximately 10-60 nm.A serious problem during cathodic electrodeposition of iron oxide was splashing of deposit into electrolyte due to its low *** problem was tackled by reducing the bath temperature and dielectric constant of solvent.

关键词： Iron Oxide Electrochemical Deposition Nano Oxides Nanostructures Characterization

Unsteady Flow of Hybrid Nanofluid with MagnetohydrodynamicsRadiation-Natural Convection Effects in a U-Shaped Wavy Porous Cavity

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Computer Modeling in Engineering & Sciences 2024年第12期141卷 2225-2251页

作者： taher Armaghani Lioua Kolsi Najiyah Safwa Khashi’ie Ahmed Muhammed Rashad Muhammed Ahmed Mansour Taha Salah Aboulbaba Eladeb Department of Engineering West Tehran BranchIslamic Azad UniversityTehran***Iran Department of Mechanical Engineering College of EngineeringUniversity of Ha’ilHa’il City81451Saudi Arabia Fakulti Teknologi dan Kejuruteraan Mekanikal Universiti Teknikal Malaysia MelakaHang Tuah JayaDurian TunggalMelaka76100Malaysia Department of Mathematics Faculty of ScienceAswan UniversityAswan81528Egypt Department of Mathematics Faculty of ScienceAssuit UniversityAssuit71515Egypt Basic and Applied Sciences Department College of Engineering and TechnologyArab Academy for Science&Technology and Maritime Transport(AASTMT)Aswan Branch81511AswanEgypt Department of Chemical and Materials Engineering College of EngineeringNorthern Border UniversityArar91431Saudi Arabia

In this paper,the unsteady magnetohydrodynamic(MHD)-radiation-natural convection of a hybrid nanofluid within a U-shaped wavy porous cavity is *** problem has relevant applications in optimizing thermal management systems in electronic devices,solar energy collectors,and other industrial applications where efficient heat transfer is very *** study is based on the application of a numerical approach using the Finite Difference Method(FDM)for the resolution of the governing equations,which incorporates the Rosseland approximation for thermal radiation and the Darcy-Brinkman-Forchheimer model for porous *** was found that the increase of Hartmann number(Ha)causes a reduction of the average Nusselt number(Nu),with a maximum decrease of 25%observed as Ha increases from 0 to *** addition,the influence of the wall’s wave amplitude and the heat source length on the heat transfer rate was quantified,and it was revealed that at high wave amplitude,the average Nu increases by up to 15%.These findings suggest that manipulating magnetic field strength and cavity geometry can significantly enhance thermal *** novelty of this is related to the exploration of a U-shaped wavy cavity,which is not covered in previous studies,and to the detailed examination of the combined effects of magnetic fields,radiation,and hybrid nanofluids.

关键词： Thermal radiation wavy wall MHD natural convection hybrid-nanofluid porous medium

A global overview of the most important zoonotic bacteria pathogens transmitted from Rattus norvegicus to humans in urban environments

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Infectious Medicine 2022年第3期1卷 192-207页

作者： Sahar Sabour taher Azimi Ahmad Nasser Nahal Hadi Amin Mohsenzadeh Aref Shariati Department of Microbiology Faculty of MedicineAhvaz Jundishapur University of Medical SciencesAhvazIran Department of Bacteriology&Virology School of MedicineShiraz University of Medical ScienceShirazIran Department of Pathobiology School of Public HealthTehran University of Medical SciencesTehranIran Department of Microbiology Ardabil BranchIslamic Azad UniversityArdabilIran Molecular and medicine research center Khomein University of Medical SciencesKhomeinIran

Zoonotic pathogens,comprising over 61%of all pathogenic microorganisms,can be transmitted from different animals to individuals in numerous ways either in the presence or the absence of a *** new emerging human infectious diseases,these pathogens could be categorized into 4 groups,bacteria,viruses,parasites,and *** the wide range of reservoirs for zoonotic pathogens,tremendous attention has been attracted to wild rats,due to their global distribution not only in urban environments but also in the sylvatic and agricultural *** the nonce,zoonotic bacteria transmitted via wild rats have turned into a global public health problem probably due to their ability to induce re-emerging diseases even after eradication and controlling *** the importance of wild rats in spreading pathogens,little data are available about the bacterial diversity present in urban wild rat *** this review,we present a complete list of zoonotic bacterial pathogens isolated from wild rats in urban environments.

关键词： Zoonosis Bacterial diseases Zoonotic diseases Wild rats Rattus rattus

IoMT-Enabled Fusion-Based Model to Predict Posture for Smart Healthcare Systems

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Computers, Materials & Continua 2022年第5期71卷 2579-2597页

作者： taher M.Ghazal Mohammad Kamrul Hasan Siti Norul Huda Abdullah Khairul Azmi Abubakkar Mohammed A.M.Afifi Faculty of Information Science and Technology University Kebangsaan MalaysiaUKM43600SelangorMalaysia Skyline University College SharjahUnited Arab Emirates

Smart healthcare applications depend on data from wearable sensors(WSs)mounted on a patient’s body for frequent monitoring *** systems depend on multi-level data for detecting illnesses and consequently delivering correct diagnostic *** collection of WS data and integration of that data for diagnostic purposes is a difficult *** paper proposes an Errorless Data Fusion(EDF)approach to increase posture recognition *** research is based on a case study in a health *** the rise in smart healthcare systems,WS data fusion necessitates careful attention to provide sensitive analysis of the recognized *** a result,it is dependent on WS inputs and performs group analysis at a similar rate to improve diagnostic *** breakdowns,the constant time factor,aggregation,and analysis results all cause errors,resulting in rejected or incorrect *** paper resolves this problem by using EDF,which is related to patient situational discovery through healthcare surveillance *** of WS data are examined extensively using active and iterative learning to identify errors in specific *** technology improves position detection accuracy,analysis duration,and error rate,regardless of user *** devices play a critical role in the management and treatment of *** can ensure that patients are provided with a unique treatment for their medical *** paper discusses the EDF technique for optimizing posture identification accuracy through multi-feature *** first,the patients’walking patterns are tracked at various time *** characteristics are then evaluated in relation to the stored data using a random forest classifier.

关键词： Data fusion(DF) posture recognition healthcare systems(HCS) wearable sensor(WS) medical data errorless data fusion(EDF)

Optimizing Resource Allocation Framework for Multi-Cloud Environment

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Computers, Materials & Continua 2023年第5期75卷 4119-4136页

作者： Tahir Alyas taher M.Ghazal Badria Sulaiman Alfurhood Ghassan F.Issa Osama Ali Thawabeh Qaiser Abbas Department of Computer Science Lahore Garrison UniversityLahore54000Pakistan School of Information Technology Skyline University CollegeUniversity City Sharjah1797SharjahUAE Center for Cyber Security Faculty of Information Science and TechnologyUniversiti Kebansaan Malaysia(UKM)43600BangiSelangorMalaysia Department of Computer Sciences College of Computer and Information SciencesPrincess Nourah bint Abdulrahman UniversityRiyadh11564Saudi Arabia Skyline University College University City Sharjah1797SharjahUAE Faculty of Computer and Information Systems Islamic University of Madinah Madinah42351Saudi Arabia

Cloud computingmakes dynamic resource provisioning more *** a functioning service is crucial,and changes are made when particular criteria are *** research explores the decentralized multi-cloud environment for allocating resources and ensuring the Quality of Service(QoS),estimating the required resources,and modifying allotted resources depending on workload and parallelism due to *** allocation is a complex challenge due to the versatile service providers and resource *** engagement of different service and resource providers needs a cooperation strategy for a sustainable quality of *** objective of a coherent and rational resource allocation is to attain the quality of *** also includes identifying critical parameters to develop a resource allocation mechanism.A framework is proposed based on the specified parameters to formulate a resource allocation process in a decentralized multi-cloud *** three main parameters of the proposed framework are data accessibility,optimization,and *** an optimization technique,these three segments are further divided into subsets for resource allocation and long-term service *** CloudSim simulator has been used to validate the suggested *** experiments have been conducted to find the best configurations suited for enhancing collaboration and resource allocation to achieve sustained *** results support the suggested structure for a decentralized multi-cloud environment and the parameters that have been determined.

关键词： Multi-cloud query optimization cloud resources allocation modelling virtualization

One-pot five-component synthesis of highly functionalized piperidines using oxalic acid dihydrate as a homogenous catalyst

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Chinese Chemical Letters 2012年第5期23卷 569-572页

作者： Seyed Sajad Sajadikhah Malek taher Maghsoodlou Nourallah Hazeri Sayyed Mostafa Habibi-Khorassani Anthony C.Willis Department of Chemistry The University of Sistan and BaluchestanP.O.Box 98135-674ZahedanIran Research School of Chemistry The Australian National UniversityCanberraACT 0200Australia

An efficient green protocol is described for the preparation of highly functionalized piperidines via a one-pot five-component reaction between aromatic aldehydes,anilines andβ-ketoesters in the presence of oxalic acid dihydrate as catalyst in ethanol at ambient *** structure as well as the relative stereochemistry of these compounds was confirmed by single X-ray crystallographic analysis.

关键词： Piperidine Heterocycle Homogeneous catalyst Oxalic acid dihydrate Multi-component reaction

IoMT-Based Healthcare Framework for Ambient Assisted Living Using a Convolutional Neural Network

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Computers, Materials & Continua 2023年第3期74卷 6867-6878页

作者： Waleed T.Al-Sit Nidal A.Al-Dmour taher M.Ghazal Ghassan F.Issa Department of Computer Engineering Mutah UniversityAl-KarakJordanHigher Colleges of TechnologyDubaiUAE Department of Computer Engineering College of EngineeringMutah UniversityJordan School of Information Technology Skyline University CollegeUniversity City SharjahSharjahUAE Center for Cyber Security Faculty of Information Science and TechnologyUKM43600BangiSelangorMalaysia

In the age of universal computing,human life is becoming smarter owing to the recent developments in the Internet of Medical Things(IoMT),wearable sensors,and telecommunication innovations,which provide more effective and smarter healthcare *** has the potential to shape the future of clinical research in the healthcare *** sensors,patients,healthcare providers,and caregivers can connect through an IoMT network using software,information,and communication *** assisted living(AAL)allows the incorporation of emerging innovations into the routine life events of *** learning(ML)teaches machines to learn from human experiences and to use computer algorithms to“learn”information directly instead of relying on a *** the sample size accessible for learning increases,the performance of the algorithms *** paper proposes a novel IoMT-enabled smart healthcare framework for AAL to monitor the physical actions of patients using a convolutional neural network(CNN)algorithm for fast analysis,improved decision-making,and enhanced treatment *** simulation results showed that the prediction accuracy of the proposed framework is higher than those of previously published approaches.

关键词： Smart healthcare system neural network machine learning