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Prediction and validation of molecular biological mechanism of Fuzheng Huayu capsule in the treatment of liver cancer

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Cancer Advances 2023年第7期6卷 1-9页

作者： Zi-Ning Wang Ayesha T.tahir Saba Waris Wen-Bo Cheng Jun Kang School of Life Sciences Tianjin UniversityTianjin 300072China Department of Biosciences COMSATS University IslamabadIslamabad 45550Pakistan Department of Gynacology Allama Lqbal Medical CollegeLahore 54000Pakistan Tianjin Key Laboratory of Medical Mass Spectrometry for Accurate Diagnosis Tianjin 300399China

Background:Fuzheng Huayu capsule(FZHY)combined with antiviral treatment has been shown to significantly reduce the risk of liver cancer in patients with hepatitis B ***,the potential of FZHY to directly treat liver cancer remains largely *** study aims to investigate the molecular mechanism underlying the potential of FZHY in treating liver ***:A network pharmacological analysis was performed using the Traditional Chinese Medicine Systems Pharmacology database to identify FZHY compounds and *** targets were searched using the Genecards database,and transcriptome data was downloaded from the NCBI *** Ontology analysis was conducted using the DAVID database,and Kyoto Encyclopedia of Genes and Genomes analysis was based on KOBAS and bioinformatics *** Swissdock database was used for molecular *** cell experiments,the half inhibitory concentration(IC50)of FZHY was determined using the CCK8 *** effects of FZHY on cell viability,apoptosis,and mitochondrial membrane potential were evaluated using a fluorescence microscope and flow *** molecular mechanism of FZHY in treating liver cancer was verified using quantitative polymerase chain ***:A total of 127 compounds and 184 proteins were identified as potential active ingredients and putative liver cancer-related ***,1,899 liver cancer targets,279 transcriptome targets,and 3 pathways(p53 signaling pathway,apoptosis and PI3K-Akt pathway)were *** FZHY-targets-liver cancer interaction network was ***50 of FZHY lyophilized powder solution to liver cancer was 5.13 mg/mL(IC50=5.13 mg/mL).FZHY treatment led to an increase in the ratio of cell apoptosis and induced mitochondrial membrane potential damage,resulting in an increase in the number of dead *** expression levels of CCNB1 and BIRC5 were induced with FZHY treatment,while the expression levels of AKR1C3 and IGF2 were ***

关键词： liver cancer Fuzheng Huayu capsule traditional Chinese medicine CCNB1 BIRC5 AKR1C3 IGF2

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Multiple quantitative trait loci contribute to resistance to bacterial canker incited by Pseudomonas syringae *** in kiwifruit(Actinidia chinensis)

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Horticulture Research 2019年第1期6卷 471-488页

作者： Jibran tahir Stephen Hoyte Heather Bassett Cyril Brendolise Abhishek Chatterjee Kerry Templeton Cecilia Deng Ross Crowhurst Mirco Montefiori Ed Morgan Andrew Wotton Keith Funnell Claudia Wiedow Mareike Knaebel Duncan Hedderley Joel Vanneste John McCallum Kirsten Hoeata Amardeep Nath David Chagné Luis Gea Susan E.Gardiner The New Zealand Institute for Plant and Food Research Limited Private Bag 11030Manawatu Mail CentrePalmerston North 4442New Zealand The New Zealand Institute for Plant Food Research Limited HamiltonNew Zealand The New Zealand Institute for Plant and Food Research Limited Private Bag 92–169Auckland 1025New Zealand New Plant via Malpighi 5Forlì47122Italy The New Zealand Institute for Plant and Food Research Limited LincolnNew Zealand The New Zealand Institute for Plant and Food Research Limited 412 No 1 RoadRD2Te Puke 3182New Zealand

Pseudomonas syringae ***(Psa)biovar 3,a virulent,canker-inducing pathogen is an economic threat to the kiwifruit(Actinidia spp.)industry *** commercially grown diploid(2×)*** *** is more susceptible to Psa than tetraploid and hexaploid *** information on the genetic loci modulating Psa resistance in kiwifruit is not *** we report mapping of quantitative trait loci(QTLs)regulating resistance to Psa in a diploid kiwifruit population,derived from a cross between an elite Psa-susceptible‘Hort16A’and a resistant male breeding parent *** high-density genetic maps and intensive phenotyping,we identified a single QTL for Psa resistance on Linkage Group(LG)27 of‘Hort16A’revealing 16–19%phenotypic variance and candidate alleles for susceptibility and resistance at this *** addition,six minor QTLs were identified in P1 on distinct LGs,exerting 4–9%*** in the F1 population is improved by additive effects from‘Hort16A’and P1 QTLs providing evidence that divergent genetic pathways interact to combat the virulent Psa *** different bioassays further identified new QTLs for tissue-specific responses to *** genetic marker at LG27 QTL was further verified for association with Psa resistance in diploid Actinidia chinensis *** analysis of Psa-resistant and susceptible genotypes in field revealed hallmarks of basal defense and provided candidate RNA-biomarkers for screening for Psa resistance in greenhouse conditions.

关键词： breeding trait

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Endoscopic pancreatic sphincterotomy:indications,outcome,and a safe stentless technique

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World Journal of Gastroenterology 1998年第3期4卷 57-57页

作者： Eric Elton, MD, Douglas A. Howell, MD, Willis G. Parsons, MD, tahir Qaseem, MD, Brian L. Hanson, MDPortland, MaineDivision of Gastroenterology, Maine Medical Center, Portland, Maine

AIM Endoscopic pancreatic sphincterotomy is less widely practiced than biliary sphincterotomy, in part because of the lack of firm data regarding its indications and safety. In addition, recent reports of ductal and parenchymal changes occurring after pancreatic stenting raise concerns about the standard practice of stent placement at the time of pancreatic sphincterotomy. We report our experience with pancreatic sphincterotomy and describe the use of a technique involving overnight nasopancreatic drainage rather than stenting.METHODS We reviewed the records of the 164 pancreatic sphincterotomies performed on 160 patients at our institution between January 1, 1991, and October 1, 1996, comparing procedures done with overnight nasopancreatic catheter placement with those done with stenting or no drainage. We also examined the longterm clinical outcome of patients after pancreatic sphincterotomy.RESULTS Of the 164 sphincterotomies, 98 were done with overnight nasopancreatic drainage, 50 with stent placement, and 16 with no drainage. Complications (all pancreatitis) were significantly more frequent in the group with no drainage (125%) as compared with those with drainage (07%); P<0003. Nasopancreatic drainage was as safe as stent placement, with no complications after 98 procedures. Pancreatic sphincterotomy was effective when used as primary therapy, with 64% of patients so treated experiencing complete and longlasting resolution of symptoms after the procedure.CONCLUSION Pancreatic sphincterotomy is safe and effective, although pancreatic drainage is required to reduce the incidence of pancreatitis. Overnight nasopancreatic drainage is the method of choice, as it carries as low a complication rate as stent placement, but without the need for a repeat procedure, and presumably without the risk of ductal and parenchymal damage.

关键词： sphincterotomy indications

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博斯腾湖与伊塞克湖水位变化特征及预测对比

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中国沙漠 2015年第3期35卷 792-799页

作者：米热古力.艾尼瓦尔海米提.依米提麦麦提吐尔逊.艾则孜夏库热.塔依尔 Yorov Hasan 新疆大学资源与环境科学学院新疆乌鲁木齐830046 新疆师范大学新疆干旱区湖泊环境与资源重点实验室新疆乌鲁木齐830054 新疆师范大学地理科学与旅游学院新疆乌鲁木齐830054

根据1961—2012年湖泊水位观测资料,采用时间序列线性趋势分析与小波分析法,对比研究了博斯腾湖与伊塞克湖近50多年来水位变化特征,并对湖泊未来水位变化趋势进行预测。结果显示:(1)1961—2012年,博斯腾湖和伊塞克湖年水位总体呈显著的... 详细信息

根据1961—2012年湖泊水位观测资料,采用时间序列线性趋势分析与小波分析法,对比研究了博斯腾湖与伊塞克湖近50多年来水位变化特征,并对湖泊未来水位变化趋势进行预测。结果显示:(1)1961—2012年,博斯腾湖和伊塞克湖年水位总体呈显著的下降趋势。20世纪80年代中期之前,两湖水位变化趋势基本一致,都平稳下降;90年代后,博斯腾湖水位变化波动比伊塞克湖更为频繁,经历了迅速上升和下降的阶段,而伊塞克湖年水位较为稳定。(2)水位小波分析结果表明,博斯腾湖和伊塞克湖年水位变化分别存在18a和22a的主周期,从水位未来变化趋势预测结果来看,博斯腾湖水位将来一段时间继续下降,伊塞克湖水位则继续上升。

关键词：博斯腾湖伊塞克湖水位小波分析对比分析

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新疆地区光伏产业的发展现状与前景分析

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太阳能 2021年第8期 19-25页

作者：阿依加马力·艾尼塔伊尔江·巴合依新疆维吾尔自治区工业经济和信息化研究院乌鲁木齐830000 国网乌鲁木齐供电公司乌鲁木齐830000

近几年来,在光伏发电成本大幅降低和政策大力支持下,光伏产业得到了快速发展,光伏发电已成为成熟的太阳能应用技术,光伏发电技术的大规模开发和利用已成为各国政府履行向清洁能源转型承诺的重要方式。在对我国光伏产业整体的发展现状及... 详细信息

近几年来,在光伏发电成本大幅降低和政策大力支持下,光伏产业得到了快速发展,光伏发电已成为成熟的太阳能应用技术,光伏发电技术的大规模开发和利用已成为各国政府履行向清洁能源转型承诺的重要方式。在对我国光伏产业整体的发展现状及新疆维吾尔自治区(下文简称“新疆地区”)光伏产业发展现状进行回顾的基础上,研究分析了新疆地区光伏产业的发展优势、当前存在的问题,以及发展潜力,并提出了相应的对策建议。

关键词：新疆地区光伏产业光伏发电政策支持成本清洁能源发展潜力

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Heavy metal contents in soil of major towns in the east coast of Peninsular Malaysia

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Chinese Journal Of Geochemistry 2006年第B8期25卷 56-56页

作者： Seng Chee Poh Norhaxati Mohd tahir Hafiza Mohamed Zuki Mohd Izwadi Musa Khai Hock Ng Noor Azhar Mohamed Shazili Department of Chemistry Science Faculty of Science and Technology KUSTEM Institute of Oceanography KUSTEM

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硅和蓝宝石基底上的高T_c薄膜(英文)

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上海师范大学学报（自然科学版） 2005年第1期34卷 29-35页

作者：贾米尔-温纳毕艾斯法塔赫尔哈希米R A 古拉姆-伊夏克-克汗工程科学与技术学院工程科学系卡拉奇大学物理系凝聚态材料实验室吉纳女子大学

使用多层沉积和大块沉积两种技术,在硅和蓝宝石的单晶基底上沉积了Yba2XCu3O7高Tc薄膜.实验显示:在硅基底上得到了转变温度为80K的期待结果.

关键词：高Tc薄膜 Yba2XCu3O7 单晶基底沉积技术

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新疆阔克阿木提果皮总黄酮的提取工艺及其抗氧化活性研究

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喀什大学学报 2016年第3期37卷 20-23页

作者：热萨莱提·伊敏塔依尔·吾拉音木合塔尔·吐尔洪阿依努尔喀什大学化学与环境科学学院新疆喀什844008 喀什大学新疆特色药食用植物资源化学实验室新疆喀什844008

考察甲醇（乙醇）超声、甲醇（乙醇）回流、甲醇（乙醇）连续回流、甲醇（乙醇）常温浸泡等不同提取方法对阔克阿木提果皮总黄酮提取效果的影响,并探讨所得黄酮类化合物的抗氧化活性.结果表明,用甲醇和乙醇回流法黄酮提取率最高且接近... 详细信息

考察甲醇（乙醇）超声、甲醇（乙醇）回流、甲醇（乙醇）连续回流、甲醇（乙醇）常温浸泡等不同提取方法对阔克阿木提果皮总黄酮提取效果的影响,并探讨所得黄酮类化合物的抗氧化活性.结果表明,用甲醇和乙醇回流法黄酮提取率最高且接近分别为21.90 mg/g和21.71 mg/g,RSD值分别为0.32和0.82,并且在给定的质量浓度范围内（0.1~0.6 mg/m L）黄酮类组分清除DPPH达到83.99%,且浓度高于0.25 mol/m L时明显高于BHT,黄酮类组分清除羟基自由的能力达92.80%,浓度大概在0.35 mol/m L以上时高于BHT.

关键词：阔克阿木提果皮总黄酮提取工艺抗氧化活性

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面向韵律层边界自动划分的维吾尔语词性自动标注技术研究

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计算机应用与软件 2011年第8期28卷 165-168页

作者：努尔比娅.塔依尔地里木拉提.吐尔逊艾斯卡尔.肉孜新疆大学信息科学与工程学院新疆乌鲁木齐830046 新疆大学数学与系统科学学院新疆乌鲁木齐830046

以语音合成系统文本分析模块中的韵律边界自动划分技术为背景,重点研究了维吾尔语词性自动标注技术:首先根据应用领域的特点确定词性的种类及其判定规则,筛选文本句子并对其进行手动词性标注,然后通过统计获得了词性概率表和词性对照表... 详细信息

以语音合成系统文本分析模块中的韵律边界自动划分技术为背景,重点研究了维吾尔语词性自动标注技术:首先根据应用领域的特点确定词性的种类及其判定规则,筛选文本句子并对其进行手动词性标注,然后通过统计获得了词性概率表和词性对照表,最后采用基于HMM模型的二元文法来实现维吾尔语词性自动标注。在实验中,为了验证算法的有效性,筛选了10000条句子作为训练样本,另选用500条句子作为测试样本。实验结果表明,该研究思路的可行性和有效性。

关键词：维吾尔语韵律层词性标注语音合成文本分析

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Effects of Supplementing Various Linoleic to α-linolenic Acid Ratios and Vitamin A on Production Performance and Egg Characteristics of Laying Hens during Summer Months

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Journal of Zoological Research 2019年第1期1卷 1-9页

作者： S.Ahmad M.Yousaf Z.Kamran M.U.Sohail M.N.tahir K.C.Koutoulis A.Manzoor 无 University College of Veterinary and Animal Sciences The Islamia University of Bahawalpur-63100Pakistan Institute of Animal Sciences University of AgricultureFaisalabad-38040Pakistan Department of Physiology GC UniversityFaisalabad-38000Pakistan Department of Avian Medicine School of Health SciencesUniversity of ThessalyKarditsa-43100Greece Department of Meat Science and Technology University of Veterinary and Animal SciencesLahore-54000Pakistan Poultry Production Division Al-Watania Poultry Institute of TechnologyAl-Bukayriyah51941Saudi Arabia

In the present feeding trial,responses of laying hens that were kept at high ambient temperature and Fed with various dietary ratios of linoleic acid(LNA)toα-linolenic acid(ALA)and vitamin A levels on production performance and egg quality traits were evaluated.A total of 360 Leghorn laying hens at 40th week of age(average initial body weight;1.79±0.23 kg)were fed with various combinations of canola oil and linseed oil containing diets to achieve LNA to ALA dietary ratios of 20:1,10:1,4:1,2:1,1:1 and 1:2,each supplemented with 3000 or 10000 IU of vitamin A/kg of *** experiment was designed as a 6×2 factorial Completely Randomized Design that continued for 12 *** intake,body weight gain,egg production and egg quality traits were recorded during the *** dietary LNA to ALA ratio or increasing poly unsaturated fatty acids(PUFA)in the diet decreased(P0.05)by dietary *** conversion ratio per kg eggs,egg weight and egg-shell thickness showed a curvilinear(P<0.05)response to decreasing dietary LNA to ALA *** the dietary ratio of LNA to ALA of 4:1 or less could produce eggs by the hens with desirable quantities of n-6 and n-3 PUFA–that are characteristics of functional diets–the performance of laying hens in terms of body weight gain and egg-yolk percentage was slightly ***,a 4:1 or 2:1 LNA to ALA combination can make a borderline between the production traits and the feed economics.

关键词： Egg quality Fatty acids Hot climate Layers performance Vitamin A

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